WO1998004702A3 - Proteines, notamment proteines membranaires, d'helicobacter pylori, leur preparation et utilisation - Google Patents

Proteines, notamment proteines membranaires, d'helicobacter pylori, leur preparation et utilisation Download PDF

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Publication number
WO1998004702A3
WO1998004702A3 PCT/IB1997/000981 IB9700981W WO9804702A3 WO 1998004702 A3 WO1998004702 A3 WO 1998004702A3 IB 9700981 W IB9700981 W IB 9700981W WO 9804702 A3 WO9804702 A3 WO 9804702A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
preparation
helicobacter pylori
particular membrane
seq
Prior art date
Application number
PCT/IB1997/000981
Other languages
English (en)
Other versions
WO1998004702A2 (fr
Inventor
Bernhard Knapp
Erika Hundt
Karl-Heinz Schmidt
Original Assignee
Chiron Behring Gmbh & Co
Bernhard Knapp
Erika Hundt
Schmidt Karl Heinz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Behring Gmbh & Co, Bernhard Knapp, Erika Hundt, Schmidt Karl Heinz filed Critical Chiron Behring Gmbh & Co
Priority to CA002259924A priority Critical patent/CA2259924A1/fr
Priority to EP97932967A priority patent/EP0918864A2/fr
Priority to JP10508651A priority patent/JP2001502886A/ja
Publication of WO1998004702A2 publication Critical patent/WO1998004702A2/fr
Publication of WO1998004702A3 publication Critical patent/WO1998004702A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne de nouvelles protéines, notamment des protéines membranaires ou protéines solidement associées à la membrane, lesquelles sont dérivées d'hélicobacter pilori (H. pilori) et lesquelles contiennent une des séquences peptidiques sélectionnées par les SEQ ID NO:1, 2, 3, 6, 10, 11, 12, 14, 15, 16, 17, 18 ou 19 selon les tableaux 1a-1c, ou des parties ou homologues de celles-ci, présentant une longueur minimum de 5 acides aminés, ainsi que leur préparation et utilisation en tant que composition pharmaceutique, notamment en tant que vaccins, ou en tant qu'agents diagnostiques. Sur la base de ces données, on a également isolé des gènes codant pour ces protéines et des protéines apparentées, telles que l'illustrent les SEQ ID NOS: 20, 21, 22, 23, 24, 25, 26 et 27.
PCT/IB1997/000981 1996-07-26 1997-07-25 Proteines, notamment proteines membranaires, d'helicobacter pylori, leur preparation et utilisation WO1998004702A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002259924A CA2259924A1 (fr) 1996-07-26 1997-07-25 Proteines, notamment proteines membranaires, d'helicobacter pylori, leur preparation et utilisation
EP97932967A EP0918864A2 (fr) 1996-07-26 1997-07-25 Proteines, notamment proteines membranaires, d'helicobacter pylori, leur preparation et utilisation
JP10508651A JP2001502886A (ja) 1996-07-26 1997-07-25 Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉのタンパク質、特に膜タンパク質、それらの調製および使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19630390.7 1996-07-26
DE19630390A DE19630390A1 (de) 1996-07-26 1996-07-26 Proteine, insbesondere Membranproteine von Helicobacter pylori, ihre Herstellung und Verwendung

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/662,126 Continuation US20050063987A1 (en) 1996-07-26 2003-09-12 Proteins, in particular membrane proteins, of Helicobacter pylori, their preparation and use

Publications (2)

Publication Number Publication Date
WO1998004702A2 WO1998004702A2 (fr) 1998-02-05
WO1998004702A3 true WO1998004702A3 (fr) 1998-04-23

Family

ID=7801051

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1997/000981 WO1998004702A2 (fr) 1996-07-26 1997-07-25 Proteines, notamment proteines membranaires, d'helicobacter pylori, leur preparation et utilisation

Country Status (5)

Country Link
EP (1) EP0918864A2 (fr)
JP (1) JP2001502886A (fr)
CA (1) CA2259924A1 (fr)
DE (1) DE19630390A1 (fr)
WO (1) WO1998004702A2 (fr)

Families Citing this family (32)

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GB2324093A (en) 1996-01-04 1998-10-14 Rican Limited Helicobacter pylori bacterioferritin
DE19847628C2 (de) * 1998-10-15 2000-10-19 Chiron Behring Gmbh & Co Helicobacter pylori-Impfstoff
AUPQ347199A0 (en) * 1999-10-15 1999-11-11 Csl Limited Novel polypeptide fragments
EP2275129A3 (fr) 2000-01-17 2013-11-06 Novartis Vaccines and Diagnostics S.r.l. Vaccin omv complèté contre la méningocoque
MX357775B (es) 2000-10-27 2018-07-20 J Craig Venter Inst Inc Acidos nucleicos y proteinas de los grupos a y b de estreptococos.
GB0107658D0 (en) 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
EP1399183B1 (fr) 2001-05-31 2010-06-30 Novartis Vaccines and Diagnostics, Inc. Particules de replicon d'alphavirus chimerique
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
GB0118249D0 (en) 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
ATE406912T1 (de) 2001-12-12 2008-09-15 Novartis Vaccines & Diagnostic Immunisierung gegen chlamydia tracheomatis
US7501134B2 (en) 2002-02-20 2009-03-10 Novartis Vaccines And Diagnostics, Inc. Microparticles with adsorbed polypeptide-containing molecules
GB0220194D0 (en) 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
LT2395073T (lt) 2002-11-01 2017-11-10 Glaxosmithkline Biologicals S.A. Džiovinimo būdas
AU2003288660A1 (en) 2002-11-15 2004-06-15 Chiron Srl Unexpected surface proteins in neisseria meningitidis
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
EP1585542B1 (fr) 2002-12-27 2012-06-13 Novartis Vaccines and Diagnostics, Inc. Immunogènes contenant des compositions de phospholipide
EP1608369B1 (fr) 2003-03-28 2013-06-26 Novartis Vaccines and Diagnostics, Inc. Utilisation de composés organiques pour l'immunopotentialisation
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
ATE437633T2 (de) 2003-06-02 2009-08-15 Novartis Vaccines & Diagnostic Immunogene zusammensetzungen auf basis von biologisch abbaubaren mikroteilchen enthaltend ein diphtherie- und ein tetanustoxoid
JP2008504292A (ja) 2004-06-24 2008-02-14 ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド 免疫増強用の化合物
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US20060165716A1 (en) 2004-07-29 2006-07-27 Telford John L Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae
US20110223197A1 (en) 2005-10-18 2011-09-15 Novartis Vaccines And Diagnostics Inc. Mucosal and Systemic Immunization with Alphavirus Replicon Particles
JP5215865B2 (ja) 2005-11-22 2013-06-19 ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド ノロウイルス抗原およびサポウイルス抗原
CA2646539A1 (fr) 2006-03-23 2007-09-27 Novartis Ag Composes d'imidazoquinoxaline utilises en tant qu'immunomodulateurs
GB0700562D0 (en) 2007-01-11 2007-02-21 Novartis Vaccines & Diagnostic Modified Saccharides
AU2008299376B2 (en) 2007-09-12 2013-02-28 Glaxosmithkline Biologicals S.A. GAS57 mutant antigens and GAS57 antibodies
KR101773114B1 (ko) 2007-12-21 2017-08-30 노파르티스 아게 스트렙토라이신 ｏ의 돌연변이 형태
AU2010204139A1 (en) 2009-01-12 2011-08-11 Novartis Ag Cna_B domain antigens in vaccines against gram positive bacteria
WO2011149564A1 (fr) 2010-05-28 2011-12-01 Tetris Online, Inc. Infrastructure de jeu informatique asynchrone hybride interactif

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026901A1 (fr) * 1993-05-19 1994-11-24 Institut Pasteur Compositions immunogenes destinees a proteger contre les infections a helicobacter, polypeptides utilises dans lesdites compositions et sequences d'acides nucleiques codant lesdits polypeptides
FR2724936A1 (fr) * 1994-09-22 1996-03-29 Pasteur Merieux Serums Vacc Recepteur lactoferrine d'helicobacter
WO1997012908A1 (fr) * 1995-10-04 1997-04-10 Pasteur Merieux Serums & Vaccins NOUVELLE PROTEINE MEMBRANAIRE p76 D'HELICOBACTER PYLORI
WO1997012909A1 (fr) * 1995-10-04 1997-04-10 Pasteur Merieux Serums & Vaccins Nouvelles proteines membranaires d'helicobacter pylori

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026901A1 (fr) * 1993-05-19 1994-11-24 Institut Pasteur Compositions immunogenes destinees a proteger contre les infections a helicobacter, polypeptides utilises dans lesdites compositions et sequences d'acides nucleiques codant lesdits polypeptides
FR2724936A1 (fr) * 1994-09-22 1996-03-29 Pasteur Merieux Serums Vacc Recepteur lactoferrine d'helicobacter
WO1997012908A1 (fr) * 1995-10-04 1997-04-10 Pasteur Merieux Serums & Vaccins NOUVELLE PROTEINE MEMBRANAIRE p76 D'HELICOBACTER PYLORI
WO1997012909A1 (fr) * 1995-10-04 1997-04-10 Pasteur Merieux Serums & Vaccins Nouvelles proteines membranaires d'helicobacter pylori

Non-Patent Citations (9)

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Title
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DOIG P ET AL: "ISOLATION AND CHARACTERIZATION OF A CONSERVED PORIN PROTEIN FROM HELICOBACTER PYLORI", JOURNAL OF BACTERIOLOGY, vol. 177, no. 19, 1 October 1995 (1995-10-01), pages 5447 - 5452, XP000570478 *
DOIG P ET AL: "PRODUCTION OF A CONSERVED ADHESIN BY THE HUMAN GASTRODUODENAL PATHOGEN HELICOBACTER PYLORI", JOURNAL OF BACTERIOLOGY, vol. 174, no. 8, April 1992 (1992-04-01), pages 2539 - 2547, XP000601442 *
DUNN B E ET AL: "PURIFICATION AND CHARACTERIZATION OF UREASE FROM HELICOBACTER PYLORI", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, no. 16, 5 June 1990 (1990-06-05), pages 9464 - 9469, XP000568708 *
EVANS D G ET AL: "CLONING, NUCLEOTIDE SEQUENCE, AND EXPRESSION OF A GENE ENCODING AN ADHESIN SUBUNIT PROTEIN OF HELICOBACTER PYLORI", JOURNAL OF BACTERIOLOGY, vol. 175, no. 3, February 1993 (1993-02-01), pages 674 - 683, XP000601419 *
EXNER M M ET AL: "ISOLATION AND CHARACTERIZATION OF A FAMILY OF PORIN PROTEINS FROM HELICOBACTER PYLORI", INFECTION AND IMMUNITY, vol. 63, no. 4, 1 April 1995 (1995-04-01), pages 1567 - 1572, XP002003585 *
M.J. BLASER ET AL.: "Identification and characterization of Campylobacter jejuni outer membrane proteins", INFECTION AND IMMUNITY, vol. 42, no. 1, October 1983 (1983-10-01), ASM,WASHINGTON,DC,US, pages 276 - 284, XP002047821 *
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Also Published As

Publication number Publication date
WO1998004702A2 (fr) 1998-02-05
DE19630390A1 (de) 1998-01-29
EP0918864A2 (fr) 1999-06-02
CA2259924A1 (fr) 1998-02-05
JP2001502886A (ja) 2001-03-06

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