WO1998048045A3 - Verfahren zur nichtinvasiven erkennung bösartiger tumoren der lunge - Google Patents

Verfahren zur nichtinvasiven erkennung bösartiger tumoren der lunge Download PDF

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Publication number
WO1998048045A3
WO1998048045A3 PCT/DE1998/001082 DE9801082W WO9848045A3 WO 1998048045 A3 WO1998048045 A3 WO 1998048045A3 DE 9801082 W DE9801082 W DE 9801082W WO 9848045 A3 WO9848045 A3 WO 9848045A3
Authority
WO
WIPO (PCT)
Prior art keywords
lung tumors
malignant lung
segments
invasive identification
dna
Prior art date
Application number
PCT/DE1998/001082
Other languages
English (en)
French (fr)
Other versions
WO1998048045A2 (de
Inventor
Timo Hillebrand
Peter Bendzko
Original Assignee
Invitek Gmbh
Timo Hillebrand
Peter Bendzko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Invitek Gmbh, Timo Hillebrand, Peter Bendzko filed Critical Invitek Gmbh
Priority to AU76381/98A priority Critical patent/AU7638198A/en
Publication of WO1998048045A2 publication Critical patent/WO1998048045A2/de
Publication of WO1998048045A3 publication Critical patent/WO1998048045A3/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Die Erfindung betrifft ein Verfahren zur Erkennung von bösartigen Lungentumoren des Menschen durch Isolierung genomischer DNA aus Atemkondensaten sowie den Einsatz dieser DNA als Substrat für eine spezifische Vervielfältigung von Abschnitten relevanter Tumormarkergene und Nachweis von Veränderungen in der DNA-Sequenz dieser Abschnitte über allelspezifische Hybridisierungsreaktionen.
PCT/DE1998/001082 1997-04-18 1998-04-14 Verfahren zur nichtinvasiven erkennung bösartiger tumoren der lunge WO1998048045A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU76381/98A AU7638198A (en) 1997-04-18 1998-04-14 Method for non-invasive identification of malignant lung tumors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19717717.4 1997-04-18
DE19717717A DE19717717B4 (de) 1997-04-18 1997-04-18 Verfahren zur nichtinvasiven Erkennung bösartiger Tumoren der Lunge

Publications (2)

Publication Number Publication Date
WO1998048045A2 WO1998048045A2 (de) 1998-10-29
WO1998048045A3 true WO1998048045A3 (de) 1999-01-28

Family

ID=7827862

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1998/001082 WO1998048045A2 (de) 1997-04-18 1998-04-14 Verfahren zur nichtinvasiven erkennung bösartiger tumoren der lunge

Country Status (3)

Country Link
AU (1) AU7638198A (de)
DE (1) DE19717717B4 (de)
WO (1) WO1998048045A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19858447A1 (de) * 1997-12-18 1999-07-01 Invitek Gmbh Verfahren zur Isolierung von kurz- und langkettigen Nukleinsäuren
AU2003299850A1 (en) 2002-12-20 2004-07-22 Amidex, Inc. Breath aerosol collection system and method
DE102006029926B4 (de) 2006-06-29 2008-11-20 Siemens Ag Anordnung und Verfahren zur Identifizierung von Personen

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995001359A1 (de) * 1993-07-01 1995-01-12 Qiagen Gmbh Verfahren zur chromatographischen reinigung und trennung von nucleinsäuregemischen
WO1995013397A1 (en) * 1993-11-12 1995-05-18 The Johns Hopkins University School Of Medicine Nucleic acid mutation detection by analysis of sputum
DE4422044A1 (de) * 1994-06-14 1995-12-21 Invitek Gmbh Verfahren zur Isolierung, Reinigung und ggf. Lagerung von Nukleinsäuren
WO1995034569A1 (de) * 1994-06-14 1995-12-21 Invitek Gmbh Universelles verfahren zur isolierung und reinigung von nukleinsäuren aus extrem geringen mengen sowie sehr stark verunreinigten unterschiedlichsten ausgangsmaterialien
DE19506887A1 (de) * 1995-02-17 1996-08-22 Invitek Gmbh Verfahren zur simultanen Isolierung von genomischer DNS und hochreiner Total RNS
WO1998008971A1 (de) * 1996-08-26 1998-03-05 Invitek Gmbh Verfahren zum nachweis klinisch relevanter veränderungen der dns-sequenz des ki-ras-onkogens, seine verwendung und testkit zur früherkennung von tumoren

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772559A (en) * 1985-10-10 1988-09-20 Monell Chemical Senses Center Method of detecting the presence of bronchogenic carcinoma by analysis of expired lung air
DE3932784C3 (de) * 1989-09-30 2002-08-01 Nmi Univ Tuebingen Verfahren zur Gewinnung nichtflüchtiger Substanzen als analytisches Probenmaterial aus der menschlichen Atemluft
US5465728A (en) * 1994-01-11 1995-11-14 Phillips; Michael Breath collection
AU2444195A (en) * 1994-05-13 1995-12-05 Filt Forschungsgesellschaft Fur Lungen-Und Thoraxerkrankungen MbH Process and device for collecting expired breath condensate

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995001359A1 (de) * 1993-07-01 1995-01-12 Qiagen Gmbh Verfahren zur chromatographischen reinigung und trennung von nucleinsäuregemischen
WO1995013397A1 (en) * 1993-11-12 1995-05-18 The Johns Hopkins University School Of Medicine Nucleic acid mutation detection by analysis of sputum
DE4422044A1 (de) * 1994-06-14 1995-12-21 Invitek Gmbh Verfahren zur Isolierung, Reinigung und ggf. Lagerung von Nukleinsäuren
WO1995034569A1 (de) * 1994-06-14 1995-12-21 Invitek Gmbh Universelles verfahren zur isolierung und reinigung von nukleinsäuren aus extrem geringen mengen sowie sehr stark verunreinigten unterschiedlichsten ausgangsmaterialien
DE19506887A1 (de) * 1995-02-17 1996-08-22 Invitek Gmbh Verfahren zur simultanen Isolierung von genomischer DNS und hochreiner Total RNS
WO1998008971A1 (de) * 1996-08-26 1998-03-05 Invitek Gmbh Verfahren zum nachweis klinisch relevanter veränderungen der dns-sequenz des ki-ras-onkogens, seine verwendung und testkit zur früherkennung von tumoren

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BERNDT ET AL.: "A MICROPLATE ASSAY FOR K-ras GENOTYPING", EUR.J.CLIN.CHEM.CLIN.BIOCHEM., vol. 34, 1996, pages 837 - 840, XP002082636 *
HESKETH: "THE ONCOGENE FACTS BOOK", 1995, ACADEMIC PRESS, LONDON,GB, XP002082641, 214530 *

Also Published As

Publication number Publication date
DE19717717A1 (de) 1998-10-22
AU7638198A (en) 1998-11-13
WO1998048045A2 (de) 1998-10-29
DE19717717B4 (de) 2007-08-02

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