MX2019002438A - Compuestos triciclicos fusionados de piridazinona utiles para tratar infecciones de orthomyxovirus. - Google Patents

Compuestos triciclicos fusionados de piridazinona utiles para tratar infecciones de orthomyxovirus.

Info

Publication number
MX2019002438A
MX2019002438A MX2019002438A MX2019002438A MX2019002438A MX 2019002438 A MX2019002438 A MX 2019002438A MX 2019002438 A MX2019002438 A MX 2019002438A MX 2019002438 A MX2019002438 A MX 2019002438A MX 2019002438 A MX2019002438 A MX 2019002438A
Authority
MX
Mexico
Prior art keywords
compounds useful
fused tricyclic
pyridazinone compounds
treat
orthomyxovirus infections
Prior art date
Application number
MX2019002438A
Other languages
English (en)
Inventor
Poon Daniel
R Manning James
Zhao Qian
R Taft Benjamin
Jain Rama
Christofer Koester Dennis
Marx Vanessa
Clifford Sutton James
Wan Lifeng
Yifru Aregahegn
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2019002438A publication Critical patent/MX2019002438A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La invención proporciona compuestos de la Fórmula (I): (ver Fórmula) como se describe adicionalmente en la presente, así como composiciones farmacéuticas que comprenden dichos compuestos, y procedimientos para usar los compuestos y composiciones farmacéuticas para el tratamiento de ciertos trastornos víricos, incluyendo la influenza.
MX2019002438A 2016-08-29 2017-08-25 Compuestos triciclicos fusionados de piridazinona utiles para tratar infecciones de orthomyxovirus. MX2019002438A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662380712P 2016-08-29 2016-08-29
PCT/IB2017/055137 WO2018042303A1 (en) 2016-08-29 2017-08-25 Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections

Publications (1)

Publication Number Publication Date
MX2019002438A true MX2019002438A (es) 2019-07-08

Family

ID=59923494

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019002438A MX2019002438A (es) 2016-08-29 2017-08-25 Compuestos triciclicos fusionados de piridazinona utiles para tratar infecciones de orthomyxovirus.

Country Status (15)

Country Link
US (3) US10160764B2 (es)
EP (3) EP3504214B1 (es)
JP (2) JP7221861B2 (es)
CN (2) CN109863151B (es)
AR (1) AR109438A1 (es)
CA (1) CA3035302A1 (es)
ES (1) ES2859510T3 (es)
JO (1) JOP20170169A1 (es)
MX (1) MX2019002438A (es)
PL (2) PL3504214T3 (es)
PT (2) PT3504214T (es)
SI (2) SI3504214T1 (es)
TW (2) TWI803467B (es)
UY (1) UY37378A (es)
WO (1) WO2018042303A1 (es)

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Also Published As

Publication number Publication date
PL3848372T3 (pl) 2024-04-22
US20220041610A1 (en) 2022-02-10
AR109438A1 (es) 2018-11-28
EP4356969A2 (en) 2024-04-24
CA3035302A1 (en) 2018-03-08
JOP20170169A1 (ar) 2019-01-30
CN109863151A (zh) 2019-06-07
US11912715B2 (en) 2024-02-27
EP4356969A3 (en) 2024-05-22
JP7221861B2 (ja) 2023-02-14
US20200123167A1 (en) 2020-04-23
EP3504214A1 (en) 2019-07-03
EP3848372A1 (en) 2021-07-14
US10160764B2 (en) 2018-12-25
SI3504214T1 (sl) 2021-04-30
TWI803467B (zh) 2023-06-01
TW202342482A (zh) 2023-11-01
PL3504214T3 (pl) 2021-07-19
TW201811800A (zh) 2018-04-01
WO2018042303A1 (en) 2018-03-08
EP3504214B1 (en) 2020-12-02
PT3504214T (pt) 2021-03-04
SI3848372T1 (sl) 2024-04-30
EP3848372B1 (en) 2023-12-20
ES2859510T3 (es) 2021-10-04
US11098051B2 (en) 2021-08-24
UY37378A (es) 2018-03-23
JP2023027102A (ja) 2023-03-01
JP2019532033A (ja) 2019-11-07
PT3848372T (pt) 2024-03-22
CN109863151B (zh) 2021-09-10
US20180057501A1 (en) 2018-03-01
CN113683614A (zh) 2021-11-23

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