WO1988001276A3 - PROCESS FOR PRODUCING (Z)-17alpha-HALOGENVINYLSTEROIDS - Google Patents

PROCESS FOR PRODUCING (Z)-17alpha-HALOGENVINYLSTEROIDS Download PDF

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Publication number
WO1988001276A3
WO1988001276A3 PCT/DE1987/000349 DE8700349W WO8801276A3 WO 1988001276 A3 WO1988001276 A3 WO 1988001276A3 DE 8700349 W DE8700349 W DE 8700349W WO 8801276 A3 WO8801276 A3 WO 8801276A3
Authority
WO
WIPO (PCT)
Prior art keywords
17alpha
halogenvinylsteroids
producing
methyl group
carbon
Prior art date
Application number
PCT/DE1987/000349
Other languages
German (de)
French (fr)
Other versions
WO1988001276A2 (en
Inventor
Helmut Hofmeister
Henry Laurent
Rudolf Wiechert
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19863627154 external-priority patent/DE3627154A1/en
Priority claimed from DE19873709378 external-priority patent/DE3709378A1/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of WO1988001276A2 publication Critical patent/WO1988001276A2/en
Priority to FI881256A priority Critical patent/FI881256A/en
Publication of WO1988001276A3 publication Critical patent/WO1988001276A3/en
Priority to DK196788A priority patent/DK196788A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta

Abstract

A process for producing (Z)-17alpha-halogenvinylsteroids having general formula (I), in which ..... represents a simple or a double bond, V represents a carbon-carbon bond or a methyl group, R1 is a hydrogen atom or a methyl group, X is an atom of chlorine, bromine or iodine and A represents the rest of the steroid molecule. The process consists of hydrating with diimide a 17alpha-halogenethinylsteroid having formula (II), in which ....., V, R1, X and A have the above meaning.
PCT/DE1987/000349 1986-08-11 1987-08-06 PROCESS FOR PRODUCING (Z)-17alpha-HALOGENVINYLSTEROIDS WO1988001276A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI881256A FI881256A (en) 1986-08-11 1988-03-16 FOERFARANDE FOER FRAMSTAELLNING AV (Z) -17 -HALOGENVINYLSTEROIDER.
DK196788A DK196788A (en) 1986-08-11 1988-04-11 METHOD OF PREPARING (Z) -17ALFA-HALOGENVINYL STEROIDS

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DEP3627154.3 1986-08-11
DE19863627154 DE3627154A1 (en) 1986-08-11 1986-08-11 METHOD FOR PRODUCING (Z) -17 (ALPHA) -HALOGENVINYL STEROIDS AND (Z) -17 (ALPHA) -CHLORVINYL STEROIDS
DE19873709378 DE3709378A1 (en) 1987-03-20 1987-03-20 Process for the preparation of (Z)-17 alpha -halovinylsteroids
DEP3709378.9 1987-03-20

Publications (2)

Publication Number Publication Date
WO1988001276A2 WO1988001276A2 (en) 1988-02-25
WO1988001276A3 true WO1988001276A3 (en) 1988-04-07

Family

ID=25846451

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1987/000349 WO1988001276A2 (en) 1986-08-11 1987-08-06 PROCESS FOR PRODUCING (Z)-17alpha-HALOGENVINYLSTEROIDS

Country Status (5)

Country Link
EP (1) EP0277161A1 (en)
JP (1) JPH01500903A (en)
DK (1) DK196788A (en)
FI (1) FI881256A (en)
WO (1) WO1988001276A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0137434A2 (en) * 1983-10-10 1985-04-17 Schering Aktiengesellschaft Estrane and androstane derivatives, process for their preparation and pharmaceutical preparations containing them
EP0169515A2 (en) * 1984-07-25 1986-01-29 Schering Aktiengesellschaft 17-Halovinyl estrane derivatives, their preparation and their use in medicines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0137434A2 (en) * 1983-10-10 1985-04-17 Schering Aktiengesellschaft Estrane and androstane derivatives, process for their preparation and pharmaceutical preparations containing them
EP0169515A2 (en) * 1984-07-25 1986-01-29 Schering Aktiengesellschaft 17-Halovinyl estrane derivatives, their preparation and their use in medicines

Also Published As

Publication number Publication date
DK196788D0 (en) 1988-04-11
FI881256A0 (en) 1988-03-16
JPH01500903A (en) 1989-03-30
WO1988001276A2 (en) 1988-02-25
DK196788A (en) 1988-04-11
FI881256A (en) 1988-03-16
EP0277161A1 (en) 1988-08-10

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