WO1997022360A3 - Control of protein synthesis, and screening method for agents - Google Patents
Control of protein synthesis, and screening method for agents Download PDFInfo
- Publication number
- WO1997022360A3 WO1997022360A3 PCT/GB1996/003186 GB9603186W WO9722360A3 WO 1997022360 A3 WO1997022360 A3 WO 1997022360A3 GB 9603186 W GB9603186 W GB 9603186W WO 9722360 A3 WO9722360 A3 WO 9722360A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- agents
- control
- protein synthesis
- screening method
- pkb
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU12004/97A AU1200497A (en) | 1995-12-20 | 1996-12-20 | Control of protein synthesis, and screening method for agents |
JP09522599A JP2000502097A (en) | 1995-12-20 | 1996-12-20 | Methods for controlling protein synthesis and screening for agonists |
EP96943208A EP0868195A2 (en) | 1995-12-20 | 1996-12-20 | Control of protein synthesis, and screening method for agents |
US11/682,135 US7897371B2 (en) | 1995-11-16 | 2007-03-05 | Activation of mutated RAC-PK |
US13/021,048 US20110275102A1 (en) | 1995-11-16 | 2011-02-04 | Activation of mutated rac-pk |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9526083.2 | 1995-12-20 | ||
GBGB9526083.2A GB9526083D0 (en) | 1995-12-20 | 1995-12-20 | Method |
GBGB9610272.8A GB9610272D0 (en) | 1996-05-16 | 1996-05-16 | Method |
GB9610272.8 | 1996-05-16 | ||
GBGB9615066.9A GB9615066D0 (en) | 1996-07-18 | 1996-07-18 | Method |
GB9615066.9 | 1996-07-18 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09091763 A-371-Of-International | 1996-12-20 | ||
US09/845,667 Continuation US20020065221A1 (en) | 1995-11-16 | 2001-04-30 | Control of protein synthesis, and screening method for agents |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997022360A2 WO1997022360A2 (en) | 1997-06-26 |
WO1997022360A3 true WO1997022360A3 (en) | 1997-07-31 |
Family
ID=27268041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1996/003186 WO1997022360A2 (en) | 1995-11-16 | 1996-12-20 | Control of protein synthesis, and screening method for agents |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0868195A2 (en) |
JP (1) | JP2000502097A (en) |
AU (1) | AU1200497A (en) |
CA (1) | CA2241080A1 (en) |
WO (1) | WO1997022360A2 (en) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9525702D0 (en) * | 1995-12-15 | 1996-02-14 | Ciba Geigy Ag | Process for activating a kinase |
US6057117A (en) * | 1996-04-04 | 2000-05-02 | Chiron Corporation | Identification and use of selective inhibitors of glycogen synthase kinase 3 |
AU4920397A (en) * | 1996-10-11 | 1998-05-11 | Chiron Corporation | Purine inhibitors of glycogen synthase kinase 3 (gsk3) |
US7361336B1 (en) | 1997-09-18 | 2008-04-22 | Ivan Bergstein | Methods of cancer therapy targeted against a cancer stem line |
AU9395098A (en) * | 1997-09-26 | 1999-04-23 | Babraham Institute, The | Compositions and methods for identifying pkb kinase inhibitors |
US6682920B1 (en) | 1997-09-26 | 2004-01-27 | Onyx Pharmaceuticals, Inc. | Compositions and methods for identifying PKB kinase inhibitors |
SE9801530D0 (en) * | 1998-04-30 | 1998-04-30 | Pharmacia & Upjohn Ab | Method of screening |
WO1999064062A1 (en) * | 1998-06-08 | 1999-12-16 | Pharmacia & Upjohn Ab | New therapeutic use of pkb (proteine kinase b) enhancers |
WO2001037852A2 (en) * | 1999-11-23 | 2001-05-31 | Regeneron Pharmaceuticals, Inc. | Methods of inhibiting atrophy or promoting hypertrophy |
IL153851A0 (en) | 2000-07-27 | 2003-07-31 | Hoffmann La Roche | 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta |
WO2002024941A2 (en) * | 2000-09-22 | 2002-03-28 | University Of Dundee | Protein kinase regulation |
IL144583A0 (en) | 2001-07-26 | 2002-05-23 | Peptor Ltd | Chimeric protein kinase inhibitors |
JP4394961B2 (en) | 2002-04-08 | 2010-01-06 | メルク エンド カムパニー インコーポレーテッド | Fusion quinoxaline derivatives as inhibitors of AKT activity |
JP4451136B2 (en) | 2002-04-08 | 2010-04-14 | メルク エンド カムパニー インコーポレーテッド | Akt activity inhibitor |
US20050182256A1 (en) | 2002-04-08 | 2005-08-18 | Duggan Mark E. | Inhibitors of akt activity |
EP1496896A4 (en) | 2002-04-08 | 2007-10-31 | Merck & Co Inc | Inhibitors of akt activity |
GB0213614D0 (en) | 2002-06-13 | 2002-07-24 | Novartis Forschungsstiftlung Z | Purified PKB Kinae and uses thereof |
CA2501365C (en) | 2002-10-30 | 2011-05-31 | Merck & Co., Inc. | Inhibitors of akt activity |
CA2522430A1 (en) | 2003-04-24 | 2004-11-11 | Merck & Co., Inc. | Inhibitors of akt activity |
CA2522262A1 (en) | 2003-04-24 | 2004-11-11 | Merck & Co., Inc. | Inhibitors of akt activity |
DE602004023838D1 (en) | 2003-04-24 | 2009-12-10 | Merck & Co Inc | HEMMER OF ACT ACTIVITY |
CA2522431A1 (en) | 2003-04-24 | 2004-11-11 | Merck & Co., Inc. | Inhibitors of akt activity |
US7354944B2 (en) | 2004-10-18 | 2008-04-08 | Amgen Inc. | Thiadiazole compounds and methods of use |
EP2173728A2 (en) | 2007-07-17 | 2010-04-14 | Amgen Inc. | Heterocyclic modulators of pkb |
AU2008276512A1 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of PKB |
WO2009125798A1 (en) * | 2008-04-09 | 2009-10-15 | 萬有製薬株式会社 | Method for screening of pharmaceutical candidate substance for treatment of cancer in which hedgehog pathway is activated |
EP3529615A1 (en) | 2016-10-24 | 2019-08-28 | Novo Nordisk A/S | Bioassay for insulin formulations |
-
1996
- 1996-12-20 JP JP09522599A patent/JP2000502097A/en active Pending
- 1996-12-20 CA CA002241080A patent/CA2241080A1/en not_active Abandoned
- 1996-12-20 AU AU12004/97A patent/AU1200497A/en not_active Abandoned
- 1996-12-20 EP EP96943208A patent/EP0868195A2/en not_active Withdrawn
- 1996-12-20 WO PCT/GB1996/003186 patent/WO1997022360A2/en not_active Application Discontinuation
Non-Patent Citations (7)
Title |
---|
B. BURGERING ET AL.: "Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction.", NATURE, vol. 376, no. 6541, 17 August 1995 (1995-08-17), LONDON, GB, pages 599 - 602, XP002032104 * |
D. ALESSI ET AL.: "Mechanism of activation of protein kinase B by insulin and IGF-1.", THE EMBO JOURNAL, vol. 15, no. 23, 2 December 1996 (1996-12-02), OXFORD, GB, pages 6541 - 6551, XP002032108 * |
D. ALESSI ET AL.: "Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase.", FEBS LETTERS, vol. 399, no. 3, 16 December 1996 (1996-12-16), AMSTERDAM, NL, pages 333 - 338, XP002032109 * |
D. CROSS ET AL.: "Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.", NATURE, vol. 378, no. 6559, 21 December 1995 (1995-12-21), LONDON, GB, pages 785 - 789, XP002025954 * |
E. SIEGFRIED ET AL.: "Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3.", NATURE, vol. 345, no. 6278, 28 June 1990 (1990-06-28), LONDON, GB, pages 825 - 829, XP002032106 * |
H. KONISHI ET AL.: "Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C gamma.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 205, no. 1, 30 November 1994 (1994-11-30), DULUTH, MN, USA, pages 817 - 825, XP002032107 * |
T. FRANKE ET AL.: "The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.", CELL, vol. 81, no. 5, 2 June 1995 (1995-06-02), CAMBRIDGE, MA, USA, pages 727 - 736, XP002032105 * |
Also Published As
Publication number | Publication date |
---|---|
CA2241080A1 (en) | 1997-06-26 |
WO1997022360A2 (en) | 1997-06-26 |
EP0868195A2 (en) | 1998-10-07 |
JP2000502097A (en) | 2000-02-22 |
AU1200497A (en) | 1997-07-14 |
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