WO1981002750A1 - Method of forming diffusion membrane units utilizing spaced mandrels - Google Patents
Method of forming diffusion membrane units utilizing spaced mandrels Download PDFInfo
- Publication number
- WO1981002750A1 WO1981002750A1 PCT/US1981/000112 US8100112W WO8102750A1 WO 1981002750 A1 WO1981002750 A1 WO 1981002750A1 US 8100112 W US8100112 W US 8100112W WO 8102750 A1 WO8102750 A1 WO 8102750A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- membrane
- tubular passages
- microns
- plastic
- plastic material
- Prior art date
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 66
- 238000009792 diffusion process Methods 0.000 title claims description 55
- 238000000034 method Methods 0.000 title claims description 18
- 239000000463 material Substances 0.000 claims abstract description 41
- 239000004033 plastic Substances 0.000 claims abstract description 27
- 229920003023 plastic Polymers 0.000 claims abstract description 27
- 238000001125 extrusion Methods 0.000 claims abstract description 12
- 230000001747 exhibiting effect Effects 0.000 claims abstract description 4
- 239000003000 extruded plastic Substances 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims description 19
- 239000001913 cellulose Substances 0.000 claims description 9
- 229920002678 cellulose Polymers 0.000 claims description 9
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 7
- 229940074928 isopropyl myristate Drugs 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 239000008280 blood Substances 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 239000000385 dialysis solution Substances 0.000 description 8
- 238000000502 dialysis Methods 0.000 description 7
- 239000000835 fiber Substances 0.000 description 6
- 239000012530 fluid Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000015271 coagulation Effects 0.000 description 3
- 238000005345 coagulation Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000001631 haemodialysis Methods 0.000 description 3
- 230000000322 hemodialysis Effects 0.000 description 3
- 235000011121 sodium hydroxide Nutrition 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000003518 caustics Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- -1 for example Polymers 0.000 description 2
- 238000006213 oxygenation reaction Methods 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- 101100043261 Caenorhabditis elegans spop-1 gene Proteins 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 210000001601 blood-air barrier Anatomy 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000007485 conventional hemodialysis Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 229910001882 dioxygen Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000002616 plasmapheresis Methods 0.000 description 1
- 229920005668 polycarbonate resin Polymers 0.000 description 1
- 239000004431 polycarbonate resin Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
- B01D63/026—Wafer type modules or flat-surface type modules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
- B01D63/021—Manufacturing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/06—Tubular membrane modules
- B01D63/061—Manufacturing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/06—Tubular membrane modules
- B01D63/066—Tubular membrane modules with a porous block having membrane coated passages
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/04—Tubular membranes
- B01D69/043—Tubular membranes characterised by the tube diameter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/42—Details of membrane preparation apparatus
Definitions
- Capillary fiber dialyzers are currently being used in the dialysis of blood, and also show promise for use as oxygenators for blood and for other types of semipermeable diffusion apparatus.
- An example of such a capillary fiber dialyzer is the CF® dialyzer sold by the Artificial Organs Division of Travenol Laboratories, Inc.
- Other forms of capillary dialyzers involving a multiple tube flow path include West German Patent No. 2,824,989 published on December 21,.1978; West German Patent No. 2,622,684, published November 24, 1977; Kohl U.S. Patent No. 3,557,962; and Riede U.S. Patent No. 4,016,082.
- capillary tubes are used, for example, in the commercial capillary fiber dialyzer mentioned above, as well as other commercial capillary fiber dialyzers.
- the diffusion membrane unit defining an internal flow path is provided in which the individual flow channels through the diffusion membrane unit may preferably have a maximum transverse dimension of less than one millimeter or one thousand microns, with a minimum transverse dimension being as low as 70 or 100 microns, for greatly improved dialysis efficiency, or corresponding improvements in any other desired diffusion process.
- a method of making a unitary membrane made of the plastic, semipermeable material in which the membrane defines a plural ity of parallel tubular passages passing longitudinally from end to end of the membrane.
- plastic mater ial is extruded through an extrusion orifice exhibiting the cross-sectional shape of the membrane, while applying mandrel means through the orifice to displace the plastic material with the mandrel means in a manner corresponding to the pattern and shape of the parallel tubular passages. Thereafter, the Extruded plastic material is allowed to harden, and the hardened plastic material is separated from the mandrel means to open the tubular passages.
- a continuous process membrane diffusion device may be formed out of an extruder and then cut into lengths and placed into a housing for use as a diffusion device such as a dialyzer, an oxygenator for blood, an ultrafiltration device, or a membrane plasma peresis device.
- a diffusion device such as a dialyzer, an oxygenator for blood, an ultrafiltration device, or a membrane plasma peresis device.
- the blood can pass through the membrane diffusion device, or a stack of such devices, in the tubular passages while dialysis solution or oxygen gas passes along the exteriors of such membrane diffusion devices.
- an opposite flow pattern can be utilized as well.
- the plastic semipermeable material may be a form of cellulose, for example, Cupraphane-type cupraamonium cellulose, particularly in the instance where dialysis of blood is contemplated.
- Other plastic materials may be used to make up the unitary membrane diffusion device as may be desired.
- mandrel means an organic liquid having a molecular weight in excess of 150, and substantially immiscible with the plastic material utilized to make the membrane diffusion device.
- the organic liquid used for the mandrel device may be isopropyl myristate.
- the technology for forming the liquid mandrel means out of an organic liquid is available to the prior art, and is presently used on a commercial basis to manufacture the capillary tubing made out of cellulose which constitutes the dialysis membrane in presently available hollow fiber-type dialysers, for example, the CF® dialyser sold by Travenol Laboratories, Inc. of Deerfield, Illinois.
- the parallel tubular passages defined by the extrusion process of this invention have diameters of less than 1000 microns, and preferably no more than 500 microns, specifically 100 to 300 microns.
- the center to center spacing of the tubular passages is most preferably from 110 to 400 microns, so that they are separated by only thin walls, the minimum wall thickness between the tubular passages and the exterior being preferably as lew as 3 to 15 microns.
- the immiscible organic liquid is utilized as the mandrel, the resulting unitary membrane device is formed with the passages being filled with the organic liquid. It may be delivered to the user in this form, so that the user may drain the organic liquid or, alternatively, the manufacturer can take the added step of removal of the organic liquid from the hardened plastic material to open the tubular passages.
- the semipermeable membrane material may be any desired membrane material besides cellulose, for example, polycarbonate resins, polyvinyl alcohol, or the like for dialysis procedures, for example hemodialysis .
- the diffusion membrane unit is used for the oxygenation of blood, polytetrafluoroethylene or silicone rubber may be used, by way of example.
- conventional membrane materials for plasmapheresis or ultrafiltration may be used if desired.
- the unitary membrane diffusion device of this invention may have a minimum wall thickness between tubular passages and the exterior of 3 to 40 microns.
- the diameter of the tubular passages used in hemodialysis may be 20.0 + 50 microns.
- the membrane diffusion device is intended for use for the oxygenation of blood, it may preferably have tubular passages of 500 + 200 microns in diameter.
- the diffusion membrane unit of this invention may have thinner walls than the usually capillary membrane tubes found in fibertype dialysers and the like, because the indivual tubular passageways are supported as a membrane unit and not just as separate fibers, which provides them a measure of protection.
- Figure 1 is a perspective view of a stack of the membrane diffusion devices of this invention, positioned within a housing for use as a diffusion device, for example a dialyser.
- Figure 2 is a sectional view, taken on line 2-2 of Figure 1.
- Figure 3 is an enlarged elevational view of the face of extrusion apparatus shown in the process of extruding the unitary membrane diffusion device of this invention.
- Figure 4 is a longitudinal sectional view of the extrusion device of Figure 3 shown in the process of extruding the diffusion device of this invention, and further showing other process steps in the manufacture thereof, said drawing being in schematic form.
- Figure 5 is a transverse sectional view of another embodiment of the unitary membrane diffusion device of this invention.
- a stack of the membrane diffusion devices of this invention is enclosed in a generally rectangular housing having enlarged manifold ends.
- the individual unitary membrane diffusion devices 10, within housing 12, are preferably present in a number sufficient to provide enough diffusion surface area for a particular use desired. Diffusion devices 10 may be sealed at their ends
- a second flow path through the diffusion device housing 12 along the exterior of diffusion devices 10 may then be defined between a second fluid inlet 20 and outlet 22, positioned in the sides of housing 12 in a manner which is analagous to conventional fiber dialyser technology.
- the rectangular shape of housing 12 and diffusion devices 10 provides a substantially simplified and efficient diffusion device, which is easy to manufacture.
- each of the diffusion devices 10 define linear humps 26 on both sides of diffusion devices, and adjacent each tubular passage 23, so that the overall thickness of each unitary membrane device adjacent each parallel tubular passage 23 is increased over the thickness of the membrane device in the space between the tubular passages, for example at area 28.
- This provides flow channels 30 for the fluid that enters and exits through ports 20, 22 along membrane devices 10 on both sides thereof.
- the individual membrane devices 10 in the stack are retained in an orientation by housing 12 so that the facing humps 26 of each membrane device 10 abut each other to provide open channels 30 between the unitary membrane devices 10, for the flow of fluid in the second flow path, for example dialysis solution in the case of hemodialysis.
- blood for example, can flow through port 19, entering the open tubular passages 23 of each of the diffusion devices 10 in the stack enclosed within housing 12, while being sealed from flow along the exterior of each diffusion device 10. Thereafter, the blood flows into manifold 18 and out of port 21, as part of a conventional hemodialysis circuit, for example.
- dialysis solution can flow through inlet 20 into a manifold area 32 at one end of housing 12, flowing, for example, through transverse interior grooves 34 positioned on inner surfaces of both sides of housing 12 to permit the distribution of dialysis solution along both sides of the stack of diffusion devices. Apertures may be punched through areas 28 at one end of devices 10, to permit distribution of dialysis solution to all faces of the diffusion devices in the stack and to interconnect flow channels 30.
- the diffusion device of this invention can function as a very simple dialyser, utilizing segments of the extruded diffusion device 10 as the diffusion membrane.
- an extrusion device 34 defining an extrusion orifice 36, through which the unitary membrane diffusion device of this invention may be extruded.
- a chamber 37 is filled with liquid plastic material 38, for example a conventional cupraamonium "dope" solution containing alpha cellulose, copper" sulfate, and ammonia, the solution being pressurized by means of pump 40, which may continuously add cupraamonium solution to container 37.
- the pressurized cupraamonium solution is extruded through orifice into a bath of caustic soda 43, which causes the prompt coagulation of the material.
- conduits 44 are provided, extending through tank 37, for the application of liquid isopropyl-myristate to serve as mandrel means and to define the open tubular passages 23 which, in this embodiment, are filled with the isopropyl myristate.
- the application of the column of isopropyl myristate can be balanced with the pressures in chamber 37 to form a solidified membrane diffusion device containing the tubular passages 23, as shown in cross-section for exmple in Figure 3.
- Chamber 37 may be vertically positioned as shown in Figure 4. Alternatively, it may be horizontally positioned, as shown in phantom, beneath the liquid level of the caustic soda bath 43, being sealed within an aperture within the wall of the container of the caustic soda bath.
- a continuous length 46 of extruded cellulose membrane sheet may be carried by rollers 48, 50 and other rollers as desired into a wash bath and an acid bath in accordance with conventional technology for the preparation of coagulated cupraamonium cellulose materials.
- the continuous strip of extruded material 46 can be severed by a knife member 52 or other means into discrete lengths 53, to form the unitary membrane diffusion devices, which may then be stacked and utilized in housing 12 as described above.
- the isopropyl myristate mandrel fluid, or other liquid as desired for the same purpose may be removed from open tubular passages 23, with the diffusion devices being preferably washed in Freon or the like, dried, and then forwarded for assembly into diffusion devices as shown on Figure 1.
- an alternative unitary membrane diffusion device 10a is shown., having flat outer faces 54 without the humps of the previous embodiment as shown in Figure 2.
- the open tubular passages 23a are provided, being made in a manner similar to that described above.
- a spacer member such as a porous screen or the like to facilitate the flow of fluid across the outer faces 54 of the membrane diffusion device lba.
- Figure 3 shows the outer faces of those mandrels within open tubular passages 23, which maintain the form of the extruded structure for a period of time sufficient to permit coagulation of the extruded structure by the caustic solution, the length of the wire mandrels being governed by the time required for coagulation to take place and the rate of advance of the extruded member.
Abstract
Unitary membranes (10, 10a) made of a plastic, semipermeable material having parallel tubular passages (23, 23a) passing longitudinally from end to end of the membrane may be made by extruding the plastic material through an extrusion orifice (36) exhibiting the cross-sectional shape of the membrane. Mandrel means are applied through the orifice (36) to displace plastic material in a manner corresponding to the pattern and shape of the parallel tubular passages (23, 23a). After the extruded plastic material is hardened, the mandrel means are separated from the hardened plastic material to open the tubular passages (23, 23a).
Description
METHOD OF FORMING DIFFUSION MEMBRANE UNITS UTILIZING SPACED MANDRELS
Background of the Invention
Capillary fiber dialyzers are currently being used in the dialysis of blood, and also show promise for use as oxygenators for blood and for other types of semipermeable diffusion apparatus. An example of such a capillary fiber dialyzer is the CF® dialyzer sold by the Artificial Organs Division of Travenol Laboratories, Inc. Other forms of capillary dialyzers involving a multiple tube flow path include West German Patent No. 2,824,989 published on December 21,.1978; West German Patent No. 2,622,684, published November 24, 1977; Kohl U.S. Patent No. 3,557,962; and Riede U.S. Patent No. 4,016,082.
It has been long known to be desirable, particularly in blood dialysis as well as other diffusion techniques involving blood, for the blood flow paths to be of capillary nature, having a transverse dimension of, for example, 500 microns or less. These capillary flow paths for the blood or other material improve the dialysis efficiency of the device. Such capillary tubes are used, for example, in the commercial capillary fiber dialyzer mentioned above, as well as other commercial capillary fiber dialyzers.
It would be desirable to form joined arrays of capillary semipermeable tubes, for example, to obtain a sheet of such joined capillary tubes. However, no efficient and effective way of manufacturing joined arrays
of such tubes having a maximum transverse inner diameter of less than one millimeter has been available prior to this present invention.
In accordance with this invention, the diffusion membrane unit defining an internal flow path is provided in which the individual flow channels through the diffusion membrane unit may preferably have a maximum transverse dimension of less than one millimeter or one thousand microns, with a minimum transverse dimension being as low as 70 or 100 microns, for greatly improved dialysis efficiency, or corresponding improvements in any other desired diffusion process.
Description of the Invention
In accordance with this invention, a method of making a unitary membrane made of the plastic, semipermeable material is provided in which the membrane defines a plural ity of parallel tubular passages passing longitudinally from end to end of the membrane.
In accordance with this invention, plastic mater ial is extruded through an extrusion orifice exhibiting the cross-sectional shape of the membrane, while applying mandrel means through the orifice to displace the plastic material with the mandrel means in a manner corresponding to the pattern and shape of the parallel tubular passages. Thereafter, the Extruded plastic material is allowed to harden, and the hardened plastic material is separated from the mandrel means to open the tubular passages.
By this extrusion technique, a continuous process membrane diffusion device may be formed out of an extruder and then cut into lengths and placed into a housing for use as a diffusion device such as a dialyzer, an oxygenator for blood, an ultrafiltration device, or a membrane plasma peresis device. For example, the blood can pass through
the membrane diffusion device, or a stack of such devices, in the tubular passages while dialysis solution or oxygen gas passes along the exteriors of such membrane diffusion devices. Alternatively, an opposite flow pattern can be utilized as well.
The plastic semipermeable material may be a form of cellulose, for example, Cupraphane-type cupraamonium cellulose, particularly in the instance where dialysis of blood is contemplated. Other plastic materials may be used to make up the unitary membrane diffusion device as may be desired.
While it is contemplated that thin, metallic wire mandrels may be used to define the tubular passages in the diffusion device of this invention, it is also contemplated to use as the mandrel means an organic liquid having a molecular weight in excess of 150, and substantially immiscible with the plastic material utilized to make the membrane diffusion device. For example, in the instance where a cellulose-type material is used, the organic liquid used for the mandrel device may be isopropyl myristate.
The technology for forming the liquid mandrel means out of an organic liquid is available to the prior art, and is presently used on a commercial basis to manufacture the capillary tubing made out of cellulose which constitutes the dialysis membrane in presently available hollow fiber-type dialysers, for example, the CF® dialyser sold by Travenol Laboratories, Inc. of Deerfield, Illinois. Preferably, the parallel tubular passages defined by the extrusion process of this invention have diameters of less than 1000 microns, and preferably no more than 500 microns, specifically 100 to 300 microns. The center to center spacing of the tubular passages is most preferably from 110 to 400 microns, so that they are separated by only thin walls, the minimum wall thickness between the tubular passages and the exterior being preferably as lew as 3 to 15 microns.
When the immiscible organic liquid is utilized as the mandrel, the resulting unitary membrane device is formed with the passages being filled with the organic liquid. It may be delivered to the user in this form, so that the user may drain the organic liquid or, alternatively, the manufacturer can take the added step of removal of the organic liquid from the hardened plastic material to open the tubular passages.
Alternatively, the semipermeable membrane material may be any desired membrane material besides cellulose, for example, polycarbonate resins, polyvinyl alcohol, or the like for dialysis procedures, for example hemodialysis . If the diffusion membrane unit is used for the oxygenation of blood, polytetrafluoroethylene or silicone rubber may be used, by way of example. Also, conventional membrane materials for plasmapheresis or ultrafiltration may be used if desired.
Preferably, the unitary membrane diffusion device of this invention may have a minimum wall thickness between tubular passages and the exterior of 3 to 40 microns. Preferably, the diameter of the tubular passages used in hemodialysis may be 20.0 + 50 microns. If the membrane diffusion device is intended for use for the oxygenation of blood, it may preferably have tubular passages of 500 + 200 microns in diameter.
As an advantage of this invention, the diffusion membrane unit of this invention may have thinner walls than the usually capillary membrane tubes found in fibertype dialysers and the like, because the indivual tubular passageways are supported as a membrane unit and not just as separate fibers, which provides them a measure of protection.
In the drawings, Figure 1 is a perspective view of a stack of the membrane diffusion devices of this invention, positioned within a housing for use as a diffusion device, for example a dialyser.
Figure 2 is a sectional view, taken on line 2-2 of Figure 1.
Figure 3 is an enlarged elevational view of the face of extrusion apparatus shown in the process of extruding the unitary membrane diffusion device of this invention. Figure 4 is a longitudinal sectional view of the extrusion device of Figure 3 shown in the process of extruding the diffusion device of this invention, and further showing other process steps in the manufacture thereof, said drawing being in schematic form. Figure 5 is a transverse sectional view of another embodiment of the unitary membrane diffusion device of this invention.
Referring to Figures 1.and 2, a stack of the membrane diffusion devices of this invention is enclosed in a generally rectangular housing having enlarged manifold ends. The individual unitary membrane diffusion devices 10, within housing 12, are preferably present in a number sufficient to provide enough diffusion surface area for a particular use desired. Diffusion devices 10 may be sealed at their ends
14 in any conventional manner to define sealed manifold chambers 16, 18 at the housing ends, respectively defining an inlet 19 and an outlet 21, which communicate only with tubular passages 23, while being sealed from the exterior of each diffusion device for the purpose of defining a first flow path through the device within tubular passages 23.
A second flow path through the diffusion device housing 12 along the exterior of diffusion devices 10 may then be defined between a second fluid inlet 20 and outlet 22, positioned in the sides of housing 12 in a manner which is analagous to conventional fiber dialyser technology. The rectangular shape of housing 12 and diffusion devices 10 provides a substantially simplified and efficient diffusion device, which is easy to manufacture.
As shown in Figure 2, each of the diffusion
devices 10 define linear humps 26 on both sides of diffusion devices, and adjacent each tubular passage 23, so that the overall thickness of each unitary membrane device adjacent each parallel tubular passage 23 is increased over the thickness of the membrane device in the space between the tubular passages, for example at area 28. This provides flow channels 30 for the fluid that enters and exits through ports 20, 22 along membrane devices 10 on both sides thereof. The individual membrane devices 10 in the stack are retained in an orientation by housing 12 so that the facing humps 26 of each membrane device 10 abut each other to provide open channels 30 between the unitary membrane devices 10, for the flow of fluid in the second flow path, for example dialysis solution in the case of hemodialysis.
Accordingly, blood, for example, can flow through port 19, entering the open tubular passages 23 of each of the diffusion devices 10 in the stack enclosed within housing 12, while being sealed from flow along the exterior of each diffusion device 10. Thereafter, the blood flows into manifold 18 and out of port 21, as part of a conventional hemodialysis circuit, for example.
In this instance, dialysis solution can flow through inlet 20 into a manifold area 32 at one end of housing 12, flowing, for example, through transverse interior grooves 34 positioned on inner surfaces of both sides of housing 12 to permit the distribution of dialysis solution along both sides of the stack of diffusion devices. Apertures may be punched through areas 28 at one end of devices 10, to permit distribution of dialysis solution to all faces of the diffusion devices in the stack and to interconnect flow channels 30.
The dialysis solution then runs along the various channels 30 along the exteriors of members 10, passing optionally through additional punched aperture sections in areas 28 between the tubular passages 23 adjacent the
other end of housing 12, so that the dialysis solution can be collected in transverse grooves 36 on the inner walls of housing 12, for flow communication with manifold 38 and dialysis solution outlet port 22. Accordingly, the diffusion device of this invention can function as a very simple dialyser, utilizing segments of the extruded diffusion device 10 as the diffusion membrane.
Referring to Figure 3, the face of an extrusion device 34 is shown, defining an extrusion orifice 36, through which the unitary membrane diffusion device of this invention may be extruded. As shown in Figure 4, a chamber 37 is filled with liquid plastic material 38, for example a conventional cupraamonium "dope" solution containing alpha cellulose, copper" sulfate, and ammonia, the solution being pressurized by means of pump 40, which may continuously add cupraamonium solution to container 37. The pressurized cupraamonium solution is extruded through orifice into a bath of caustic soda 43, which causes the prompt coagulation of the material.
Simultaneously with this extrusion process, which takes place through extrusion orifice 36, conduits 44 are provided, extending through tank 37, for the application of liquid isopropyl-myristate to serve as mandrel means and to define the open tubular passages 23 which, in this embodiment, are filled with the isopropyl myristate. The application of the column of isopropyl myristate can be balanced with the pressures in chamber 37 to form a solidified membrane diffusion device containing the tubular passages 23, as shown in cross-section for exmple in Figure 3.
Chamber 37 may be vertically positioned as shown in Figure 4. Alternatively, it may be horizontally positioned, as shown in phantom, beneath the liquid level of the caustic soda bath 43, being sealed within an aperture within the wall of the container of the caustic soda bath.
Following the caustic treatment in container 42, a continuous length 46 of extruded cellulose membrane sheet may be carried by rollers 48, 50 and other rollers as desired into a wash bath and an acid bath in accordance with conventional technology for the preparation of coagulated cupraamonium cellulose materials. Thereafter, as shown schematically in Figure 4, the continuous strip of extruded material 46 can be severed by a knife member 52 or other means into discrete lengths 53, to form the unitary membrane diffusion devices, which may then be stacked and utilized in housing 12 as described above. Upon cutting, the isopropyl myristate mandrel fluid, or other liquid as desired for the same purpose, may be removed from open tubular passages 23, with the diffusion devices being preferably washed in Freon or the like, dried, and then forwarded for assembly into diffusion devices as shown on Figure 1.
Referring to Figure 5, an alternative unitary membrane diffusion device 10a is shown., having flat outer faces 54 without the humps of the previous embodiment as shown in Figure 2. The open tubular passages 23a are provided, being made in a manner similar to that described above. In this particular embodiment, if stack of the diffusion devices 10a are used in a housing, it is desirable to separate them with a spacer member such as a porous screen or the like to facilitate the flow of fluid across the outer faces 54 of the membrane diffusion device lba.
Alternatively, as a substitute for the liquid mandrel system shown in Figure 4, short metal mandrels of wire may be utilized. In this instance, Figure 3 shows the outer faces of those mandrels within open tubular passages 23, which maintain the form of the extruded structure for a period of time sufficient to permit coagulation of the extruded structure by the caustic solution, the length of the wire mandrels being governed by the time required for
coagulation to take place and the rate of advance of the extruded member.
The above has been offered for illustrative purposes only, and is not intended to limit the invention of this application, which is as disclosed in the claims below.
Claims
1. The method of making a unitary membrane diffusion device made of a plastic, semipermeable material, and defining a plurality of parallel tubular passages passing longitudinally from end to end of said diffusion device, the improvement comprising: extruding said plastic material through an extrusion orifice exhibiting the cross-sectional shape of said membrane diffusion device, while applying mandrel means having diameters of less than 1000 microns through said orifice to displace said plastic material with said mandrel means in a manner corresponding to the pattern and shape of said parallel tubular passages, and thereafter allowing said extruded plastic material to harden, and separating said hardened plastic material and the mandrel means to open said tubular passages.
2. The method of Claim 1 in which said plastic, semipermeable material is a form of cellulose.
3. The method of Claim 2 in which said mandrel means is an organic liquid having a molecular weight in excess of 150 and substantially immiscible with the plastic cellulose material.
4. The method of Claim 3 in which said organic liquid is isopropylmyristate.
5. The method of making a unitary membrane made of plastic, semipermeable material and defining a plurality of parallel tubular passages having diameters of less than 1000 microns, said passages passing longitudinally from end to end of said membrane, the improvement comprising: extruding said plastic material through an extrusion orifice exhibiting the cross-sectional shape of said membrane, while applying mandrel means through said orifice to displace said plastic material with said mandrel means in a manner corresponding to the pattern and shape of said parallel tubular passages, said mandrel means comprising an organic liquid having a molecular weight in excess of 150 and being substantially immiscible with the plastic, semipermeable material, and thereafter allowing said extruded plastic material to harden.
6. The method of Claim 5 in which said parallel tubular passages define diameters of 100 to 300 microns.
7. The method of Claim 6 in which the center-to- center spacing of said tubular passages .is 110 to 400 microns
8. A unitary membrane device made of a plastic semipermeable material and defining a plurality of parallel tubular passages bf less than 1000 microns in diameter passing longitudinally from end to end of said membrane, said passages being filled with an organic liquid having a molecular weight in excess of 150 and substantially immiscible with the plastic material.
9. The unitary membrane device of Claim 8 in which said plastic material is a form of cellulose.
10. The unitary membrane device of Claim 9 in which said organic liquid is isopropyl myristate.
11. The unitary membrane device of Claim 8 in which the diameters of the tubular passages are 100 to 300 microns.
12. The unitary membrane device of Claim 11 in which the center-to-center spacings of said parallel tubular passages are 110 to 400 microns.
13. The unitary membrane device of Claim 8 in which the thickness thereof adjacent each parallel tubular passage is increased over the thickness of said membrane device in the space between said tubular passages.
14. The unitary membrane device of Claim 13 in which the minimum wall thickness between the tubular passages and the exterior is from 3 to 15 microns.
15. The unitary membrane device in which the diameters of said tubular passage are no more than 500 microns.
16. The method of forming a diffusion membrane unit defining an internal flow path which comprises: extruding semipermeable membrane material in a film about a plurality of spaced, elongated mandrels to form a thin membrane, said mandrels each having a maximum transverse dimension of less than 1 millimeter, and hardening said membrane material to define said diffusion membrane unit, said internal flow path being defined by the spaces occupied by said mandrels.
17. The method of Claim 16 including the step of removing said mandrels from said diffusion membrane unit.
18. The method of Claim 1 in which said mandrels comprise an organic liquid substantially immiscible with the plastic material.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU70795/81A AU7079581A (en) | 1980-03-24 | 1981-01-26 | Method of forming diffusion membrane units utilizing spaced mandrels |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13315180A | 1980-03-24 | 1980-03-24 | |
US133151 | 1980-03-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1981002750A1 true WO1981002750A1 (en) | 1981-10-01 |
Family
ID=22457250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1981/000112 WO1981002750A1 (en) | 1980-03-24 | 1981-01-26 | Method of forming diffusion membrane units utilizing spaced mandrels |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP0048267A1 (en) |
WO (1) | WO1981002750A1 (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0080777A2 (en) * | 1981-12-02 | 1983-06-08 | Baxter Travenol Laboratories, Inc. | Multichanneled flow device and method making same |
FR2616812A1 (en) * | 1987-06-18 | 1988-12-23 | Lyonnaise Eaux | Process for the manufacture of an organic porous material and especially of an organic semipermeable membrane, die for making use of this process, membranes produced and filter modules containing these membranes |
EP0375003A1 (en) * | 1988-12-22 | 1990-06-27 | SOCIETE LYONNAISE DES EAUX Société Anonyme | Process for making a porous organic material, in particular an organic semi-permeable membrane comprising multiple longitudinal spaced bores |
EP0375004A1 (en) * | 1988-12-22 | 1990-06-27 | Lyonnaise Des Eaux - Dumez | Process for manufacturing a porous organic material, particularly a semi permeable organic membrane having a multitude of different longitudinal channels |
NL1009866C2 (en) * | 1998-08-14 | 2000-02-15 | Search B V S | Filtration membrane prepared by extruding sheet of semi permeable material with parallel channels in its top side |
WO2003022410A2 (en) * | 2001-08-10 | 2003-03-20 | Gkss-Forschungszentrum | Membrane body and method for the production thereof |
EP2089211A2 (en) * | 2006-10-12 | 2009-08-19 | Cambridge Enterprise Limited | Extruded materials having capillary channels |
WO2011005657A1 (en) | 2009-07-09 | 2011-01-13 | Dow Global Technologies Inc. | Spiral wound module including membrane sheet with capillary channels |
WO2011025698A1 (en) | 2009-08-28 | 2011-03-03 | Dow Global Technologies Llc | Filtration module including membrane sheet with capillary channels |
US8114478B1 (en) | 2010-09-17 | 2012-02-14 | Dow Global Technologies Llc | Dual-sided membrane sheet and method for making the same |
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EP0080777A2 (en) * | 1981-12-02 | 1983-06-08 | Baxter Travenol Laboratories, Inc. | Multichanneled flow device and method making same |
EP0080777A3 (en) * | 1981-12-02 | 1983-08-31 | Baxter Travenol Laboratories, Inc. | Multichanneled flow device and method making same |
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WO2003022410A2 (en) * | 2001-08-10 | 2003-03-20 | Gkss-Forschungszentrum | Membrane body and method for the production thereof |
WO2003022410A3 (en) * | 2001-08-10 | 2003-10-09 | Gkss Forschungszentrum | Membrane body and method for the production thereof |
EP2089211A2 (en) * | 2006-10-12 | 2009-08-19 | Cambridge Enterprise Limited | Extruded materials having capillary channels |
EP2089211B1 (en) * | 2006-10-12 | 2013-12-25 | Cambridge Enterprise Limited | Method and apparatus of extruding materials having capillary channels |
WO2011005657A1 (en) | 2009-07-09 | 2011-01-13 | Dow Global Technologies Inc. | Spiral wound module including membrane sheet with capillary channels |
US8911625B2 (en) | 2009-07-09 | 2014-12-16 | Dow Global Technologies Llc | Spiral wound module including membrane sheet with capillary channels |
WO2011025698A1 (en) | 2009-08-28 | 2011-03-03 | Dow Global Technologies Llc | Filtration module including membrane sheet with capillary channels |
US8114478B1 (en) | 2010-09-17 | 2012-02-14 | Dow Global Technologies Llc | Dual-sided membrane sheet and method for making the same |
Also Published As
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EP0048267A1 (en) | 1982-03-31 |
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