WO1990004420A1 - Balloon-carrying instrument for continuous injection of liquid medicine - Google Patents

Balloon-carrying instrument for continuous injection of liquid medicine Download PDF

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Publication number
WO1990004420A1
WO1990004420A1 PCT/JP1988/001055 JP8801055W WO9004420A1 WO 1990004420 A1 WO1990004420 A1 WO 1990004420A1 JP 8801055 W JP8801055 W JP 8801055W WO 9004420 A1 WO9004420 A1 WO 9004420A1
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WO
WIPO (PCT)
Prior art keywords
tubular body
balloon
liquid medicine
resin
fluid resin
Prior art date
Application number
PCT/JP1988/001055
Other languages
French (fr)
Japanese (ja)
Inventor
Osamu Tsukada
Original Assignee
Tsukada Medical Research Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tsukada Medical Research Co., Ltd. filed Critical Tsukada Medical Research Co., Ltd.
Priority to PCT/JP1988/001055 priority Critical patent/WO1990004420A1/en
Publication of WO1990004420A1 publication Critical patent/WO1990004420A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/152—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags pressurised by contraction of elastic reservoirs

Definitions

  • the present invention relates to a continuous drug injector with a balloon used for injecting a drug solution into a balloon and injecting a predetermined amount of drug solution into a human body within a predetermined time.
  • a method for injecting a drug solution into the human body for a relatively long time is to connect a syringe containing a drug solution to an injection needle or catheter and operate the injector manually, by a spring, or electrically to discharge the drug solution.
  • the drug solution was placed in a drip bottle or container, and the drug solution flowed out naturally or electrically.
  • the patient and the practitioner are restrained and fixed in the human body for a fixed period of time, causing great physical and mental pain.
  • the limit is one or two minutes.
  • a large amount of replenishment fluid is required in addition to the medicinal solution, and even a patient who does not need rehydration fluid will need to inject unnecessary fluid.
  • the IV bin or container must be located higher than the patient, and The need for a complex and long conduit between the catheter and the IV bottle restricted the patient's body movements and required practitioners to perform appropriate checks.
  • the continuous medicine injector with a balloon of this patent is provided with a tubular body having a drug solution flow path formed along a longitudinal axis, and a drug solution injection section having a check valve at one end of the tubular body.
  • a liquid injection section provided at the other end of the tubular main body; a member for blocking the chemical liquid flow path provided in the middle of the tubular main body;
  • Outflow holes or outflow holes to which a microporous membrane is adhered are formed on the side of the pouring part by penetrating the tube wall of the tubular body, and the inflow holes and the outflow holes are covered with a balloon made of an elastic material.
  • the structure is such that the circumference of the balloon is hermetically fixed to the outer circumference of the tubular body.
  • the applicant of the present application has proposed a “continuous infusion catheter for bladder” which has a simple structure, is easy to handle, and has high safety when infusing a medical solution into a human body for a relatively long time (Japanese Patent Application Laid-Open No. Sho 62). — No. 11464).
  • This catheter uses a conventional general bladder catheter
  • a concave portion is provided in a part of the outer periphery of the proximal end side of the catheter, the concave portion is surrounded by a balloon made of an elastic material, and the periphery of the balloon is airtightly fixed to the outer periphery of the catheter;
  • a thin tube is provided on the tube wall of the catheter along the axis, a base end of the thin tube is opened to form a drug solution outlet, and the base end of the thin tube is communicated with the recess, and a center of the balloon is formed.
  • the liquid medicine injection section is fixed in an airtight manner, a central passage is provided in the center of the liquid medicine injection section, a valve is provided on the inlet side of the central passage, and the outlet side is communicated with the recess. I have.
  • the above-mentioned injector or catheter is provided with pores or capillaries to control the outflow time of the drug solution.
  • pores or capillaries to control the outflow time of the drug solution.
  • An object of the present invention is to provide a continuous drug injector with a balloon having a structure capable of relatively easily forming a thin tube for controlling the outflow time of a drug solution and preventing clogging of the thin tube. .
  • the continuous drug injector according to the present invention includes a tubular body having a drug solution flow path formed along a longitudinal axis, a drug solution injector having a check valve at one end of the tubular body, The other end is provided with a chemical liquid injection section, and the other end of the tubular body is filled with a predetermined amount of a normal temperature or thermosetting fluid resin having no adhesive ability only to a specific material, and is specified in the fluid resin.
  • a thin wire made of a material having a predetermined diameter is embedded in a straight line, spiral shape, or meandering shape, and one end of the thin wire is connected to the tubular book.
  • Penetrating the body guiding the other end of the thin wire material to the outside through the chemical solution discharging portion, forming a hole through the tube wall of the tubular main body, and forming the hole with a balloon made of an elastic material. It surrounds the hole, and has a structure in which the periphery of the balun is air-tightly fixed to the outer periphery of the tubular body.
  • the room temperature or thermosetting fluid resin is of a type having an adhesive property to the tubular body, and examples thereof include a silicone resin, a polyurethane resin, and a butyl rubber resin.
  • the fine wire is one of a resin yarn, a metal yarn, a carbon fiber yarn, and a ceramic yarn.
  • the fine wire is pulled out of the tubular main body to form pores in the fluid resin, and a human body indwelling device can be attached to the chemical solution discharging section.
  • FIG. 1 is a longitudinal sectional view of a continuous drug solution injector of the present invention.
  • FIG. 2 is a cross-sectional view taken along line ⁇ —E in FIG. Fig. 3 is a cross-sectional view taken along the line H-IE in Fig. 1.
  • FIG. 4 is a side view showing an example of a human indwelling device connected to the continuous drug solution injector of the present invention.
  • FIG. 5 is a diagram illustrating the operation of the continuous drug injector according to the present invention.
  • FIG. 6 is a longitudinal sectional view of an example of a bladder catheter in which the continuous drug solution injector of the present invention is surrounded.
  • FIG. 7 is a longitudinal sectional view of a bladder force catheter to which the present invention is applied.
  • the continuous drug solution injector according to the present invention includes a tubular main body 1 and a balloon 2. .
  • the tubular main body 1 has a chemical liquid channel 11 formed along the longitudinal axis.
  • a chemical liquid injection section 12 is provided, and at the other end (the left end in the illustrated example), a chemical liquid discharge section 13 is provided.
  • the chemical liquid injection section 12 and the chemical liquid discharge section 13 may be formed integrally with the tubular body 1, but it is preferable to connect separate parts as shown in the figure in view of the convenience of manufacture and handling.
  • a conventional check valve 121 is provided in the liquid injector 12.
  • the check valve 121 may have a function of permitting the injection of the chemical solution in the direction of arrow 122 but not allowing the reverse flow.
  • Balloon 2 is preferably made of a wear-resistant, high-toughness material that is highly elastic and does not easily damage external action. In particular, transparent or translucent materials are preferred. As such a material, for example, a commercially available material such as silicon rubber or latex rubber is optimal.
  • the balloon 2 is in close contact with the outer periphery of the tubular main body 1 in a normal state before the injection of the drug solution, and as shown in FIG. 5 during operation after the injection of the drug solution.
  • the remaining portion expands apart from the outer periphery of the tubular body 1 except for the periphery 21.
  • the fluid resin 3 is filled in the chemical solution passage 11 inside the chemical solution discharge section 13.
  • the fine wire 4 is embedded by penetrating the fluid resin 3 in the pipe axis direction.
  • One end 41 of the fine wire 4 is guided into the chemical solution passage 11.
  • the other end 42 of the fine wire 4 penetrates the chemical solution discharge section 13 and goes out of the tubular body 1 Induce.
  • a ring 43 is connected to the tip of the other end 42.
  • the fluid resin 3 has a property of adhering to the inner surface of the chemical solution passage but not to the thin wire 4, for example, a resin such as a silicon resin, a polyvinyl resin, or a butyl rubber resin.
  • the fine wire 4 does not adhere to the flowable resin 3 and has a very small diameter of about 10 to 500 //, but relatively high tensile strength, for example, resin thread, metal thread, glass fiber thread, carbon Fibers such as textile yarns and ceramic yarns are preferred.
  • the filling amount of the fluid resin 3 defines the length of the pores 31 (FIG. 5 (c)) formed after the thin wire 4 is drawn.
  • the length of the pore 31 is an important factor that determines the outflow time of the chemical solution.
  • FIG. 4 shows a typical example of a human body indwelling device connected to the chemical solution discharging section 13 of the continuous chemical solution injector in one direction.
  • A shows an ordinary injection needle
  • B shows an injection needle having a flexible conduit
  • C shows an ordinary catheter.
  • Balloon 2 is basically spherical, but it can be formed into any shape according to the shape of the place where the human body is used. For example, it may be a flat ellipsoid.
  • FIG. 6 shows an example in which the continuous drug injector 100 of the present invention is connected to the drug injector 51 of the normal bladder catheter 5.
  • FIG. 7 shows an improved example in which the present invention is applied to a bladder catheter 5 similar to that of FIG.
  • the tip of the chemical liquid injection channel 52 is filled with the fluid resin 3 and the fine wire 4 is buried, and a hole 521 is provided in the middle of the channel 52, and the balloon 2 is attached to the outer periphery thereof. It is a thing.
  • an example of operation of the continuous drug solution injector according to the present invention will be described with reference to FIG.
  • a predetermined amount of the drug solution is injected from the drug solution injection section 12 of the continuous drug solution injector, and the drug solution flows into the balloon 2 through the drug solution flow path 11 and the hole 111 of the tubular main body 1, and the balloon 2 is inflated while the balloon 2 is inflated.
  • the liquid medicine filled in the balloon 2 does not flow backward by the check valve 121.
  • the same kind of chemical liquid or physiological saline is injected into the flow path 11 in advance, or as described later.
  • the wire 4 is pulled out to form a pore 31 (FIG. 5 (c)), and the pore 31 may be used as an air vent hole.
  • the user pulls the ring connected to the other end of the fine wire 4 with a finger (B). Since the fine wire 4 is not adhered to the hardened fluid resin 3, it can be removed from the hardened fluid resin 3 with a relatively small force. As a result, pores 31 are formed in the cured fluid resin 3 (C).
  • a necessary human indwelling device for example, an injection needle 6 is attached to the drug solution discharge section 13 (C).
  • the chemical liquid filled in the balun 2 flows into the injection needle 6 through the hole 11 1, the chemical liquid flow path 11, the fine hole 31, and the chemical liquid discharge section 13 due to the contraction force of the balun itself. I do.
  • the pouring time of the liquid medicine is determined by the injection amount and viscosity of the liquid medicine, the contraction characteristics of the balloon 2, the cross-sectional area and length of the pore 31, the internal pressure of the injection point, and the like. In practice, it is sufficient to actually measure the dispensing time for each continuous drug injector with a standard drug solution.
  • the target is three-way 'fore catering.
  • a fluorocarbon yarn with a diameter of 0.126 cm was passed through the drug solution injection channel in this catheter, and a room temperature-curable silicone RTV was injected and cured there.
  • the balloon is 150 urn thick and 2 cm long.
  • Table 1 shows the results of examining the pouring time under various conditions using water as the chemical.
  • a transparent cover over the outside of the balloon (not shown) to prevent the balloon from bursting by touching an external sharp object. May be removably attached to the tubular body 1.
  • the continuous drug solution injector of the present invention functions integrally as a drug solution container and a drug solution injecting device, so that its structure is simple and handling is easy. Therefore, the activity and body movement of the patient are not suppressed, and the operator's labor and restraint time are reduced. Also, once the air has been bleeded, no air will mix until the balloon is completely deflated.
  • the continuous drug injector of the present invention can very easily form pores that greatly affect the injection time, and the pores are formed immediately before use, so that the pores are formed immediately before use. There is no clogging problem. [Industrial applicability]

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

This instrument for the continuous injection of a liquid medicine has a tubular body (1) provided therein with a liquid medicine flow passage (11) formed so as to extend in the direction of the longitudinal axis thereof. The tubular body (1) is provided at one end thereof with a liquid medicine injection section (12) having a check valve (121) therein, and at the other end thereof with a liquid medicine discharge section (13). A predetermined quantity of a fluid resin (3) which does not have a bonding capability with respect to a specific material alone is packed in the front end of the tubular body (1), and a thin wire rod (4) made of a specific material and having a predetermined diameter is buried linearly in the fluid resin, and one end (41) of this thin wire rod is passed through the fluid resin into the interior of the tubular body while the other end (42) thereof is passed through the liquid medicine discharge section and drawn to the outside. A bore (111) is formed so as to extend through the wall of the tubular body and is enclosed with a balloon (2) made of an elastic material, and the circumferential edges of the balloon are fastened air-tightly to the outer circumferential surface of the tubular body. In order to use this instrument in practice, a predetermined quantity of a liquid medicine is injected through the liquid medicine injection portion into the balloon, and the thin wire rod is drawn to the outside of the tubular body, an indwelling fitting being then fixed to the liquid medicine discharge portion. After the thin wire rod has been drawn out, the liquid medicine flows out continuously for a long period of time through a thin bore formed in the fluid resin.

Description

明 細 書  Specification
バルーン付き薬液持続注入器  Continuous drug injector with balloon
〔技術分野〕  〔Technical field〕
本発明は、 バルーン内に薬液を注入し、 所定量の薬液を所定 時間内に人体内に注入するために用いるバルーン付き薬液持続 注入器に関するものである。  TECHNICAL FIELD The present invention relates to a continuous drug injector with a balloon used for injecting a drug solution into a balloon and injecting a predetermined amount of drug solution into a human body within a predetermined time.
〔背景技術〕  (Background technology)
従来、 人体に薬液を比較的長時間注入する方法としては、 注 射針またはカテーテルに薬液を入れた注射器を接続し、 その注 射器を手動、 バネ、 電動によって作動して薬液を流出するか、 あるいは点滴ビンまたは容器内に薬液を入れ、 自然滴下または 電動により薬液を流出していた。  Conventionally, a method for injecting a drug solution into the human body for a relatively long time is to connect a syringe containing a drug solution to an injection needle or catheter and operate the injector manually, by a spring, or electrically to discharge the drug solution. Alternatively, the drug solution was placed in a drip bottle or container, and the drug solution flowed out naturally or electrically.
薬液を数分から数時間かけて人体内に注入する場合には、 そ の時間だけ薬液供給源としての注射器または点滴ビ ンを注射針 または力テ一テルに接続していなければならないので、 患者お よび施術者にとって多く の不都合を強いていた。  When injecting a drug solution into a human body over a period of several minutes to several hours, the patient or patient must be connected to a syringe or drip bottle as a drug solution supply source for a short period of time. And had many inconveniences for the practitioner.
例えば、 手動による持続注入の場合には、 患者および施術者 がー定時間人体を拘束固定されるので、 肉体的にも精神的にも 大きな苦痛をともなう。 実際には、 1 〜 2分が限度であるとさ れている。 電動またはパネを利用したとしても、 電源の確保、 注射器の設置などが必要であり、 患者の行動が制限される。 点滴による薬液の持続注入の場合には、 薬液に く らベて大量 の補液を入れることになり、 また、 補液を必要としない患者で も不必要な液を入れるこ とになる。 点滴ビ ンまたは容器を患者 より も高い位置に設置しなければならず、 また、 注射針または カテーテルと点滴ビンとを結ぶ複雑で長い管路を必要とするの で、 患者の体動を制約するとともに、 施術者も適宜点検する必 要があつた。 For example, in the case of manual continuous infusion, the patient and the practitioner are restrained and fixed in the human body for a fixed period of time, causing great physical and mental pain. In practice, the limit is one or two minutes. Even if electric or panel-based equipment is used, it is necessary to secure a power source and install a syringe, which limits the behavior of patients. In the case of continuous infusion of a medicinal solution by infusion, a large amount of replenishment fluid is required in addition to the medicinal solution, and even a patient who does not need rehydration fluid will need to inject unnecessary fluid. The IV bin or container must be located higher than the patient, and The need for a complex and long conduit between the catheter and the IV bottle restricted the patient's body movements and required practitioners to perform appropriate checks.
そこで、 本出願人等は、 薬液を比較的長時間持続して人体内 に注入するさいに、 構造が簡単で取扱が簡便で、 安全性の高い 薬液持繞注入器を得るために、 先に 「バルーン付き薬液持続注 入器」 （特許第 1384289 号） を提案した。  In order to obtain a drug-containing syringe having a simple structure, easy handling, and high safety, the applicant of the present invention has proposed the following in order to inject a drug solution into a human body for a relatively long time. We have proposed a "continuous infusion device with balloon" (Patent No. 1384289).
この特許のバル一ン付き薬液持続注入器は、 長手方向軸心に そって形成された薬液流路を有する管状本体を設け、 該管状本 体の一端に逆止弁を有する薬液注入部を設け、 前記管状本体の 他端に薬液注出部を設け、 前記管状本体の中間に前記薬液流路 を遮断する部材を設け、 該遮断部材の付近で前記薬液注入部側 に流入穴をまた前記薬液注出部側に流出穴または微細多孔質膜 を貼り付けた流出穴をそれぞれ前記管状本体の管壁を貫通して 形成し、 弾性材料からなるバルーンによって前記流入穴および 流出穴を包面し、 前記バルーンの周緣を前記管状本体の外周に 気密状に固定した構造になっている。  The continuous medicine injector with a balloon of this patent is provided with a tubular body having a drug solution flow path formed along a longitudinal axis, and a drug solution injection section having a check valve at one end of the tubular body. A liquid injection section provided at the other end of the tubular main body; a member for blocking the chemical liquid flow path provided in the middle of the tubular main body; Outflow holes or outflow holes to which a microporous membrane is adhered are formed on the side of the pouring part by penetrating the tube wall of the tubular body, and the inflow holes and the outflow holes are covered with a balloon made of an elastic material. The structure is such that the circumference of the balloon is hermetically fixed to the outer circumference of the tubular body.
また、 本出願人は、 前記特許の注入器の薬液注出部に血管内 留置器具を接続した 「血管用バルーン付き薬液持続注入器」 (特開昭 62— 11465 号公報） を先に開示した。  In addition, the present applicant has previously disclosed a “continuous infusion device for a blood vessel with a balloon for a blood vessel” (Japanese Patent Application Laid-Open No. 62-11465) in which an intravascular indwelling device is connected to the infusion portion of the infusion device of the patent. .
さらに、 本出願人は、 薬液を比較的長時間持続して人体内に 注入するさいに、 構造が簡単で取扱が簡便で、 安全性の高い 「膀胱用薬液持続注入カテーテル」 （特開昭 62— 11464 号公報） を先に開示した。  In addition, the applicant of the present application has proposed a “continuous infusion catheter for bladder” which has a simple structure, is easy to handle, and has high safety when infusing a medical solution into a human body for a relatively long time (Japanese Patent Application Laid-Open No. Sho 62). — No. 11464).
このカテーテルは、 従来の一般的な膀胱用カテーテルを使用 し、 カテーテルの基端側外周の一部に凹所を設け、 弾性材料か らなるバルーンによって前記凹所を包囲し、 該バルーンの周緣 を前記カテーテルの外周に気密状に固定し、 前記長手方向軸心 にそって前記カテーテルの管壁に細管を設け、 該細管の基端側 を開口して薬液流出口を形成し、 該細管の基端側を前記凹所に 連通させ、 前記バルーンの中央部分に薬液注入部を気密状に固 定し、 該薬液注入部の中央部分に中央通路を設け、 該中央通路 の入側に弁を設けかつ出側を前記凹所に連通した構成になって いる。 This catheter uses a conventional general bladder catheter A concave portion is provided in a part of the outer periphery of the proximal end side of the catheter, the concave portion is surrounded by a balloon made of an elastic material, and the periphery of the balloon is airtightly fixed to the outer periphery of the catheter; A thin tube is provided on the tube wall of the catheter along the axis, a base end of the thin tube is opened to form a drug solution outlet, and the base end of the thin tube is communicated with the recess, and a center of the balloon is formed. In this configuration, the liquid medicine injection section is fixed in an airtight manner, a central passage is provided in the center of the liquid medicine injection section, a valve is provided on the inlet side of the central passage, and the outlet side is communicated with the recess. I have.
上述した注入器またはカテーテルには、 薬液の流出時間を制 御するために細孔または細管を設けている。 しかし、 これら細 孔または細管を実際に形成することは非常に困難であり、 また、 微細なごみ等によって簡単に詰ってしまう ことがある。  The above-mentioned injector or catheter is provided with pores or capillaries to control the outflow time of the drug solution. However, it is very difficult to actually form these pores or capillaries, and they may be easily clogged by fine dust and the like.
〔発明の開示〕  [Disclosure of the Invention]
本発明の目的は、 薬液の流出時間を制御するための細管を比 較的容易に形成できるようにするとともに、 細管の詰りを防止 できる構造を備えたバルーン付き薬液持続注入器を得ることに ある。  SUMMARY OF THE INVENTION An object of the present invention is to provide a continuous drug injector with a balloon having a structure capable of relatively easily forming a thin tube for controlling the outflow time of a drug solution and preventing clogging of the thin tube. .
本発明の薬液持続注入器は、 長手方向軸心にそって形成され た薬液流路を有する管状本体を設け、 該管状本体の一端に逆止 弁を有する薬液注入部を設け、 前記管状本体の他端に薬液注出 部を設け、 前記管状本体の他端に特定の材料に対してのみ接着 能力のない常温または熱硬化型流動性樹脂を所定量充瑱し、 該 流動性樹脂内に特定材料からなる所定直径の細線材を直線状、 螺旋状、 または蛇行状に埋設し、 該細線材の一端を前記管状本 体内に貫通させ、 該細線材の他端を前記薬液注出部を通して外 部に誘導し、 前記管状本体の管壁を貫通して穴を形成し、 弾性 材料からなるバル一ンによつて前記穴を包囲し、 前記バル一ン の周縁を前記管状本体の外周に気密状に固定した構造になって いる。 The continuous drug injector according to the present invention includes a tubular body having a drug solution flow path formed along a longitudinal axis, a drug solution injector having a check valve at one end of the tubular body, The other end is provided with a chemical liquid injection section, and the other end of the tubular body is filled with a predetermined amount of a normal temperature or thermosetting fluid resin having no adhesive ability only to a specific material, and is specified in the fluid resin. A thin wire made of a material having a predetermined diameter is embedded in a straight line, spiral shape, or meandering shape, and one end of the thin wire is connected to the tubular book. Penetrating the body, guiding the other end of the thin wire material to the outside through the chemical solution discharging portion, forming a hole through the tube wall of the tubular main body, and forming the hole with a balloon made of an elastic material. It surrounds the hole, and has a structure in which the periphery of the balun is air-tightly fixed to the outer periphery of the tubular body.
前記常温または熱硬化型流動性樹脂は管状本体に接着性のあ る種類であり、 例えば、 シリ コ一ン系樹脂、 ポリ ウレタ ン系樹 脂、 ブチルゴム系樹脂等である。  The room temperature or thermosetting fluid resin is of a type having an adhesive property to the tubular body, and examples thereof include a silicone resin, a polyurethane resin, and a butyl rubber resin.
前記細線材は樹脂糸、 金属糸、 炭素繊維糸、 セラ ミ ックス糸 のうちの 1種である。  The fine wire is one of a resin yarn, a metal yarn, a carbon fiber yarn, and a ceramic yarn.
前記細線材を前記管状本体の外部に引き抜いて前記流動性樹 脂に細孔を形成し、 前記薬液注出部に人体留置器具を取り付け ることができる。  The fine wire is pulled out of the tubular main body to form pores in the fluid resin, and a human body indwelling device can be attached to the chemical solution discharging section.
〔図面の簡単な説明〕  [Brief description of drawings]
第 1図ば本発明の薬液持続注入器の縦断面図。 第 2図は第 1 図の Π— E線からみた横断面図。 第 3図は第 1図の H— IE線か らみた横断面図。 第 4図は本発明の薬液持続注入器に接続され る人体留置器具の例を示す側面図。 第 5図は本発明の薬液持続 注入器の操作説明図。 第 6図は本発明の薬液持続注入器が接繞 される膀胱カテーテルの一例の縦断面図。 第 7図は本発明を適 用した膀胱力テーテルの縦断面図。  FIG. 1 is a longitudinal sectional view of a continuous drug solution injector of the present invention. FIG. 2 is a cross-sectional view taken along line Π—E in FIG. Fig. 3 is a cross-sectional view taken along the line H-IE in Fig. 1. FIG. 4 is a side view showing an example of a human indwelling device connected to the continuous drug solution injector of the present invention. FIG. 5 is a diagram illustrating the operation of the continuous drug injector according to the present invention. FIG. 6 is a longitudinal sectional view of an example of a bladder catheter in which the continuous drug solution injector of the present invention is surrounded. FIG. 7 is a longitudinal sectional view of a bladder force catheter to which the present invention is applied.
〔発明を実施するための最良の形態〕  [Best mode for carrying out the invention]
第 1図から第 3図までを参照して本発明の薬液持続注入器の 基本的構造について説明する。 本発明の薬液持続注入器は、 管 状本体 1 とバルーン 2 とからできている。 . 管状本体 1 は長手方向軸心にそって薬液流路 11が形成されて いる。 管状本体 1 の一端 （図示例では右端） には薬液注入部 12 が、 また、 他端 （図示例では左端） には薬液注出部 13がそれぞ れ設けられる。 薬液注入部 12および薬液注出部 13は管状本体 1 と一体に成形されてもよいが、 製造および取扱いの便宜を考慮 して図示例のように別個の部品を接続することが好ましい。 薬 液注入部 12には慣用の逆止弁 121 を設ける。 逆止弁 121 は矢印 方向 122 への薬液の注入を許すが、 その逆の流れを許さない機 能を有しているものでよい。 The basic structure of the continuous drug injector according to the present invention will be described with reference to FIGS. The continuous drug solution injector according to the present invention includes a tubular main body 1 and a balloon 2. . The tubular main body 1 has a chemical liquid channel 11 formed along the longitudinal axis. At one end (the right end in the illustrated example) of the tubular main body 1, a chemical liquid injection section 12 is provided, and at the other end (the left end in the illustrated example), a chemical liquid discharge section 13 is provided. The chemical liquid injection section 12 and the chemical liquid discharge section 13 may be formed integrally with the tubular body 1, but it is preferable to connect separate parts as shown in the figure in view of the convenience of manufacture and handling. A conventional check valve 121 is provided in the liquid injector 12. The check valve 121 may have a function of permitting the injection of the chemical solution in the direction of arrow 122 but not allowing the reverse flow.
管状本体 1 の中間には、 その管壁を貫通して薬液流路 11に連 通した穴 111 を設ける。 バルーン 2 は、 穴 111 を包囲し、 バル ーン 2の周縁 21が管状本体 1 の外周に気密状に固定される。 バ ルーン 2 は伸縮性に富み、 外部からの作用に対しても容易に損 傷のしない耐摩耗性、 高靭性の材料からつく られることが好ま しい。 特に、 透明または半透明材料のものが好ま しい。 このよ うな材料としては例えば、 市販のシリ コ ンゴムまたはラテック スゴム等のものが最適である。  In the middle of the tubular main body 1, a hole 111 penetrating the pipe wall and communicating with the chemical liquid flow path 11 is provided. The balloon 2 surrounds the hole 111 and the peripheral edge 21 of the balloon 2 is fixed to the outer periphery of the tubular body 1 in an airtight manner. Balloon 2 is preferably made of a wear-resistant, high-toughness material that is highly elastic and does not easily damage external action. In particular, transparent or translucent materials are preferred. As such a material, for example, a commercially available material such as silicon rubber or latex rubber is optimal.
バルーン 2 は、 第 1図に示すように、 薬液を注入する前の常 態時においては、 管状本体 1 の外周に密着し、 また、 薬液注入 後の作動時においては第 5図に示すように周緣 21を残して他の 部分が管状本体 1 の外周から離れて膨張する。  As shown in FIG. 1, the balloon 2 is in close contact with the outer periphery of the tubular main body 1 in a normal state before the injection of the drug solution, and as shown in FIG. 5 during operation after the injection of the drug solution. The remaining portion expands apart from the outer periphery of the tubular body 1 except for the periphery 21.
薬液注出部 13より内側の薬液通路 11内に流動性樹脂 3を充塡 する。 このとき、 流動性樹脂 3を管軸方向に貫通して細線材 4 を埋設する。 細線材 4 の一端 41を薬液通路 11内に誘導する。 細 線材 4 の他端 42を薬液注出部 13を貫通して管状本体 1 の外部に 誘導する。 他端 42の先端にはリ ング 43を連結する。 The fluid resin 3 is filled in the chemical solution passage 11 inside the chemical solution discharge section 13. At this time, the fine wire 4 is embedded by penetrating the fluid resin 3 in the pipe axis direction. One end 41 of the fine wire 4 is guided into the chemical solution passage 11. The other end 42 of the fine wire 4 penetrates the chemical solution discharge section 13 and goes out of the tubular body 1 Induce. A ring 43 is connected to the tip of the other end 42.
流動性樹脂 3 は薬液通路内面には接着するが細線材 4には接 着しない性質を有するもの、 例えば、 シリ コ ン系樹脂、 ポリ ゥ レタ ン系樹脂、 ブチルゴム系樹脂等のものが好ましい。  It is preferable that the fluid resin 3 has a property of adhering to the inner surface of the chemical solution passage but not to the thin wire 4, for example, a resin such as a silicon resin, a polyvinyl resin, or a butyl rubber resin.
細線材 4 は流動性樹脂 3に接着せず、 直径は 10〜500 //程度 と非常に細いが、 引張強さは比較的強靱なもの、 例えば、 樹脂 糸、 金属糸、 ガラス繊維糸、 炭素織維糸、 セラ ミ ックス糸等の ものが好ましい。  The fine wire 4 does not adhere to the flowable resin 3 and has a very small diameter of about 10 to 500 //, but relatively high tensile strength, for example, resin thread, metal thread, glass fiber thread, carbon Fibers such as textile yarns and ceramic yarns are preferred.
流動性樹脂 3 の充填量は、 後述するように、 細線材 4を引き 抜いた後に形成される細孔 31 (第 5図 (c) ) の長さを規定する。 細孔 31の長さは薬液の流出時間を決定する重要な因子になる。  As will be described later, the filling amount of the fluid resin 3 defines the length of the pores 31 (FIG. 5 (c)) formed after the thin wire 4 is drawn. The length of the pore 31 is an important factor that determines the outflow time of the chemical solution.
第 4図は、 方向の薬液持続注入器の薬液注出部 13に接続され る人体留置器具の代表例を示す。 (A) は通常の注射針を、 （B) は可撓性管路を有する注射針を、 （C) は通常のカテーテルをそ れぞれ示す。  FIG. 4 shows a typical example of a human body indwelling device connected to the chemical solution discharging section 13 of the continuous chemical solution injector in one direction. (A) shows an ordinary injection needle, (B) shows an injection needle having a flexible conduit, and (C) shows an ordinary catheter.
バルー ン 2 は、 基本的には球形のものであるが、 人体の使用 箇所の形状に合せて任意の形状に成形することができる。 例え ば、 扁平の長円体形状のものでもよい。  Balloon 2 is basically spherical, but it can be formed into any shape according to the shape of the place where the human body is used. For example, it may be a flat ellipsoid.
第 6図は、 通常の膀胱カテーテル 5の薬液注入部 51に、 本発 明の薬液持続注入器 100 を接続した例を示す。  FIG. 6 shows an example in which the continuous drug injector 100 of the present invention is connected to the drug injector 51 of the normal bladder catheter 5.
第 7図は、 第 6図と同様の膀胱カテーテル 5に本発明を適用 して、 薬液持続注入機能をもたせた改良例を示す。 この実施例 においては、 薬液注入流路 52の先端に流動性樹脂 3を充塡し、 細線材 4を埋設し、 また、 流路 52の中間に穴 521 を設け、 その 外周にバルーン 2を取り付けたものである。 次に、 第 5図を参照して、 本発明の薬液持続注入器の操作例 について説明する。 FIG. 7 shows an improved example in which the present invention is applied to a bladder catheter 5 similar to that of FIG. In this embodiment, the tip of the chemical liquid injection channel 52 is filled with the fluid resin 3 and the fine wire 4 is buried, and a hole 521 is provided in the middle of the channel 52, and the balloon 2 is attached to the outer periphery thereof. It is a thing. Next, an example of operation of the continuous drug solution injector according to the present invention will be described with reference to FIG.
薬液は薬液持続注入器の薬液注入部 12から所定量注入される, 薬液は管状本体 1 の薬液流路 11、 穴 111 を通ってバルーン 2内 に流入し、 バルーン 2を膨張させながら、 バルーン 2内に充満 される（A ) 。 バルーン 2内に充満された薬液は逆止弁 121 によ つて逆流するこ とはない。  A predetermined amount of the drug solution is injected from the drug solution injection section 12 of the continuous drug solution injector, and the drug solution flows into the balloon 2 through the drug solution flow path 11 and the hole 111 of the tubular main body 1, and the balloon 2 is inflated while the balloon 2 is inflated. (A). The liquid medicine filled in the balloon 2 does not flow backward by the check valve 121.
バルーン 2または薬液流路 11内にエアの混入を防止する必要 がある場合には、 流路 11内に予め同種の薬液もし く は生理食塩 水を注入しておく か、 または後述するように細線材 4を引き抜 いて細孔 31 (第 5図 (c) ) を形成し、 この細孔 31をエア抜き穴と して利用すればよい。  If it is necessary to prevent air from entering the balloon 2 or the chemical liquid flow path 11, the same kind of chemical liquid or physiological saline is injected into the flow path 11 in advance, or as described later. The wire 4 is pulled out to form a pore 31 (FIG. 5 (c)), and the pore 31 may be used as an air vent hole.
所定量の薬液が注入された後に、 細線材 4 の他端に連結して あるリ ングを、 使用者が指に掛けて引っ張る（B) 。 細線材 4 は 硬化した流動性樹脂 3 に接着されていないので、 比較的小さな 力で硬化した流動性樹脂 3中から抜き取ることができる。 その 結果、 硬化した流動性樹脂 3中には細孔 31が形成される（C) 。 次いで、 薬液注出部 13に必要な人体留置器具、 例えば注射針 6を取り付ける（C) 。  After a predetermined amount of the drug solution has been injected, the user pulls the ring connected to the other end of the fine wire 4 with a finger (B). Since the fine wire 4 is not adhered to the hardened fluid resin 3, it can be removed from the hardened fluid resin 3 with a relatively small force. As a result, pores 31 are formed in the cured fluid resin 3 (C). Next, a necessary human indwelling device, for example, an injection needle 6 is attached to the drug solution discharge section 13 (C).
バル一ン 2内に充塡された薬液は、 バル一ン自体の収縮力に より、 穴 11 1 、 薬液流路 11、 細孔 31、 薬液注出部 13を通って注 射針 6 に流入する。  The chemical liquid filled in the balun 2 flows into the injection needle 6 through the hole 11 1, the chemical liquid flow path 11, the fine hole 31, and the chemical liquid discharge section 13 due to the contraction force of the balun itself. I do.
最後に、 必要に応じて、 通常のエア抜きを行う。 エア抜きを 確認するために、 各要素はすべて透明または半透明になってい ることが好ましい。 - 薬液の注出時間は、 薬液の注入量および粘性、 バルーン 2の 収縮特性、 細孔 31の横断面積および長さ、 注入箇所の体内の圧 力等によって定まる。 実際には、 各薬液持続注入器について標 準の薬液で注出時間を実測すればよい。 Finally, if necessary, perform normal air bleeding. It is preferable that all elements are transparent or translucent to confirm air bleeding. - The pouring time of the liquid medicine is determined by the injection amount and viscosity of the liquid medicine, the contraction characteristics of the balloon 2, the cross-sectional area and length of the pore 31, the internal pressure of the injection point, and the like. In practice, it is sufficient to actually measure the dispensing time for each continuous drug injector with a standard drug solution.
注出時間についての実験結果の一例を以下に示す。  An example of the experimental results for the pouring time is shown below.
使用対象は、 スリーウェイ ' フ ォーリ カテ一テルである。 こ のカテーテル内の薬液注入流路内に、 直径 0. 126 讓のフロロ力 一ボン糸を通し、 そこへ常温硬化型シリ コーン製 R T Vを注入 し硬化した。  The target is three-way 'fore catering. A fluorocarbon yarn with a diameter of 0.126 cm was passed through the drug solution injection channel in this catheter, and a room temperature-curable silicone RTV was injected and cured there.
バルーンの肉厚は 150 urn, 長さ 2 cmである。  The balloon is 150 urn thick and 2 cm long.
薬液として水を使用し、 各種条件下での注出時間を調べた結 果を第 1表に示す。  Table 1 shows the results of examining the pouring time under various conditions using water as the chemical.
第 1 表  Table 1
Figure imgf000010_0001
バルーンが万が一外部の鋭利な物体に触れて破裂しるような とのないように、 バルーン外部を覆う透明なカバー （図示せ ず） を管状本体 1 に着脱自在に取り付けてもよい。
Figure imgf000010_0001
A transparent cover over the outside of the balloon (not shown) to prevent the balloon from bursting by touching an external sharp object. May be removably attached to the tubular body 1.
本発明の薬液持続注入器は、 薬液の容器として、 また薬液の 注入器具として一体に機能するので、 構造が簡単で取扱いが簡 便になる。 したがって、 患 の行動および体動を制跟せず、 施 術者の労力および拘束時間を軽減する。 また、 一度エア抜きを しておけば、 バルーンが完全に収縮してしまうまでエアの混入 は起らない。  The continuous drug solution injector of the present invention functions integrally as a drug solution container and a drug solution injecting device, so that its structure is simple and handling is easy. Therefore, the activity and body movement of the patient are not suppressed, and the operator's labor and restraint time are reduced. Also, once the air has been bleeded, no air will mix until the balloon is completely deflated.
さ らに、 本発明の薬液持続注入器は、 注入時間に大きな影響 を与える細孔の形成が非常に簡単にでき、 また、 その細孔の形 成が使用直前に行われるので、 細孔の詰りの問題も生じない。 〔産業上の利用可能性〕  In addition, the continuous drug injector of the present invention can very easily form pores that greatly affect the injection time, and the pores are formed immediately before use, so that the pores are formed immediately before use. There is no clogging problem. [Industrial applicability]
人間または動物の医療用器具として広く利用できる。  It can be widely used as a human or animal medical device.

Claims

請 求 の 範 囲 The scope of the claims
1. 長手方向軸心にそって形成された薬液流路（11)を有する管 状本体 (1)を設け、 該管状本体の一端に逆止弁（121) を有する薬 液注入部（12)を設け、 前記管状本体の他端に薬液注出部（13)を 設け、 前記管状本体の他端に特定の材料に対してのみ接着能力 のない常温または熱硬化型流動性樹脂 (3)を所定量充璦し、 該流 動性樹脂内に特定材料からなる所定直径の細線材 (4)を直線状に 埋設し、 該細線材の一端（41)を前記管状本体内に貫通させ、 該 細線材の他端（42)を前記薬液注出部を通して外部に誘導し、 前 記管状本体の管壁を貫通して穴（111) を形成し、 弾性材料から なるバルーン（2)によつて前記穴を包囲し、 前記バルーンの周緣 (21)を前記管犹本体の外周に気密状に固定してなるバルーン付 き薬液持続注入器。  1. A tubular body (1) having a drug solution flow path (11) formed along a longitudinal axis thereof is provided, and a drug injection part (12) having a check valve (121) at one end of the tubular body. A chemical solution discharging section (13) is provided at the other end of the tubular body, and a room temperature or thermosetting fluid resin (3) having no adhesive ability only to a specific material is provided at the other end of the tubular body. A predetermined amount is filled, a thin wire (4) of a predetermined diameter made of a specific material is linearly embedded in the fluid resin, and one end (41) of the thin wire is penetrated into the tubular body. The other end (42) of the fine wire is guided to the outside through the chemical solution discharging portion, and a hole (111) is formed through the tube wall of the tubular body, and the balloon (2) made of an elastic material is used. A continuous drug injector with a balloon, which surrounds the hole and hermetically fixes the periphery (21) of the balloon to the outer periphery of the pipe main body.
2. 前記流動性樹脂はシリ コーン系樹脂、 ボリ ウ レタ ン系樹脂、 ブチルゴム系樹脂のうちの 1種であることを特徴とした請求項 2. The fluid resin according to claim 2, wherein the resin is one of a silicone resin, a polyurethane resin, and a butyl rubber resin.
1記載のバルーン付き薬液持続注入器。 The continuous drug injector with a balloon according to 1.
3. 前記細線材は樹脂糸、 金属糸、 ガラス繊維糸、 炭素織維糸、 セラ ミ ックス糸のうち 1種であることを特徴とした請求項 1記 載のバルーン付き薬液持続注入器。  3. The continuous drug injector with a balloon according to claim 1, wherein the fine wire is one of a resin thread, a metal thread, a glass fiber thread, a carbon woven thread, and a ceramic thread.
4. 前記細線材を前記管状本体の外部に引き抜いて前記接着剤 内に細孔を形成し、 前記薬液注出部に人体留置器具を取り付け たことを特徴とした請求項 1記載のバル一ン付き薬液持統注入  4. The balloon according to claim 1, wherein the fine wire material is pulled out of the tubular main body to form a pore in the adhesive, and a human body indwelling device is attached to the chemical solution discharging section. Liquid injection
PCT/JP1988/001055 1988-10-18 1988-10-18 Balloon-carrying instrument for continuous injection of liquid medicine WO1990004420A1 (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002058739A (en) * 2000-08-23 2002-02-26 Daiken Iki Kk One shot injector of liquid medicine and liquid medicine injecting device
JP2018501053A (en) * 2014-12-18 2018-01-18 マーク アンドリュー コスカ， Disposable injection system

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56102252A (en) * 1980-01-18 1981-08-15 Alza Corp Medical syringe

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56102252A (en) * 1980-01-18 1981-08-15 Alza Corp Medical syringe

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002058739A (en) * 2000-08-23 2002-02-26 Daiken Iki Kk One shot injector of liquid medicine and liquid medicine injecting device
JP2018501053A (en) * 2014-12-18 2018-01-18 マーク アンドリュー コスカ， Disposable injection system

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