WO1992000287A3 - Analogues d'inhibiteurs d'anhydrase carbonique et leur emploi comme ihnibiteurs topiques de pression intra-oculaire - Google Patents

Analogues d'inhibiteurs d'anhydrase carbonique et leur emploi comme ihnibiteurs topiques de pression intra-oculaire Download PDF

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Publication number
WO1992000287A3
WO1992000287A3 PCT/US1991/003928 US9103928W WO9200287A3 WO 1992000287 A3 WO1992000287 A3 WO 1992000287A3 US 9103928 W US9103928 W US 9103928W WO 9200287 A3 WO9200287 A3 WO 9200287A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
analogs
carbonic anhydrase
iop
topical
Prior art date
Application number
PCT/US1991/003928
Other languages
English (en)
Other versions
WO1992000287A2 (fr
Inventor
Ronald D Schoenwald
Charles F Barfknecht
Original Assignee
Univ Iowa Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Iowa Res Found filed Critical Univ Iowa Res Found
Priority to AU87546/91A priority Critical patent/AU649080B2/en
Priority to JP91517783A priority patent/JPH05507286A/ja
Publication of WO1992000287A2 publication Critical patent/WO1992000287A2/fr
Publication of WO1992000287A3 publication Critical patent/WO1992000287A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/76—Sulfur atoms attached to a second hetero atom
    • C07D277/80—Sulfur atoms attached to a second hetero atom to a nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

On a préparé des analogues des inhibiteurs d'anhydrase carbonique dérivés de méthazolamide, et dichlorephénamide. Les analogues lient un groupe fonctionnel clivable à l'inhibiteur d'anhydrase carbonique pharmacologiquement acif se trouvant dans des composés d'une perméabilité cornéenne améliorée, lesquels n'irritent pas les yeux et sont localement efficaces pour inhiber la pression intra-oculaire.
PCT/US1991/003928 1990-06-11 1991-06-03 Analogues d'inhibiteurs d'anhydrase carbonique et leur emploi comme ihnibiteurs topiques de pression intra-oculaire WO1992000287A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU87546/91A AU649080B2 (en) 1990-06-11 1991-06-03 Analogs of carbonic anhydrase inhibitors and their use as topical IOP inhibitors
JP91517783A JPH05507286A (ja) 1990-06-11 1991-06-03 炭酸脱水酵素阻害剤の類縁体、および局所的眼内圧阻害剤としてのその使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US535,573 1990-06-11
US07/535,573 US5157044A (en) 1983-02-04 1990-06-11 Analogs of carbonic anhydrase inhibitors and their use as topical IOP inhibitors

Publications (2)

Publication Number Publication Date
WO1992000287A2 WO1992000287A2 (fr) 1992-01-09
WO1992000287A3 true WO1992000287A3 (fr) 1992-03-19

Family

ID=24134815

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/003928 WO1992000287A2 (fr) 1990-06-11 1991-06-03 Analogues d'inhibiteurs d'anhydrase carbonique et leur emploi comme ihnibiteurs topiques de pression intra-oculaire

Country Status (6)

Country Link
US (1) US5157044A (fr)
EP (1) EP0539527A1 (fr)
JP (1) JPH05507286A (fr)
AU (1) AU649080B2 (fr)
CA (1) CA2084658A1 (fr)
WO (1) WO1992000287A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5095026A (en) * 1983-02-04 1992-03-10 University Of Iowa Research Foundation Prodrugs of carbonic anhydrase inhibitors
US5270338A (en) * 1988-07-29 1993-12-14 Istituto Chimico Internazionale Dr. Giuseppe Rende S.R.L. Acetazolamide-related compounds, process for their preparation, and pharmaceutical composition containing the same
US5225424A (en) * 1992-10-21 1993-07-06 University Of Iowa Research Foundation Methazolamide-derived carbonic anhydrase inhibitors
DE19506652A1 (de) * 1995-02-25 1996-08-29 Nycomed Arzneimittel Gmbh Heterocyclische Amide, Verfahren zu ihrer Herstellung und ihre Verwendung
FR2754712B1 (fr) 1996-10-17 1999-09-03 Merck Sharp Dohme Chibret Lab Compositions ophtalmiques
US6214381B1 (en) 1998-09-08 2001-04-10 Effcon, Inc. Methazolamide composition and method of use
DE10012120A1 (de) * 2000-03-13 2001-09-27 Ktb Tumorforschungs Gmbh Therapeutische und diagnostische Ligandensysteme mit Transportmolekülbindenden Eigenschaften und diese enthaltende Arzneimittel
US20030100594A1 (en) * 2001-08-10 2003-05-29 Pharmacia Corporation Carbonic anhydrase inhibitor
US20030220376A1 (en) * 2001-08-10 2003-11-27 Pharmacia Corporation Methods for treating carbonic anhydrase mediated disorders
US20040067992A1 (en) * 2001-08-10 2004-04-08 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a carbonic anhydrase inhibitor for the treatment of neoplasia
CN100387584C (zh) * 2005-07-05 2008-05-14 杭州保灵有限公司 一种醋甲唑胺的制备方法
BRPI0811248A2 (pt) * 2007-05-16 2014-11-04 Ktb Tumorforschungs Gmbh Formulação de antraciclina de baixa viscosidade.
JP2015520748A (ja) * 2012-05-08 2015-07-23 セリックスビオ プライヴェート リミテッド 炭酸脱水酵素活性の抑制のための組成物及び方法
US9980946B1 (en) 2017-01-25 2018-05-29 Effcon Laboratories, Inc. Extended release methazolamide formulation

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483864A (en) * 1983-02-04 1984-11-20 University Of Iowa Research Foundation Non-classical topical treatment for glaucoma
US4629738A (en) * 1984-06-25 1986-12-16 University Of Iowa Research Foundation Non-classical topical treatment for glaucoma
EP0354881A1 (fr) * 1988-07-29 1990-02-14 Istituto Chimico Internazionale Dr. Giuseppe Rende S.R.L. Composés apparentés à l'acétazolamide, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0396201A1 (fr) * 1989-05-02 1990-11-07 Seymour F. Trager Thiadiazoline-sulphonamides utiles dans le traitement du glaucome
EP0419311A2 (fr) * 1989-09-22 1991-03-27 University Of Iowa Research Foundation Prodrogues d'inhibiteurs d'anhydrase carbonique
WO1991014430A1 (fr) * 1990-03-19 1991-10-03 Research Corporation Technologies, Inc. Inhibiteurs d'anhydrase carbonique du thiadiazole sulfonamide a activite topique oculaire
WO1991014683A1 (fr) * 1990-03-19 1991-10-03 Research Corporation Technologies, Inc. Inhibiteurs d'anhydrase carbonique au gem-diacylthiadiazole sulfonamide ayant une activite topique oculaire

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483864A (en) * 1983-02-04 1984-11-20 University Of Iowa Research Foundation Non-classical topical treatment for glaucoma
US4629738A (en) * 1984-06-25 1986-12-16 University Of Iowa Research Foundation Non-classical topical treatment for glaucoma
EP0354881A1 (fr) * 1988-07-29 1990-02-14 Istituto Chimico Internazionale Dr. Giuseppe Rende S.R.L. Composés apparentés à l'acétazolamide, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0396201A1 (fr) * 1989-05-02 1990-11-07 Seymour F. Trager Thiadiazoline-sulphonamides utiles dans le traitement du glaucome
EP0419311A2 (fr) * 1989-09-22 1991-03-27 University Of Iowa Research Foundation Prodrogues d'inhibiteurs d'anhydrase carbonique
WO1991014430A1 (fr) * 1990-03-19 1991-10-03 Research Corporation Technologies, Inc. Inhibiteurs d'anhydrase carbonique du thiadiazole sulfonamide a activite topique oculaire
WO1991014683A1 (fr) * 1990-03-19 1991-10-03 Research Corporation Technologies, Inc. Inhibiteurs d'anhydrase carbonique au gem-diacylthiadiazole sulfonamide ayant une activite topique oculaire

Also Published As

Publication number Publication date
AU8754691A (en) 1992-01-23
AU649080B2 (en) 1994-05-12
JPH05507286A (ja) 1993-10-21
WO1992000287A2 (fr) 1992-01-09
EP0539527A1 (fr) 1993-05-05
US5157044A (en) 1992-10-20
CA2084658A1 (fr) 1991-12-12

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