UY36023A - “derivados cristalinos de (s)-1-((2r,3r,4s,5s)-5-alil-3-metoxi-4-(tosilmetil) tetrahidrofuran-2-il)-3-aminopropan-2-ol “. - Google Patents
“derivados cristalinos de (s)-1-((2r,3r,4s,5s)-5-alil-3-metoxi-4-(tosilmetil) tetrahidrofuran-2-il)-3-aminopropan-2-ol “.Info
- Publication number
- UY36023A UY36023A UY0001036023A UY36023A UY36023A UY 36023 A UY36023 A UY 36023A UY 0001036023 A UY0001036023 A UY 0001036023A UY 36023 A UY36023 A UY 36023A UY 36023 A UY36023 A UY 36023A
- Authority
- UY
- Uruguay
- Prior art keywords
- tosilmetil
- tetrahidrofuran
- metoxi
- alil
- aminopropan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Se describen sales de un compuesto de fórmula 1, como se muestra a continuación, donde R1, R2, R3, R4, R5, R6 y R7 son como se describe en la presente. También se describe un procedimiento para la preparación de las sales de los compuestos de fórmula 1, e intermediarios utilizados en el mismo.Las sales del compuesto de fórmula 1 pueden ser útiles en la preparación de análogos de Halicondrina tales como eribulina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461948875P | 2014-03-06 | 2014-03-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY36023A true UY36023A (es) | 2015-10-30 |
Family
ID=54054307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY0001036023A UY36023A (es) | 2014-03-06 | 2015-03-06 | “derivados cristalinos de (s)-1-((2r,3r,4s,5s)-5-alil-3-metoxi-4-(tosilmetil) tetrahidrofuran-2-il)-3-aminopropan-2-ol “. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10301274B2 (es) |
| EP (1) | EP3114112B1 (es) |
| JP (1) | JP6528251B2 (es) |
| CN (1) | CN106458947B (es) |
| AR (1) | AR099692A1 (es) |
| AU (1) | AU2015226806B2 (es) |
| CA (1) | CA2940609A1 (es) |
| TW (1) | TW201617326A (es) |
| UY (1) | UY36023A (es) |
| WO (1) | WO2015131286A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10548986B2 (en) | 2016-03-02 | 2020-02-04 | Eisai R&D Management Co., Ltd. | Eribulin-based antibody-drug conjugates and methods of use |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL139960A0 (en) * | 1998-06-17 | 2002-02-10 | Eisai Co Ltd | Macrocylic analogs and methods of their use and preparation |
| AU764154B2 (en) * | 1998-09-23 | 2003-08-14 | Lonza A.G. | Method for producing (-)-alpha-(difluoromethyl)ornithine-monohydrochloride monohydrate |
| SI2522663T1 (sl) | 2004-06-03 | 2015-08-31 | Eisai R&D Management Co., Ltd. | Vmesne spojine za pripravo halihondrina B |
| CN105801599A (zh) | 2008-04-04 | 2016-07-27 | 卫材R&D管理有限公司 | 软海绵素b类似物 |
| JP6300030B2 (ja) | 2011-12-29 | 2018-03-28 | サンド アクツィエンゲゼルシャフト | ２−（（２ｓ，３ｓ，４ｒ，５ｒ）−５−（（ｓ）−３−アミノ−２−ヒドロキシプロプ−１−イル）−４−メトキシ−３−（フェニルスルホニルメチル）テトラヒドロフラン−２−イル）アセトアルデヒド誘導体およびこれらを調製するためのプロセス |
| IN2014MN02106A (es) | 2012-03-30 | 2015-09-11 | Alphora Res Inc | |
| US9850254B2 (en) * | 2013-07-03 | 2017-12-26 | Sandoz Ag | Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein including intermediates containing-SO2-(p-tolyl) groups |
-
2015
- 2015-03-04 TW TW104106860A patent/TW201617326A/zh unknown
- 2015-03-06 CN CN201580011869.9A patent/CN106458947B/zh active Active
- 2015-03-06 US US15/123,310 patent/US10301274B2/en not_active Expired - Fee Related
- 2015-03-06 UY UY0001036023A patent/UY36023A/es not_active Application Discontinuation
- 2015-03-06 EP EP15759027.4A patent/EP3114112B1/en active Active
- 2015-03-06 CA CA2940609A patent/CA2940609A1/en not_active Abandoned
- 2015-03-06 WO PCT/CA2015/050168 patent/WO2015131286A1/en active Application Filing
- 2015-03-06 JP JP2016555719A patent/JP6528251B2/ja not_active Expired - Fee Related
- 2015-03-06 AU AU2015226806A patent/AU2015226806B2/en not_active Ceased
- 2015-03-06 AR ARP150100686A patent/AR099692A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR099692A1 (es) | 2016-08-10 |
| US10301274B2 (en) | 2019-05-28 |
| US20170066735A1 (en) | 2017-03-09 |
| CN106458947A (zh) | 2017-02-22 |
| AU2015226806B2 (en) | 2018-11-08 |
| TW201617326A (zh) | 2016-05-16 |
| JP2017507159A (ja) | 2017-03-16 |
| WO2015131286A1 (en) | 2015-09-11 |
| EP3114112B1 (en) | 2021-12-15 |
| CA2940609A1 (en) | 2015-09-11 |
| CN106458947B (zh) | 2021-01-12 |
| EP3114112A4 (en) | 2017-10-04 |
| JP6528251B2 (ja) | 2019-06-12 |
| AU2015226806A1 (en) | 2016-08-25 |
| EP3114112A1 (en) | 2017-01-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20220610 |