WO1999010385A1 - Gel d'acide hyaluronique, son procede de production et substance therapeutique le contenant - Google Patents
Gel d'acide hyaluronique, son procede de production et substance therapeutique le contenant Download PDFInfo
- Publication number
- WO1999010385A1 WO1999010385A1 PCT/JP1998/003536 JP9803536W WO9910385A1 WO 1999010385 A1 WO1999010385 A1 WO 1999010385A1 JP 9803536 W JP9803536 W JP 9803536W WO 9910385 A1 WO9910385 A1 WO 9910385A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hyaluronic acid
- gel
- aqueous solution
- acid gel
- molecular weight
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
Definitions
- the present invention relates to a novel hyaluronic acid gel and a method for producing the same, and more particularly to a biomaterial having good biocompatibility.
- a is the Mark-Houwink constant, which is 0.78 for hyaluronic acid.
- e is a factor of bareness and is set to 1.0.
- the solubilized hyaluronic acid has a branched structure confirmed by polymer solution theory. .
- a chemical modifier for hyaluronic acid is a compound that forms a covalent bond by reacting with the carboxyl group, hydroxyl group, or acetamido group of hyaluronic acid.
- substances that are not directly related to the introduction of a crosslinked structure into hyaluronic acid, the insolubilization of hyaluronic acid, or the insolubilization of hyaluronic acid can be added when the hyaluronic acid gel of the present invention is formed.
- a material having excellent biocompatibility like hyaluronic acid for example, chondroitin sulfate, carboxymethylcellulose and the like can be mixed and complexed to form a hyaluronic acid gel, and is not limited at all.
- hyaluronic acid according to the present invention is used in a concept that also includes alkali metal salts thereof, for example, sodium, potassium, and lithium salts.
- the washed hyaluronic acid gel can be used as a medical material in a state of being immersed in a solvent, in a wet state containing a solvent, in a dry state after being subjected to air drying, reduced pressure drying, or freeze drying. Served as
- Processing such as molding and processing of hyaluronic acid gel is performed in the form of sheet, film, crushed, sponge, lump, fibrous, etc., depending on the container and method used for freezing the acidic solution with adjusted hyaluronic acid during preparation.
- a hyaluronic acid gel having a desired shape in the form of a tube.
- film and sheet forms can be obtained by casting and freezing on a plate, and crushed forms can be obtained by freezing and thawing with vigorous mixing and stirring with an organic solvent immiscible with water.
- the anti-adhesion agent for hyaluronic acid gel obtained in the present invention is used for surgery in the form of sheet, film, crushed, sponge, lump, fiber, tube, and the like.
- a form to be used it is preferable to apply directly to a surgical site in the form of a film or a sheet. Or the surgical site with a finely crushed syringe It is preferable to apply it. Alternatively, it is preferably applied as a gel or film to a surgical site with a laparoscope.
- the anti-adhesion preventive agent for the hyaluronic acid gel obtained in the present invention may be administered at any time during which post-operative adhesion can be prevented, and can be administered during or at the end of surgery, especially when administered immediately before the end of surgery. preferable.
- the hyaluronic acid gel obtained in the present invention has a feature that it is hardly soluble in a neutral aqueous solution, but rapidly dissolves in an alkaline aqueous solution.
- the hyaluronic acid gel obtained in the present invention was allowed to coexist in a culture of fibroblasts derived from normal human skin without contact, and the cytotoxicity was evaluated by observing the cell growth behavior.
- the sponge-like hyaluronic acid gel produced by the method of Example 1 was freeze-dried by the same treatment as in Example 8.
- the freeze-dried product was mechanically ground and 2 Omg was placed in a cell culture insert (bore size: 3 / m) manufactured by Falcon and immersed in the medium in which the cells were seeded. Culture in the absence of hyaluronic acid gel was used as control.
- Example 13 The same operation as in Example 13 was performed except that sodium hyaluronate having a molecular weight of 6 ⁇ 10 5 daltons was used. As a result, a sheet-shaped hyaluronic acid gel adhesion preventive agent was obtained.
- the molecular weight 2 X 1 0 6 daltons sodium hyaluronate were dissolved in distilled water, to 0.05%, further pH l. 5 hyaluronic acid acidic aqueous solution 1 00m l adjusted to take into vessel 200 meters l with 1 N hydrochloric acid Placed in a freezer set at 20 ° C.
- Example 13 25 ml of an acidic aqueous solution of hyaluronic acid having a molecular weight of 2 ⁇ 10 6 daltons and a pH of 1.5 adjusted in Example 13 was placed in a plastic petri dish and placed in a freezer set at 120 ° C. Freezing for 22 hours and thawing for 2 hours at 25 ° C were repeated twice to obtain a spongy hyaluronic acid gel. Next, this was treated with phosphate buffer as in Example 13. After immersion in physiological saline, washing, and light dehydration, 5 ml of a 1% by weight aqueous solution of hyaluronic acid was added, and the mixture was rolled while sandwiching the same, and freeze-dried. As a result, a sheet-shaped anti-adhesion agent for hyaluronic acid gel using hyaluronic acid in combination was obtained.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69830240T DE69830240T2 (de) | 1997-08-22 | 1998-08-07 | Hyaluronsäure-gel, verfahren zur dessen herstellung und hyaluronsäure-gel enthaltendes medizinisches material |
EP98936706A EP1005874B1 (en) | 1997-08-22 | 1998-08-07 | Hyaluronic acid gel, process for producing the same and medical material containing the same |
AU85616/98A AU742675B2 (en) | 1997-08-22 | 1998-08-07 | Hyaluronic acid gel, method of its production and medical material containing it |
DK98936706T DK1005874T3 (da) | 1997-08-22 | 1998-08-07 | Hyaluronsyregel, fremgangsmåde til fremstilling af samme og medicinsk materiale indeholdende samme |
JP2000507710A JP3359909B2 (ja) | 1997-08-22 | 1998-08-07 | ヒアルロン酸ゲルとその製造方法及びそれを含有する医用材料 |
NZ502815A NZ502815A (en) | 1997-08-22 | 1998-08-07 | Hyaluronic acid gel formed from a freeze/thawing process of an acidified hyaluronic acid aqueous solution |
US09/463,993 US6387413B1 (en) | 1997-08-22 | 1998-08-07 | Hyaluronic acid gel, a method of its production and medical material containing it |
AT98936706T ATE295745T1 (de) | 1997-08-22 | 1998-08-07 | Hyaluronsäure-gel, verfahren zur dessen herstellung und hyaluronsäure-gel enthaltendes medizinisches material |
CA002301018A CA2301018C (en) | 1997-08-22 | 1998-08-07 | Hyaluronic acid gel, method of its production and medical material containing it |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9/226734 | 1997-08-22 | ||
JP22673497 | 1997-08-22 | ||
JP11756498 | 1998-04-27 | ||
JP10/117564 | 1998-04-27 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/463,993 A-371-Of-International US6387413B1 (en) | 1997-08-22 | 1998-08-07 | Hyaluronic acid gel, a method of its production and medical material containing it |
US10/047,091 Continuation US6790461B2 (en) | 1997-08-22 | 2002-01-17 | Hyaluronic acid gel, method of its production and medical material containing it |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999010385A1 true WO1999010385A1 (fr) | 1999-03-04 |
Family
ID=26455658
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1998/003536 WO1999010385A1 (fr) | 1997-08-22 | 1998-08-07 | Gel d'acide hyaluronique, son procede de production et substance therapeutique le contenant |
Country Status (11)
Country | Link |
---|---|
US (2) | US6387413B1 (ja) |
EP (1) | EP1005874B1 (ja) |
JP (1) | JP3359909B2 (ja) |
KR (1) | KR100374666B1 (ja) |
CN (1) | CN1101405C (ja) |
AT (1) | ATE295745T1 (ja) |
AU (1) | AU742675B2 (ja) |
CA (1) | CA2301018C (ja) |
DE (1) | DE69830240T2 (ja) |
NZ (1) | NZ502815A (ja) |
WO (1) | WO1999010385A1 (ja) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001329002A (ja) * | 2000-05-25 | 2001-11-27 | Denki Kagaku Kogyo Kk | 修飾ヒアルロン酸ゲルとその製造方法及びそれを含有する医用材料 |
JP2002348243A (ja) * | 2001-05-28 | 2002-12-04 | Denki Kagaku Kogyo Kk | 関節症治療用注入剤 |
EP1281722A1 (en) * | 2000-02-03 | 2003-02-05 | Denki Kagaku Kogyo Kabushiki Kaisha | Hyaluronic acid gel, process for producing the same, and medical material containing the same |
WO2005000374A1 (ja) * | 2003-06-30 | 2005-01-06 | Denki Kagaku Kogyo Kabushiki Kaisha | 脊椎・脊髄手術用癒着防止材 |
JP2005000512A (ja) * | 2003-06-13 | 2005-01-06 | Yasuharu Noisshiki | 管腔形成誘導性材料 |
WO2008041514A1 (ja) | 2006-09-22 | 2008-04-10 | Kochi University | 放射線または抗がん化学療法増感剤 |
US7807657B2 (en) | 2002-08-16 | 2010-10-05 | Denki Kagaku Kogyo Kabushiki Kaisha | Separate type medical material |
JP2011025013A (ja) * | 2009-06-25 | 2011-02-10 | Doshisha | 癒着防止材及びその製造方法 |
JP2011136218A (ja) * | 2011-04-11 | 2011-07-14 | Denki Kagaku Kogyo Kk | ヒアルロン酸ゲルの製造方法及びそれを含有する医用材料 |
WO2015002091A1 (ja) * | 2013-07-03 | 2015-01-08 | 株式会社リタファーマ | 水溶性ヒアルロン酸ゲル及びその製造方法 |
WO2015115609A1 (ja) | 2014-01-31 | 2015-08-06 | 生化学工業株式会社 | ジアミン架橋剤、酸性多糖架橋体、及び医用材料 |
US9101697B2 (en) | 2004-04-30 | 2015-08-11 | Abbott Cardiovascular Systems Inc. | Hyaluronic acid based copolymers |
JP2016515821A (ja) * | 2013-03-20 | 2016-06-02 | イルドン ファーム カンパニー リミテッド | ヒアルロン酸の製造方法及び前記製造方法で製造されたヒアルロン酸を含む癒着防止用組成物 |
WO2021256427A1 (ja) | 2020-06-15 | 2021-12-23 | 株式会社Kortuc | 抗がん療法の増感剤 |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE295745T1 (de) | 1997-08-22 | 2005-06-15 | Denki Kagaku Kogyo Kk | Hyaluronsäure-gel, verfahren zur dessen herstellung und hyaluronsäure-gel enthaltendes medizinisches material |
KR20010089882A (ko) * | 1998-11-10 | 2001-10-12 | 야노 쓰네오 | 히알루론산 겔과 그 제조방법 및 이를 함유하는 의료용 재료 |
NZ513517A (en) | 1999-02-19 | 2003-08-29 | Denki Kagaku Kogyo Kk | Hyaluronic acid gel composition containing a polymer for use as a wound dressing |
FR2819722B1 (fr) * | 2001-01-19 | 2006-11-24 | Corneal Ind | Utilisation de l'acide hyaluronique ou d'au moins l'un de ses sels dans le cadre d'un traitemnet chirurgical de la presbytie |
US7923431B2 (en) | 2001-12-21 | 2011-04-12 | Ferrosan Medical Devices A/S | Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis |
CZ12015U1 (cs) * | 2002-01-18 | 2002-02-25 | Cpn Spol. S R.O. | Přípravek pro prevenci adheze bandáľe na ránu |
AU2003221078A1 (en) * | 2002-04-08 | 2003-10-20 | Denki Kagaku Kogyo Kabushiki Kaisha | Therapeutic composition for bone infectious disease |
AU2003230321B8 (en) * | 2002-05-09 | 2009-07-30 | Medigenes | A pharmaceutical composition for treatment of wounds containing blood plasma or serum |
EP1573295A2 (en) | 2002-12-11 | 2005-09-14 | Ferrosan A/S | Gelatine-based materials as swabs |
CA2562415C (en) | 2003-04-10 | 2015-10-27 | Tufts University | Concentrated aqueous silk fibroin solutions free of organic solvents and uses thereof |
ATE475434T1 (de) * | 2004-01-30 | 2010-08-15 | Ferrosan As | Hämostatische sprays und zusammensetzungen |
US20050281880A1 (en) * | 2004-05-20 | 2005-12-22 | Wei Wang | Methods for making injectable polymer hydrogels |
WO2006005340A1 (en) * | 2004-07-09 | 2006-01-19 | Ferrosan A/S | Haemostatic composition comprising hyaluronic acid |
US20070048391A1 (en) * | 2005-08-23 | 2007-03-01 | Cambridgemed, Inc. | Composition for reduction of scar formation on wound scar |
US7579403B2 (en) * | 2006-04-04 | 2009-08-25 | E. I. Du Pont De Nemours And Company | Stain resist comprising hyperbranched maleic anhydride-diene polymers |
US7579420B2 (en) | 2006-04-04 | 2009-08-25 | E. I. Du Pont De Nemours And Company | Hyperbranched maleic anhydride-diene polymers |
US20100028451A1 (en) | 2006-09-26 | 2010-02-04 | Trustees Of Tufts College | Silk microspheres for encapsulation and controlled release |
DK2252290T3 (en) | 2008-02-15 | 2018-03-05 | Bone Therapeutics Sa | PHARMACEUTICAL COMPOSITION FOR USE FOR TREATMENT AND / OR PREVENTION OF OSTEOARTICULAR DISEASES |
EP2257289B1 (en) * | 2008-02-15 | 2018-09-19 | Bone Therapeutics | Pharmaceutical composition for use in the treatment or prevention of osteoarticular diseases |
WO2009109194A2 (en) | 2008-02-29 | 2009-09-11 | Ferrosan A/S | Device for promotion of hemostasis and/or wound healing |
JP5722217B2 (ja) | 2008-09-02 | 2015-05-20 | アラーガン・ホールディングス・フランス・ソシエテ・パール・アクシオン・サンプリフィエAllergan Holdings France S.A.S. | ヒアルロン酸および/またはその誘導体の糸、その作製方法、ならびにその使用 |
KR101062068B1 (ko) * | 2008-12-01 | 2011-09-02 | 포항공과대학교 산학협력단 | 유착방지용 조성물 |
CN102343110A (zh) * | 2010-07-29 | 2012-02-08 | 中国科学院化学研究所 | 消炎促愈合复合功能防粘连载药敷料 |
JP5730556B2 (ja) * | 2010-12-07 | 2015-06-10 | 株式会社ブリヂストン | ゴムの分析方法 |
US8455436B2 (en) | 2010-12-28 | 2013-06-04 | Depuy Mitek, Llc | Compositions and methods for treating joints |
US8398611B2 (en) | 2010-12-28 | 2013-03-19 | Depuy Mitek, Inc. | Compositions and methods for treating joints |
WO2012145652A1 (en) | 2011-04-20 | 2012-10-26 | Trustees Of Tufts College | Dynamic silk coatings for implantable devices |
US8623839B2 (en) * | 2011-06-30 | 2014-01-07 | Depuy Mitek, Llc | Compositions and methods for stabilized polysaccharide formulations |
EP2822474B1 (en) | 2012-03-06 | 2018-05-02 | Ferrosan Medical Devices A/S | Pressurized container containing haemostatic paste |
WO2013155404A1 (en) | 2012-04-13 | 2013-10-17 | Trustees Of Tufts College | Methods and compositions for preparing a silk microsphere |
EP2825216B1 (en) | 2012-06-12 | 2015-08-19 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
US9925299B2 (en) | 2012-10-26 | 2018-03-27 | Tufts University | Silk-based fabrication techniques to prepare high strength calcium phosphate ceramic scaffolds |
US10245075B2 (en) * | 2013-03-15 | 2019-04-02 | Eurica Califorrniaa | Nondestructive means of ectopic pregnancy management |
US10285702B2 (en) | 2013-04-24 | 2019-05-14 | Trustees Of Tufts College | Bioresorbable biopolymer anastomosis devices |
US9724078B2 (en) | 2013-06-21 | 2017-08-08 | Ferrosan Medical Devices A/S | Vacuum expanded dry composition and syringe for retaining same |
JP6077663B2 (ja) | 2013-08-29 | 2017-02-08 | 大日精化工業株式会社 | 水不溶性成形体の製造方法及び水不溶性成形体 |
JP6489485B2 (ja) | 2013-12-11 | 2019-03-27 | フェロサン メディカル デバイシーズ エイ/エス | 押し出し増強因子を含んでいる乾燥組成物 |
JP6726852B2 (ja) | 2014-10-13 | 2020-07-22 | フェッローサン メディカル ディバイス エー/エス | 止血および創傷治癒に使用するための乾燥組成物 |
KR101521058B1 (ko) | 2014-12-08 | 2015-05-15 | 이노팜 주식회사 | 생체적합성 조성물 및 이의 제조방법 |
US10758645B2 (en) | 2014-12-17 | 2020-09-01 | Tufts University | Injectable, flexible hydroxyapatite-silk foams for osteochondral and dental repair |
CN107206165B (zh) | 2014-12-24 | 2020-10-23 | 弗罗桑医疗设备公司 | 用于保持并混合第一和第二物质的注射器 |
US9682099B2 (en) | 2015-01-20 | 2017-06-20 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
KR101841469B1 (ko) * | 2015-01-30 | 2018-03-23 | (주)메디팁 | 바이오폴리머를 이용한 창상 피복재의 제조방법 및 이를 이용하여 제조된 바이오폴리머를 이용한 창상 피복재 |
JP6374088B2 (ja) * | 2015-02-27 | 2018-08-15 | 大日精化工業株式会社 | 医療用材料及び癒着防止材 |
CN107427602A (zh) * | 2015-02-27 | 2017-12-01 | 大日精化工业株式会社 | 医疗用/美容材料和防粘连材料 |
CN107249657A (zh) * | 2015-02-27 | 2017-10-13 | 大日精化工业株式会社 | 医疗用材料的制造方法、医疗用材料以及防粘连材料 |
JP6747651B2 (ja) | 2015-07-03 | 2020-08-26 | フェロサン メディカル デバイシーズ エイ/エス | 保管状態で真空を保持するための、及び2種の成分を混合するためのシリンジ |
CA2995233C (en) | 2015-07-20 | 2024-01-02 | Tufts University | Biodegradable silk ear tubes |
KR101597794B1 (ko) * | 2015-09-22 | 2016-02-25 | 바이오플러스 주식회사 | 겔 시트 |
WO2017052133A1 (ko) * | 2015-09-22 | 2017-03-30 | 바이오플러스 주식회사 | 히알루론산을 이용한 겔 시트 및 그 제조방법 |
US10864299B2 (en) | 2016-04-29 | 2020-12-15 | Trustees Of Tufts College | Artificial silk based innervated cornea |
WO2018006037A1 (en) | 2016-07-01 | 2018-01-04 | Trustees Of Tufts College | Innervated artificial skin |
US11248313B2 (en) | 2016-08-01 | 2022-02-15 | Trustees Of Tufts College | Biomimetic mechanical tension driven fabrication of nanofibrillar architecture |
CN107115557B (zh) * | 2017-04-17 | 2019-12-20 | 江苏昌吉永生物科技股份有限公司 | 一种医用止血防粘连材料的制备方法 |
CN107029281A (zh) * | 2017-04-17 | 2017-08-11 | 江苏昌吉永生物科技股份有限公司 | 一种可吸收止血材料的制备方法 |
JP6925233B2 (ja) | 2017-10-27 | 2021-08-25 | 大日精化工業株式会社 | 化粧料用成形物及びその製造方法 |
KR20210008479A (ko) | 2018-05-09 | 2021-01-22 | 훼로산 메디칼 디바이스 에이/에스 | 지혈 조성물을 제조하는 방법 |
CN111001035A (zh) * | 2019-12-25 | 2020-04-14 | 玉子涛 | 一种生物活性玻璃复合创面凝胶的制备方法 |
EP4335876A1 (en) | 2022-09-06 | 2024-03-13 | Scivision Biotech Inc. | Method of manufacturing auto-crosslinked hyaluronic acid gel and products thereof |
CN117281260A (zh) * | 2023-11-24 | 2023-12-26 | 上海威高医疗技术发展有限公司 | 一种不含有交联剂的凝胶及其制备方法和应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5056436A (ja) * | 1973-09-20 | 1975-05-17 | ||
JPH0558881A (ja) * | 1991-08-27 | 1993-03-09 | Shiseido Co Ltd | ヒアルロン酸ゲル及びその製造方法 |
JPH07102002A (ja) * | 1993-09-30 | 1995-04-18 | Gunze Ltd | 架橋ヒアルロン酸及びこれらの複合材料 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1086323A (en) | 1963-07-18 | 1967-10-11 | Courtaulds Ltd | Derivative of carboxy methyl cellulose |
DE1577860A1 (de) | 1964-10-02 | 1969-04-17 | Metrimpex Magyar Mueszeripari | Riss- und Graviermaschine |
EP0010519A1 (fr) | 1978-10-12 | 1980-04-30 | Battelle Memorial Institute | Procédé pour réticuler la carboxyméthyl-cellulose et produits obtenus suivant ce procédé |
IT1198449B (it) | 1986-10-13 | 1988-12-21 | F I D I Farmaceutici Italiani | Esteri di alcoli polivalenti di acido ialuronico |
IT1219587B (it) | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
US5143724A (en) * | 1990-07-09 | 1992-09-01 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
EP0516026A1 (en) | 1991-05-28 | 1992-12-02 | Takeda Chemical Industries, Ltd. | Hydrogel and method of producing same |
JPH055881A (ja) | 1991-06-27 | 1993-01-14 | Sanyo Electric Co Ltd | 液晶プロジエクタ |
CA2079205C (en) * | 1992-09-25 | 1998-02-10 | Rudolf Edgar Falk | Use of hyaluronic acid and forms to prevent arterial restenosis |
US5616568A (en) * | 1993-11-30 | 1997-04-01 | The Research Foundation Of State University Of New York | Functionalized derivatives of hyaluronic acid |
ATE295745T1 (de) | 1997-08-22 | 2005-06-15 | Denki Kagaku Kogyo Kk | Hyaluronsäure-gel, verfahren zur dessen herstellung und hyaluronsäure-gel enthaltendes medizinisches material |
-
1998
- 1998-08-07 AT AT98936706T patent/ATE295745T1/de active
- 1998-08-07 DE DE69830240T patent/DE69830240T2/de not_active Expired - Lifetime
- 1998-08-07 CA CA002301018A patent/CA2301018C/en not_active Expired - Fee Related
- 1998-08-07 EP EP98936706A patent/EP1005874B1/en not_active Expired - Lifetime
- 1998-08-07 US US09/463,993 patent/US6387413B1/en not_active Expired - Lifetime
- 1998-08-07 NZ NZ502815A patent/NZ502815A/en not_active IP Right Cessation
- 1998-08-07 JP JP2000507710A patent/JP3359909B2/ja not_active Expired - Fee Related
- 1998-08-07 AU AU85616/98A patent/AU742675B2/en not_active Ceased
- 1998-08-07 KR KR10-2000-7001812A patent/KR100374666B1/ko not_active IP Right Cessation
- 1998-08-07 CN CN98808365A patent/CN1101405C/zh not_active Expired - Lifetime
- 1998-08-07 WO PCT/JP1998/003536 patent/WO1999010385A1/ja active IP Right Grant
-
2002
- 2002-01-17 US US10/047,091 patent/US6790461B2/en not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5056436A (ja) * | 1973-09-20 | 1975-05-17 | ||
JPH0558881A (ja) * | 1991-08-27 | 1993-03-09 | Shiseido Co Ltd | ヒアルロン酸ゲル及びその製造方法 |
JPH07102002A (ja) * | 1993-09-30 | 1995-04-18 | Gunze Ltd | 架橋ヒアルロン酸及びこれらの複合材料 |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1281722A1 (en) * | 2000-02-03 | 2003-02-05 | Denki Kagaku Kogyo Kabushiki Kaisha | Hyaluronic acid gel, process for producing the same, and medical material containing the same |
JP4755795B2 (ja) * | 2000-02-03 | 2011-08-24 | 電気化学工業株式会社 | ヒアルロン酸ゲルの製造方法及びそれを含有する医用材料 |
EP1281722A4 (en) * | 2000-02-03 | 2005-06-08 | Denki Kagaku Kogyo Kk | HYALURONIC ACID GEL, METHOD FOR THE PRODUCTION THEREOF, AND THE MEDICAL MATERIAL CONTAINING GEL |
US7014860B1 (en) | 2000-02-03 | 2006-03-21 | Denki Kagaku Kogyo Kabushiki Kaisha | Hyaluronic acid gel, process for producing the same, and medical material containing the same |
JP2001329002A (ja) * | 2000-05-25 | 2001-11-27 | Denki Kagaku Kogyo Kk | 修飾ヒアルロン酸ゲルとその製造方法及びそれを含有する医用材料 |
JP2002348243A (ja) * | 2001-05-28 | 2002-12-04 | Denki Kagaku Kogyo Kk | 関節症治療用注入剤 |
US7807657B2 (en) | 2002-08-16 | 2010-10-05 | Denki Kagaku Kogyo Kabushiki Kaisha | Separate type medical material |
JP2005000512A (ja) * | 2003-06-13 | 2005-01-06 | Yasuharu Noisshiki | 管腔形成誘導性材料 |
JPWO2005000374A1 (ja) * | 2003-06-30 | 2006-08-03 | 電気化学工業株式会社 | 脊椎・脊髄手術用癒着防止材 |
JP4690892B2 (ja) * | 2003-06-30 | 2011-06-01 | 電気化学工業株式会社 | 脊椎・脊髄手術用癒着防止材 |
WO2005000374A1 (ja) * | 2003-06-30 | 2005-01-06 | Denki Kagaku Kogyo Kabushiki Kaisha | 脊椎・脊髄手術用癒着防止材 |
US9101697B2 (en) | 2004-04-30 | 2015-08-11 | Abbott Cardiovascular Systems Inc. | Hyaluronic acid based copolymers |
WO2008041514A1 (ja) | 2006-09-22 | 2008-04-10 | Kochi University | 放射線または抗がん化学療法増感剤 |
US10219997B2 (en) | 2006-09-22 | 2019-03-05 | Kochi University | Radiation sensitizer or anti-cancer chemotherapy sensitizer |
US10758477B2 (en) | 2006-09-22 | 2020-09-01 | Yasuhiro Ogawa | Radiation sensitizer or anti-cancer chemotherapy sensitizer |
US10512604B2 (en) | 2006-09-22 | 2019-12-24 | Yasuhiro Ogawa | Radiation sensitizer or anti-cancer chemotherapy sensitizer |
JP2011025013A (ja) * | 2009-06-25 | 2011-02-10 | Doshisha | 癒着防止材及びその製造方法 |
JP2011136218A (ja) * | 2011-04-11 | 2011-07-14 | Denki Kagaku Kogyo Kk | ヒアルロン酸ゲルの製造方法及びそれを含有する医用材料 |
JP2016515821A (ja) * | 2013-03-20 | 2016-06-02 | イルドン ファーム カンパニー リミテッド | ヒアルロン酸の製造方法及び前記製造方法で製造されたヒアルロン酸を含む癒着防止用組成物 |
JPWO2015002091A1 (ja) * | 2013-07-03 | 2017-02-23 | 株式会社リタファーマ | 水溶性ヒアルロン酸ゲル及びその製造方法 |
US10639266B2 (en) | 2013-07-03 | 2020-05-05 | Ritapharma, Co., Ltd | Water-soluble hyaluronic acid gel and method for producing same |
WO2015002091A1 (ja) * | 2013-07-03 | 2015-01-08 | 株式会社リタファーマ | 水溶性ヒアルロン酸ゲル及びその製造方法 |
US10294195B2 (en) | 2014-01-31 | 2019-05-21 | Seikagaku Corporation | Diamine crosslinking agents, crosslinked acidic polysaccharides and medical materials |
WO2015115609A1 (ja) | 2014-01-31 | 2015-08-06 | 生化学工業株式会社 | ジアミン架橋剤、酸性多糖架橋体、及び医用材料 |
US10919840B2 (en) | 2014-01-31 | 2021-02-16 | Seikagaku Corporation | Diamine crosslinking agents, crosslinked acidic polysaccharides and medical materials |
WO2021256427A1 (ja) | 2020-06-15 | 2021-12-23 | 株式会社Kortuc | 抗がん療法の増感剤 |
Also Published As
Publication number | Publication date |
---|---|
NZ502815A (en) | 2002-03-01 |
DE69830240T2 (de) | 2005-10-13 |
EP1005874A4 (en) | 2001-02-07 |
ATE295745T1 (de) | 2005-06-15 |
US6387413B1 (en) | 2002-05-14 |
CA2301018A1 (en) | 1999-03-04 |
AU8561698A (en) | 1999-03-16 |
EP1005874A1 (en) | 2000-06-07 |
US20020098244A1 (en) | 2002-07-25 |
US6790461B2 (en) | 2004-09-14 |
CA2301018C (en) | 2006-06-20 |
CN1267308A (zh) | 2000-09-20 |
CN1101405C (zh) | 2003-02-12 |
EP1005874B1 (en) | 2005-05-18 |
AU742675B2 (en) | 2002-01-10 |
KR100374666B1 (ko) | 2003-03-04 |
DE69830240D1 (de) | 2005-06-23 |
KR20010023185A (ko) | 2001-03-26 |
JP3359909B2 (ja) | 2002-12-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP3359909B2 (ja) | ヒアルロン酸ゲルとその製造方法及びそれを含有する医用材料 | |
KR100730527B1 (ko) | 히알루론산 겔 조성물과 그의 제조방법 및 그것을함유하는 의용 재료 | |
US8178663B2 (en) | Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring | |
KR101478849B1 (ko) | 크로스링크된 히알루론산 및 이의 제조방법 | |
EP2121026B1 (en) | Novel injectable chitosan mixtures forming hydrogels | |
CA2578678C (en) | Photoreactive polysaccharide, photocrosslinked polysaccharide products, the method of making them and medical materials therefrom | |
WO2001057093A1 (fr) | Gel de l'acide hyaluronique, son procede de production et produit medical le contenant | |
WO2001034214A1 (fr) | Utilisation de derives de cellulose solubles rendus difficilement solubles dans l'eau et methode de preparation de ces derives | |
Chen et al. | Preparation of enzymatically cross-linked sulfated chitosan hydrogel and its potential application in thick tissue engineering | |
WO1996003147A1 (en) | Synthesis of chemical gels from polyelectrolyte polysaccharides by gamma-irradiation | |
JP4460663B2 (ja) | ヒアルロン酸ゲルスラリー及びその用途 | |
JP3420851B2 (ja) | 癒着防止剤 | |
JP2000248002A (ja) | 自己架橋ヒアルロン酸とその製造方法及びその用途 | |
de Azevedo | Aldehyde-functionalized chitosan and cellulose: chitosan composites: application as drug carriers and vascular bypass grafts | |
JP2001329002A (ja) | 修飾ヒアルロン酸ゲルとその製造方法及びそれを含有する医用材料 | |
JP4460662B2 (ja) | 溶解速度が制御されたヒアルロン酸ゲル及びその製造方法 | |
JP2003019194A (ja) | ヒアルロン酸とカルボキシメチルセルロースからなる共架橋ゲル組成物 | |
JP2004149599A (ja) | ヒアルロン酸ゲル及びその製造方法 | |
JP2000239303A (ja) | シート状成形物及びそれを含有する医用材料 | |
EP2146755A1 (en) | Device made at least partially of n-acetylchitosan with controlled biodissolution | |
JP4460665B2 (ja) | 生体吸収性薬物担体 | |
JP2000191702A (ja) | 成形物の製造方法 | |
JP2000239304A (ja) | 細胞培養用基材 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 98808365.5 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 502815 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 85616/98 Country of ref document: AU |
|
ENP | Entry into the national phase |
Ref document number: 2301018 Country of ref document: CA Ref document number: 2301018 Country of ref document: CA Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1998936706 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020007001812 Country of ref document: KR |
|
WWP | Wipo information: published in national office |
Ref document number: 1998936706 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 09463993 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 1020007001812 Country of ref document: KR |
|
WWG | Wipo information: grant in national office |
Ref document number: 85616/98 Country of ref document: AU |
|
WWG | Wipo information: grant in national office |
Ref document number: 1020007001812 Country of ref document: KR |
|
WWG | Wipo information: grant in national office |
Ref document number: 1998936706 Country of ref document: EP |