WO1994004691A3 - Formes dimeres et multimeres de polypeptides monocatenaires - Google Patents

Formes dimeres et multimeres de polypeptides monocatenaires Download PDF

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Publication number
WO1994004691A3
WO1994004691A3 PCT/US1993/007918 US9307918W WO9404691A3 WO 1994004691 A3 WO1994004691 A3 WO 1994004691A3 US 9307918 W US9307918 W US 9307918W WO 9404691 A3 WO9404691 A3 WO 9404691A3
Authority
WO
WIPO (PCT)
Prior art keywords
single chain
dimer
chain polypeptides
antibodies
multimers
Prior art date
Application number
PCT/US1993/007918
Other languages
English (en)
Other versions
WO1994004691A2 (fr
Inventor
Peter S Mezes
Ruth A Richard
Joseph A Affholter
Nicolas J Kotite
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Priority to AU50872/93A priority Critical patent/AU5087293A/en
Publication of WO1994004691A2 publication Critical patent/WO1994004691A2/fr
Publication of WO1994004691A3 publication Critical patent/WO1994004691A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody

Abstract

L'invention concerne de nouvelles protéines constituant des dimères et des multimères d'anticorps monocaténaires. Les anticorps monocaténaires contiennent des polypeptides de deux domaines dérivés des domaines variables d'anticorps joints par une liaison peptidique. Les dimères et multimères sont formés par liaison non covalente des polypeptides monocaténaires. On peut citer parmi les emplois tous ceux appropriés à des anticorps monoclonaux et polyclonaux et des fragments de ceux-ci, y compris comme molécule de fixation d'antigène bispécifique.
PCT/US1993/007918 1992-08-21 1993-08-20 Formes dimeres et multimeres de polypeptides monocatenaires WO1994004691A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU50872/93A AU5087293A (en) 1992-08-21 1993-08-20 Dimer and multimer forms of single chain polypeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/935,695 1992-08-21
US07/935,695 US6329507B1 (en) 1992-08-21 1992-08-21 Dimer and multimer forms of single chain polypeptides

Publications (2)

Publication Number Publication Date
WO1994004691A2 WO1994004691A2 (fr) 1994-03-03
WO1994004691A3 true WO1994004691A3 (fr) 1994-03-31

Family

ID=25467525

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/007918 WO1994004691A2 (fr) 1992-08-21 1993-08-20 Formes dimeres et multimeres de polypeptides monocatenaires

Country Status (3)

Country Link
US (2) US6329507B1 (fr)
AU (1) AU5087293A (fr)
WO (1) WO1994004691A2 (fr)

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Also Published As

Publication number Publication date
US6071515A (en) 2000-06-06
WO1994004691A2 (fr) 1994-03-03
AU5087293A (en) 1994-03-15
US6329507B1 (en) 2001-12-11

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