WO1997028826A3 - Kontrazeptive freisetzungssysteme mit antibakterieller und/oder antiviraler wirkung - Google Patents

Kontrazeptive freisetzungssysteme mit antibakterieller und/oder antiviraler wirkung Download PDF

Info

Publication number
WO1997028826A3
WO1997028826A3 PCT/DE1997/000321 DE9700321W WO9728826A3 WO 1997028826 A3 WO1997028826 A3 WO 1997028826A3 DE 9700321 W DE9700321 W DE 9700321W WO 9728826 A3 WO9728826 A3 WO 9728826A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibacterial
contraceptive
antiviral effect
release systems
compound
Prior art date
Application number
PCT/DE1997/000321
Other languages
English (en)
French (fr)
Other versions
WO1997028826A2 (de
Inventor
Klaus Stoeckemann
Arwed Cleve
Karin Hoffmann
Ulrich Koch
Original Assignee
Schering Ag
Klaus Stoeckemann
Arwed Cleve
Karin Hoffmann
Ulrich Koch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU23792/97A priority Critical patent/AU2379297A/en
Priority to JP9528064A priority patent/JP2000506515A/ja
Priority to EE9800239A priority patent/EE9800239A/xx
Priority to EP97919251A priority patent/EP0880364A2/de
Application filed by Schering Ag, Klaus Stoeckemann, Arwed Cleve, Karin Hoffmann, Ulrich Koch filed Critical Schering Ag
Priority to SK1070-98A priority patent/SK107098A3/sk
Priority to IL12548197A priority patent/IL125481A0/xx
Priority to APAP/P/1998/001306A priority patent/AP9801306A0/en
Priority to PL97328333A priority patent/PL328333A1/xx
Priority to BR9707416A priority patent/BR9707416A/pt
Priority to EA199800714A priority patent/EA199800714A1/ru
Publication of WO1997028826A2 publication Critical patent/WO1997028826A2/de
Publication of WO1997028826A3 publication Critical patent/WO1997028826A3/de
Priority to IS4802A priority patent/IS4802A/is
Priority to NO983672A priority patent/NO983672L/no
Priority to BG102682A priority patent/BG102682A/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/08Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/14Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0039Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Die vorliegende Erfindung betrifft die Kombination mindestens einer Verbindung mit kontrazeptiver Wirkung und/oder einer Verbindung mit antibakterieller und/oder antiviraler Wirkung zum Einarbeiten/Aufbringen auf ein intravaginales, intrauterines oder intracervicales Freisetzungssystem und die Verwendung eines solchen Freisetzungssystems.
PCT/DE1997/000321 1996-02-12 1997-02-11 Kontrazeptive freisetzungssysteme mit antibakterieller und/oder antiviraler wirkung WO1997028826A2 (de)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IL12548197A IL125481A0 (en) 1996-02-12 1997-02-11 Contraceptive release system with an antibacterial action and/or an antiviral action
EE9800239A EE9800239A (et) 1996-02-12 1997-02-11 Antibakteriaalse ja/või viirusvastase toimega kontratseptiivseid aineid vabastavad süsteemid
EP97919251A EP0880364A2 (de) 1996-02-12 1997-02-11 Kontrazeptive freisetzungssysteme mit antibakterieller und/oder antiviraler wirkung
PL97328333A PL328333A1 (en) 1996-02-12 1997-02-11 Contraceptive releasing systems of antibacterial and/or antiviral activity
SK1070-98A SK107098A3 (en) 1996-02-12 1997-02-11 Contraceptive release systems with antibacterial and/or antiviral effect
JP9528064A JP2000506515A (ja) 1996-02-12 1997-02-11 抗菌及び/又は抗ウイルス作用を有する避妊薬放出システム
APAP/P/1998/001306A AP9801306A0 (en) 1996-02-12 1997-02-11 Contraceptive release system with an antibacterial action and/or antiviral action.
AU23792/97A AU2379297A (en) 1996-02-12 1997-02-11 Contraceptive release systems with antibacterial and/or antiviral effect
BR9707416A BR9707416A (pt) 1996-02-12 1997-02-11 Sistemas de liberação contraceptivos com ação antibacteriana e/ou antiviral
EA199800714A EA199800714A1 (ru) 1996-02-12 1997-02-11 Контрацептивные системы высвобождения, обладающие антибактериальным и/или антивирусным действием
IS4802A IS4802A (is) 1996-02-12 1998-07-21 Getnaðarvarnar losunarkerfi með bakteríueyðandi og/eða veirueyðandi verkun
NO983672A NO983672L (no) 1996-02-12 1998-08-11 Prevensjonssystem med antibakteriell effekt og/eller antiviruseffekt
BG102682A BG102682A (en) 1996-02-12 1998-08-11 System for the release of contraceptives having bactericidal and/or antiviral effect

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19606355A DE19606355A1 (de) 1996-02-12 1996-02-12 Kontrazeptive Freisetzungssysteme mit antiviraler und/oder antibakterieller Wirkung
DE19606355.8 1996-02-12

Publications (2)

Publication Number Publication Date
WO1997028826A2 WO1997028826A2 (de) 1997-08-14
WO1997028826A3 true WO1997028826A3 (de) 1997-10-16

Family

ID=7785948

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1997/000321 WO1997028826A2 (de) 1996-02-12 1997-02-11 Kontrazeptive freisetzungssysteme mit antibakterieller und/oder antiviraler wirkung

Country Status (21)

Country Link
EP (1) EP0880364A2 (de)
JP (1) JP2000506515A (de)
KR (1) KR19990082434A (de)
CN (1) CN1211193A (de)
AP (1) AP9801306A0 (de)
AU (1) AU2379297A (de)
BG (1) BG102682A (de)
BR (1) BR9707416A (de)
CA (1) CA2245920A1 (de)
CZ (1) CZ253298A3 (de)
DE (1) DE19606355A1 (de)
EA (1) EA199800714A1 (de)
EE (1) EE9800239A (de)
HU (1) HUP9901977A3 (de)
IL (1) IL125481A0 (de)
IS (1) IS4802A (de)
NO (1) NO983672L (de)
PL (1) PL328333A1 (de)
SK (1) SK107098A3 (de)
TR (1) TR199801551T2 (de)
WO (1) WO1997028826A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002524481A (ja) * 1998-09-10 2002-08-06 ジェネーラ・コーポレーション 他の抗癌剤または理学療法と組み合わせたスクアラミンを使用する癌腫の処置
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
WO2003082336A1 (en) * 2002-04-03 2003-10-09 Jencap Research Ltd. Female birth control method
ES2710662T3 (es) 2005-06-24 2019-04-26 Biotron Ltd Compuestos de acilguanidina con actividad antiviral
DE102008006416A1 (de) * 2008-01-28 2009-07-30 Mayer, Thomas, Dr. med. Clindamycin zur Verwendung bei der Behandlung oder Vorbeugung der bakteriellen Vaginosis
KR20110045065A (ko) * 2008-09-16 2011-05-03 플레이텍스 프로덕츠, 엘엘씨. 월경 억제, 피임 및 호르몬 대체 요법을 위한 약제 및 이를 투여하는 방법
FI20095563A (fi) * 2009-05-20 2010-11-21 Bayer Schering Pharma Oy Vaginaalinen antojärjestelmä
GB201203768D0 (en) * 2012-03-05 2012-04-18 John Richard W Medical device
PL2982352T3 (pl) * 2014-06-28 2019-01-31 Laboratorios Andrómaco S.A. Krążek szyjki macicy zawierający progesteron do długotrwałego, przedłużonego i ciągłego uwalniania, stosowany w celu zapobiegania przed przedwczesnym porodem
CN105796572A (zh) * 2014-08-25 2016-07-27 郭曙平 一种避孕药物及其制备方法
CN109248140A (zh) * 2017-07-14 2019-01-22 国家卫生计生委科学技术研究所 ***抗菌***环的制备方法和应用
EP3446664A1 (de) 2017-08-21 2019-02-27 Karl-Heinz Kurz Intrauterine vorrichtung

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2101533A1 (de) * 1970-01-15 1971-09-16 Biological Concepts Inc , New York, NY (V St A ) Gerat zur dosierten Abgabe von Medikamenten
FR2250520A1 (de) * 1973-11-09 1975-06-06 Cournut Rene
US4180064A (en) * 1972-12-27 1979-12-25 Alza Corporation System for delivering agent to environment of use over prolonged time
GB2026320A (en) * 1978-07-25 1980-02-06 Gutnick Morton Devices for the prevention of venereal disease
US4393871A (en) * 1977-06-27 1983-07-19 Vli Corporation Vaginal device

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034749A (en) * 1973-12-06 1977-07-12 Schering Aktiengesellschaft Intrauterine contraceptive device
US4578076A (en) * 1984-03-20 1986-03-25 The Population Council, Inc. Medicated intracervical and intrauterine devices
US5229423A (en) * 1992-03-06 1993-07-20 Albert Einstein College Of Medicine Of Yeshiva University Use of butylurea as a contraceptive agent

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2101533A1 (de) * 1970-01-15 1971-09-16 Biological Concepts Inc , New York, NY (V St A ) Gerat zur dosierten Abgabe von Medikamenten
US4180064A (en) * 1972-12-27 1979-12-25 Alza Corporation System for delivering agent to environment of use over prolonged time
FR2250520A1 (de) * 1973-11-09 1975-06-06 Cournut Rene
US4393871A (en) * 1977-06-27 1983-07-19 Vli Corporation Vaginal device
GB2026320A (en) * 1978-07-25 1980-02-06 Gutnick Morton Devices for the prevention of venereal disease

Also Published As

Publication number Publication date
HUP9901977A2 (hu) 1999-10-28
CN1211193A (zh) 1999-03-17
IS4802A (is) 1998-07-21
EA199800714A1 (ru) 1999-02-25
EE9800239A (et) 1998-12-15
BG102682A (en) 1999-03-31
EP0880364A2 (de) 1998-12-02
BR9707416A (pt) 1999-05-25
PL328333A1 (en) 1999-01-18
NO983672L (no) 1998-10-09
AU2379297A (en) 1997-08-28
HUP9901977A3 (en) 2000-06-28
TR199801551T2 (xx) 1998-11-23
NO983672D0 (no) 1998-08-11
WO1997028826A2 (de) 1997-08-14
KR19990082434A (ko) 1999-11-25
CA2245920A1 (en) 1997-08-14
CZ253298A3 (cs) 1999-01-13
IL125481A0 (en) 1999-03-12
SK107098A3 (en) 1999-01-11
DE19606355A1 (de) 1997-08-14
AP9801306A0 (en) 1998-09-30
JP2000506515A (ja) 2000-05-30

Similar Documents

Publication Publication Date Title
GB9710699D0 (en) Gastro-retentive controlled release system
HK1018396A1 (en) Delivery system of an active agent.
MX9201235A (es) Procedimiento para la fabricacion de boehmita dispersable.
WO1997028826A3 (de) Kontrazeptive freisetzungssysteme mit antibakterieller und/oder antiviraler wirkung
DE69626187T2 (de) Fahrzeugnotrufnachrichtensystem
HK1037393A1 (en) Fixing and release systems.
BR9610507A (pt) Sistemas de liberação
HK1037861A1 (en) Formulations for the prevention or the treatment of diseases affecting mucosae or skin, or for pregnancy prevention
ZA9711317B (en) Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them.
AU5926798A (en) Transcervical contraceptive platinum microcoil
ZA942874B (en) Systems for the controlled release of pilocarpine
EP0154494A3 (de) Phenylimidazole inotropische Mittel
FR2657675B1 (fr) Systeme de protection thermique, notamment pour vehicules spatiaux.
AU4214497A (en) Composition comprising an antiviral or antibacterial agent for preventing transmission of diseases
EP0970697A4 (de) Stoff zur zervikalen reifung
IT1308018B1 (it) Dispositivo per la trasmissione di momenti frenanti per autoveicoli.
ES1034556Y (es) Insertador perfeccionado de dispositivos intrauterinos.
ES1044976Y (es) "dispositivo de seguridad para vehiculos de emergencia".
ES1021275Y (es) Enganche de emergencia para vehiculos.
MX9205295A (es) Composicion de balata semimetalica para el sistemacomposicion de balata semimetalica para el sistemade frenado, en vehiculos automotrices. de frenado, en vehiculos automotrices
ES1031444Y (es) Dispositivo para la colocacion de preservativos.
NL1001243A1 (nl) Voorbehoedmiddel, ter voorkoming van zwangerschap en sexueel overdraagbare aandoeningen.
ITGO940002A0 (it) Vetturetta per la citta' di mt. 2,10 ca.
AU5166998A (en) Vaginal device for preventing conception or the transmission of sexually transmitted diseases, or both
TW405545U (en) Improvement of structure of throttle, brake and clutch padels for the automobile

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 97192207.1

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AU AZ BB BG BR BY CA CN CZ EE GE HU IL IS JP KE KG KP KR KZ LK LR LS LT LV MD MG MK MN MW MX NO NZ PL RO RU SD SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AU AZ BB BG BR BY CA CN CZ EE GE HU IL IS JP KE KG KP KR KZ LK LR LS LT LV MD MG MK MN MW MX NO NZ PL RO RU SD SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1997919251

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 331259

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 107098

Country of ref document: SK

WWE Wipo information: entry into national phase

Ref document number: 1019980706167

Country of ref document: KR

ENP Entry into the national phase

Ref document number: 2245920

Country of ref document: CA

Ref document number: 2245920

Country of ref document: CA

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PA/a/1998/006479

Country of ref document: MX

Ref document number: PV1998-2532

Country of ref document: CZ

Ref document number: 1998/01551

Country of ref document: TR

WWE Wipo information: entry into national phase

Ref document number: 199800714

Country of ref document: EA

WWP Wipo information: published in national office

Ref document number: 1997919251

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: PV1998-2532

Country of ref document: CZ

WWP Wipo information: published in national office

Ref document number: 1019980706167

Country of ref document: KR

WWW Wipo information: withdrawn in national office

Ref document number: 1997919251

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1019980706167

Country of ref document: KR

WWR Wipo information: refused in national office

Ref document number: PV1998-2532

Country of ref document: CZ