WO1997013505A3 - UTILISATION D'UN LIGAND AGONISTE SPECIFIQUE RAR-η POUR AUGMENTER LE TAUX D'APOPTOSE - Google Patents

UTILISATION D'UN LIGAND AGONISTE SPECIFIQUE RAR-η POUR AUGMENTER LE TAUX D'APOPTOSE Download PDF

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Publication number
WO1997013505A3
WO1997013505A3 PCT/FR1996/001568 FR9601568W WO9713505A3 WO 1997013505 A3 WO1997013505 A3 WO 1997013505A3 FR 9601568 W FR9601568 W FR 9601568W WO 9713505 A3 WO9713505 A3 WO 9713505A3
Authority
WO
WIPO (PCT)
Prior art keywords
rar
apoptosis
specific agonist
agonist ligand
composition
Prior art date
Application number
PCT/FR1996/001568
Other languages
English (en)
Other versions
WO1997013505A2 (fr
Inventor
Laszlo Fesus
Zsuzsa Szondy
Uwe Reichert
Original Assignee
Cird
Laszlo Fesus
Zsuzsa Szondy
Uwe Reichert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cird, Laszlo Fesus, Zsuzsa Szondy, Uwe Reichert filed Critical Cird
Priority to NZ319646A priority Critical patent/NZ319646A/xx
Priority to AU72209/96A priority patent/AU705993B2/en
Priority to US09/051,407 priority patent/US6593359B1/en
Priority to JP09514767A priority patent/JP3135266B2/ja
Priority to EP96933502A priority patent/EP0854710A2/fr
Priority to KR1019980702620A priority patent/KR19990064139A/ko
Priority to PL96326077A priority patent/PL185826B1/pl
Priority to BR9610967A priority patent/BR9610967A/pt
Publication of WO1997013505A2 publication Critical patent/WO1997013505A2/fr
Publication of WO1997013505A3 publication Critical patent/WO1997013505A3/fr
Priority to NO981592A priority patent/NO981592L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Utilisation d'au moins un ligand agoniste spécifique aux récepteurs de type RAR-η dans la préparation d'une composition pharmaceutique destinée à augmenter le taux d'apoptose dans au moins une population cellulaire pour laquelle l'apoptose peut être induite par activation des récepteurs de type RAR-η. Cette composition peut servir notamment à traiter une maladie ou un désordre lié à une insuffisance du taux d'apoptose dans au moins une population cellulaire pour laquelle l'apoptose peut être induite par activation des récepteurs de type RAR-η. Utilisation d'au moins un ligand agoniste spécifique aux récepteurs de type RAR-η dans une composition cosmétique en tant qu'inducteur d'apoptose. Cette composition peut permettre de prévenir et/ou de lutter contre le vieillissement photoinduit ou chronologique de la peau.
PCT/FR1996/001568 1995-10-09 1996-10-08 UTILISATION D'UN LIGAND AGONISTE SPECIFIQUE RAR-η POUR AUGMENTER LE TAUX D'APOPTOSE WO1997013505A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
NZ319646A NZ319646A (en) 1995-10-09 1996-10-08 Use of a rar-y-specific agonist ligand for increasing the rate of apoptosis
AU72209/96A AU705993B2 (en) 1995-10-09 1996-10-08 Use of a RAR-gamma-specific agonist ligand for increasing the rate of apoptosis
US09/051,407 US6593359B1 (en) 1995-10-09 1996-10-08 Use of a RAR-γ-specific agonist ligand for increasing the rate of apoptosis
JP09514767A JP3135266B2 (ja) 1995-10-09 1996-10-08 アポプトシス速度向上のためのＲＡＲ−γ−特異的アゴニストリガンドの使用
EP96933502A EP0854710A2 (fr) 1995-10-09 1996-10-08 UTILISATION D'UN LIGAND AGONISTE SPECIFIQUE RAR-$g(g) POUR AUGMENTER LE TAUX D'APOPTOSE
KR1019980702620A KR19990064139A (ko) 1995-10-09 1996-10-08 세포 소멸 속도를 증가시키는 감마-알에이알-특이성 작용 물질리간드의 용도
PL96326077A PL185826B1 (pl) 1995-10-09 1996-10-08 Zastosowanie specyficznego ligandu agonistycznegoZastosowanie specyficznego ligandu agonistycznegoRAR-y do zwiększenia stopnia apoptozyRAR-y do zwiększenia stopnia apoptozy
BR9610967A BR9610967A (pt) 1995-10-09 1996-10-08 Utilização de pelo menos um ligante agonista específico aos receptores de tipo rar e processo cosmético para previnir e/ou combater o envelhecimento fotoinduzido ou cronológico da pele
NO981592A NO981592L (no) 1995-10-09 1998-04-07 Anvendelse av <gamma>-RAR-spesifikk agonistligand for Õ °ke apoptosisraten

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9512179A FR2739557B1 (fr) 1995-10-09 1995-10-09 Utilisation d'un ligand agoniste specifique rar-gamma
FR95/12179 1995-10-09

Related Child Applications (5)

Application Number Title Priority Date Filing Date
US09/051,407 A-371-Of-International US6593359B1 (en) 1995-10-09 1996-10-08 Use of a RAR-γ-specific agonist ligand for increasing the rate of apoptosis
US09/431,920 Division US6686386B1 (en) 1995-10-09 1999-11-02 Use of a RAR-γ-specific agonist ligand for increasing the rate of apoptosis
US09/624,771 Division US6506796B1 (en) 1995-10-09 2000-07-25 Use of a RAR-γ-specific agonist ligand for increasing the rate of apoptosis
US09/801,664 Continuation US20010018456A1 (en) 1995-10-09 2001-03-09 Use of a RAR-gamma-specific agonist ligand for increasing the rate of apoptosis
US10/183,518 Continuation-In-Part US20030092758A1 (en) 1995-10-09 2002-06-28 Use of a RAR-gamma-specific agonist ligand for increasing the rate of apoptosis

Publications (2)

Publication Number Publication Date
WO1997013505A2 WO1997013505A2 (fr) 1997-04-17
WO1997013505A3 true WO1997013505A3 (fr) 1997-05-29

Family

ID=9483613

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1996/001568 WO1997013505A2 (fr) 1995-10-09 1996-10-08 UTILISATION D'UN LIGAND AGONISTE SPECIFIQUE RAR-η POUR AUGMENTER LE TAUX D'APOPTOSE

Country Status (16)

Country Link
US (4) US6593359B1 (fr)
EP (1) EP0854710A2 (fr)
JP (1) JP3135266B2 (fr)
KR (1) KR19990064139A (fr)
CN (1) CN1121857C (fr)
AU (1) AU705993B2 (fr)
BR (1) BR9610967A (fr)
CA (1) CA2231561A1 (fr)
FR (1) FR2739557B1 (fr)
HU (1) HUP9900453A3 (fr)
NO (1) NO981592L (fr)
NZ (1) NZ319646A (fr)
PL (1) PL185826B1 (fr)
RU (1) RU2188037C2 (fr)
TR (1) TR199800645T1 (fr)
WO (1) WO1997013505A2 (fr)

Families Citing this family (36)

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US20030053991A1 (en) * 2000-10-04 2003-03-20 Kingsman Alan John Retinoic acid receptor beta-2, its agonists, and gene theraphy vectors for the treatment of neurological disorders
US20070213290A1 (en) * 1996-10-17 2007-09-13 Kingsman Alan J Neurite regeneration
US20040266715A1 (en) * 1999-03-31 2004-12-30 Wong Liang Fong Neurite regeneration
GB9907461D0 (en) * 1999-03-31 1999-05-26 King S College London Neurite regeneration
FR2757852B1 (fr) 1996-12-31 1999-02-19 Cird Galderma Composes stilbeniques a groupement adamantyl, compositions les contenant et utilisations
KR100440836B1 (ko) * 1997-11-12 2004-07-19 에프. 호프만-라 로슈 아게 레티노이드 길항제를 이용한 제2형 ｔ-보조세포 중재 면역질환의 치료
US6083973A (en) * 1998-03-09 2000-07-04 Syntex (U.S.A.) Inc. Methods for inhibiting mucin secretion using RAR α selective antagonists
US6949528B1 (en) * 1998-03-18 2005-09-27 Goddard John G Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
JO2178B1 (en) * 1999-10-19 2003-04-23 اف . هوفمان لاروش ايه جي Treatment of invasive diseases, using selected anti-PAR materials
US20060151574A1 (en) * 2002-11-29 2006-07-13 Gpc Biotech Ag Formulations useful against hepatitis C virus infections
US20050202055A1 (en) * 2004-03-11 2005-09-15 Koichi Shudo, Tokyo, Japan Anti-wrinkle agent
WO2005092283A1 (fr) * 2004-03-26 2005-10-06 Dsm Ip Assets B.V. Composition comprenant un inhibiteur d'hdac combine a un retinoide
US7713266B2 (en) 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US7850683B2 (en) * 2005-05-20 2010-12-14 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US9254162B2 (en) 2006-12-21 2016-02-09 Myoscience, Inc. Dermal and transdermal cryogenic microprobe systems
US8409185B2 (en) 2007-02-16 2013-04-02 Myoscience, Inc. Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling
WO2009065061A1 (fr) 2007-11-14 2009-05-22 Myoscience, Inc. Gestion de la douleur à l'aide du remodelage cryogénique
CA2748043A1 (fr) 2008-12-22 2010-07-01 Myoscience, Inc. Systeme de cryochirurgie integre avec fluide frigorigene et source d'energie electrique
JP5986570B2 (ja) 2010-09-01 2016-09-06 トーマス・ジェファーソン・ユニバーシティＴｈｏｍａｓ Ｊｅｆｆｅｒｓｏｎ Ｕｎｉｖｅｒｓｉｔｙ 筋修復および再生のための組成物および方法
EP3616701A1 (fr) * 2011-06-24 2020-03-04 GRI Bio, Inc. Prévention et traitement de maladies inflammatoires
CA2861116A1 (fr) 2012-01-13 2013-07-18 Myoscience, Inc. Systeme de filtration de sonde cryogenique
BR112014017175A8 (pt) 2012-01-13 2017-07-04 Myoscience Inc proteção de pele para remodelagem criogênica subdérmica para tratamentos cosméticos e outros
EP2802279B1 (fr) 2012-01-13 2017-08-16 Myoscience, Inc. Aiguille cryogénique avec régulation de la zone de congélation
US9017318B2 (en) 2012-01-20 2015-04-28 Myoscience, Inc. Cryogenic probe system and method
WO2014146126A1 (fr) 2013-03-15 2014-09-18 Myoscience, Inc. Méthodes et dispositifs cryogéniques de dissection par extrémité émoussée
US9295512B2 (en) 2013-03-15 2016-03-29 Myoscience, Inc. Methods and devices for pain management
WO2014146127A1 (fr) 2013-03-15 2014-09-18 Myoscience, Inc. Procédés et systèmes pour le traitement de la spasticité
US9610112B2 (en) 2013-03-15 2017-04-04 Myoscience, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
WO2015069792A1 (fr) 2013-11-05 2015-05-14 Myoscience, Inc. Système de traitement cryochirurgical sécurisé
DK3380086T3 (da) 2015-11-25 2021-11-22 Io Therapeutics Inc Cyp26-resistente rar-alpha-selektive agonister i behandling af cancer
US11311327B2 (en) 2016-05-13 2022-04-26 Pacira Cryotech, Inc. Methods and systems for locating and treating nerves with cold therapy
AU2017278220C1 (en) 2016-06-10 2022-10-13 Io Therapeutics, Inc. Receptor selective retinoid and rexinoid compounds and immune modulators for cancer immunotherapy
EP3651764A4 (fr) * 2017-07-13 2021-09-22 IO Therapeutics, Inc. Composés rétinoïdes et rexinoïdes immunomodulateurs en combinaison avec des modulateurs immunitaires pour l'immunothérapie du cancer
CN111148514A (zh) 2017-08-31 2020-05-12 Io治疗公司 与免疫调节剂联合应用于癌症免疫治疗的rar选择性激动剂
US11134998B2 (en) 2017-11-15 2021-10-05 Pacira Cryotech, Inc. Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods
US11135236B2 (en) * 2018-04-10 2021-10-05 Northwestern University Retinoic acid receptor gamma agonists to attenuate anthracycline-induced cardiotoxicity

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Patent Citations (1)

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WO1997003682A1 (fr) * 1995-07-17 1997-02-06 Centre International De Recherches Dermatologiques C.I.R.D. Galderma Procedes de traitement de cancers a l'aide de 6-[3-[1-adamantyl]-4-hydroxyphenyl]

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Also Published As

Publication number Publication date
NZ319646A (en) 2000-08-25
JP3135266B2 (ja) 2001-02-13
HUP9900453A3 (en) 1999-11-29
US6506796B1 (en) 2003-01-14
CN1203528A (zh) 1998-12-30
CN1121857C (zh) 2003-09-24
AU7220996A (en) 1997-04-30
US6593359B1 (en) 2003-07-15
RU2188037C2 (ru) 2002-08-27
FR2739557A1 (fr) 1997-04-11
NO981592L (no) 1998-06-09
PL185826B1 (pl) 2003-08-29
WO1997013505A2 (fr) 1997-04-17
BR9610967A (pt) 1999-03-02
US20010018456A1 (en) 2001-08-30
US6686386B1 (en) 2004-02-03
JPH11501661A (ja) 1999-02-09
KR19990064139A (ko) 1999-07-26
CA2231561A1 (fr) 1997-04-17
AU705993B2 (en) 1999-06-03
HUP9900453A2 (hu) 1999-05-28
EP0854710A2 (fr) 1998-07-29
TR199800645T1 (xx) 1998-06-22
PL326077A1 (en) 1998-08-17
FR2739557B1 (fr) 1997-11-14
NO981592D0 (no) 1998-04-07

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