WO1996017616A1 - Trousse pour cycle de traitement de l'osteoporose - Google Patents
Trousse pour cycle de traitement de l'osteoporose Download PDFInfo
- Publication number
- WO1996017616A1 WO1996017616A1 PCT/FR1995/001596 FR9501596W WO9617616A1 WO 1996017616 A1 WO1996017616 A1 WO 1996017616A1 FR 9501596 W FR9501596 W FR 9501596W WO 9617616 A1 WO9617616 A1 WO 9617616A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tiludronic acid
- calcium
- pharmaceutically acceptable
- kit
- acceptable salts
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the present invention relates to a kit for use in a therapeutic cycle for the treatment and / or prevention of osteoporosis. More particularly, the invention relates to a kit for use in the therapy of osteoporosis where a bisphosphonate and a nutritional supplement (or a placebo) are administered sequentially.
- EP-A-0100718 describes new compounds having a structure
- bisphosphonate including (4-chlorophenyl) - tiomethylenediphosphonic acid, the corresponding INN of which is tiludronic acid. This compound has shown very interesting properties in the treatment of osteoporosis (J.Y. Reginster et al., The Lancet, Dec. 23/30, 1989).
- EP-A-0162510, BE 902308 and AU 8541619 describe sequential treatments for osteoporosis with kits containing a bone cell activator compound, a phosphonate and a nutritional supplement (or a placebo), to be administered in sequence, for periods defined times.
- EP-A-210728 describes a kit for use in the treatment of osteoporosis containing a bisphosphonate - to be administered for 1-90 days - and a nutritional supplement (or a placebo) - to be administered for the following 50-120 days.
- WO 94/00129 describes a method of treating osteoporosis comprising the administration of a "high potency" phosphonate in a treatment cycle of 1 to 30 days, optionally followed by a rest period of at least one day .
- the above international application lists "high potency” phosphonates which can be used according to the invention; in this patent application, tiludronate is indicated as one of the "low power” phosphonates, which are not suitable for carrying out the invention.
- the present invention therefore relates to a kit intended for the treatment and / or prevention of osteoporosis comprising the sequential administration of tiludronic acid or one of its salts and / or solvates and a nutritive supplement, said kit being characterized in that it contains:
- compositions of tiludronic acid include salts with physiologically compatible inorganic and organic bases; pharmaceutically acceptable salts of tiludronic acid are disodium tiludronate, disodium tiludronate hydrated and disodium tiludronate monohydrate (EP-582515), the latter two being preferred.
- the term "nutritional supplement in the present description indicates one or more substances which normally should be introduced into the organism by the regular food, like for example calcium and vitamin D; when these substances are not taken in sufficient quantity the normal diet runs the risk of jeopardizing the success of therapy with tiludronic acid or one of its salts and / or solvates, which is why therapy with tiludronic acid or one of its salts and / or solvates is associated with the administration of said nutritional supplement, a particularly advantageous nutritional supplement being calcium.
- the calcium is in salified form with pharmaceutically acceptable inorganic or organic acids.
- Such calcium salts include carbonate, chloride, chloride hexahydrate, citrate, formate, glucoheptonate, gluconate, gluconolactate, glutamate, glycerophosphate, hydrogenophosphate, lactate, lactobionate, lactophosphate, l ⁇ vulinate, oleate, monobasic or tribasic phosphate, pidolate, sulfate; gluconolactate, carbonate and gluconate are the particularly preferred calcium salts. Therefore, when talking about calcium, we are referring to a calcium salt in an amount corresponding to the desired dose of Ca ++ .
- the above calcium salts can be administered alone or in combination.
- the kit according to the invention allows the patient suffering from osteoporosis to carry out therapeutic cycles, based on the sequential administration of tiludronic acid or one of its salts and / or solvates and a nutritive supplement, convenient and safe way.
- the doses of tiludronic acid or one of its salts and / or solvates and nutritional supplement will be in the form of compositions intended for oral administration.
- said oral pharmaceutical compositions are solid forms, such as for example tablets, optionally scored, chewable or effervescent, capsules or granules.
- the main active ingredient tiludronic acid or one of its pharmaceutically acceptable salts and / or solvates
- a pharmaceutical vehicle such as gelatin, starch , lactose, magnesium stearate, talc, gum arabic, sodium lauryl sulfate, crospovidone, cellulose derivatives or the like.
- the tablets can be coated with sucrose or other suitable materials, for example for coloring, or they can be treated so that they have a prolonged or delayed activity and that they release continuously a predetermined amount of active ingredient.
- compositions of this type contain from 1.5% to 6% by weight of sodium lauryl sulfate relative to tiludronic acid (EP-A-336851).
- a preparation in capsules is obtained by mixing the active ingredient with a diluent and by pouring the mixture obtained into soft or hard capsules.
- Water dispersible powders or granules may contain the active ingredient in admixture with dispersing agents or wetting agents, or suspending agents, such as polyvinylpyrrolidone, as well as with sweeteners or correctors taste.
- the active principle can also be formulated in the form of microcapsules, optionally with one or more carriers or additives.
- compositions based on calcium salts are prepared according to pharmaceutical techniques well known to those skilled in the art; preferably these compositions will be optionally scored tablets or effervescent tablets or chewable tablets.
- tiludronic acid or one of its salts and / or solvates and the nutritive supplement necessary for a therapy cycle of 28 to 31 days as described above will be contained in the same packaging; the pharmaceutical compositions respectively containing tiludronic acid or one of its salts and / or solvates and the nutritive supplement could possibly be formulated in different colors or numbered, to facilitate the administration of this type of medicament in a long-term therapy.
- the daily dose of tiludronic acid or one of its salts and / or solvates to be administered varies according to the characteristics of the subject to be treated such as age, weight and severity of the conditions; in general the daily dose is between 10 and 400 g of tiludronic acid, advantageously between 30 and 300 mg, preferably 50, 75, 100, 125, 150, 175 or 200 mg, for example 50 or 200 mg per day.
- tiludronic acid is advantageously administered in the form of its disodium salt monohydrate or hemihydrate.
- tiludronic acid refers to tiludronic acid.
- the amount administered will be that corresponding to the dose of tiludronic acid desired.
- the daily dose of nutritional supplement depends on the type of substance administered and the patient's diet.
- the nutritional supplement is calcium
- the amount can vary between 200 and 2000 mg per day, advantageously 500 or 1000 mg per day, expressed in mg of Ca ++ .
- the therapy cycle described above must be repeated several times, as part of a long-term treatment, which can range from 6 months to several years.
- the treatment cycle should be repeated until the desired increase in bone mass is achieved.
- the present invention relates to a method of treatment and / or prevention of osteoporosis, which comprises the administration of tiludronic acid or one of its salts and / or solvates during a period of 7 days, followed by a rest period of 21-24 days during which a nutritional supplement, including calcium, can be administered.
- the present invention also relates to a method for the treatment and / or prevention of osteoporosis in mammals, which comprises administering to said mammals an effective amount of tiludronic acid or a salt thereof and / or pharmaceutically acceptable solvates and a nutritional supplement according to the following scheme:
- EXAMPLE 1 A Tablets are prepared having the following composition disodium tiludronate hemihydrate 58.6 mg (corresponding to 50 mg of tiludronic aci) lactose 10.06 mg sodium lauryl sulfate 1.125 mg crospovidone 3.75 mg methyl hydroxypropyl cellulose 1.3 125 mg 0.15 mg magnesium stearate
- the granulation is carried out using purified water which is eliminated in the following preparation steps.
- Tablets having the following composition are prepared: disodium tiludronate hemihydrate 234.5 mg (corresponding to 200 mg of tiludronic acid) lactose 40.15 mg sodium lauryl sulfate 4.5 mg crospovidone 15 mg methyl hydroxypropyl cellulose 5.25 mg magnesium stearate 0.6 mg
- the granulation is carried out using purified water which is eliminated in the following preparation steps.
- B. Tablets are prepared having the following composition (total Ca ++ 500 mg): calcium carbonate 1.25 g sucrose 0.85 g sodium chloride 0.02 g sodium saccharin 0.02 g polyethylene glycol 0.2 g bicarbonate sodium 1 g citric acid 1.65 g orange essence 0.02 g
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95941761A EP0797444A1 (fr) | 1994-12-06 | 1995-12-05 | Trousse pour cycle de traitement de l'osteoporose |
SK685-97A SK68597A3 (en) | 1994-12-06 | 1995-12-05 | Kit for osteoporosis treatment cycle |
AU43073/96A AU4307396A (en) | 1994-12-06 | 1995-12-05 | Kit for osteoporosis treatment cycle |
BR9509961A BR9509961A (pt) | 1994-12-06 | 1995-12-05 | Kit para ciclo de tratamento de osteoporose |
CZ971753A CZ175397A3 (en) | 1994-12-06 | 1995-12-05 | Kit used for treating or prevention of osteoporosis |
PL95320564A PL320564A1 (en) | 1994-12-06 | 1995-12-05 | Therapeutic set for treating osteoporosis |
JP8517359A JPH10509729A (ja) | 1994-12-06 | 1995-12-05 | 骨粗鬆症治療サイクル用キット |
MXPA/A/1997/004105A MXPA97004105A (en) | 1994-12-06 | 1997-06-03 | Set for use in a therapeutic treatment cycle of osteoporo |
FI972383A FI972383A0 (fi) | 1994-12-06 | 1997-06-05 | Osteoporoosihoitojaksoon tarkoitettu pakkaus |
NO972558A NO972558L (no) | 1994-12-06 | 1997-06-05 | Sett for osteoporose-behandlingssyklus |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR94/14630 | 1994-12-06 | ||
FR9414630A FR2727629A1 (fr) | 1994-12-06 | 1994-12-06 | Trousse pour cycle de traitement de l'osteoporose |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996017616A1 true WO1996017616A1 (fr) | 1996-06-13 |
Family
ID=9469504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1995/001596 WO1996017616A1 (fr) | 1994-12-06 | 1995-12-05 | Trousse pour cycle de traitement de l'osteoporose |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0797444A1 (fr) |
JP (1) | JPH10509729A (fr) |
KR (1) | KR980700083A (fr) |
CN (1) | CN1168634A (fr) |
AR (1) | AR002946A1 (fr) |
AU (1) | AU4307396A (fr) |
BR (1) | BR9509961A (fr) |
CA (1) | CA2207028A1 (fr) |
CZ (1) | CZ175397A3 (fr) |
FI (1) | FI972383A0 (fr) |
FR (1) | FR2727629A1 (fr) |
HU (1) | HUT77382A (fr) |
IL (1) | IL116168A0 (fr) |
MA (1) | MA23737A1 (fr) |
NO (1) | NO972558L (fr) |
PL (1) | PL320564A1 (fr) |
SK (1) | SK68597A3 (fr) |
TR (1) | TR199501530A1 (fr) |
WO (1) | WO1996017616A1 (fr) |
ZA (1) | ZA9510184B (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5994329A (en) * | 1997-07-22 | 1999-11-30 | Merck & Co., Inc. | Method for inhibiting bone resorption |
US6432932B1 (en) | 1997-07-22 | 2002-08-13 | Merck & Co., Inc. | Method for inhibiting bone resorption |
US7192938B2 (en) | 2002-05-10 | 2007-03-20 | Hoffmann-La Roche Inc. | Method of treatment using bisphosphonic acid |
US7923028B2 (en) | 2002-12-20 | 2011-04-12 | Hoffman-La Roche Inc. | High dose oral formulation of bisphosphonate and a process for making thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0210728A2 (fr) * | 1985-06-06 | 1987-02-04 | The Procter & Gamble Company | Kit contenant du polyphosphonate pour le traitement de l'ostéoporose |
EP0381296A1 (fr) * | 1984-04-30 | 1990-08-08 | THE PROCTER & GAMBLE COMPANY | Equipement pour utilisation dans le traitement de l'ostéoporose |
WO1994000129A1 (fr) * | 1992-06-30 | 1994-01-06 | Procter & Gamble Pharmaceuticals, Inc. | Utilisation de phosphonates dans le traitement de l'osteoporose |
EP0582515A1 (fr) * | 1992-08-05 | 1994-02-09 | Sanofi | Monohydrate du sel disodique de l'acide 4-chlorophénylthiométhylène bisphosphonique, sa préparation, les compositions pharmaceutiques en contenant |
-
1994
- 1994-12-06 FR FR9414630A patent/FR2727629A1/fr active Granted
-
1995
- 1995-11-28 IL IL11616895A patent/IL116168A0/xx unknown
- 1995-11-30 ZA ZA9510184A patent/ZA9510184B/xx unknown
- 1995-12-04 TR TR95/01530A patent/TR199501530A1/xx unknown
- 1995-12-04 MA MA24086A patent/MA23737A1/fr unknown
- 1995-12-05 EP EP95941761A patent/EP0797444A1/fr not_active Withdrawn
- 1995-12-05 AR ARP950100438A patent/AR002946A1/es unknown
- 1995-12-05 HU HU9702097A patent/HUT77382A/hu unknown
- 1995-12-05 JP JP8517359A patent/JPH10509729A/ja not_active Ceased
- 1995-12-05 WO PCT/FR1995/001596 patent/WO1996017616A1/fr not_active Application Discontinuation
- 1995-12-05 BR BR9509961A patent/BR9509961A/pt not_active Application Discontinuation
- 1995-12-05 PL PL95320564A patent/PL320564A1/xx unknown
- 1995-12-05 SK SK685-97A patent/SK68597A3/sk unknown
- 1995-12-05 CZ CZ971753A patent/CZ175397A3/cs unknown
- 1995-12-05 AU AU43073/96A patent/AU4307396A/en not_active Abandoned
- 1995-12-05 KR KR1019970703784A patent/KR980700083A/ko not_active Application Discontinuation
- 1995-12-05 CA CA002207028A patent/CA2207028A1/fr not_active Abandoned
- 1995-12-05 CN CN95196670A patent/CN1168634A/zh active Pending
-
1997
- 1997-06-05 FI FI972383A patent/FI972383A0/fi not_active Application Discontinuation
- 1997-06-05 NO NO972558A patent/NO972558L/no unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0381296A1 (fr) * | 1984-04-30 | 1990-08-08 | THE PROCTER & GAMBLE COMPANY | Equipement pour utilisation dans le traitement de l'ostéoporose |
EP0210728A2 (fr) * | 1985-06-06 | 1987-02-04 | The Procter & Gamble Company | Kit contenant du polyphosphonate pour le traitement de l'ostéoporose |
WO1994000129A1 (fr) * | 1992-06-30 | 1994-01-06 | Procter & Gamble Pharmaceuticals, Inc. | Utilisation de phosphonates dans le traitement de l'osteoporose |
EP0582515A1 (fr) * | 1992-08-05 | 1994-02-09 | Sanofi | Monohydrate du sel disodique de l'acide 4-chlorophénylthiométhylène bisphosphonique, sa préparation, les compositions pharmaceutiques en contenant |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5994329A (en) * | 1997-07-22 | 1999-11-30 | Merck & Co., Inc. | Method for inhibiting bone resorption |
US6225294B1 (en) | 1997-07-22 | 2001-05-01 | Merck & Co., Inc. | Method for inhibiting bone resorption |
US6333316B1 (en) | 1997-07-22 | 2001-12-25 | Merck & Co., Inc. | Method for inhibiting bone resorption |
US6432932B1 (en) | 1997-07-22 | 2002-08-13 | Merck & Co., Inc. | Method for inhibiting bone resorption |
US6465443B2 (en) | 1997-07-22 | 2002-10-15 | Merck & Co., Inc. | Method for inhibiting bone resorption |
US6544967B2 (en) | 1997-07-22 | 2003-04-08 | Merck & Co., Inc. | Method for inhibiting bone resorption |
US7192938B2 (en) | 2002-05-10 | 2007-03-20 | Hoffmann-La Roche Inc. | Method of treatment using bisphosphonic acid |
US7718634B2 (en) | 2002-05-10 | 2010-05-18 | Hoffman-La Roche Inc. | Method of treatment using bisphosphonic acid |
US7923028B2 (en) | 2002-12-20 | 2011-04-12 | Hoffman-La Roche Inc. | High dose oral formulation of bisphosphonate and a process for making thereof |
Also Published As
Publication number | Publication date |
---|---|
MX9704105A (es) | 1997-09-30 |
NO972558D0 (no) | 1997-06-05 |
FI972383A (fi) | 1997-06-05 |
ZA9510184B (en) | 1996-06-11 |
SK68597A3 (en) | 1997-11-05 |
JPH10509729A (ja) | 1998-09-22 |
NO972558L (no) | 1997-08-05 |
FI972383A0 (fi) | 1997-06-05 |
CA2207028A1 (fr) | 1996-06-13 |
AR002946A1 (es) | 1998-05-27 |
MA23737A1 (fr) | 1996-07-01 |
AU4307396A (en) | 1996-06-26 |
PL320564A1 (en) | 1997-10-13 |
TR199501530A1 (tr) | 1996-10-21 |
FR2727629B1 (fr) | 1997-02-28 |
CZ175397A3 (en) | 1997-10-15 |
KR980700083A (ko) | 1998-03-30 |
IL116168A0 (en) | 1996-01-31 |
FR2727629A1 (fr) | 1996-06-07 |
EP0797444A1 (fr) | 1997-10-01 |
BR9509961A (pt) | 1997-11-25 |
HUT77382A (hu) | 1998-04-28 |
CN1168634A (zh) | 1997-12-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0385846B1 (fr) | Composition pharmaceutique à libération prolongée d'acide valproîque | |
EP0336851B1 (fr) | Composition pharmaceutique pour administration orale à base d'un dérivé d'acide diphosphonique | |
EP2018158A1 (fr) | Nouvelle forme d'administration du racecadotril | |
DE3346525A1 (de) | Pharmazeutische zubereitung mit speziellen 1,2-diacyl-glycero-3-phosphocholinen zur behandlung von erkrankungen im magen-darmbereich | |
JP2001513506A (ja) | タイプii糖尿病のクロム/ビオチン治療 | |
FR2904774A1 (fr) | Composition pharmaceutique solide contenant une combinaison d'un agent regulateur de la motilite intestinale et d'un antiflatulent. | |
WO1996017616A1 (fr) | Trousse pour cycle de traitement de l'osteoporose | |
JP2002537325A (ja) | NF−κBの活性化を阻害することにより治療上の影響を与えることができる、ヒトおよび動物における病気を治療するための医薬を製造するためのR−アリールプロピオン酸の使用 | |
NL8702297A (nl) | Medicament voor het verschaffen van fluoride-ionen voor de behandeling en preventie van met botverlies gepaardgaande ziekten. | |
JPH07330593A (ja) | 疲労改善剤 | |
WO1990007334A1 (fr) | Agent carcinostatique non injecte permettant de supprimer l'inflammation due a 5-fluorouracil, et procede de traitement du cancer | |
EP0542979B1 (fr) | Composition therapeutique pour liberation prolongee de magnesium | |
JP3096052B2 (ja) | 脂質代謝調節剤 | |
FR2605884A1 (fr) | Nouvelle association medicamenteuse | |
FR2857593A1 (fr) | Composition pharmaceutique orodispersible d'un compose antithrombotique | |
FR2566665A1 (fr) | Composition pour inhiber le developpement des tumeurs, a base d'un derive d'acide peroxydiphosphorique | |
FR2758460A1 (fr) | Utilisation des agonistes des recepteurs beta-3 adrenergiques pour la preparation de medicaments cicatrisants | |
FR2584604A1 (fr) | Composition therapeutique constituant une nouvelle forme galenique orale pour ameliorer la cinetique de la biodisponibilite | |
EP0774253A1 (fr) | Nouvelles compositions pharmaceutiques à action anti-migraineuse contenant du paracetamol et du metoclopramide | |
EP0412877A1 (fr) | Nouvelle forme galénique orale améliorant la biodisponibilité | |
JPS5942318A (ja) | 製薬組成物、その製造法及び応用 | |
JP3756449B2 (ja) | 抗潰瘍剤、抗潰瘍剤の製造方法、α−ラクトアルブミンの使用、及び潰瘍の治療方法 | |
JP2538422B2 (ja) | 5―フルオロウラシル類により起こる炎症の発生を抑制する非注射剤形態の制癌剤 | |
MXPA97004105A (en) | Set for use in a therapeutic treatment cycle of osteoporo | |
FR2842425A1 (fr) | Utilisation d'extraits de ginkgo biloba pour favoriser la masse musculaire au detriment de la masse graisseuse |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 95196670.7 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AT AU BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TT UA UG US UZ VN |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 68597 Country of ref document: SK |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/1997/004105 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 297827 Country of ref document: NZ |
|
ENP | Entry into the national phase |
Ref document number: 2207028 Country of ref document: CA Ref document number: 2207028 Country of ref document: CA Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1019970703784 Country of ref document: KR Ref document number: 972383 Country of ref document: FI |
|
WWE | Wipo information: entry into national phase |
Ref document number: PV1997-1753 Country of ref document: CZ |
|
ENP | Entry into the national phase |
Ref document number: 1997 836470 Country of ref document: US Date of ref document: 19970618 Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1995941761 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1995941761 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: PV1997-1753 Country of ref document: CZ |
|
WWP | Wipo information: published in national office |
Ref document number: 1019970703784 Country of ref document: KR |
|
WWR | Wipo information: refused in national office |
Ref document number: PV1997-1753 Country of ref document: CZ |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1995941761 Country of ref document: EP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1019970703784 Country of ref document: KR |