WO2000031263A3 - Gtpase associated proteins - Google Patents

Gtpase associated proteins Download PDF

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Publication number
WO2000031263A3
WO2000031263A3 PCT/US1999/028013 US9928013W WO0031263A3 WO 2000031263 A3 WO2000031263 A3 WO 2000031263A3 US 9928013 W US9928013 W US 9928013W WO 0031263 A3 WO0031263 A3 WO 0031263A3
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WO
WIPO (PCT)
Prior art keywords
gtpap
associated proteins
provides
gtpase
gtpase associated
Prior art date
Application number
PCT/US1999/028013
Other languages
French (fr)
Other versions
WO2000031263A2 (en
Inventor
Jennifer L Hillman
Y Tom Tang
Olga Bandman
Preeti Lal
Henry Yue
Dyung Aina M Lu
Mariah R Baughn
Junming Yang
Yalda Azimzai
Original Assignee
Incyte Pharma Inc
Jennifer L Hillman
Y Tom Tang
Olga Bandman
Preeti Lal
Henry Yue
Dyung Aina M Lu
Mariah R Baughn
Junming Yang
Yalda Azimzai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharma Inc, Jennifer L Hillman, Y Tom Tang, Olga Bandman, Preeti Lal, Henry Yue, Dyung Aina M Lu, Mariah R Baughn, Junming Yang, Yalda Azimzai filed Critical Incyte Pharma Inc
Priority to CA002351361A priority Critical patent/CA2351361A1/en
Priority to EP99960585A priority patent/EP1135484A2/en
Priority to AU17449/00A priority patent/AU1744900A/en
Priority to JP2000584072A priority patent/JP2002530109A/en
Publication of WO2000031263A2 publication Critical patent/WO2000031263A2/en
Publication of WO2000031263A3 publication Critical patent/WO2000031263A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C07K14/4706—Guanosine triphosphatase activating protein, GAP
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Abstract

The invention provides human GTPase associated proteins (GTPAP) and polynucleotides which identify and encode GTPAP. The invention also provides expression vectors, host cells, antibodies, agonist, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of GTPAP.
PCT/US1999/028013 1998-11-23 1999-11-23 Gtpase associated proteins WO2000031263A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002351361A CA2351361A1 (en) 1998-11-23 1999-11-23 Gtpase associated proteins
EP99960585A EP1135484A2 (en) 1998-11-23 1999-11-23 Gtpase associated proteins
AU17449/00A AU1744900A (en) 1998-11-23 1999-11-23 Gtpase associated proteins
JP2000584072A JP2002530109A (en) 1998-11-23 1999-11-23 GTPase-related protein

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10959298P 1998-11-23 1998-11-23
US11861099P 1999-02-04 1999-02-04
US12799099P 1999-04-06 1999-04-06
US60/127,990 1999-04-06
US60/118,610 1999-04-06
US60/109,592 1999-04-06

Publications (2)

Publication Number Publication Date
WO2000031263A2 WO2000031263A2 (en) 2000-06-02
WO2000031263A3 true WO2000031263A3 (en) 2000-09-14

Family

ID=27380691

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/028013 WO2000031263A2 (en) 1998-11-23 1999-11-23 Gtpase associated proteins

Country Status (5)

Country Link
EP (1) EP1135484A2 (en)
JP (1) JP2002530109A (en)
AU (1) AU1744900A (en)
CA (1) CA2351361A1 (en)
WO (1) WO2000031263A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6730778B2 (en) * 1997-12-19 2004-05-04 Pharmacia And Upjohn Company Human sel-10 polypeptides and polynucleotides that encode them
US7820619B1 (en) 1998-02-18 2010-10-26 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Antimicrobial peptides and derived metapeptides
WO1999042119A1 (en) 1998-02-18 1999-08-26 Harbor-Ucla Research And Education Institute Antimicrobial peptides and derived metapeptides
US6448073B1 (en) * 2000-01-28 2002-09-10 Ludwig Institute For Cancer Research Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
EP1278848A1 (en) * 2000-05-05 2003-01-29 MERCK PATENT GmbH New ras guanine-nucleotide-exchange factor 1 (nrg1)
WO2002018577A2 (en) * 2000-08-30 2002-03-07 Millennium Pharmaceuticals, Inc. 48921, a novel human gtp releasing factor and uses therefor
WO2002079401A2 (en) * 2001-03-28 2002-10-10 Wyeth Novel rgs9 protein binding interactions and methods of use thereof
WO2003024999A2 (en) * 2001-09-14 2003-03-27 Novartis Pharma Gmbh THE F-BOX PROTEIN hCdc4 TARGETS CYCLIN E FOR UBIQUITINYLATION AND DEGRADATION
US7138512B2 (en) * 2002-04-10 2006-11-21 Georgetown University Gene SHINC-2 and diagnostic and therapeutic uses thereof
CA2501602A1 (en) * 2002-10-11 2004-04-22 Thomas Jefferson University Novel tumor suppressor gene and compositions and methods for making and using the same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990000607A2 (en) * 1988-07-08 1990-01-25 Cetus Corporation Gap gene sequences and diagnostic uses thereof
WO1991015582A2 (en) * 1990-03-30 1991-10-17 Cetus Corporation PURIFIED RAP GAPs, RAP GAP SEQUENCES, AND USES THEREOF
WO1994016069A2 (en) * 1993-01-15 1994-07-21 Schering Corporation Ras associated gap proteins
WO1998037196A1 (en) * 1997-02-25 1998-08-27 Ludwig Institute For Cancer Research PARG, A GTPase ACTIVATING PROTEIN WHICH INTERACTS WITH PTPL1

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990000607A2 (en) * 1988-07-08 1990-01-25 Cetus Corporation Gap gene sequences and diagnostic uses thereof
WO1991015582A2 (en) * 1990-03-30 1991-10-17 Cetus Corporation PURIFIED RAP GAPs, RAP GAP SEQUENCES, AND USES THEREOF
WO1994016069A2 (en) * 1993-01-15 1994-07-21 Schering Corporation Ras associated gap proteins
WO1998037196A1 (en) * 1997-02-25 1998-08-27 Ludwig Institute For Cancer Research PARG, A GTPase ACTIVATING PROTEIN WHICH INTERACTS WITH PTPL1

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MOOSLEHNER K ET AL: "STRUCTURE AND EXPRESSION OF A GENE ENCODING A PUTATIVE GTP-BINDING PROTEIN IDENTIFIED BY PROVIRUS INTEGRATION IN A TRANSGENIC MOUSE STRAIN", MOLECULAR AND CELLULAR BIOLOGY 1991, vol. 11, no. 2, 1991, pages 886 - 893, XP000891270, ISSN: 0270-7306 *

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Publication number Publication date
CA2351361A1 (en) 2000-06-02
EP1135484A2 (en) 2001-09-26
WO2000031263A2 (en) 2000-06-02
AU1744900A (en) 2000-06-13
JP2002530109A (en) 2002-09-17

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