WO1993018173A3 - Cd4 binding agents and inhibitors of collagenase and protein kinase c - Google Patents

Cd4 binding agents and inhibitors of collagenase and protein kinase c Download PDF

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Publication number
WO1993018173A3
WO1993018173A3 PCT/GB1993/000511 GB9300511W WO9318173A3 WO 1993018173 A3 WO1993018173 A3 WO 1993018173A3 GB 9300511 W GB9300511 W GB 9300511W WO 9318173 A3 WO9318173 A3 WO 9318173A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
compound
collagenase
protein kinase
binding agents
Prior art date
Application number
PCT/GB1993/000511
Other languages
French (fr)
Other versions
WO1993018173A2 (en
Inventor
Peter John Hylands
Stephen Keith Wrigley
Glenda Louise Chandler
Mark Anthony David Collins
Frances Fox
Michael Moore
Original Assignee
Xenova Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929205311A external-priority patent/GB9205311D0/en
Priority claimed from GB929207166A external-priority patent/GB9207166D0/en
Priority claimed from GB929207290A external-priority patent/GB9207290D0/en
Priority claimed from GB929208189A external-priority patent/GB9208189D0/en
Application filed by Xenova Ltd filed Critical Xenova Ltd
Priority to GB9418110A priority Critical patent/GB2280439B/en
Publication of WO1993018173A2 publication Critical patent/WO1993018173A2/en
Publication of WO1993018173A3 publication Critical patent/WO1993018173A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/80—Penicillium

Abstract

A compound which is obtainable from Penicillium glabrum X8063 (CMI 336456) and which has a molecular formula of C27H16O12, a molecular weight of 532 and defined spectral characteristics; a compound which is obtainable from Penicillium glabrum X8063 (CMI 336456) and which has a molecular formula of C14H10O6, a molecular weight of 274 and defined spectral characteristics; anhydrofulvic acid; and citromycetin; and pharmaceutically and veterinarily acceptable salts, esters and ethers thereof; are useful as CD4 binding agents, inhibitors of collagenase and in the case of the compound of molecular formula C27H16O12 and the compound having the molecular formula C14H10O6 inhibitors of protein kinase C.
PCT/GB1993/000511 1992-03-11 1993-03-11 Cd4 binding agents and inhibitors of collagenase and protein kinase c WO1993018173A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9418110A GB2280439B (en) 1992-03-11 1993-03-11 CD4 binding agents and inhibitors of collagenase and protein kinase C

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB9205311.5 1992-03-11
GB929205311A GB9205311D0 (en) 1992-03-11 1992-03-11 Pharmaceutical compound
GB929207166A GB9207166D0 (en) 1992-04-01 1992-04-01 Pharmaceutical compound
GB9207166.1 1992-04-01
GB929207290A GB9207290D0 (en) 1992-04-02 1992-04-02 Pharmaceutical compound
GB9207290.9 1992-04-02
GB929208189A GB9208189D0 (en) 1992-04-13 1992-04-13 Pharmaceutical compound
GB9208189.2 1992-04-13

Publications (2)

Publication Number Publication Date
WO1993018173A2 WO1993018173A2 (en) 1993-09-16
WO1993018173A3 true WO1993018173A3 (en) 1993-10-28

Family

ID=27450843

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/000511 WO1993018173A2 (en) 1992-03-11 1993-03-11 Cd4 binding agents and inhibitors of collagenase and protein kinase c

Country Status (2)

Country Link
GB (1) GB2280439B (en)
WO (1) WO1993018173A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9414157D0 (en) * 1994-07-13 1994-08-31 Smithkline Beecham Plc Medical use
GB9601042D0 (en) * 1996-01-17 1996-03-20 Smithkline Beecham Plc Medical use
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5831004A (en) * 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
JPH11512708A (en) 1995-09-11 1999-11-02 オステオアルスリィティス サイエンシズ，インコーポレイテッド Protein tyrosine kinase inhibitors for treating osteoarthritis
EP0795554A3 (en) * 1996-03-05 1998-01-28 Takeda Chemical Industries, Ltd. (Oxo-)xanthene derivatives, their preparation and their use as immunomodulators
US6103713A (en) * 1998-03-05 2000-08-15 Eli Lilly And Company Therapeutic treatment for autoimmune diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0319333A2 (en) * 1987-12-02 1989-06-07 Becton, Dickinson and Company Method for the prevention of graft versus host disease
WO1992016517A1 (en) * 1991-03-22 1992-10-01 Xenova Limited Pharmaceutical xanthone derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0319333A2 (en) * 1987-12-02 1989-06-07 Becton, Dickinson and Company Method for the prevention of graft versus host disease
WO1992016517A1 (en) * 1991-03-22 1992-10-01 Xenova Limited Pharmaceutical xanthone derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. CHEM. SOC. PERKIN TRANSACTION I 1988 no. 4, April 1988, ROYAL SOCIETY OF CHEM., LONDON, UK; pages 763 - 768 A.K. DEMETRIADOU ET AL. 'Isolation and structure elucidation of polivione, a polyketide co-metabolite of citromycetin in Penecillium frequentans' cited in the application the whole document *
J. CHEM. SOC. PERKIN TRANSACTION I, 1987 no. 2, 1987, ROYAL SOCIETY OF CHEM., LONDON UK; pages 395 - 398 M. YAMAUCHI ET AL. 'Studies on the syntheses of heterocyclic compounds containing benzopyrone. Part6. Biomimetic total syntheses of citromycetin' *
T. KORZYBSKI ET AL. IN: ANTIBIOTICS vol. II, 1967, PERGAMON PRESS,OXFORD, UK; pages 1254 - 1255 'Frequentic acid, syn. Citromycetin' the whole document *

Also Published As

Publication number Publication date
GB9418110D0 (en) 1994-10-26
GB2280439B (en) 1995-11-22
WO1993018173A2 (en) 1993-09-16
GB2280439A (en) 1995-02-01

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