FR2872170B1 - NON-INTERACTIVE AND NON-REPLICATIVE LENTIVIRUS, PREPARATION AND USES - Google Patents

NON-INTERACTIVE AND NON-REPLICATIVE LENTIVIRUS, PREPARATION AND USES

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Publication number
FR2872170B1
FR2872170B1 FR0407017A FR0407017A FR2872170B1 FR 2872170 B1 FR2872170 B1 FR 2872170B1 FR 0407017 A FR0407017 A FR 0407017A FR 0407017 A FR0407017 A FR 0407017A FR 2872170 B1 FR2872170 B1 FR 2872170B1
Authority
FR
France
Prior art keywords
interactive
preparation
vivo
nervous system
central nervous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0407017A
Other languages
French (fr)
Other versions
FR2872170A1 (en
Inventor
Jacques Mallet
Che Serguera
Stephanie Philippe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite Pierre et Marie Curie Paris 6
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0407017A priority Critical patent/FR2872170B1/en
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to CNA2005800209389A priority patent/CN101023177A/en
Priority to CA2579753A priority patent/CA2579753C/en
Priority to AT05779704T priority patent/ATE524554T1/en
Priority to EP05779704A priority patent/EP1761635B1/en
Priority to PCT/FR2005/001604 priority patent/WO2006010834A1/en
Priority to AU2005266221A priority patent/AU2005266221B2/en
Priority to US11/628,534 priority patent/US8119119B2/en
Priority to JP2007517365A priority patent/JP4861314B2/en
Publication of FR2872170A1 publication Critical patent/FR2872170A1/en
Application granted granted Critical
Publication of FR2872170B1 publication Critical patent/FR2872170B1/en
Priority to IL179740A priority patent/IL179740A0/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
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    • A61P27/02—Ophthalmic agents
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N15/09—Recombinant DNA-technology
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
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    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
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    • C12N2810/6072—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses
    • C12N2810/6081—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses rhabdoviridae, e.g. VSV

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Abstract

The invention concerns a non-integrative and non-replicative recombinant lentivirus as well as its uses, in particular for preparing a composition for transferring genes in vitro, ex vivo or in vivo. The invention is useful for transferring genes in any mammal organism, for example in liver, muscle, pancreas or central nervous system (including the ocular sphere) tissues or cells, and in particular for treating disorders or pathologies such as, for example, central nervous system, including the ocular sphere, disorders.
FR0407017A 2004-06-25 2004-06-25 NON-INTERACTIVE AND NON-REPLICATIVE LENTIVIRUS, PREPARATION AND USES Expired - Fee Related FR2872170B1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR0407017A FR2872170B1 (en) 2004-06-25 2004-06-25 NON-INTERACTIVE AND NON-REPLICATIVE LENTIVIRUS, PREPARATION AND USES
JP2007517365A JP4861314B2 (en) 2004-06-25 2005-06-24 Non-integrating and non-replicating recombinant lentivirus, its preparation and use
AT05779704T ATE524554T1 (en) 2004-06-25 2005-06-24 NON-INTEGRATIVE AND NON-REPLICATIVE LENTIVIRUS, PRODUCTION AND USES
EP05779704A EP1761635B1 (en) 2004-06-25 2005-06-24 Non-integrative and non-replicative lentivirus, preparation and uses thereof
PCT/FR2005/001604 WO2006010834A1 (en) 2004-06-25 2005-06-24 Non-integrative and non-replicative lentivirus, preparation and uses thereof
AU2005266221A AU2005266221B2 (en) 2004-06-25 2005-06-24 Non-integrative and non-replicative lentivirus, preparation and uses thereof
CNA2005800209389A CN101023177A (en) 2004-06-25 2005-06-24 Non-integrative and non-replicative lentivirus, preparation and uses thereof
CA2579753A CA2579753C (en) 2004-06-25 2005-06-24 Non-integrative and non-replicative lentivirus, preparation and uses thereof
US11/628,534 US8119119B2 (en) 2004-06-25 2005-06-24 Non-integrative and non-replicative lentivirus, preparation and uses thereof
IL179740A IL179740A0 (en) 2004-06-25 2006-11-30 Non-integrative and non-replicative lentivirus, preparation and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0407017A FR2872170B1 (en) 2004-06-25 2004-06-25 NON-INTERACTIVE AND NON-REPLICATIVE LENTIVIRUS, PREPARATION AND USES

Publications (2)

Publication Number Publication Date
FR2872170A1 FR2872170A1 (en) 2005-12-30
FR2872170B1 true FR2872170B1 (en) 2006-11-10

Family

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FR0407017A Expired - Fee Related FR2872170B1 (en) 2004-06-25 2004-06-25 NON-INTERACTIVE AND NON-REPLICATIVE LENTIVIRUS, PREPARATION AND USES

Country Status (10)

Country Link
US (1) US8119119B2 (en)
EP (1) EP1761635B1 (en)
JP (1) JP4861314B2 (en)
CN (1) CN101023177A (en)
AT (1) ATE524554T1 (en)
AU (1) AU2005266221B2 (en)
CA (1) CA2579753C (en)
FR (1) FR2872170B1 (en)
IL (1) IL179740A0 (en)
WO (1) WO2006010834A1 (en)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0526211D0 (en) * 2005-12-22 2006-02-01 Oxford Biomedica Ltd Viral vectors
WO2007091066A1 (en) * 2006-02-07 2007-08-16 Ucl Business Plc Applications of non-integrating lentiviral vectors
DK2020444T3 (en) * 2007-08-03 2017-09-11 Pasteur Institut DEFECTIVE NON-INTEGRATIVE LENTIVIRAL TRANSMISSION VECTORS FOR VACCINES
CN108114276A (en) * 2007-08-03 2018-06-05 巴斯德研究院 Lentiviral gene transfer vector and its medical application
AU2013203416B2 (en) * 2007-08-03 2016-10-13 Centre National De La Recherche Scientifique (Cnrs) Lentiviral gene transfer vectors and their medicinal applications
WO2009054985A1 (en) 2007-10-25 2009-04-30 Sangamo Biosciences, Inc. Methods and compositions for targeted integration
US20110142880A1 (en) * 2008-03-28 2011-06-16 Franck Yann Lemiale Lentivirus-based immunogenic vectors
WO2009131706A1 (en) * 2008-04-26 2009-10-29 Yung-Nien Chang Site-specific-integration lentiviral vectors
RU2012140691A (en) * 2009-03-13 2014-03-27 Лентиген Корпорейшен VACCINES BASED ON A NON-INTEGRABLE RETROVIRAL VECTOR
WO2010117464A1 (en) 2009-04-09 2010-10-14 Sangamo Biosciences, Inc. Targeted integration into stem cells
US8956828B2 (en) 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
EP2534163B1 (en) 2010-02-09 2015-11-04 Sangamo BioSciences, Inc. Targeted genomic modification with partially single-stranded donor molecules
DK2385107T3 (en) 2010-05-03 2016-12-12 Pasteur Institut Lentiviral vector-based immunological compounds against malaria
WO2012152912A1 (en) 2011-05-12 2012-11-15 Newvectys Genetically modified pig as a cancer prone model
ES2651922T3 (en) 2011-11-08 2018-01-30 Institut Pasteur High-affinity polypeptides for MAST2 and uses thereof
GB201202516D0 (en) 2012-02-13 2012-03-28 Ucl Business Plc Materials and methods relating to packaging cell lines
DK2831095T3 (en) 2012-03-30 2019-02-18 Immune Design Corp LENTIVIRAL VECTOR PARTICLES WITH IMPROVED TRANSDUCTION EFFICIENCY FOR CELL EXPRESSING DC SIGN
US9713635B2 (en) 2012-03-30 2017-07-25 Immune Design Corp. Materials and methods for producing improved lentiviral vector particles
SG10201912328UA (en) 2012-12-12 2020-02-27 Broad Inst Inc Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications
WO2014093709A1 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
WO2014152177A1 (en) 2013-03-15 2014-09-25 Anthrogenesis Corporation Modified t lymphocytes
CA2915845A1 (en) * 2013-06-17 2014-12-24 The Broad Institute, Inc. Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells
WO2014204724A1 (en) 2013-06-17 2014-12-24 The Broad Institute Inc. Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
EP3011034B1 (en) * 2013-06-17 2019-08-07 The Broad Institute, Inc. Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
AU2014281028B2 (en) 2013-06-17 2020-09-10 Massachusetts Institute Of Technology Delivery and use of the CRISPR-Cas systems, vectors and compositions for hepatic targeting and therapy
EP3725885A1 (en) 2013-06-17 2020-10-21 The Broad Institute, Inc. Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
WO2014204725A1 (en) 2013-06-17 2014-12-24 The Broad Institute Inc. Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
WO2015040063A1 (en) * 2013-09-17 2015-03-26 Inserm (Institut National De La Sante Et De La Recherche Medicale) Lentiviral vectors having a mutated integrase protein and uses thereof
EP2878667A1 (en) 2013-11-29 2015-06-03 Institut Pasteur TAL effector means useful for partial or full deletion of DNA tandem repeats
CN111206032A (en) 2013-12-12 2020-05-29 布罗德研究所有限公司 Delivery, use and therapeutic applications of CRISPR-CAS systems and compositions for genome editing
WO2015089364A1 (en) 2013-12-12 2015-06-18 The Broad Institute Inc. Crystal structure of a crispr-cas system, and uses thereof
EP3080271B1 (en) 2013-12-12 2020-02-12 The Broad Institute, Inc. Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
CA2932472A1 (en) 2013-12-12 2015-06-18 Massachusetts Institute Of Technology Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders
GB201322798D0 (en) 2013-12-20 2014-02-05 Oxford Biomedica Ltd Production system
BR112016024481A2 (en) 2014-04-25 2017-10-10 Bluebird Bio Inc chimeric mnd promoter antigen receptors
SI3151672T1 (en) 2014-06-06 2021-03-31 Bluebird Bio, Inc. Improved t cell compositions
EP3031923A1 (en) 2014-12-11 2016-06-15 Institut Pasteur Lentiviral vector-based japanese encephalitis immunogenic composition
EP3889260A1 (en) 2014-12-12 2021-10-06 The Broad Institute, Inc. Protected guide rnas (pgrnas)
BR112017012502B1 (en) 2014-12-12 2020-09-15 Bluebird Bio, Inc. POLYNUCLEOTIDE, CAR POLYPEPTIDE CODED BY THE SAID POLINUCLEOTIDE, VECTOR UNDERSTANDING THE SAID POLYNUCLEOTIDE, COMPOSITION UNDERSTANDING THE SAID VECTOR AND METHOD FOR GENERATING AN IMMUNE EFFECTIVE CELL UNDERSTANDING A CAR
CN109536474A (en) 2015-06-18 2019-03-29 布罗德研究所有限公司 Reduce the CRISPR enzyme mutant of undershooting-effect
WO2016205759A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
US10701165B2 (en) 2015-09-23 2020-06-30 Sensoriant, Inc. Method and system for using device states and user preferences to create user-friendly environments
WO2017060662A1 (en) * 2015-10-07 2017-04-13 The Secretary Of State For Health Method for providing a control for use in a screen for pathogenic virus
US11479755B2 (en) 2015-12-07 2022-10-25 2Seventy Bio, Inc. T cell compositions
CA3020993A1 (en) 2016-04-14 2017-10-19 Bluebird Bio, Inc. Salvage chimeric antigen receptor systems
WO2017214938A1 (en) * 2016-06-16 2017-12-21 毛侃琅 Lentiviral expression vector for specifically promoting high expression of bace1 gene, and applications thereof
EP3500696A4 (en) 2016-08-16 2020-04-08 Bluebird Bio, Inc. Il-10 receptor alpha homing endonuclease variants, compositions, and methods of use
US20190262398A1 (en) 2016-08-23 2019-08-29 Bluebird Bio, Inc. Tim3 homing endonuclease variants, compositions, and methods of use
CA3035455A1 (en) 2016-09-08 2018-03-15 Bluebird Bio, Inc. Pd-1 homing endonuclease variants, compositions, and methods of use
US11530395B2 (en) 2016-10-17 2022-12-20 2Seventy Bio, Inc. TGFBetaR2 endonuclease variants, compositions, and methods of use
MX2019005724A (en) 2016-11-17 2019-07-08 Bluebird Bio Inc TGFß SIGNAL CONVERTOR.
CA3046079A1 (en) * 2016-12-06 2018-06-14 Bluebird Bio, Inc. Gene therapy for mucopolysaccharidosis, type i
KR20190088554A (en) * 2016-12-06 2019-07-26 블루버드 바이오, 인코포레이티드. Gene therapy for type II mucopolysaccharidosis
EP3357506A1 (en) 2017-02-02 2018-08-08 Institut Pasteur Multiple malaria pre-erythrocytic antigens and their use in the elicitation of a protective immune response in a host
EP3357504A1 (en) 2017-02-02 2018-08-08 Institut Pasteur Functional screening of antigenic polypeptides - use for the identification of antigens eliciting a protective immune response and for the selection of antigens with optimal protective activity
EP3583203B1 (en) 2017-02-15 2023-11-01 2seventy bio, Inc. Donor repair templates multiplex genome editing
MA48797A (en) 2017-05-25 2020-04-08 Bluebird Bio Inc CBLB ENDONUCLEASE VARIANTS, COMPOSITIONS AND METHODS OF USE
US11779654B2 (en) 2017-10-04 2023-10-10 2Seventy Bio, Inc. PCSK9 endonuclease variants, compositions, and methods of use
EP3696272A1 (en) 2017-12-22 2020-08-19 Oxford BioMedica (UK) Limited Retroviral vector
DE102018010282A1 (en) 2018-01-17 2019-07-18 Immatics US, Inc. Method for determining the effectiveness of viral vectors
DE102018100967B4 (en) 2018-01-17 2019-08-14 Immatics US, Inc. METHOD FOR DETERMINING THE EFFECTIVENESS OF VIRAL VECTORS
DK3806903T3 (en) 2018-06-14 2024-04-15 2Seventy Bio Inc CD79A CHIMERIC ANTIGEN RECEPTORS
CN112689516A (en) 2018-07-11 2021-04-20 细胞基因公司 Use of anti-BCMA chimeric antigen receptors
KR20210102870A (en) 2018-08-30 2021-08-20 테나야 테라퓨틱스, 인코포레이티드 Cardiac Cell Reprogramming with Myocardin and ASCL1
WO2020072059A1 (en) 2018-10-04 2020-04-09 Bluebird Bio, Inc. Cblb endonuclease variants, compositions, and methods of use
US20230137971A1 (en) 2019-07-11 2023-05-04 Tenaya Therapeutics Inc. Cardiac cell reprogramming with micrornas and other factors
EP3770264A1 (en) 2019-07-22 2021-01-27 Genethon Precise integration using nuclease targeted idlv
US20220331363A1 (en) 2019-09-20 2022-10-20 Shanghai GenBase Biotechnology Co., Ltd. Bcma-targeted antibody and chimeric antigen receptor
CA3160178A1 (en) 2019-11-05 2021-05-14 Celgene Corporation Uses of anti-bcma chimeric antigen receptors
CN114667161A (en) 2019-11-12 2022-06-24 牛津生物医学（英国）有限公司 Production system
WO2021160993A1 (en) 2020-02-13 2021-08-19 Oxford Biomedica (Uk) Limited Production of lentiviral vectors
EP4118217A1 (en) 2020-03-13 2023-01-18 Oxford BioMedica (UK) Limited Lentiviral vectors
WO2021212279A1 (en) * 2020-04-20 2021-10-28 广东东阳光药业有限公司 Titer improved transfer plasmid for lentivirus
CN114807228B (en) * 2020-04-27 2023-12-15 北京化工大学 Expression system of T7RNA polymerase and T7 promoter and method for expressing protein in eukaryote by using same
GB202007199D0 (en) 2020-05-15 2020-07-01 Oxford Biomedica Ltd Viral vector production
US11781156B2 (en) 2020-10-09 2023-10-10 Tenaya Therapeutics, Inc. Plakophillin-2 gene therapy methods and compositions
EP3984548A1 (en) 2020-10-16 2022-04-20 Institut Pasteur Generation of lentiviral vectors enabling routing antigens to mhc-ii pathway and inducing cd4+ and cd8+ t-cell responses immune response in a host
JP2023550309A (en) 2020-11-04 2023-12-01 セルジーン コーポレーション CAR T cell therapy in patients who previously received anticancer alkylating agent therapy
GB202017725D0 (en) 2020-11-10 2020-12-23 Oxford Biomedica Ltd Method
EP4272002A1 (en) 2020-12-04 2023-11-08 Celgene Corporation Uses of chimeric antigen receptor (car) t-cell therapies in combination with inhibitors of inflammation-related soluble factors
CA3209285A1 (en) 2021-03-12 2022-09-15 Pierre Charneau Lentiviral vectors targeting antigens to mhc-ii pathway and inducing protective cd8+ and cd4+ t-cell immunity in a host
IL307598A (en) 2021-04-16 2023-12-01 Juno Therapeutics Inc T cell therapy in patients who have had prior stem cell transplant
AU2022310862A1 (en) 2021-07-14 2024-02-01 Regeneron Pharmaceuticals, Inc. Engineered t cell receptors fused to binding domains from antibodies
GB202114530D0 (en) 2021-10-12 2021-11-24 Oxford Biomedica Ltd Retroviral vectors
GB202114534D0 (en) 2021-10-12 2021-11-24 Oxford Biomedica Ltd Novel viral regulatory elements
GB202114529D0 (en) 2021-10-12 2021-11-24 Oxford Biomedica Ltd Lentiviral vectors
GB202114528D0 (en) 2021-10-12 2021-11-24 Oxford Biomedica Ltd Lentiviral vectors
GB202114532D0 (en) 2021-10-12 2021-11-24 Oxford Biomedica Ltd Lentiviral Vectors
CN114181972A (en) * 2021-11-23 2022-03-15 上海本导基因技术有限公司 Lentiviral vectors suitable for gene therapy of refractory angiogenic eye diseases
GB202117844D0 (en) 2021-12-09 2022-01-26 Oxford Biomedica Ltd Purification method
WO2023196996A2 (en) 2022-04-08 2023-10-12 2Seventy Bio, Inc. Multipartite receptor and signaling complexes
WO2023198828A1 (en) 2022-04-13 2023-10-19 Universitat Autònoma De Barcelona Treatment of neuromuscular diseases via gene therapy that expresses klotho protein
WO2023220641A2 (en) 2022-05-11 2023-11-16 Juno Therapeutics, Inc. Methods and uses related to t cell therapy and production of same
WO2023230512A1 (en) 2022-05-26 2023-11-30 2Seventy Bio, Inc. Compositions for maintaining lentiviral vector and uses thereof
GB202211935D0 (en) 2022-08-16 2022-09-28 Oxford Biomedica Ltd envelope proteins
WO2024084041A2 (en) 2022-10-21 2024-04-25 Institut Pasteur Polynucleotides and lentiviral vectors expressing non-structural antigens of a flavivirus selected from the group of denv, zikv and yfv, inducing protective cd8+ t-cell immunity in a host
WO2024102954A1 (en) 2022-11-10 2024-05-16 Massachusetts Institute Of Technology Activation induced clipping system (aics)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3140757B2 (en) 1989-02-06 2001-03-05 デイナ・フアーバー・キヤンサー・インステイテユート Packaging defective HIV provirus, cell lines and uses thereof
US5665577A (en) 1989-02-06 1997-09-09 Dana-Farber Cancer Institute Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
US5981276A (en) 1990-06-20 1999-11-09 Dana-Farber Cancer Institute Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
ATE429505T1 (en) * 1996-02-21 2009-05-15 Genetic Immunity Kft METHOD AND COMPOSITIONS FOR GENETIC PROTECTIVE AND THERAPEUTIC IMMUNIZATION
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
ES2291025T3 (en) 1998-05-13 2008-02-16 Genetix Pharmaceuticals Inc. LENTIVIRAL PACKAGING CELLS.
WO2000039304A2 (en) * 1998-12-31 2000-07-06 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
WO2000072886A1 (en) * 1999-05-26 2000-12-07 Dana-Farber Cancer Institute, Inc. Episomally replicating lentiviral vectors
WO2001027304A2 (en) 1999-10-12 2001-04-19 Institut Pasteur Lentiviral triplex dna, and vectors and recombinant cells containing lentiviral triplex dna
WO2002024897A2 (en) * 2000-09-22 2002-03-28 Virxsys Conditionally replicating viral vectors and their use
FR2825372B1 (en) 2001-06-01 2004-06-18 Centre Nat Rech Scient PSEUDOTYPING OF HIV-1 VECTORS WITH RHABDOVIRUS ENVELOPES
US20070042494A1 (en) * 2005-05-31 2007-02-22 Tal Kafri Heterologous retroviral packaging system

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