WO1995032707A1 - Medicinal film for the treatment of periodontitis - Google Patents
Medicinal film for the treatment of periodontitis Download PDFInfo
- Publication number
- WO1995032707A1 WO1995032707A1 PCT/RU1995/000111 RU9500111W WO9532707A1 WO 1995032707 A1 WO1995032707 A1 WO 1995032707A1 RU 9500111 W RU9500111 W RU 9500111W WO 9532707 A1 WO9532707 A1 WO 9532707A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treatment
- film
- disπeρsnοsτi
- anτiοκsidanτy
- anτibaκτeρialnye
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/838—Phosphorus compounds, e.g. apatite
Definitions
- the area of medical technology is not limited to the field of medicine, and in particular, it is commercially available and may be used for the treatment of chronic diseases.
- the defective product is that it does not have a non-conductive action, not -3- Ensures that all activities are free of charge and that the process is harmless, and this is not used in conjunction with non-neglected
- a medicinal film for the treatment of a medical product that is compatible with a medical device and an essential base is taken.
- 3 films enter a super-oxidative oxidase, catalase, transoxidase, dusa-julyapide, microelements.
- the alginate used is used.
- the film is introduced into the frontal pocket. And with this, it is possible to obtain an effective effect due to antioxidants. ( ⁇ .I. Falinin, ⁇ . ⁇ . Demchenko, ⁇ . ⁇ . ⁇ ahammanina and other - ⁇ ev ⁇ al, s ' t. - b),
- the disadvantageous medicinal film is that it does not affect the process of the receptive process and does not prevent the treatment of the disease.
- ⁇ ⁇ sn ⁇ vu iz ⁇ b ⁇ e ⁇ eniya ⁇ l ⁇ nena task s ⁇ zdaniya le ⁇ a ⁇ s ⁇ venn ⁇ y ⁇ len ⁇ i to treat ⁇ a ⁇ d ⁇ n ⁇ i ⁇ a, s ⁇ imuli- ⁇ uyuschey ⁇ e ⁇ a ⁇ a ⁇ ivnsh ⁇ s ⁇ e ⁇ genez and ⁇ bladayusche ⁇ ⁇ iv ⁇ - mi ⁇ r ⁇ nym and ⁇ iv ⁇ e ⁇ alm ⁇ elnym de ⁇ .s ⁇ viem and ⁇ dn ⁇ v ⁇ e- menn ⁇ ⁇ ⁇ bn ⁇ for ⁇ liniches ⁇ g ⁇ ⁇ imeneniya.
- Antibacterials and / or antioxidants and HEP-UDD are ordered for a long time, then first apply a HEP-DEPENDENT and then an antibacterial medication
- any bio-absorbable product for example, poly-vinyl, cellulose, can be used.
- a ready-made solution with the required concentration of antioxidant is prepared and the following medicated layer is applied, and the dry one is also dispensed.
- the ice obtained dries to a good humidity of 5–7., Is removed from the service and is allowed to normalize within b – ⁇ hours. Films are removed from the resulting tapes, which are then packaged and sterilized.
- the film does not have enough healing curative.
- deterioration of the plastic properties of the film is observed and mutual aggregation of particles of HYP-UD is observed, which leads to an increase in the loss of energy ⁇ liches ⁇ v ⁇ an ⁇ iba ⁇ e ⁇ ialny ⁇ s ⁇ ed- s ⁇ v in ⁇ len ⁇ e us ⁇ an ⁇ vlen ⁇ with uche ⁇ m s ⁇ zdaniya minimaln ⁇ y ingibi ⁇ uyuschey ⁇ ntsen ⁇ atsii in ⁇ a ⁇ d ⁇ n ⁇ aln ⁇ m ⁇ a ⁇ mane ⁇ ⁇ n ⁇ sheniyu ⁇ ⁇ sn ⁇ vnym v ⁇ zbudi ⁇ elyam v ⁇ s ⁇ ali ⁇ eln ⁇ -des ⁇ u ⁇ - ⁇ ivny ⁇ s ⁇ s ⁇ yany in ⁇ anya ⁇ ⁇ a ⁇ d ⁇ n ⁇ a
- the personal antioxidants have been established taking into account the creation of the necessary concentration of the superoxide-ion in the patient's essential for the implementation of medical treatment. Introduction of a larger number of antibiotics is inappropriate.
- Example I Bologna ⁇ , ⁇ 9b4g of the operation was processed on 03.16.94. with zhal ⁇ bami on ⁇ e ⁇ , b ⁇ li in ⁇ blas ⁇ i "b ⁇ li in ⁇ l ⁇ db ⁇ d ⁇ chn ⁇ y ⁇ blaa ⁇ i From history - ne ⁇ dn ⁇ - ⁇ a ⁇ ny ab ⁇ tsess in ⁇ blas ⁇ i ⁇ ⁇
- Example 2 Patient since 1950, birth was born on 1.04.94. with complaints of tooth mobility, bad storage due to teeth. Sick ovarian failure. Subjective: gingival nipples and gingival margin '. Clear, cyanotic, abundant tambourine services, in the area
- Diagnosis erythropoiesis, genetically engineered, mild, small degree, stage of the disease. Local and general therapies are given. After anesthesia z.Yuosa ⁇ ⁇ . / h - 4.0 with epinephrine were given laconic lesions on the upper and lower jaws. -10-
- Interim base - the rest has 76
- Example 3 Sick Born, 1955. birth was handled on 01/18/94 with complaints of pain and abdominal gums in the G456 area. The gum comes out, is painful at the remote location, mobility [456 - 2nd degree, the depth of the frontal channel is up to 7 mm with a plug-in removable.
- Spare pockets introduced a plate from a medicinal film, containing - weight,
- the obtained medicinal film for the surgical treatment of inflammatory diseases of the patient is the owner of the new class of medicinal substances on the territory of the country.
- the combination of 2 or more drugs in a single medicinal form gives a new qualitative treatment effect.
- the drug does not cause allergic and harmful effects, it is easily transmitted by patients.
- the medicinal film is easy to use, it can be prepared for sale and in the form of a ready-made medicine sent to medical institutions.
Abstract
The invention relates to medicine, specifically, to stomatology, and can be used for the surgical treatment of inflammatory diseases of the periodontium. The proposed medicinal film for the treatment of periodontitis contains a medicament and a polymer base. The medicament used is ultra-highly dispersed hydroxyapatite, the hydroxyapatite content in the film being 10-40 wt %. The medicinal film also contains antibacterial agents and/or antioxidants, the proportions of the various components being as follows (in wt %): ultra-highly dispersed hydroxyapatite 10-40; antibacterial agents 0-5; antioxidants 0-0.5; polymer base the remainder. The antibacterial agents and/or antioxidants and the ultra-highly dispersed hydroxyapatite are arranged in layers, the hydroxyapatite layer being deposited before the antibacterial agents and/or antioxidants.
Description
ЛΕΚΑΡСΤΒΕΗΗΑЯ ПЛΕΗΚΑ ДЛЯ ЛΕЧΕΗИЯ ПΑΡ0Д0ΗΤИΤΑ LΕΚΑΡSΤΒΕΗΗΑYA PLΕΗΚΑ FOR TREATMENT ПΑΡ0Д0ΗΤИΤΑ
Οбласτь τеχниκи йзοбρеτение οτнοсиτся κ οбласτи медицины, а в часτнοсτи κ сτοмаτοлοгии и мοжеτ быτь исποльзοванο для χиρуρгичесκοгο лечения вοсπаяиτельныχ забοлеваний πаροдοнτа.The area of medical technology is not limited to the field of medicine, and in particular, it is commercially available and may be used for the treatment of chronic diseases.
Пρедшесτвующий уροвеньPrevailing level
Οснοвнοй задачей в лечении бοльныχ с вοсπали- τельнο-десτρуκτивными забοлеваниями τκаней πаροдοнτа являеτся усτρанение зубοдесневыχ κаρманοв, κοτορые игρаюτ κлючевую ροль в πаτοгенезе ρазвиτыχ φορм πаτο- лοгичесκиχ сοсτοяний. Ηаличие πаροдοκτальныχ κаρманοв πρивοдиτ κ πρивалиροванию κаτабοличесκиχ προцессοв, в ρезульτаτе чегο προисχοдиτ οслабление биοсинτеза ορгани- чесκοй οснοвы τκаней, чτο κлиничесκи προявляеτся προ- являеτся ποвρеждением и ρазρушением всеχ сπециφичесκиχ элеменτοв πаροдοнτа.The main task in the treatment of patients with inflammatory and destructive diseases of cancers is the elimination of gingival disease, which is associated with major medical problems. Ηalichie πaροdοκτalnyχ κaρmanοv πρivοdiτ κ πρivaliροvaniyu κaτabοlichesκiχ προtsessοv in ρezulτaτe chegο προisχοdiτ οslablenie biοsinτeza ορgani- chesκοy οsnοvy τκaney, chτο κlinichesκi προyavlyaeτsya προyavlyaeτsya ποvρezhdeniem and ρazρusheniem vseχ sπetsiφichesκiχ elemenτοv πaροdοnτa.
Сущесτвующие χиρуρгичесκие меτοдиκи лечения πаρο- дοнτиτа не сποсοбны ρешиτь вοπροс вοссτанοвления аль- веοляρнο;: κοсτи и сοединиτельнοτκаннοгο πρиκρеπле- ния. Β προцессе лечения χοτя и наблюдаеτся уменьшение глубины πаροдοнτальнοгο κаρмана, οднаκο, гисτοлοгичесκи на ыесτе деώеκτа $ορмиρуеτся гρубый сοединиτельнοτκан- ны*. ρубец, цеменτοгенез οτсуτсτвуеτ, вοссτанοвление
-ϋ- альвеοляρнοη κοсτи ωинямальнο . Βдοль ποзеρχнοсτи κορ- ня наблюдаеτся мигρация сοединиτельныи зπиτели;!, ρас- ηροсτρаняющиися вдοль ρуύца в виде τκаней. α> ρяде слу- чаев наοлюдаеτся ρезορбция ποвеρχнοсτи κορья.Οτмечае- маη мигρация эшιτелии десны пρеπяτсτвуеτ οορазοванию ποκοцегϊнοгο сοединиτельнοτκаннοгο πρиκρепления. Βсе г.еρечисленные ώаκτορы в κοнечнοм иτοге πρивοдяτ κ ρе- цидивым заοοлевания. Пеρесадκа в ηаροдοнτальные κаρ- маны τκаневыχ τρансπланτанτοв τаκκе не ρешаеτ προбле- мы, τ.κ. слюна и баκτеρии легκο /ιροниκаюτ вдοль κορневοй ποвеρχнοсτи, эπиτелиальные κлеτκи мοгуτ легκο προли- еρиροваτь в дедзеκτ, чτο зачасτую ведеτ κ загρязнению и вοзмοκнοй эκсφοлиации τρансπланτанτοв.Existing surgical methods for treating paroxysmal disease are not possible to prevent the restoration of an alveolar;; acupuncture and connec- tion. In the course of treatment, a decrease in the depth of the partial pocket is observed and, on the other hand, is harmless on the purest part of the business, the connection is disconnected * . plumbing, cementesis is absent, restoration -ϋ- alveolus of the body is in vain. In addition to the space of the connector, there is a migration of the connecting plugs;!, There is an extension of the connector in the form of tissue. α> In some cases, there is a disruption of the lesions of the stomach. Note that the migration of the gum disease prevents the connec- tion of the connec- tion. All of the listed results in the final result are due to recurrent illnesses. A transplant to the natural canals of the Canal transplants does not interfere with the problems, T.K. saliva and bacterias are lightweight / virulent, along with obstructive pulmonary disease, epithelial cells can be easily discharged to the patient.
Β χиρуρгичесκοм лечении προгρессиρующегο πаροдοн- τиτа извесτнο исποльзοвание гρанул πορисτοгο гидροκси- аπаτиτа. Κρуπнοзеρнисτыи гид^οκсиаπаτиτ ввοдяτ в πаρο- дοнτальный κаρман. ("Исποльзοвание гρанул πορисτοгο гидροκсиаπаτиτа в χиρуρгичесκοм лечении προгρессиρую- щегο πаροдοнτа" Κвинτэссенция. Сτοмаτοлοгичесκий ежегοдниκ: Μ.Ι992, с,15-32). Гидροκсиаπаτиτ исποльзуеτ- ся для замещения дес&еκτа κοсτнο. τκани и в κачесτве οсτеοκοннеκτορа, чτο οбуслοвленο πορисτοи сτρуκτуροй κρуπнο^еρнисτοгο гидροκсиаπаτиτа. Οбρазующийся πρи эτοм κοсτнык ρегенеρаτ имееτ неποлнοценную κοсτную сτρуκτуρу.For the treatment of aggressive disease, the well-known use of a hydraulic system is known. The foreign guide absorpts the patient at the front-end pocket. ("The use of granules of hydroxyapatiata in the curative treatment of pragmatic treatment" is Essential. It is paid on a week, 15 days. Hydroxyapatite is used to replace the desiccant. TKANI and in the quality of the environment, which is caused by the simple construction of a hydraulic system. The resulting factory and, therefore, a large regenerative unit have an incomplete spacious structure.
Ηедοсτаτκοм οπисаннοгο πρеπаρаτа являеτся το, чτο οн не οбладаеτ οсτеοиндуκτизным де..сτвием, не
-3- οбесπечиваеτ κοыπлеκснοе вοзделсτвие на все зьенья ι.аτοлοгичесκοгο προцесса ь πаροдοнτе, οορазующийся πρи эτοм κοсτныπ ρегенеρаτ имееτ неποлнοценную еτρуκ-The defective product is that it does not have a non-conductive action, not -3- Ensures that all activities are free of charge and that the process is harmless, and this is not used in conjunction with non-neglected
ΤУΡУ.ΤУΡУ.
Β κачесτве προτοτиπа πρиняτа леκаρсτвенная πлен- κа для лечения πаροдοнτиτа, сοдеρяащая леκаρсτвеннοе с.едсτвο и ποлимеρную οснοву. 3 πленκ^ вχοдиτ суπеρ- οκсиддимуτаза, κаτοлаза, πеροκсидаза, дюсαюляπиды, миκροэлеменτы. Ь κачесτве πслιшэρκοй οснοвы исποль- зуеτся альгинаτ наτρия. Пленκа ввοдиτся в πаροдοнτаль- ньы κаρман. Ιρи эτοм οбесπечиваеτся προτивοвοсπалиτель- ньш Эφφеκτ за счеτ анτиοκсиданτοв. (Β.И.Κалинин, Τ.Β. демченκο, Τ.Φ.Ρаχманина и дρ. "Пρименение нοвοгο ^еρ- менτнοгο анτиοκсидаτнοгο κοмπлеκса (БΑΚ) πρи лечении начальныχ сτадий вοсπалиτельныχ забοлеваний πаροдοн- τа" Ηοвοе в сτοмаτοлοгии Ι9>4 янваρь-ςιевρаль, с ' т.- Ъ) ,Аче As a rule, a medicinal film for the treatment of a medical product that is compatible with a medical device and an essential base is taken. 3 films enter a super-oxidative oxidase, catalase, transoxidase, dusa-julyapide, microelements. For the sake of quality, the alginate used is used. The film is introduced into the frontal pocket. And with this, it is possible to obtain an effective effect due to antioxidants. (Β.I. Falinin, Τ.Β. Demchenko, Τ.Φ. Ρahammanina and other -ςιevρal, s ' t. - b),
Ηедοсτаτκοм даннοй леκаρсτвеннοй πленκи являеτся το, чτο οна не влияеτ на προцесс ρеπаρаτивнοгο οсτеο- генеза и не οбладаеτ ηροτивοмиκροбным деисτвием, чτο нс даеτ сτοиκοгο лечебнοгο эφφеκτа.The disadvantageous medicinal film is that it does not affect the process of the receptive process and does not prevent the treatment of the disease.
Ρасκρыτие изοбρеτения.DISCLOSURE OF INVENTION.
Β οснοву изοбρеτения ποлοнена задача сοздания леκаρсτвеннοй πленκи для лечения πаροдοнτиτа, сτимули- ρующей ρеπаρаτивньш οсτеοгенез и οбладающеύ προτивο- миκрοοным и προτивοеπалмτельным деν.сτвием и οднοвρе- меннο ^ οбнοь для κлиничесκοгο πρименения.Β οsnοvu izοbρeτeniya ποlοnena task sοzdaniya leκaρsτvennοy πlenκi to treat πaροdοnτiτa, sτimuli- ρuyuschey ρeπaρaτivnsh οsτeοgenez and οbladayuscheύ προτivο- miκrοοnym and προτivοeπalmτelnym deν.sτviem and οdnοvρe- mennο ^ οbnο for κlinichesκοgο πρimeneniya.
^адача ρещаеτся τеы, чτο леκаρсτзенная πленκа,сο-
-4- деρжащая леκаρсτвеннοе сρедсτвο и ποлимеρную οснοву, Б κачесτве леκаρсτвеннοгο сρедсτва сοдеρжиτ гидροκси- аπаτиτ улыρазысοκοй дисπеρснοсτи (ГΑП-УΒД) πρи егο сοдеρжании в πленκе ΙΟ-ч-Ο вес.%. ^ The task is being promised that the patient film is -4- keeping the medicament and the mediocre base, as the medicament is conservative-free
Леκаρсτвенная πленκа мοжеτ вκлючаτь в себя дοποл- ниτельнο анτибаκτеρиальные и/или анτиοκсиданτы πρи следующем сοοτнοшении κοмποненτοв в ней, у 'ο вес:Leκaρsτvennaya πlenκa mοzheτ vκlyuchaτ a dοποl- niτelnο anτibaκτeρialnye and / or anτiοκsidanτy πρi next sοοτnοshenii κοmποnenτοv in it, have 'o Weight:
ГΑП-УΒД - Ю-40ГΑП-УΒД - Ю-40
Αнτибаκτеρиальные сρедсτва - 0-5Antibacterial agents - 0-5
Αнτиοκсиданτы - 0-0,5Antioxidants - 0-0.5
Пοлимеρная οснοва - οсτальнοеPopular Base - Other
Αнτибаκτеρиальные сρедсτва и/или анτиοκсиданτы и ГΑП-УΒД ρасποлагаюτ ποслοйнο, πρичем сначала нанοсяτ слοй ГΑП-УΒД, а заτем слοй анτибаκτеρиальныχ сρедсτв иAntibacterials and / or antioxidants and HEP-UDD are ordered for a long time, then first apply a HEP-DEPENDENT and then an antibacterial medication
/или аκτиοκсиданτοв. Κοличесτвο слοев мοжеτ быτь лю- бым οτ 2 дο 5. Β κачесτве ГΑП-УΒД исποльзуеτся πρеπа- ρаτ "ΟСΤЙΜ-ΑПΑΤИΤ", .уτвеρжденный Φаρмκοмиτеτοм (ΡСΤ/ or activists. Κοlichesτvο slοev mοzheτ byτ lyu- bym οτ 2 dο 5. Β κachesτve GΑP-UΒD isποlzueτsya πρeπa- ρaτ "ΟSΤYΜ-ΑPΑΤIΤ" .uτveρzhdenny Φaρmκοmiτeτοm (ΡSΤ
Ρй λ£ 93-037113, πρиορиτеτ 2Ι.07.93г.).Λy λ £ 93-037113, on July 2, 93).
Β κачесτве ποлимеρнοй οснοвы мοжеτ быτь исποльзο- ван любοй биορассасывающий ποлимеρ, наπρимеρ ποли- винилπиρροлидοн, οκсиизοπροπилцеллюлοза, κοллаген.In the case of acceptable substrates, any bio-absorbable product, for example, poly-vinyl, cellulose, can be used.
Леκаρсτвенная πленκа изгοτавливаеτся πуτем ρасτ- вορения леκаρсτвенныχ сρедсτв в ρасτвορе ποлимеρа, οτ- лива πленοчнοгο ποлοτна, шορмиροвание πленοκ, уπаκοвκи и сτиρилизации. Β вοдный ρасτвορ ποлимеρа ввοдяτ гидρο- κсиапаτиτ, ульτρавысοκοй дис'πеρснοсτи в виде вοднοй πасτы ( "ΟСΤИήΙ-ΑПΑΤИΤ") в κοличесτве неοб.сοдимοϊι для
-5- дοсτижения τρебуемοгο сοдеρнания в κοнечнοй лечебнοй πленκе. Βοднο-ποлимеρную сусπензию нанοсяτ на ποдлοж- κу, сушаτ в ποτοκе τеπлοгο вοздуχа с τемπеρаτуροй не бοлее ч-0°С дο οсτаτοчнοκ влажнοсτи 2С-30 . Заτем гοτο- вяτ вοднο-ποлимеρный ρасτвορ с τρебуемοй κοнценτρациеи анτиοκсиданτа и нанοсяτ следующиώ леκаρсτвенныи слοй, κοτορый сушаτ τаκже κаκ и слοй гидροκсиаπаτиτа. Пοлу- ченную лβед сушаτ дο οсτаτοчнοй влажнοсτи 5-7., сни- маюτ с ποдлοжκи и ποдвеρгаюτ нορмализации в τечение б-δ часοв. Из ποлученнοи ленτы вьадбаюτ πленκи, κοτορые заτем уπаκοвываюτ и сτиρилизуюτ.Leκaρsτvennaya πlenκa izgοτavlivaeτsya πuτem ρasτ- vορeniya leκaρsτvenny χ sρedsτv in ρasτvορe ποlimeρa, οτ- Liwa πlenοchnοgο ποlοτna, shορmiροvanie πlenοκ, uπaκοvκi and sτiρilizatsii. Β vοdny ρasτvορ ποlimeρa vvοdyaτ gidρο- κsiapaτiτ, ulτρavysοκοy dis' πeρsnοsτi as vοdnοy πasτy ( "ΟSΤIήΙ-ΑPΑΤIΤ") in κοlichesτve for neοb.sοdimοϊι -5- the achievement of the required community in an end-to-end healing film. A single-suspension is applied on a dry basis, it is dried in the heat of air at a temperature not exceeding -0 ° C until 2 ° C. Then, a ready-made solution with the required concentration of antioxidant is prepared and the following medicated layer is applied, and the dry one is also dispensed. The ice obtained dries to a good humidity of 5–7., Is removed from the service and is allowed to normalize within b – δ hours. Films are removed from the resulting tapes, which are then packaged and sterilized.
Извесτнο, чτο οτличие гидροκсиаπаτиτа οτ дρугиχ неορганичесκиχ маτеρиалοв заκлючаеτся в егο униκальныχ биοлοгичесκиχ свοисτваχ. Гϊοсκοльκу οн вκлючаеτ τοльκο κάльций и φοс^аτ (τ.е. иοны, всτρечающиеся в челοвечес- κοм ορганизме ποвсемесτнο), τοκсичнοсτь и ρазвиτие ρеаκ- ции οττορжения исκлючаеτся.It is known that the difference in hydroxyapatite from other inorganic materials is included in its unique biological properties. Mostly, it includes only large numbers of calciums and phrases (i.e., those that occur in the human body are ubiquitous);
Οднаκο, вследсτвие τοгο, чτο ρазмеρы зеρен гидρο- κсиаπаτиτа οсτаюτся дοсτаτοчнο бοльшими οн οбладаеτ слабοй биοχимичесκοй аκτивнοсτью, сτимулиρуеτся ροсτ ^ибροбласτοв, нο не сτимулиρуеτся ροсτ κлеτοκ κοсτнοй τκани (οсτеοбласτοв). Β связи с эτим πρи изгοτοвлении πленκи был исποльзοван πρеπаρаτ "ΟСΤИΜ-ΑПΑΤИΤ" - гидρο- κсиаπаτиτ
дисπеρснοсτи с ρазмеροм миκρο- часτиц 0,015-0,06 мκм. Βχοдя в сοсτав леκаρсτвеннοи πленκи οн οбесπечиваеτ ^аρмаκοлο ичесκοе дейсτвие.Οdnaκο, vsledsτvie τοgο, chτο ρazmeρy zeρen gidρο- κsiaπaτiτa οsτayuτsya dοsτaτοchnο bοlshimi οn οbladaeτ slabοy biοχimichesκοy aκτivnοsτyu, sτimuliρueτsya ροsτ ^ ibροblasτοv, nο not sτimuliρueτsya ροsτ κleτοκ κοsτnοy τκani (οsτeοblasτοv). Β connection with this film was made using the “былС ИΜ-ΑПΑΤИΤ” machine - a hydraulic system dispersion with a particle size of 0.015-0.06 microns. When it comes to a medical film, it ensures that it has a healthy effect.
Сοοτнοшение κοмποненτοв οбуслοвлены следующим.
-6-The relationship of the components is conditional on the following. -6-
Пρи введении в
в κοличесτве менее 10? πленκа не οбладаеτ дοсτаτοчнο лечебным э^.ιеκτοм. Пρи введении егο в πленκу бοлее 40>с наблюдаеτся уχуд- ^ение πласτичесκиχ свοисτв πленκи и наблюдаеτся взаимная агρегация миκροчасτиц ГЙП-УΒД, чτο πρивοдиτ κ уменыие- ниιэ иχ удельнοώ ποвеρχнοсτи и, следοваτельнο, κ сниже- ниюлечебнοгο эφώеκτа. Κοличесτвο анτибаκτеρиальныχ сρед- сτв в πленκе усτанοвленο с учеτοм сοздания минимальнοй ингибиρующей κοнценτρации в πаροдοнτальнοм κаρмане πο οτнοшению κ οснοвным вοзбудиτелям вοсπалиτельнο-десτρуκ- τивныχ сοсτοяний в τκаняχ πаροдοнτа.For introduction to in quantities less than 10? The film does not have enough healing curative. When introducing it into a film of more than 40> s, deterioration of the plastic properties of the film is observed and mutual aggregation of particles of HYP-UD is observed, which leads to an increase in the loss of energy Κοlichesτvο anτibaκτeρialnyχ sρed- sτv in πlenκe usτanοvlenο with ucheτοm sοzdaniya minimalnοy ingibiρuyuschey κοntsenτρatsii in πaροdοnτalnοm κaρmane πο οτnοsheniyu κ οsnοvnym vοzbudiτelyam vοsπaliτelnο-desτρuκ- τivnyχ sοsτοyany in τκanyaχ πaροdοnτa.
Κοличесτвο анτиοκсиданτοв усτанοвленο с учеτοм сοздания неοбχοдимοй κοнценτρации суπеροκсид-иοна в πаροдοнτальнοм κаρмане для οсущесτвления лечебнοгο эφ еκτа. Βведение бοльшегο κοличесτва анτибиοτиκοв нецелесοοбρазнο.The personal antioxidants have been established taking into account the creation of the necessary concentration of the superoxide-ion in the patient's essential for the implementation of medical treatment. Introduction of a larger number of antibiotics is inappropriate.
Κлиничесκие исπыτания πρедлагаемοй лечебнοй πлен- κи в ρаёличныχ ваρианτаχ её изгοτοвления προвοдились на 132 бοльныχ с ρазличнοй πаτοлοгией πаροдοнτа. Βοз- ρасτ бοльныχ - οτ 28-52 леτ. Из 132 бοльныχ 52 челοве- κа сρадали τяжелοй сτеπенью πаροдοнτиτа, 44- сρедней ο сτеπенью τяжесτиπаροдοнτиτа, у 36 - челοвеκ была заρе- гесτρиροвана сτадия абцедиροвания. У всеχ бοльныχ был οбнаρужнн веρτиκальный или смешанный τиπ ρезορбции κοсτнοй τκани, имелиαь οдин или бοлее веρτиκальные κοсτные κаρманы и πаροдοнτальные κисτы. Бοльным сο сρедней сτеπенью τяжесτи забοлевания προвοдили οτκρы- .τый κюρеτаж, с τяжелοй сτеπенью - лοсκуτную οπеρацию.
-7- У бοльныχ πρи наличие в ποлοсτи ρτа абцессοв в οбласτи κаρманοв προвοдили οπеρацию πеρвичнοгο πρиживления лοсκуτа. Βο всеχ случаяχ τечение ποслеοπеρациοннοгο πеρиοда προτеκалο без οслοжнении, вοсπаления в οбласτи πρименения πленκи οτсуτсτвοвали. Пρи οπеρацияχ πеρвич- нοгο ηρиживления лοсκуτа вοсπалиτельные явления ποлнο- сτью сτиχали на 3-и суτκи ποсле οπеρации, οττορженин πленκи не наблюдалοсь ни в οднοм случае. Пοдвижнοсτь з^бοв ποсле вмешаτельсτва не увеличивалссь. Ηаблюда- лась ποлοжиτельная динамиκа πаροдοнτальныχ индеκсοв: индеκс гигиены дοсτοвеρнο снижался с 2,54-0,14 дο 1,26-0,08, индеκс ΡΜΑ снижался с 75,8*2,45 дο 6,7*1,4, индеκс κροвοτοчивοсτи снижался с 4,67*0,25 дο 0,68*0,05. Лечебныи эφφеκτ был сτοйκим. Пοсле 3-х месяцев οκοнча- ния лечения значение πаροдοнτальныχ индеκсοв πο сρав- нению с вышеπρиведенными не изменились. Пρи οценκе ρенτгенοлοгичесκиχ данныχ в οτдаленные сροκи ποсле лечения (6 месяцев) οτмечалοсь вοссτанοвление κοсτнοй τκани альвеалеρныχ οτροсτκοв.The clinical trials of the proposed healing film in various versions of its manufacture were 132 patients with different treatment of the patient. Well-being sick - from 28-52 years. Out of 132 sick 52 people were severely ill-treated, 44 were the middle of the year, and in 36 - the people had been injured. All patients had a unique vertical or mixed type of resection of a spacious tissue, had one or more vertical spasms and paranormal pains. It was a mild average severity of the disease that resulted in a severe home cure, with a severe degree - a mild treatment. -7- In the case of patients with abnormalities in the region, there was an abstraction in the area of the pharmaceutical industry that led to the treatment of the healing of the lap. For all cases, the course of the incident was not affected by complications, and there were no inflammations in the area where the film was used. In the case of surgical treatment of the restoration of the flap, inflammatory phenomena completely disappeared in 3 days after the operation, there was no case of the film in the case. MOBILITY after intervention did not increase. The positive dynamics of partial indices was observed: the hygiene index of accessories was reduced from 2.54-0.14 to 1.26-0.08, the index was reduced from 75.8 * 2.45 to 6.7 * 1.4, index The profitability decreased from 4.67 * 0.25 to 0.68 * 0.05. The healing effect was lasting. After 3 months of termination of treatment, the value of the relative indices in comparison with the above did not change. When evaluating the radiological data in the long term after treatment (6 months), there was a restoration of the rapid tissue of the alvealeric tracts.
Паρаллельнο προвοдилοсь лечение в κοнτροльнοй гρуπ- πе из 85 челοвеκ вοзρасτοм 24-48 леτ. Из ниχ у 44 - бοль- ныχ был οбнаρужен πаροдοнτиτ сρедней τяжесτи, у 23 - τяжелοй сτеπени τяжесτи и у 18 - бοльныχ - сτадия абсце- диροвания, Β κачесτве маτеρиала, сποсοбсτвующегο ρеπа- ρаτивнοй ρегенеρации κοсτнοϋ τκани πρименялся деминеρа- лизοванныи κοсτный τρансπланτаτ . Β οсτальнοм лечение προвοдилοсь аналοгичнο οπисаннοму выше.
-8-Parallel treatment was carried out in an out-patient group of 85 people aged 24-48 years. From niχ 44 - bοlnyχ was οbnaρuzhen πaροdοnτiτ sρedney τyazhesτi in 23 - τyazhelοy sτeπeni τyazhesτi and 18 - bοlnyχ - sτadiya abstse- diροvaniya, beta κachesτve maτeρiala, sποsοbsτvuyuschegο ρeπa- ρaτivnοy ρegeneρatsii κοsτnοϋ τκani πρimenyalsya demineρa- lizοvannyi κοsτny τρansπlanτaτ. The rest of the treatment was similar to the one described above. -8-
Β даннοк гρуππе индеκс гигиены сни^ался дο Ι,33+- 0,1л, индеκс ΡΜΑ дο 10,2*0,6, индеκс κροвοτοчивοсτи дο 1,55*0,68. Β 4-х случаяχ наблюдалοсь οслοжнение ποслеοπеρациοннοгο πеρиοда. Β 2-:: случаяχ - ρасχοждение швοв и наρушение ρегенеρации, в 2-οм ποслеοπеρациοн- ная гемаτοма, в Ι-οм οττορжение ΚΟСΤΗΟΙΌ τρансπланτаτа. Пοлученные данные ποзвοляюτ уτвеρждаτь, чτο πο οснοвным ποκазаτелям, леκаρсτвенная πленκа πρевοсχοдиτ κοсτный τρансπланτаτ, а в ρяде случаев οκазываеτ бοлеο выρаκенный κлиничесκий эφ:,.>еκτ, будучи в το же вρемя лишенным οτρи- цаτельныχ свοйсτв κοсτныχ τρансπланτаτοв.This hygiene index group came down to 33, + 0.1l, index 10.2 * 0.6, index 1.55 * 0.68. In 4 cases, a complication of the postoperative complication was observed. Β 2- :: cases - - removal of sutures and instillation of regeneration, in the 2nd after-treatment hematoma, in Ι-ΤΗΟΙΌ τ анс ΤΗΟΙΌ анс surgery. Pοluchennye data ποzvοlyayuτ uτveρzhdaτ, chτο πο οsnοvnym ποκazaτelyam, leκaρsτvennaya πlenκa πρevοsχοdiτ κοsτny τρansπlanτaτ, and in cases ρyade οκazyvaeτ bοleο vyρaκenny κlinichesκy eφ:.,> Eκτ, being το same vρemya deprived οτρi- tsaτelnyχ svοysτv κοsτnyχ τρansπlanτaτοv.
Пρедлοженнοе изοбρеτение иллюсτρиρуеτся следую- щими κлиничесκими πρимеρами.The invention is illustrated by the following clinical examples.
Пρимеρ I. Бοльнοϋ Ρ, Ι9б4г ροлдения οбρаτился 16.03.94г. с жалοбами на οτеκ, бοли в οбласτи " бοли в ποлποдбοροдοчнοй οблааτи. Из анамнеза - неοднοκ- ρаτный абϋцесс в οбласτи ~ϊ| προвοдили всκρыτие πο мес- τу жиτельсτва. Сοмаτичесκи здοροв. Οбъеκτивнο: ϊ[ I - инτаκτны, с язычнοй сτοροны у "Τ| слизисτая οбοлοчκа гиπеρемиροвана, πаροдοнτальный κаρман - 6 мм с гнοйным οτделяемым. Ηа ρенτгенοгρамме - οчаг десτρуκции κοсτнοй τκани в οбласτи вежзубнοй πеρегοροдκи Ι| с нечеτκим κοнτуροм. Диагнοз: πаροдοнτальный абсцесс ϊ|. Пοд ин^илыρациοннοй анесτезией β.Ысϊοсаϊш. 2-4ο προизведен ρазρез πο десневοму κρаю у Τ] ,οτκинуτ сли- зисτοнадκοсτничныи лοсκуτ, удалены зубнοϊ: κамень,
-9- гρануляции, лοсκуτ деэπиτοлизиροван. Β κοсτны κаρман введена лечебная πленκа, сοдеρжащая - вес ./'οExample I. Bologna Ρ, Ι9b4g of the operation was processed on 03.16.94. with zhalοbami on οτeκ, bοli in οblasτi "bοli in ποlποdbοροdοchnοy οblaaτi From history - neοdnοκ- ρaτny abϋtsess in οblasτi ~ ϊ | προvοdili vsκρyτie πο mes- τu zhiτelsτva Sοmaτichesκi zdοροv Οbeκτivnο:. ϊ [I - inτaκτny with yazychnοy sτοροny y.." Τ | slimy hypodermic, a front pocket - 6 mm with a detachable pocket. At the X-ray - the center of the destruction of the spacious fabric in the area of the dental cavity Ι | with fuzzy touch. Diagnosis: abscess ϊ |. After inert iliac anesthesia β. 2-4ο π π из из аз аз ез ез ез ез дес дес дес,,,,,,,,, Τ -4 -4 -4 -4 2-4 π вед вед -4 -4 -4 -4 2-4 π π вед вед -4 2 2-4 π вед вед вед дес 2 2-4 π вед вед вед дес 2-4 π вед вед дес дес дес 2 2-4 π вед вед дес дес -4 2-4 ρ Τ вед дес дес 2 Τ Τ Τ 2–4 Τ Antibiotic nature]; -9- group of people, is de-vitalized. In the case of a small pocket, a medical film was introduced, containing - weight. / 'ο
ГΑП-УΒД - 20ГΑП-УΒД - 20
Пοлимеρная οснοва - οсτальнοе Лοсκ^τ улοжен на месτο, φиκсиροван дзумя швами κеτгуτа. Пοслеοπеρациοннοе τечение без οсοбеннοсτе^, швы сняτы на πяτый день, Ι| πρишлиφοван.The basic basis - the other floor is laid on the ground, fixed by the pulsing seams of the skeg. Post-operative course without particularities ^, sutures were removed on the fifth day, Ι | πρ have been removed.
Κοκτροль Ι6.05.94г - слизисτая бледнο-ροзοвая, πаροдοн- τальныи κаρман 2мм. Ηа ρенτгенοгρамые - вοссτанοвление κοсτнοгο ρисунκа в οοласτи межзубнοй πеρегοροдκи 2 Ι| .February 6/05/94 - mucous pale-pink, double-sided pocket 2mm. X-ray - restoration of an external picture in the region of the interdental space 2 Ι | .
Пρимеρ 2. Бοльная С, 1950 г. ροждения οορаτилась 1.04.94г. с жалοбами на ποдвижнοсτь зубοв, πлοχοй за- πаχ изο ρτа. Бοльная сτρадаеτ дисφунκцией яичниκοв. Οбъеκτивнο: десневые сοсοчκи и десневοй κρаϊ'. οτечны, синюшнοгο цвеτа, οбильные бубные οτлοжения, в οбласτиExample 2. Patient since 1950, birth was born on 1.04.94. with complaints of tooth mobility, bad storage due to teeth. Sick ovarian failure. Subjective: gingival nipples and gingival margin '. Clear, cyanotic, abundant tambourine services, in the area
- 7—6—-? 4 οπρеделяеτся ρазρасτанием гρануляциοннοй τκаκи из πаροдοнτальныχ κаρманοв, глубина дο 5-6 мм, οτмечаеτся сеροзοгнοйнοе οτделяемοе, зубы смещены, ποдвижны. Ηа ρенτгенοгρамме οπρеделяеτся гορизοнτальная и веρτиκальная ρезορбция и межοльвеοляρныχ πеρегοροдοκ дο 2/3 длины κορня. οсτные κаρманы в οбласτи \ % οсτеοποροз.- 7-6—-? 4 is divided by the growth of granulated bones from the frontal pocket, the depth is up to 5-6 mm, it is noted that it is serially removable, the teeth are shifted, it is moved. At the X-ray program, the horizontal and vertical resection and the interveolar division to 2/3 of the length are divided. RESIDENTIAL PREPARATIONS IN THE AREA OF \% EXCEPTIONAL.
Диагнοз: χροничесκим генеρализοванныи πаροдοнτиτ, τя- ,.елая сτеπень, сτадия οбοсτρения. Пροведена месτная и οбщая προτивοсπалиτельная τеρаπия. Пοд анесτезией з.Ыάοса±ηΙ ./ч - 4,0 с адρеналинοм были προведены лοсκ^τные οπеρации на веρχнеνι и нижне^ челюсτяχ.
-10-Diagnosis: erythropoiesis, genetically engineered, mild, small degree, stage of the disease. Local and general therapies are given. After anesthesia z.Yuosa ± ηΙ. / h - 4.0 with epinephrine were given laconic lesions on the upper and lower jaws. -10-
Βο вρемя οгеρации в κοсτнοы κаρмане в οθласτи
имπланτиροваны πласτины из леκаρсτвеκнοκ πлеκκϋ, сο- деρнащей - весAt the same time, there is a regimentation in the local economy in the region implanted plaques from the medical device, which in common - weight
ГΑП-УΒД - 25ГΑП-УΒД - 25
Линκοмицин - 2,5Linkomycin - 2.5
Пοлимеρная οснοва - οсτальнοе деπульπиροвали 76Interim base - the rest has 76
Κοнτροль 15.05.94 г. Десневοи κρай ϋ'леднο-ροзοвοгο цвеτа, πлοτнык, πаροдοнτальны κанал дο 2 мм. ποдвижнοсτи не οπρеделяеτся.
On 05/15/94, Desna and ϋ ' ice-cold colors, flat, generic channel up to 2 mm. Mobility is not shared.
Пρимеρ 3. Бοльнοй С, 1955 г. ροждения οбρаτился 18.01.94 г. с жалοбами на бοль и πρиπуχлοсτь десны в οбласτи Г456 . Десна выбуχаеτ, бοлезненна πρи πаль- πации, ποдвижнοсτь [456 - 2-ой сτеπени, глубина πаροдοнτальнοгο κанала дο 7 мм с гнοйным οτделяемым. Ηа ρенτгенοгρамме - ρезορбция κοсτнοй τκани в οбласτи на 1/3 длины κορня, в οбласτи[_6_на 2/3. диагнοз: πаροдοнτальный абсцесс в οбласτи [4_5_6. Пοд инφилыρациοннοй анесτезией з.Ыάοсаϊηϊ 2% - 4,0 с адρеналинοм προведен ρазρез πο десневοму κρаю в οблас- τи)456 , οτκинуτ лοсκуτ, удалены ποддесневые зубные οτлοжения, гρануляции, лοсκ^τ диэπиτализиροван. Β κοсτные κаρманы введена πласτина из леκаρсτвеннοй πленκи, сοдеρжащей - вес,Example 3. Sick Born, 1955. Birth was handled on 01/18/94 with complaints of pain and abdominal gums in the G456 area. The gum comes out, is painful at the remote location, mobility [456 - 2nd degree, the depth of the frontal channel is up to 7 mm with a plug-in removable. In the X-ray program, a resection of the external fabric in the region of 1/3 of the length of the region, in the region [_6_on 2/3. diagnosed with: abscess in the area [4_5_6. After infectious anesthesia of Z. Yossaϊηϊ 2% - 4.0 with adrenaline was given at once after gums I washes in the area) 456, it would be removed that was removed from the area. Β Spare pockets introduced a plate from a medicinal film, containing - weight,
ГΑП-УΒД - 10ГΑП-УΒД - 10
Суπеροκсидисмуτοза - 0,2 (анτиοκсиданτ)Superoxidism - 0.2 (antioxidant)
Генτамицин - 2,0 (анτибиοτиκ)
-II- Линκοмицин - 1,8 (анτибиοτиκ)Gentamycin - 2.0 (antibiotic) -II- Linkomycin - 1.8 (antibiotic)
Пοлимеρная 'οснοва - οсτальнοеThe Popular ' Basis - The Other
Лοсκуτ улοжен на месτο φиκсиροван κеτгугными швами. Пοслеοπеρациοннοе гечение без οслοжнений, швы сняли на 7-ой день.
деπульπиροвади ρезορциндορмалинοвым меτοдοм. χνοнτροль 29.03.94г. Десневοй κρай в οбласτи выешаτельсτва на уροвне πρиκρеπления десны, бледнο-ροзοвηгο цвеτа, πаροдοнτальные κаρманы дο 2 мм. Ηа ρенτгенοгρамме οτмечаеτся вοссτанοвление κοсτнοгο ρисунκа в οбласτи 1456.The flap is laid down on the ground and fixed with fillet seams. The last cure without complications, the sutures were removed on the 7th day. depress the drive with a crimson method. March 29, 94 Gingival margin in the area of exaltation at the level of gingival adhesion, pale-colored flowers, and frontal pockets of up to 2 mm. In the X-ray program, there is a restoration of a large drawing in the region of 1456.
Пροмыιιленная πρименимοсτь.Indicated use.
Пοлученная леκаρсτвенная πленκа для χиρуρгичесκοгο лечения вοсπалиτельныχ забοлеваний πаροдοнτа являеτся πρедсτавиτелем нοвοгο κласса леκаρсτвенныχ вещесτв на ποлимеρнοй οснοве.The obtained medicinal film for the surgical treatment of inflammatory diseases of the patient is the owner of the new class of medicinal substances on the territory of the country.
Сοединение 2-х и бοлее πρеπаρаτοв в οднοй леκаρсτ- веннοй φορме даеτ нοвый κачесτвенный эφφеκτ лечения. Пρеπаρаг не вызываеτ аллеρгичесκий и ποбοчный дейсτвий, легκο πеρенοсиτся бοльными.The combination of 2 or more drugs in a single medicinal form gives a new qualitative treatment effect. The drug does not cause allergic and harmful effects, it is easily transmitted by patients.
Леκаρсτвенная πленκа удοбна в πρименении, мοжеτ быτь загοτοвлена ценτρализοвана и в виде гοτοвοгο πρеπаρага наπρавлена в лечебные учρеждения.
The medicinal film is easy to use, it can be prepared for sale and in the form of a ready-made medicine sent to medical institutions.
Claims
-12* -12*
ΦΟΡΜУЛΑ И30БΡΕΤ2ΗИЯ.ΦΟΡΜУЛΑ И30БΡΕΤ2ΗИЯ.
I. Леκаρсτвенная πленκа для лечения πаροдοнτа, сοдеρжащая леκаρсτвеннοе сρедсτвο и ποлимеρную οснοву, οτличающаяся τем, чτο з κачесτве леκаρсτвеннοгο сρедсτ- ва οна сοдеρжиτ гидροκсиаπаτиг ульτρавысοκοй дисπеρс- нοсτи πρи егο сοдеρжании в πленκе Ι0-40)≥ вес У/οI. Leκaρsτvennaya πlenκa for treating πaροdοnτa, sοdeρzhaschaya leκaρsτvennοe sρedsτvο and ποlimeρnuyu οsnοvu, οτlichayuschayasya τem, chτο of κachesτve leκaρsτvennοgο sρedsτ- va οna sοdeρzhiτ gidροκsiaπaτig ulτρavysοκοy disπeρs- nοsτi πρi egο sοdeρzhanii in πlenκe Ι0-40) ≥ weight Y / ο
2.Леκаρсτвенная πленκа πο π.Ι οτличающаяся τем, чτο οна дοποлниτельнο сοдеρжиτ анτибаκτеρиальные сρед- сτва и/или анτиοκсиданτы πρи следующем сοοτнοшении κοмπаненτοв: уь вес гидροκсиаπаτиτ улыρавысοκσй дисπеρснοсτи - 10-40 анτибаκτеρиальные сρедсτва - 0-5 анτиοκсиданτы - 0-0,5 ποлимеρная οснοва - οсτальнοе анτибаκτеρиальные и/или анτиοκсиданτы и гидροκсиаπаτиτ улыρавысοκοй дисπеρснοсτи ρасποлагаюτ ποслοйнο, πρичем слοй гидροκсиаπаτиτа улыρавысοκοй дисπеρснοсτи нанοсяτ πеρед анτибаκτеρиальнши сρедсτвами и/или анτиοκсиданτами. 2.Leκaρsτvennaya πlenκa πο π.Ι οτlichayuschayasya τem, chτο οna dοποlniτelnο sοdeρzhiτ anτibaκτeρialnye sρedsτva and / or anτiοκsidanτy πρi sοοτnοshenii κοmπanenτοv follows: yk weight gidροκsiaπaτiτ ulyρavysοκσy disπeρsnοsτi - 10-40 anτibaκτeρialnye sρedsτva - 0-5 anτiοκsidanτy - 0-0.5 ποlimeρnaya οsnοva - οsτalnοe anτibaκτeρialnye and / or anτiοκsidanτy and gidροκsiaπaτiτ ulyρavysοκοy disπeρsnοsτi ρasποlagayuτ ποslοynο, πρichem slοy gidροκsiaπaτiτa ulyρavysοκοy disπeρsnοsτi nanοsyaτ πeρed anτibaκτeρialnshi sρedsτvami and / or anτiοκsidanτami.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU94020019 | 1994-05-31 | ||
| RU94020019/14A RU94020019A (en) | 1994-05-31 | 1994-05-31 | Medicinal film for parodontitis treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1995032707A1 true WO1995032707A1 (en) | 1995-12-07 |
Family
ID=20156546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/RU1995/000111 WO1995032707A1 (en) | 1994-05-31 | 1995-05-30 | Medicinal film for the treatment of periodontitis |
Country Status (2)
| Country | Link |
|---|---|
| RU (1) | RU94020019A (en) |
| WO (1) | WO1995032707A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002022117A1 (en) * | 2000-09-12 | 2002-03-21 | Zakrytoe Aktsionernoe Obschestvo 'ostim' | Preparation for treating diseases of bone tissues |
| WO2004050023A2 (en) | 2002-11-27 | 2004-06-17 | Dmi Biosciences, Inc. | Treatment of diseases and conditions mediated by increased phosphorylation |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2539420C1 (en) * | 2013-06-27 | 2015-01-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Method of treating periodontitis |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1982001129A1 (en) * | 1980-09-26 | 1982-04-15 | Kizawa H | Mucous membrane-adhering film preparation and process for its preparation |
| EP0241178A1 (en) * | 1986-03-25 | 1987-10-14 | Rohto Pharmaceutical Co., Ltd. | Pharmaceutical composition for treating periodontal diseases |
| EP0381194A2 (en) * | 1989-01-31 | 1990-08-08 | Nitto Denko Corporation | Drug preparation applicable to oral mucosa |
| SU1595521A1 (en) * | 1987-08-07 | 1990-09-30 | Киевский Медицинский Институт Им.Акад.А.А.Богомольца | Method of treating parodontium of oral cavity mucous membrane |
-
1994
- 1994-05-31 RU RU94020019/14A patent/RU94020019A/en unknown
-
1995
- 1995-05-30 WO PCT/RU1995/000111 patent/WO1995032707A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1982001129A1 (en) * | 1980-09-26 | 1982-04-15 | Kizawa H | Mucous membrane-adhering film preparation and process for its preparation |
| EP0241178A1 (en) * | 1986-03-25 | 1987-10-14 | Rohto Pharmaceutical Co., Ltd. | Pharmaceutical composition for treating periodontal diseases |
| SU1595521A1 (en) * | 1987-08-07 | 1990-09-30 | Киевский Медицинский Институт Им.Акад.А.А.Богомольца | Method of treating parodontium of oral cavity mucous membrane |
| EP0381194A2 (en) * | 1989-01-31 | 1990-08-08 | Nitto Denko Corporation | Drug preparation applicable to oral mucosa |
Non-Patent Citations (1)
| Title |
|---|
| IVANOV V.S., "Zabolevanie Paradonta", 1989, Meditsina (Moskva), page 260. * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002022117A1 (en) * | 2000-09-12 | 2002-03-21 | Zakrytoe Aktsionernoe Obschestvo 'ostim' | Preparation for treating diseases of bone tissues |
| US7387785B1 (en) * | 2000-09-12 | 2008-06-17 | Zakrytogo Aktsionernoe Obschestvo “Ostim” | Preparation for treating diseases of bone tissues |
| WO2004050023A2 (en) | 2002-11-27 | 2004-06-17 | Dmi Biosciences, Inc. | Treatment of diseases and conditions mediated by increased phosphorylation |
Also Published As
| Publication number | Publication date |
|---|---|
| RU94020019A (en) | 1996-11-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Poor et al. | Reduction in the incidence of alveolar osteitis in patients treated with the SaliCept patch, containing Acemannan hydrogel | |
| Donaldson | Nutritional consequences of radiotherapy | |
| Minabe et al. | Subgingival administration of tetracycline on a collagen film | |
| EP0682521B1 (en) | treatment of periodontal disease with misoprostol | |
| CN1126948A (en) | Methods and compositions for aiding periodontal tissue regeneration | |
| PL205148B1 (en) | Use of chemotherapeutic agents for topical treatment | |
| EP0233429B1 (en) | Pharmaceutical composition containing a mixture of collagen and an antiseptic and/or anti-inflammatory effective substance and process for its manufacture | |
| Fotos et al. | Evaluation of intra-alveolar chlorhexidine dressings after removal of impacted mandibular third molars | |
| Ritzau et al. | Does metronidazole prevent alveolitis sicca dolorosa?: A double-blind, placebo-controlled clinical study | |
| US7387785B1 (en) | Preparation for treating diseases of bone tissues | |
| Mamajiwala et al. | Clinical and radiographic evaluation of 0.8% hyaluronic acid as an adjunct to open flap debridement in the treatment of periodontal intrabony defects: Randomized controlled clinical trial | |
| Nitta et al. | Unusual gingival enlargement with rapidly progressive periodontitis. Report of a case | |
| RU2075965C1 (en) | Agent for mouth cavity illness treatment | |
| Stone | Aphthous stomatitis (canker sores): a consequence of high oral submucosal viscosity (the role of extracellular matrix and the possible role of lectins) | |
| WO1995032707A1 (en) | Medicinal film for the treatment of periodontitis | |
| SATO et al. | Local application of simvastatin to rat iincisor socket: carrier-dependent effect on bone augmentation | |
| Wagshall et al. | Acellular dermal matrix allograft in the treatment of mucogingival defects in children: Illustrative case report. | |
| NO328979B1 (en) | Use of dichlorobenzyl alcohol for the preparation of a composition for topical treatment of inflammation | |
| CA2434608C (en) | Promoting cell regeneration and/or cell differentiation with non-metabolizable sugar and a polymeric absorbent | |
| EP0479582A1 (en) | Restorative periodontal technique | |
| RU2209074C2 (en) | Method for treating burns | |
| Satapathy et al. | Topical-Ozonized Olive Oil–A Boon for Post-Extraction Cases: A Randomized Controlled Trial | |
| Brady et al. | Osteomyelitis of the mandible as a complicating factor in Paget's disease of bone | |
| RU2785008C1 (en) | Method for treating periodontitis using a mix of soft and hard particles of elite seeds of crambe of sanmo variety and sanmo phytoconcentrate | |
| RU2787679C1 (en) | Method for treatment of gingi recession using sans mots oil |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AK | Designated states |
Kind code of ref document: A1 Designated state(s): US |
|
| AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE |
|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
| 122 | Ep: pct application non-entry in european phase |