UY33392A - Lactamas sustituidas con piperidinilo como moduladores de gpr119 - Google Patents
Lactamas sustituidas con piperidinilo como moduladores de gpr119Info
- Publication number
- UY33392A UY33392A UY0001033392A UY33392A UY33392A UY 33392 A UY33392 A UY 33392A UY 0001033392 A UY0001033392 A UY 0001033392A UY 33392 A UY33392 A UY 33392A UY 33392 A UY33392 A UY 33392A
- Authority
- UY
- Uruguay
- Prior art keywords
- gpr119
- modulators
- readers
- piperidinyl
- replaced
- Prior art date
Links
- 102100033839 Glucose-dependent insulinotropic receptor Human genes 0.000 title abstract 2
- 101000996752 Homo sapiens Glucose-dependent insulinotropic receptor Proteins 0.000 title abstract 2
- -1 PIPERIDINYL Chemical class 0.000 title 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Compuestos de la Fórmula I y sales farmacéuticamente de ellos, en donde X 1 , X2 , L, R3 , R4 ,R5 , R6 , R6a , R7 , R9 , R9a , y n tienen las definiciones que se dieron en la memoria descriptiva, son moduladores de GPR119 y son útiles en el tratamiento o la prevención de enfermedades tales como, en forma no taxativa, diabetes tipo 2, complicaciones diabéticas, síntomas de la diabetes, síndrome metabólico, obesidad, dislipidemia y condiciones relacionadas .
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34546110P | 2010-05-17 | 2010-05-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY33392A true UY33392A (es) | 2012-11-30 |
Family
ID=44584599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001033392A UY33392A (es) | 2010-05-17 | 2011-05-17 | Lactamas sustituidas con piperidinilo como moduladores de gpr119 |
Country Status (20)
Country | Link |
---|---|
US (1) | US8754226B2 (es) |
EP (1) | EP2571864A1 (es) |
JP (1) | JP2013530947A (es) |
KR (1) | KR20130113948A (es) |
CN (1) | CN103080101A (es) |
AR (1) | AR081197A1 (es) |
AU (1) | AU2011256455A1 (es) |
BR (1) | BR112012029395A2 (es) |
CA (1) | CA2799779A1 (es) |
CL (1) | CL2012003211A1 (es) |
CO (1) | CO6670520A2 (es) |
CR (1) | CR20120642A (es) |
IL (1) | IL223092A0 (es) |
MX (1) | MX2012013465A (es) |
RU (1) | RU2012154308A (es) |
SG (1) | SG185615A1 (es) |
TW (1) | TW201141849A (es) |
UY (1) | UY33392A (es) |
WO (1) | WO2011146335A1 (es) |
ZA (1) | ZA201209605B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2012013465A (es) | 2010-05-17 | 2013-12-02 | Array Biopharma Inc | Lactamas sustituidas con piperidinilo como moduladores de gpr119. |
AU2012267556B9 (en) | 2011-06-09 | 2017-05-11 | Rhizen Pharmaceuticals Sa | Novel compounds as modulators of GPR-119 |
KR101415742B1 (ko) * | 2011-12-21 | 2014-07-04 | 영남대학교 산학협력단 | 6―아미노피리딘―3―올 유도체 또는 이의 약제학적 허용가능한 염 및 이를 유효성분으로 함유하는 혈관신생으로 인한 질환의 예방 또는 치료용 약학조성물 |
EP2872127A1 (en) | 2012-07-11 | 2015-05-20 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
EP2892897A1 (en) | 2012-09-05 | 2015-07-15 | Bristol-Myers Squibb Company | Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists |
AR092924A1 (es) | 2012-10-09 | 2015-05-06 | Sanofi Sa | Derivados de pirrolidinona como moduladores de gpr119 para el tratamiento de diabetes, obesidad, dislipidemia y trastornos relacionados |
JP2016527193A (ja) * | 2013-06-07 | 2016-09-08 | バイエル・ファルマ・アクティエンゲゼルシャフト | 置換トリアゾロピリジン |
AR099937A1 (es) | 2014-04-04 | 2016-08-31 | Sanofi Sa | Compuestos de isoindolinona como moduladores de gpr119 para el tratamiento de diabetes, obesidad, dislipidemia y trastornos relacionados |
AU2015239020A1 (en) * | 2014-04-04 | 2016-10-13 | Sanofi | Substituted indanone compounds as GPR119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders |
AR099936A1 (es) * | 2014-04-04 | 2016-08-31 | Sanofi Sa | Heterociclos condensados sustituidos como moduladores de gpr119 para el tratamiento de la diabetes, obesidad, dislipidemia y trastornos relacionados |
CN107207268A (zh) | 2015-01-19 | 2017-09-26 | 福吉米株式会社 | 改性胶体二氧化硅及其制造方法、以及使用其的研磨剂 |
KR102604533B1 (ko) | 2015-01-19 | 2023-11-22 | 가부시키가이샤 후지미인코퍼레이티드 | 연마용 조성물 |
CN108368099B (zh) | 2015-12-17 | 2021-11-12 | 先正达参股股份有限公司 | 杀微生物的噁二唑衍生物 |
US10392366B2 (en) | 2017-02-21 | 2019-08-27 | Sanofi | Azetidine compounds as GPR119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders |
JP2023526625A (ja) | 2020-05-19 | 2023-06-22 | キャリーオペ,インク. | Ampkアクチベーター |
MX2022016455A (es) | 2020-06-22 | 2023-02-01 | Hoffmann La Roche | Derivados de sulfona. |
CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
CN114539073A (zh) * | 2022-02-18 | 2022-05-27 | 郑州萃智医药科技有限公司 | 3-溴-2-氯-4,6-二氟苯胺的合成方法 |
WO2024033374A1 (en) | 2022-08-11 | 2024-02-15 | Syngenta Crop Protection Ag | Novel arylcarboxamide or arylthioamide compounds |
WO2024089216A1 (en) | 2022-10-27 | 2024-05-02 | Syngenta Crop Protection Ag | Novel sulfur-containing heteroaryl carboxamide compounds |
WO2024126650A1 (en) | 2022-12-15 | 2024-06-20 | Syngenta Crop Protection Ag | Novel bicyclic-carboxamide compounds useful as pesticides |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
JP4958560B2 (ja) | 2003-12-24 | 2012-06-20 | プロシディオン・リミテッド | Gpcr受容体作動薬としてのヘテロ環誘導体 |
BRPI0507971A (pt) | 2004-02-23 | 2007-07-24 | Tufts College | composto, composição farmacêutica, uso de um composto,método para inibir a atividade proteolìtica de uma enzima de clivagem pós-prolina e remédio empacotado |
TW200610761A (en) | 2004-04-23 | 2006-04-01 | Astrazeneca Ab | Chemical compounds |
DK1756084T3 (da) | 2004-06-04 | 2009-03-23 | Arena Pharm Inc | Substituerede aryl- og heteroarylderivater som modulatorer af metabolisme og forebyggelse og behandling af forstyrrelser beslægtet dermed |
CA2586883A1 (en) * | 2004-11-22 | 2006-06-01 | Merck & Co., Inc. | Piperidinyl piperidine tachykinin receptor antagonists |
WO2006091450A1 (en) * | 2005-02-18 | 2006-08-31 | Lexicon Genetics Incorporated | 4-piperidin-1-yl-7h-pyrrolo[2,3-d]pyrimidine compounds |
US20090264650A1 (en) * | 2005-03-31 | 2009-10-22 | Nobuo Cho | Prophylactic/Therapeutic Agent for Diabetes |
TW200724139A (en) | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
KR20080025190A (ko) | 2005-06-30 | 2008-03-19 | 프로시디온 리미티드 | G-단백질 결합된 수용체 효능제 |
NZ564759A (en) | 2005-06-30 | 2011-08-26 | Prosidion Ltd | GPCR agonists |
US20080025795A1 (en) * | 2006-07-28 | 2008-01-31 | Cliff Purnell | Methods, apparatus and system for drain tiles |
JP2010501629A (ja) * | 2006-08-30 | 2010-01-21 | ビオヴィトルム・アクチボラゲット(プブリクト) | Gpr119関連障害を治療するためのピリジン化合物 |
AU2007342531B2 (en) | 2006-12-20 | 2011-10-13 | Merck Sharp & Dohme Corp. | Bipiperidinyl compounds, compositions containing such compounds and methods of treatment |
CN101754962B (zh) | 2007-07-19 | 2013-12-25 | 赛马拜制药公司 | 作为rup3或gpr119受体的激动剂治疗糖尿病和代谢性病症的n-氮杂环状经取代吡咯、吡唑、咪唑、***和四唑衍生物 |
EP2321308B9 (en) | 2008-07-10 | 2012-08-08 | Prosidion Limited | Piperidine gpcr agonists |
TW201006821A (en) | 2008-07-16 | 2010-02-16 | Bristol Myers Squibb Co | Pyridone and pyridazone analogues as GPR119 modulators |
CA3082212C (en) * | 2009-09-04 | 2023-03-07 | Sunesis Pharmaceuticals, Inc. | Bruton's tyrosine kinase inhibitors |
JP2013523819A (ja) | 2010-04-06 | 2013-06-17 | アリーナ ファーマシューティカルズ, インコーポレイテッド | Gpr119レセプターのモジュレーターおよびそれに関連する障害の処置 |
MX2012013465A (es) | 2010-05-17 | 2013-12-02 | Array Biopharma Inc | Lactamas sustituidas con piperidinilo como moduladores de gpr119. |
KR20130099970A (ko) | 2010-09-17 | 2013-09-06 | 어레이 바이오파마 인크. | Gpr119 조절제로서의 피페리디닐-치환된 락탐류 |
US20140256756A1 (en) | 2011-11-03 | 2014-09-11 | Array Biopharma Inc. | Piperidinyl-substituted lactams as gpr119 modulators |
WO2013074641A1 (en) | 2011-11-16 | 2013-05-23 | Array Biopharma Inc. | Piperidinyl- substituted cyclic ureas as gpr119 modulators |
-
2011
- 2011-05-13 MX MX2012013465A patent/MX2012013465A/es not_active Application Discontinuation
- 2011-05-13 EP EP11754769A patent/EP2571864A1/en not_active Withdrawn
- 2011-05-13 BR BR112012029395A patent/BR112012029395A2/pt not_active IP Right Cessation
- 2011-05-13 SG SG2012084471A patent/SG185615A1/en unknown
- 2011-05-13 AU AU2011256455A patent/AU2011256455A1/en not_active Abandoned
- 2011-05-13 KR KR1020127032867A patent/KR20130113948A/ko not_active Application Discontinuation
- 2011-05-13 RU RU2012154308/04A patent/RU2012154308A/ru not_active Application Discontinuation
- 2011-05-13 WO PCT/US2011/036443 patent/WO2011146335A1/en active Application Filing
- 2011-05-13 JP JP2013511238A patent/JP2013530947A/ja not_active Withdrawn
- 2011-05-13 CA CA2799779A patent/CA2799779A1/en not_active Abandoned
- 2011-05-13 US US13/698,257 patent/US8754226B2/en not_active Expired - Fee Related
- 2011-05-13 CN CN2011800291586A patent/CN103080101A/zh active Pending
- 2011-05-17 UY UY0001033392A patent/UY33392A/es not_active Application Discontinuation
- 2011-05-17 AR ARP110101683A patent/AR081197A1/es unknown
- 2011-05-17 TW TW100117276A patent/TW201141849A/zh unknown
-
2012
- 2012-11-16 CL CL2012003211A patent/CL2012003211A1/es unknown
- 2012-11-18 IL IL223092A patent/IL223092A0/en unknown
- 2012-12-17 CR CR20120642A patent/CR20120642A/es unknown
- 2012-12-17 CO CO12228271A patent/CO6670520A2/es not_active Application Discontinuation
- 2012-12-18 ZA ZA2012/09605A patent/ZA201209605B/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2012013465A (es) | 2013-12-02 |
US8754226B2 (en) | 2014-06-17 |
SG185615A1 (en) | 2012-12-28 |
US20130158009A1 (en) | 2013-06-20 |
AR081197A1 (es) | 2012-07-04 |
EP2571864A1 (en) | 2013-03-27 |
JP2013530947A (ja) | 2013-08-01 |
CL2012003211A1 (es) | 2013-04-26 |
AU2011256455A1 (en) | 2013-01-10 |
TW201141849A (en) | 2011-12-01 |
IL223092A0 (en) | 2013-02-03 |
CR20120642A (es) | 2013-03-11 |
ZA201209605B (en) | 2014-05-28 |
WO2011146335A1 (en) | 2011-11-24 |
CO6670520A2 (es) | 2013-05-15 |
BR112012029395A2 (pt) | 2016-07-26 |
CA2799779A1 (en) | 2011-11-24 |
CN103080101A (zh) | 2013-05-01 |
KR20130113948A (ko) | 2013-10-16 |
RU2012154308A (ru) | 2014-06-27 |
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