WO1995035374A1 - Human monoclonal antibodies specific to cell cycle independent glioma surface antigen - Google Patents

Human monoclonal antibodies specific to cell cycle independent glioma surface antigen Download PDF

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Publication number
WO1995035374A1
WO1995035374A1 PCT/CA1995/000361 CA9500361W WO9535374A1 WO 1995035374 A1 WO1995035374 A1 WO 1995035374A1 CA 9500361 W CA9500361 W CA 9500361W WO 9535374 A1 WO9535374 A1 WO 9535374A1
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WO
WIPO (PCT)
Prior art keywords
seq
amino acid
immunoglobulin
chain
cells
Prior art date
Application number
PCT/CA1995/000361
Other languages
English (en)
French (fr)
Inventor
Michael D. Dan
Original Assignee
Dan Michael D
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dan Michael D filed Critical Dan Michael D
Priority to AU27092/95A priority Critical patent/AU686394B2/en
Priority to NZ288157A priority patent/NZ288157A/en
Priority to EP95922373A priority patent/EP0766736B1/de
Priority to AT95922373T priority patent/ATE205532T1/de
Priority to DE69522689T priority patent/DE69522689T2/de
Priority to CA002192079A priority patent/CA2192079C/en
Priority to MX9605895A priority patent/MX9605895A/es
Priority to JP8501432A priority patent/JPH10501411A/ja
Publication of WO1995035374A1 publication Critical patent/WO1995035374A1/en
Priority to NO965395A priority patent/NO965395L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/863—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgM
    • Y10S530/864—Monoclonal
    • Y10S530/865—Human
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain

Definitions

  • a human MAb (CLN-IgG) that recognizes a glioma- associated antigen whose surface expression is influenced by cell cycle state has been reported by Kokunai, et al. • 1990. Expression of the antigen recognized by CLN-IgG was shown to be markedly increased on the surface of glioma cells in the G 2 /M phase of the cell cycle, but significantly reduced on cells in the G o /G x phase.
  • Gly Trp lie Ser Ala His Asn Gly Asn Thr Asn Ser Ala Gin Lys Phe

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PCT/CA1995/000361 1994-06-21 1995-06-16 Human monoclonal antibodies specific to cell cycle independent glioma surface antigen WO1995035374A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU27092/95A AU686394B2 (en) 1994-06-21 1995-06-16 Human monoclonal antibodies specific to cell cycle independent glioma surface antigen
NZ288157A NZ288157A (en) 1994-06-21 1995-06-16 Human anti-glioma monoclonal antibodies from patients with astrocytic tumours
EP95922373A EP0766736B1 (de) 1994-06-21 1995-06-16 Zellzyklus-unabhängige, gliomaoberflach-spezifische, menschliche monoklonale antikörper
AT95922373T ATE205532T1 (de) 1994-06-21 1995-06-16 Zellzyklus-unabhängige, gliomaoberflach- spezifische, menschliche monoklonale antikörper
DE69522689T DE69522689T2 (de) 1994-06-21 1995-06-16 Zellzyklus-unabhängige, gliomaoberflach-spezifische, menschliche monoklonale antikörper
CA002192079A CA2192079C (en) 1994-06-21 1995-06-16 Human monoclonal antibodies specific to cell cycle independent glioma surface antigen
MX9605895A MX9605895A (es) 1994-06-21 1995-06-16 Anticuerpos monoclonales humanos especificos para antigeno de superficie de glioma independiente del ciclo celular.
JP8501432A JPH10501411A (ja) 1994-06-21 1995-06-16 細胞周期非依存性グリオーマ細胞表面抗原特異的ヒト・モノクロナール抗体
NO965395A NO965395L (no) 1994-06-21 1996-12-13 Humane, monoklonale antistoffer som er spesifikke mot cellecyklus-uavhengig gliom-overflateantigen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/264,093 US5639863A (en) 1994-06-21 1994-06-21 Human monoclonal antibodies specific to cell cycle independent glioma surface antigen
US08/264,093 1994-06-21

Publications (1)

Publication Number Publication Date
WO1995035374A1 true WO1995035374A1 (en) 1995-12-28

Family

ID=23004543

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1995/000361 WO1995035374A1 (en) 1994-06-21 1995-06-16 Human monoclonal antibodies specific to cell cycle independent glioma surface antigen

Country Status (12)

Country Link
US (1) US5639863A (de)
EP (1) EP0766736B1 (de)
JP (1) JPH10501411A (de)
CN (1) CN1074458C (de)
AT (1) ATE205532T1 (de)
AU (1) AU686394B2 (de)
CA (1) CA2192079C (de)
DE (1) DE69522689T2 (de)
MX (1) MX9605895A (de)
NO (1) NO965395L (de)
NZ (1) NZ288157A (de)
WO (1) WO1995035374A1 (de)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997044461A2 (en) * 1996-05-22 1997-11-27 Novopharm Biotech, Inc. Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
WO1999006834A2 (en) * 1997-08-04 1999-02-11 Ixsys, Incorporated Methods for identifying ligand specific binding molecules
WO2001018058A2 (en) * 1999-09-07 2001-03-15 Viventia Biotech Inc. Enhanced phage display library of human vh fragments and methods for producing same
US7115722B1 (en) 1997-05-22 2006-10-03 Viventia Biotech, Inc. Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
WO2008036341A2 (en) * 2006-09-20 2008-03-27 Amgen Inc. Compositions and methods relating to glucagon receptor antibodies
WO2008038127A2 (en) * 2006-09-28 2008-04-03 Merck Serono S.A. Junctional adhesion molecule-c (jam-c) binding compounds and methods of their use

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7109170B2 (en) * 1999-06-16 2006-09-19 Saint Louis University Region of factor IXa protease domain that interacts with factor VIIIa and methods therefor
WO2002051870A2 (en) * 2000-12-22 2002-07-04 GRAD, Carole Legal Representative of KAPLAN, Howard Phage display libraries of human vh fragments
DE10210427A1 (de) * 2002-03-09 2003-10-09 Hans Konrad Mueller-Hermelink Humaner monoklonaler Antikörper
AU2003249533A1 (en) * 2002-07-04 2004-01-23 Oncomab Gmbh Neoplasm specific antibodies and uses thereof
DE10311248A1 (de) * 2003-03-14 2004-09-30 Müller-Hermelink, Hans Konrad, Prof. Dr. Humaner monoklonaler Antikörper
AU2004317819A1 (en) * 2003-11-12 2005-10-13 Patrys, Limited Methods of identifying neoplasm-specific antibodies and uses thereof
DE10353175A1 (de) * 2003-11-14 2005-06-16 Müller-Hermelink, Hans Konrad, Prof. Dr. Humaner monoklonaler Antikörper mit fettsenkender Wirkung
EP1531162A1 (de) * 2003-11-14 2005-05-18 Heinz Vollmers Antikörper SAM-6, der spezifisch von Adenocarzinom ist, und dessen Verwendungen
DE102004015179A1 (de) * 2004-03-25 2005-10-13 Oncomab Gmbh Antigen des PM-2 Antikörpers und dessen Verwendung
US20080199475A1 (en) * 2006-11-27 2008-08-21 Patrys Limited Novel glycosylated peptide target in neoplastic cells
US20110207917A1 (en) * 2009-02-09 2011-08-25 Patrys Limited Sam-6 variants, target and methods of use
CN103127528B (zh) * 2012-09-14 2016-04-20 苏州大学 人类dcx基因在制备胶质瘤放疗增敏剂中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2035088A1 (en) * 1990-01-29 1991-07-30 Michael D. Dan Human monoclonal antibodies for brain tumor diagnosis and therapy

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
M.D.DAN ET AL.: "Human antiglioma monoclonal antibodies from patients with astrocytic tumors", JOURNAL OF NEUROSURGERY, vol. 76, no. 4, pages 660 - 669 *
T.KISHIMOTO ET AL.: "Nucleotide sequence of the cDNAs encoding the V-regions of H- and L-chains of a human monoclonal antibody with broad activity to malignant tumor cells", NUCLEIC ACIDS RESEARCH, vol. 17, no. 11, 26 June 1989 (1989-06-26), OXFORD GB, pages 4385 *
U.BRINKMANN ET AL.: "Independent folding of Pseudomonas exotoxin and single-chain immunotoxins. Influence of interdomain connections", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 89, no. 7, 1 April 1992 (1992-04-01), WASHINGTON US, pages 3075 - 3079 *

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997044461A3 (en) * 1996-05-22 1998-05-07 Novopharm Biotech Inc Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
WO1997044461A2 (en) * 1996-05-22 1997-11-27 Novopharm Biotech, Inc. Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
US6207153B1 (en) 1996-05-22 2001-03-27 Viventia Biotech, Inc. Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
US7166286B2 (en) 1996-05-22 2007-01-23 Viventia Biotech Inc. Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for prophylaxis and detection of cancers
US7115722B1 (en) 1997-05-22 2006-10-03 Viventia Biotech, Inc. Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
WO1999006834A2 (en) * 1997-08-04 1999-02-11 Ixsys, Incorporated Methods for identifying ligand specific binding molecules
WO1999006834A3 (en) * 1997-08-04 1999-05-14 Ixsys Inc Methods for identifying ligand specific binding molecules
WO2001018058A2 (en) * 1999-09-07 2001-03-15 Viventia Biotech Inc. Enhanced phage display library of human vh fragments and methods for producing same
WO2001018058A3 (en) * 1999-09-07 2001-10-04 Novopharm Biotech Inc Enhanced phage display library of human vh fragments and methods for producing same
WO2008036341A2 (en) * 2006-09-20 2008-03-27 Amgen Inc. Compositions and methods relating to glucagon receptor antibodies
WO2008036341A3 (en) * 2006-09-20 2009-02-05 Amgen Inc Compositions and methods relating to glucagon receptor antibodies
US7947809B2 (en) 2006-09-20 2011-05-24 Amgen Inc. Compositions and methods relating to glucagon receptor antibodies
US8158759B2 (en) 2006-09-20 2012-04-17 Amgen Inc. Compositions and methods relating to glucagon receptor antibodies
CN101589062B (zh) * 2006-09-20 2014-08-20 安姆根有限公司 与胰高血糖素受体抗体相关的组合物和方法
WO2008038127A2 (en) * 2006-09-28 2008-04-03 Merck Serono S.A. Junctional adhesion molecule-c (jam-c) binding compounds and methods of their use
WO2008038127A3 (en) * 2006-09-28 2008-05-29 Serono Lab Junctional adhesion molecule-c (jam-c) binding compounds and methods of their use
US8007797B2 (en) 2006-09-28 2011-08-30 Merck Serono S.A. Junctional adhesion molecule-C (JAM-C) binding compounds and methods of their use

Also Published As

Publication number Publication date
CA2192079A1 (en) 1995-12-28
CN1074458C (zh) 2001-11-07
AU686394B2 (en) 1998-02-05
DE69522689T2 (de) 2002-08-08
AU2709295A (en) 1996-01-15
EP0766736A1 (de) 1997-04-09
ATE205532T1 (de) 2001-09-15
EP0766736B1 (de) 2001-09-12
DE69522689D1 (de) 2001-10-18
CA2192079C (en) 2001-01-09
NO965395L (no) 1996-12-17
JPH10501411A (ja) 1998-02-10
US5639863A (en) 1997-06-17
MX9605895A (es) 1997-12-31
NO965395D0 (no) 1996-12-13
NZ288157A (en) 1999-09-29
CN1151184A (zh) 1997-06-04

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