AU8071698A - Novel heteroaryl compounds for the modulation of protein tyrosine enzyme relatedcellular signal transduction - Google Patents
Novel heteroaryl compounds for the modulation of protein tyrosine enzyme relatedcellular signal transductionInfo
- Publication number
- AU8071698A AU8071698A AU80716/98A AU8071698A AU8071698A AU 8071698 A AU8071698 A AU 8071698A AU 80716/98 A AU80716/98 A AU 80716/98A AU 8071698 A AU8071698 A AU 8071698A AU 8071698 A AU8071698 A AU 8071698A
- Authority
- AU
- Australia
- Prior art keywords
- relatedcellular
- modulation
- signal transduction
- protein tyrosine
- heteroaryl compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4956097P | 1997-06-13 | 1997-06-13 | |
| US60049560 | 1997-06-13 | ||
| PCT/US1998/012333 WO1998056376A1 (en) | 1997-06-13 | 1998-06-12 | Novel heteroaryl compounds for the modulation of protein tyrosine enzyme related cellular signal transduction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU8071698A true AU8071698A (en) | 1998-12-30 |
Family
ID=21960475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU80716/98A Abandoned AU8071698A (en) | 1997-06-13 | 1998-06-12 | Novel heteroaryl compounds for the modulation of protein tyrosine enzyme relatedcellular signal transduction |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1007042A4 (en) |
| JP (1) | JP2002512628A (en) |
| AU (1) | AU8071698A (en) |
| CA (1) | CA2293400A1 (en) |
| WO (1) | WO1998056376A1 (en) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6147106A (en) | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US6316635B1 (en) | 1995-06-07 | 2001-11-13 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| US6486185B1 (en) | 1997-05-07 | 2002-11-26 | Sugen, Inc. | 3-heteroarylidene-2-indolinone protein kinase inhibitors |
| US6316429B1 (en) | 1997-05-07 | 2001-11-13 | Sugen, Inc. | Bicyclic protein kinase inhibitors |
| AU3363599A (en) * | 1998-03-26 | 1999-10-18 | Max-Planck Institut Fur Biochemie | Heterocyclic families of compounds for the modulation of tyrosine protein kinase |
| US6514981B1 (en) | 1998-04-02 | 2003-02-04 | Sugen, Inc. | Methods of modulating tyrosine protein kinase function with indolinone compounds |
| US6395734B1 (en) | 1998-05-29 | 2002-05-28 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
| US6689806B1 (en) | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
| EP2308833A3 (en) * | 1999-04-15 | 2011-09-28 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| CA2382789A1 (en) * | 1999-08-27 | 2001-03-08 | Sugen, Inc. | Phosphate mimics and methods of treatment using phosphatase inhibitors |
| US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
| PE20030008A1 (en) | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | DUAL INHIBITORS OF PDE 7 AND PDE 4 |
| JP2005508968A (en) * | 2001-10-19 | 2005-04-07 | トランス テック ファーマ，インコーポレイテッド | Β-carboline derivatives as PTP inhibitors |
| MY133406A (en) * | 2001-11-28 | 2007-11-30 | Ipsen Pharma Sas | 5-sulphanyl-4h-1,2,4-triazole derivatives and their use as a medicament |
| US7049333B2 (en) | 2002-06-04 | 2006-05-23 | Sanofi-Aventis Deutschland Gmbh | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis |
| WO2005035551A2 (en) | 2003-10-08 | 2005-04-21 | Incyte Corporation | Inhibitors of proteins that bind phosphorylated molecules |
| WO2005081954A2 (en) | 2004-02-25 | 2005-09-09 | Wyeth | Inhibitors of protein tyrosine phosphatase 1b |
| US10894784B2 (en) | 2015-12-18 | 2021-01-19 | Bayer Pharma Aktiengesellschaft | Heteroarylbenzimidazole compounds |
| WO2017207534A1 (en) | 2016-06-03 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituted heteroarylbenzimidazole compounds |
| CN116478131A (en) | 2016-07-12 | 2023-07-25 | 锐新医药公司 | 2, 5-disubstituted and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors |
| CN110023313B (en) | 2016-12-02 | 2022-10-25 | 豪夫迈·罗氏有限公司 | Bicyclic amide compounds and methods of use thereof |
| BR112019014527A2 (en) * | 2017-01-23 | 2020-02-27 | Revolution Medicines, Inc. | PYRIDINE COMPOUNDS AS ALLOSTIC SHP2 INHIBITORS |
| KR20190111079A (en) | 2017-01-23 | 2019-10-01 | 레볼루션 메디슨즈, 인크. | Bicyclic Compounds as Allosteric SHP2 Inhibitors |
| EP3652178B1 (en) | 2017-07-14 | 2024-01-24 | F. Hoffmann-La Roche AG | Bicyclic ketone compounds and methods of use thereof |
| CN111344017A (en) | 2017-09-07 | 2020-06-26 | 锐新医药公司 | SHP2 inhibitor compositions and methods for treating cancer |
| RU2020114670A (en) | 2017-10-11 | 2021-11-12 | Ф. Хоффманн-Ля Рош Аг | BICYCLIC COMPOUNDS FOR USE AS RIP1 KINASE INHIBITORS |
| JP2020536881A (en) | 2017-10-12 | 2020-12-17 | レヴォリューション・メディスンズ，インコーポレイテッド | Pyridine, pyrazine and triazine compounds as allosteric SHP2 inhibitors |
| CA3078688A1 (en) | 2017-10-31 | 2019-05-09 | F. Hoffmann-La Roche Ag | Bicyclic sulfones and sulfoxides and methods of use thereof |
| MX2020006273A (en) | 2017-12-15 | 2020-09-14 | Revolution Medicines Inc | Polycyclic compounds as allosteric shp2 inhibitors. |
| RS64272B1 (en) | 2018-05-01 | 2023-07-31 | Revolution Medicines Inc | C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors |
| US11548885B2 (en) | 2020-09-21 | 2023-01-10 | Landos Biopharma, Inc. | NLRX1 ligands |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9323290D0 (en) * | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
| US5798374A (en) * | 1995-06-07 | 1998-08-25 | Sugen Inc. | Methods of inhibiting phosphatase activity and treatment of disorders associated therewith |
| GB9514265D0 (en) * | 1995-07-13 | 1995-09-13 | Wellcome Found | Hetrocyclic compounds |
-
1998
- 1998-06-12 AU AU80716/98A patent/AU8071698A/en not_active Abandoned
- 1998-06-12 JP JP50329999A patent/JP2002512628A/en active Pending
- 1998-06-12 EP EP98929059A patent/EP1007042A4/en not_active Withdrawn
- 1998-06-12 WO PCT/US1998/012333 patent/WO1998056376A1/en not_active Application Discontinuation
- 1998-06-12 CA CA002293400A patent/CA2293400A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1007042A4 (en) | 2001-07-04 |
| EP1007042A1 (en) | 2000-06-14 |
| CA2293400A1 (en) | 1998-12-17 |
| WO1998056376A1 (en) | 1998-12-17 |
| JP2002512628A (en) | 2002-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |