WO1979000922A1 - Uracil derivatives,process for preparing the same,and oncotic preparation thereof - Google Patents

Uracil derivatives,process for preparing the same,and oncotic preparation thereof Download PDF

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Publication number
WO1979000922A1
WO1979000922A1 PCT/JP1979/000089 JP7900089W WO7900922A1 WO 1979000922 A1 WO1979000922 A1 WO 1979000922A1 JP 7900089 W JP7900089 W JP 7900089W WO 7900922 A1 WO7900922 A1 WO 7900922A1
Authority
WO
WIPO (PCT)
Prior art keywords
oncotic
preparation
preparing
same
uracil derivatives
Prior art date
Application number
PCT/JP1979/000089
Other languages
French (fr)
Japanese (ja)
Inventor
T Okada
Original Assignee
T Okada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by T Okada filed Critical T Okada
Publication of WO1979000922A1 publication Critical patent/WO1979000922A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1-Acetyl-(3-o-toluyl)-5-fluorouracil having the following chemical structural formula: (FORMULA) is prepared by reacting 5-fluoro(3-o-toluryl)-uracil with acetic anhydride, or by reacting 1-acetyl-5-fluorouracil with o-toluyl halide. In the production of an oncotic preparation, this compound is dissolved in a material such as a mixed oil of glyceride and lecithin.
PCT/JP1979/000089 1978-04-12 1979-04-05 Uracil derivatives,process for preparing the same,and oncotic preparation thereof WO1979000922A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4349678A JPS54135782A (en) 1978-04-12 1978-04-12 11acetyll*33ootoluyl**55fluorouracil and its manufacture andantitumor
JP78/43496 1978-04-12

Publications (1)

Publication Number Publication Date
WO1979000922A1 true WO1979000922A1 (en) 1979-11-15

Family

ID=12665314

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1979/000089 WO1979000922A1 (en) 1978-04-12 1979-04-05 Uracil derivatives,process for preparing the same,and oncotic preparation thereof

Country Status (2)

Country Link
JP (1) JPS54135782A (en)
WO (1) WO1979000922A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6036411A (en) * 1983-08-09 1985-02-25 Okada Raifu Corp:Kk Antineoplastic agent and its preparation
JPS6296078U (en) * 1985-12-02 1987-06-19

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5186480A (en) * 1975-01-22 1976-07-29 Asahi Chemical Ind 55 furuororashirujudotainoseiho

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5186480A (en) * 1975-01-22 1976-07-29 Asahi Chemical Ind 55 furuororashirujudotainoseiho

Also Published As

Publication number Publication date
JPS5550023B2 (en) 1980-12-16
JPS54135782A (en) 1979-10-22

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