WO1996040302A1 - Prothese-tissu souple bioabsorbable comblant un espace - Google Patents
Prothese-tissu souple bioabsorbable comblant un espace Download PDFInfo
- Publication number
- WO1996040302A1 WO1996040302A1 PCT/US1996/005525 US9605525W WO9640302A1 WO 1996040302 A1 WO1996040302 A1 WO 1996040302A1 US 9605525 W US9605525 W US 9605525W WO 9640302 A1 WO9640302 A1 WO 9640302A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- prosthesis
- soft tissue
- substrate
- solution
- tissue prosthesis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L31/129—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00357—Wound bandages implanted wound fillings or covers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
Definitions
- the present invention relates to a composite bioabsorbable and biocompatible soft tissue prosthesis which has an inert hydrophobic side and an absorbable hydrophilic side that will expand to absorb and displace fluids that have accumulated adjacent the prosthesis and more particularly the present invention relates to a soft tissue prosthesis intended primarily to be used as a pericardial prosthesis having a substrate of biocompatible material such as ePTFE with a coating or layer of bioabsorbable, swellable material bonded or adhered to it.
- biocompatible material such as ePTFE
- the present invention generally pertains to the use of a biocompatible soft tissue prosthesis having specialized characteristics for medical use and more particularly relates to a prosthesis having a substrate of ePTFE which will absorb secretions. It is known to laminate or otherwise modify ePTFE or other membranes to produce various products and product characteristics including the ability to absorb fluids.
- U.S. Patent No. 5,135,755 discloses a wound secretion-absorbing hydrogel which is cross-linked on the basis of multi-valent alcohols, biopolymers and synthetic polymers and used as wound dressings.
- the hydrogels, according to the invention promote accelerated healing and are transparent permitting observation of the wound healing process.
- Patent No. 4,161 ,948 discloses an artificial membrane for wound dressings composed of two polypeptide layers, one of which contacts the wound.
- the membrane is biologically resorbable and the membrane serves as an artificial skin which is permeable to water and to drug solutions but practically impervious to outside pathogenic agents.
- European Patent Application No. 0261470 discloses a bioabsorbable coating for surgical articles which comprises a polymer manufactured from at least the monomer caprolactone.
- the article can be a bioabsorbable suture or a ligature.
- U.S. Patent No. 5,126,140 discloses a biocompatible thrombo-resistant substance for implantable and extracorporeal devices in contact with the vascular system.
- the biocompatible thrombo-resistant substance comprises a synthetic biocompatible material at least one bio-compatible base coat layer adhered to at least one surface of the material and the thrombogenesis inhibitor thrombomoduiin immobilized on the base coat layer via a component capable of binding the inhibitor without affecting its thrombogenesis inhibiting activity.
- U.S. Patent No. 5,087,243 shows an implantable delivery system for use in applying medicinal materials to a specific subcutaneous tissue sites in conjunction with an implanted defibulator.
- Expanded, porous PTFE films have acquired wide acceptance since their introduction because of their unique qualities. Expanded PTFE films have been used alone or laminated to other substrates or impregnated with various compositions to produce a range of products. It has been found that a substrate of expanded PTFE having a layer, film or coating of bioabsorbable, swellable material bonded to it performs well as a space-filling soft tissue prosthesis, particularly in the pericardial environment. Accordingly, the present invention relates to an absorbable layer which will swell and displace any fluids that have accumulated between a surface of the membrane and an internal organ or tissue to minimize fluid accumulation.
- One particular application is the prevention of epicardial thickening by use of a soft tissue prosthesis fabricated using a substrate of a biocompatible material such as expanded PTFE.
- the preferred material is that material sold under the designation GORE-TEX® Surgical Membrane available from W.L. Gore & Associates of Flagstaff, Arizona.
- the preferred material is fabricated by expanding porous PTFE to create a membrane of porous, expanded PTFE having a microstructure of nodes interconnected by fibrils.
- the manufacture of a porous, expanded PTFE membrane is described in detail in U.S. Patent Nos. 3,953,566 and 4,187,390 incorporated by reference herein.
- a layer or coating of a bioabsorbable, swellable material is bonded or otherwise applied or adhesed to the biomaterial substrate.
- the coating material preferably is a weak gel or a highly viscous fluid when hydrated.
- the absorbable material will swell to displace fluids that have accumulated adjacent the tissue such as the epicardium.
- the preferred material applied to the membrane has no or a very low yield strength when hydrated.
- Gums such as Xanthan gum, modified celluloses such as carboxymethyl cellulose (CMC), hydroxylpropylmethyl cellulose, and hyaluronic acid derivatives are good examples. Gelling agents may also be used to stiffen the hydrated membrane.
- the dried membrane may also be plasticized with a plasticizer such as glycerol or glycerine to improve workability and flexibility.
- GORE-TEX® Surgical Membrane of the type described above is widely used for the reconstruction and repair of the pericardium or peritoneum.
- GORE-TEX® Surgical Membrane is a unique configuration of expanded PTFE that maintains long-term flexibility and limits tissue attachment between adjacent tissue structures.
- Many years of clinical experience have established that GORE-TEX® Surgical Membrane provides an effective plane of dissection without adding to patient morbidity and mortality. Adhesion formation is limited due to the structure of the material. Re-entry into the pericardial space is facilitated and complications associated with re-entry are minimized.
- the surgical membrane is packaged sterile and various implant techniques have been used in reconstructing the integrity of the pericardium following cardiac surgery.
- Nonabsorbable sutures are commonly used to anchor the surgical membrane to the pericardium. Clips may also be used to anchor the surgical membrane and have the advantage of acting as locators when standard imaging techniques are subsequently used.
- the ePTFE membrane is a white, generally opaque material and after implantation the material becomes wetted with proteinaceous aqueous fluids and turns translucent due to the porous nature of the material. This is an advantage as if re-operation is necessary, it may be possible for the surgeons to view the epicardial anatomy of the heart surface through the membrane.
- a drain at the surgical site to remove accumulating fluid.
- additional drains such as plural cavities may be placed and use of a closed suction draining system may be utilized to avoid contamination. Post-operatively, these drains are removed and trapped blood, proteinaceous material and fluid may then accumulate next to the epicardial surface may cause a slight thickening of the epicardium.
- the purpose of the present invention is to address the perception or concern of some cardiac surgeons that accumulations of fluid under the pericardial prosthesis will cause such a thickening.
- a soft tissue prosthesis which is generally termed a "space-filling soft tissue prosthesis" that is applied to a surgical site and expands to occupy space between the prosthesis and adjacent tissue or organs such as the pericardial surface.
- the prosthesis consists of a substrate of expanded PTFE having a layer or coating of bioabsorbable, swellable material bonded to it to form a composite membrane.
- This material may be a weak gel or a highly viscous fluid when hydrated. When dehydrated, the material is a flexible film.
- the composite structure of the substrate and coating is positioned with the absorbable side adjacent the surgical site which would normally be disposed downwardly. As fluids tend to collect at the site, the absorbable layer will hydrate and swell displacing any fluids that have accumulated beneath the prosthesis.
- the preferred swellable material bonded to the substrate has no or low- yield strength when hydrated.
- Gums such as plant gums and mucilages, Xanthan gum, modified celluloses such as carbomethylcellulose (CMC), hydroxypropylmethylcellulose (HPMC) and Hyaluronic acid derivatives are preferred.
- gelling agents may be used to stiffen the hydrated membrane.
- Good gelling agents for this purpose are hydrophilic colloids and may be selected from the following groups: algins, alginates, elastic gelatins, hyaluronic acid, and polyetherglycols such as polyethylene glycol.
- the membrane may also be stiffened by cross-linking with a cross-linking agent such as a polyvalent aldehyde compound of glutaraldehyde, dialdehyde starch, calcium ions or boric acid, etc.
- a cross-linking agent such as a polyvalent aldehyde compound of glutaraldehyde, dialdehyde starch, calcium ions or boric acid, etc.
- the hydrating swellable material may be applied in various ways and may be adhered to a surface of the ePTFE substrate or may be bonded to a surface of the ePTFE or may be applied as a coating and allowed to dry.
- the dried composite product may then be plasticized with a suitable plasticizer glycerin to improve handling.
- Example 1 A preferred material may be fabricated by preparing a solution for one part carbomethylcellulose (CMC) to two parts glycerin with up to one part calcium alginate in a 0.7% saline solution.
- the concentration of the solution may be variable but should be greater than about 4% CMC and is used to make a film which is then dried. The dried film is then placed on a substrate of wetted, expanded PTFE. The expanded PTFE being wetted with the above solution.
- the composite structure is then allowed to dry and the resulting composite structure is suitable as a pericardial prosthesis as described above.
- the completed soft tissue prosthesis is sterilized by conventional autoclaving techniques and provided to the surgeon in suitable sterile packaging.
- the prosthesis is surgicaliy implantable as described above being particularly useful in reconstructing the integrity of the pericardium following cardiac surgery to fill voids which may exist under the conventional graft. After a period of time the swellable material will absorb leaving the expanded PTFE substrate as a permanent membrane in the patient.
- a solution is initially prepared from one part CMC to two parts glycerin with up to one part calcium alginate in a 0.7% saline solution.
- a concentration in the range of 0.5% to 1.5% CMC is maintained and some of the solution is applied to a glass plate by conventional coating techniques and allowed to dry to form a film.
- the remainder of the solution is applied to the ePTFE substrate material by conventional coating techniques as by immersion to cause the solution to impregnate the GSM.
- Impregnation is enhanced by application of hydrostatic pressure in the range of 150 to 1000 PSIG. Once impregnation has occurred, normally after about 5 minutes, the substrate is removed from the hydrostatic chamber and the film is applied to the impregnated substrate. The composite is allowed to dry and is then sterilized and packaged as described above.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Materials For Medical Uses (AREA)
Abstract
L'invention porte sur une prothèse-tissu souple, destinée à être implantée entre l'épicarde et le tissu contigu, qui absorbera du fluide et se dilatera pour déloger des fluides pouvant être à l'origine de la survenue d'un épaississement de l'épicarde. Sous la forme préférée, la prothèse possède un substrat en polytétrafluoroéthylène (PTFE) poreux et expansé auquel est fixé un gel par placage ou liaison. Lorsqu' elle est déshydratée, la prothèse est souple. Parmi les matériaux préférés susceptibles d'être fixé au substrat figurent des gommes, des celluloses modifiées et des dérivés d'acide hyaluronique. Il est possible d'ajouter des agents gélifiants et des durcisseurs. L'invention porte également sur un procédé de production de cette prothèse ainsi que sur une procédure chirurgicale faisant appel à cette prothèse.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU53919/96A AU5391996A (en) | 1995-06-07 | 1996-04-19 | Bioabsorbable space filling soft tissue prosthesis |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47580595A | 1995-06-07 | 1995-06-07 | |
US08/475,805 | 1995-06-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996040302A1 true WO1996040302A1 (fr) | 1996-12-19 |
Family
ID=23889230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/005525 WO1996040302A1 (fr) | 1995-06-07 | 1996-04-19 | Prothese-tissu souple bioabsorbable comblant un espace |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU5391996A (fr) |
WO (1) | WO1996040302A1 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002064184A2 (fr) * | 2001-02-13 | 2002-08-22 | Ethicon Gmbh | Procede de preparation d'un implant chirurgical |
JP2012075858A (ja) * | 2010-10-01 | 2012-04-19 | Tyco Healthcare Group Lp | 移植可能なポリマーフィルム |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0000949A1 (fr) * | 1977-08-26 | 1979-03-07 | Philip Nicholas Sawyer | Prothèses cardiaques et vasculaires et procédé pour leur fabrication |
US4193138A (en) * | 1976-08-20 | 1980-03-18 | Sumitomo Electric Industries, Ltd. | Composite structure vascular prostheses |
EP0183365A2 (fr) * | 1984-11-30 | 1986-06-04 | Vascutek Limited | Greffe vasculaire |
WO1989011857A1 (fr) * | 1988-05-31 | 1989-12-14 | University Of Florida | Procede et composition empechant les adherences chirurgicales |
WO1990014810A1 (fr) * | 1989-05-26 | 1990-12-13 | Ramon Berguer | Piece pour vaisseau sanguin |
EP0531547A1 (fr) * | 1991-03-29 | 1993-03-17 | Vascular Graft Research Center Co., Ltd. | Vaisseau sanguin artificiel et composite |
WO1995001190A1 (fr) * | 1993-06-29 | 1995-01-12 | W.L. Gore & Associates, Inc. | Matieres pour patch cardio-vasculaire et leur procede de fabrication |
-
1996
- 1996-04-19 WO PCT/US1996/005525 patent/WO1996040302A1/fr active Application Filing
- 1996-04-19 AU AU53919/96A patent/AU5391996A/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4193138A (en) * | 1976-08-20 | 1980-03-18 | Sumitomo Electric Industries, Ltd. | Composite structure vascular prostheses |
EP0000949A1 (fr) * | 1977-08-26 | 1979-03-07 | Philip Nicholas Sawyer | Prothèses cardiaques et vasculaires et procédé pour leur fabrication |
EP0183365A2 (fr) * | 1984-11-30 | 1986-06-04 | Vascutek Limited | Greffe vasculaire |
WO1989011857A1 (fr) * | 1988-05-31 | 1989-12-14 | University Of Florida | Procede et composition empechant les adherences chirurgicales |
WO1990014810A1 (fr) * | 1989-05-26 | 1990-12-13 | Ramon Berguer | Piece pour vaisseau sanguin |
EP0531547A1 (fr) * | 1991-03-29 | 1993-03-17 | Vascular Graft Research Center Co., Ltd. | Vaisseau sanguin artificiel et composite |
WO1995001190A1 (fr) * | 1993-06-29 | 1995-01-12 | W.L. Gore & Associates, Inc. | Matieres pour patch cardio-vasculaire et leur procede de fabrication |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002064184A2 (fr) * | 2001-02-13 | 2002-08-22 | Ethicon Gmbh | Procede de preparation d'un implant chirurgical |
WO2002064184A3 (fr) * | 2001-02-13 | 2002-11-14 | Ethicon Gmbh | Procede de preparation d'un implant chirurgical |
JP2012075858A (ja) * | 2010-10-01 | 2012-04-19 | Tyco Healthcare Group Lp | 移植可能なポリマーフィルム |
EP2465548A3 (fr) * | 2010-10-01 | 2014-09-03 | Covidien LP | Films polymères implantables |
US9572907B2 (en) | 2010-10-01 | 2017-02-21 | Covidien Lp | Implantable polymeric films |
Also Published As
Publication number | Publication date |
---|---|
AU5391996A (en) | 1996-12-30 |
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