GB2280439A - CD4 binding agents and inhibitors of collagenase and protein kinase C - Google Patents

CD4 binding agents and inhibitors of collagenase and protein kinase C

Info

Publication number
GB2280439A
GB2280439A GB9418110A GB9418110A GB2280439A GB 2280439 A GB2280439 A GB 2280439A GB 9418110 A GB9418110 A GB 9418110A GB 9418110 A GB9418110 A GB 9418110A GB 2280439 A GB2280439 A GB 2280439A
Authority
GB
United Kingdom
Prior art keywords
inhibitors
compound
collagenase
protein kinase
binding agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9418110A
Other versions
GB9418110D0 (en
GB2280439B (en
Inventor
Stephen Keith Wrigley
Michael Moore
Frances Fox
Glenda Louise Chandler
Peter John Hylands
Mark Anthony David Collins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenova Ltd
Original Assignee
Xenova Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929205311A external-priority patent/GB9205311D0/en
Priority claimed from GB929207166A external-priority patent/GB9207166D0/en
Priority claimed from GB929207290A external-priority patent/GB9207290D0/en
Priority claimed from GB929208189A external-priority patent/GB9208189D0/en
Application filed by Xenova Ltd filed Critical Xenova Ltd
Publication of GB9418110D0 publication Critical patent/GB9418110D0/en
Publication of GB2280439A publication Critical patent/GB2280439A/en
Application granted granted Critical
Publication of GB2280439B publication Critical patent/GB2280439B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/80—Penicillium

Abstract

A compound which is obtainable from Penicillium glabrum X8063 (CMI 336456) and which has a molecular formula of C27H16O12, a molecular weight of 532 and defined spectral characteristics; a compound which is obtainable from Penicillium glabrum X8063 (CMI 336456) and which has a molecular formula of C14 H10O6, a molecular weight of 274 and defined spectral characteristics; anhydrofulvic acid; and citromycetin; and pharmaceutically and veterinarily acceptable salts, esters and ethers thereof; are useful as CD4 binding agents, inhibitors of collagenase and in the case of the compound of molecular formula C27H16O12 and the compound having the molecular formula C14H10O6 inhibitors of protein kinase C.
GB9418110A 1992-03-11 1993-03-11 CD4 binding agents and inhibitors of collagenase and protein kinase C Expired - Fee Related GB2280439B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB929205311A GB9205311D0 (en) 1992-03-11 1992-03-11 Pharmaceutical compound
GB929207166A GB9207166D0 (en) 1992-04-01 1992-04-01 Pharmaceutical compound
GB929207290A GB9207290D0 (en) 1992-04-02 1992-04-02 Pharmaceutical compound
GB929208189A GB9208189D0 (en) 1992-04-13 1992-04-13 Pharmaceutical compound
PCT/GB1993/000511 WO1993018173A2 (en) 1992-03-11 1993-03-11 Cd4 binding agents and inhibitors of collagenase and protein kinase c

Publications (3)

Publication Number Publication Date
GB9418110D0 GB9418110D0 (en) 1994-10-26
GB2280439A true GB2280439A (en) 1995-02-01
GB2280439B GB2280439B (en) 1995-11-22

Family

ID=27450843

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9418110A Expired - Fee Related GB2280439B (en) 1992-03-11 1993-03-11 CD4 binding agents and inhibitors of collagenase and protein kinase C

Country Status (2)

Country Link
GB (1) GB2280439B (en)
WO (1) WO1993018173A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9414157D0 (en) * 1994-07-13 1994-08-31 Smithkline Beecham Plc Medical use
GB9601042D0 (en) * 1996-01-17 1996-03-20 Smithkline Beecham Plc Medical use
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5831004A (en) * 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
JPH11512708A (en) 1995-09-11 1999-11-02 オステオアルスリィティス サイエンシズ，インコーポレイテッド Protein tyrosine kinase inhibitors for treating osteoarthritis
EP0795554A3 (en) * 1996-03-05 1998-01-28 Takeda Chemical Industries, Ltd. (Oxo-)xanthene derivatives, their preparation and their use as immunomodulators
US6103713A (en) * 1998-03-05 2000-08-15 Eli Lilly And Company Therapeutic treatment for autoimmune diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0319333A2 (en) * 1987-12-02 1989-06-07 Becton, Dickinson and Company Method for the prevention of graft versus host disease
WO1992016517A1 (en) * 1991-03-22 1992-10-01 Xenova Limited Pharmaceutical xanthone derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0319333A2 (en) * 1987-12-02 1989-06-07 Becton, Dickinson and Company Method for the prevention of graft versus host disease
WO1992016517A1 (en) * 1991-03-22 1992-10-01 Xenova Limited Pharmaceutical xanthone derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Antibiotics vol.II,1967,pages 1254-1255 *
J.Chem.Soc.Perkin Transaction I,1987,no.2,pages 395-398 *
J.Chem.Soc.Perkin Transaction I,1988,no.4,pages 763-768 *

Also Published As

Publication number Publication date
WO1993018173A3 (en) 1993-10-28
GB9418110D0 (en) 1994-10-26
GB2280439B (en) 1995-11-22
WO1993018173A2 (en) 1993-09-16

Similar Documents

Publication Publication Date Title
MY132671A (en) Substituted 6,6-hetero-bicyclic derivatives
TR199700844T1 (en) Pyrazolyl-Benzoil T�revleri.
GR3034507T3 (en) Pyrazolopyrimidines as crf antagonists.
GB2126226B (en) Pyridine derivatives
AP2002002637A0 (en) Novel piperazine
YU5399A (en) Substituted pyrido-or pyrimido-containing 6,6-or 6,7- bicyclic derivatives
IL99759A (en) Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them
MY111556A (en) Substituted azadioxacycloalkenes.
AU586731B2 (en) 5,6-dihydro-2-(substituted phenyl)-1,2,4 triazine-3,5(2h,4h) -diones
CA2135751A1 (en) 4-Mercaptoacetylamino-[2] Benzazepinone(3) Derivatives, and Use as Enkephalinase Inhibitors
WO2002032901A3 (en) Bridged piperazine derivatives
GB2280439A (en) CD4 binding agents and inhibitors of collagenase and protein kinase C
GB2269382A (en) Pharmaceutical xanthone derivatives
MD1753B2 (en) Herbicidal composition and process for weed control in the cereals growing zones
DE69625505D1 (en) GUANIDINO PROTEIASE INHIBITORS
TW252979B (en)
CO4890846A1 (en) SUBSTITUTED PYRROLES
WO1990012577A3 (en) Topical anti-angiogenic as hair growth inhibitors
MY115430A (en) Glutaramide derivatives.
AU7451491A (en) 15-deoxyprostaglandin derivative
AP9400608A0 (en) "New nicotinic acid derivative".
EP0509098A4 (en) Ataractic
AU1459192A (en) Aminoacyl derivatives of gem-diphosphonic acids, a process for the preparation thereof and pharmaceutical compositions containing them
MY108690A (en) Mildewproofing agent for timber
AU2859792A (en) 5,6-dihydro-dibenz(b,e)azepine-6,11-dione-11-oximes

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20030311