UY32364A - Derivados oxadiazole como agonistas de los receptores de esfingosina-1-fosfato (s1p1) - Google Patents

Derivados oxadiazole como agonistas de los receptores de esfingosina-1-fosfato (s1p1)

Info

Publication number
UY32364A
UY32364A UY0001032364A UY32364A UY32364A UY 32364 A UY32364 A UY 32364A UY 0001032364 A UY0001032364 A UY 0001032364A UY 32364 A UY32364 A UY 32364A UY 32364 A UY32364 A UY 32364A
Authority
UY
Uruguay
Prior art keywords
alkyl
nrarb
carboxyalkyl
haloalkyl
hydroxyalkyl
Prior art date
Application number
UY0001032364A
Other languages
English (en)
Inventor
Nuria Aguilar Izquierdo;
Marta Carrascal Riera
Julio Cesar Castro Palomino Laria
Monserrat Erra Sola
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of UY32364A publication Critical patent/UY32364A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Compuestos de fórmula (I), sales o N-óxidos de los mismos farmacéuticamente aceptables, donde A : - N-, -O-y -S-; B y C : -N- y -O-, al menos 2 de A, B y C sean N; G1 : H, y -CRc-, Rc es H, halógeno, alquilo C1-4, o alcoxi C1-4; R1 : H, alquilo C1-4, alcoxi C1-4, cicloalquilo C3-4, y -NRdRe Rd y Re son independientemente H o alquilo C1-4; R2 y R3 : H, alquilo C1-4; R4 , R5 y R7 son independientemente H, halógeno, alquilo C1-4, alcoxi C1-4 y haloalquilo C1-4; R6 : alquilo C1-4 o hidroxialquio C1-4; o R6 es : -S(O)2-NRaRb, -(CRfRg)n-(CRhRi)x-(CRjRk)y-NRaRb, -(CH2)n-NRaRb, -(CH2)n-COOH, -(CH2)n-NRa-CO-Rb', -(CH2)n-NRa-(CH2)p-(NH)q-SO-CH3y - (CH2)n-CO-NRaRb, n,p,x e y, son enteros 0 a 3, q es 0 o 1, Rf, Rg, Rh, Ri, Rj y Rk independientemente H, halógeno, Rb' : metilsulfonilo, alquilo C1-4, hidroxiaquilo C1-4, carboxialquilo C1-4, y haloalquilo C1-4, o Ra y Rb : H, metilsulfonilo, alquilo C1-4, hidroxialquilo C1-4, carboxialquilo C1-4, y haloalquilo C1-4, o Ra y Rb con el N uni do forman heterocíclico saturado, 4 a 6 miembros teniendo, 1 o 2 átomos de N y sustituido con carboxilo o carboxialquilo C1-4; o Rc con R6 forman ani llo carbocíclico C5-8 opcionalmente sustituido con -NHR´ y R´ es H o carboxialquilo C1-4.
UY0001032364A 2009-01-19 2009-12-23 Derivados oxadiazole como agonistas de los receptores de esfingosina-1-fosfato (s1p1) UY32364A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09382004A EP2210890A1 (en) 2009-01-19 2009-01-19 Oxadiazole derivatives as S1P1 receptor agonists

Publications (1)

Publication Number Publication Date
UY32364A true UY32364A (es) 2010-02-26

Family

ID=40568602

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032364A UY32364A (es) 2009-01-19 2009-12-23 Derivados oxadiazole como agonistas de los receptores de esfingosina-1-fosfato (s1p1)

Country Status (17)

Country Link
US (1) US20110274657A1 (es)
EP (2) EP2210890A1 (es)
JP (1) JP2012515182A (es)
KR (1) KR20110110198A (es)
CN (1) CN102282144A (es)
AR (1) AR075022A1 (es)
AU (1) AU2010205825A1 (es)
BR (1) BRPI1005153A2 (es)
CA (1) CA2748394A1 (es)
EA (1) EA201101089A1 (es)
EC (1) ECSP11011200A (es)
IL (1) IL213630A0 (es)
MX (1) MX2011007455A (es)
SG (1) SG172452A1 (es)
TW (1) TW201028407A (es)
UY (1) UY32364A (es)
WO (1) WO2010081692A1 (es)

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Also Published As

Publication number Publication date
WO2010081692A1 (en) 2010-07-22
AR075022A1 (es) 2011-03-02
EP2210890A1 (en) 2010-07-28
EA201101089A1 (ru) 2012-02-28
MX2011007455A (es) 2011-08-03
TW201028407A (en) 2010-08-01
JP2012515182A (ja) 2012-07-05
EP2387571A1 (en) 2011-11-23
CA2748394A1 (en) 2010-07-22
AU2010205825A1 (en) 2011-07-07
IL213630A0 (en) 2011-07-31
US20110274657A1 (en) 2011-11-10
KR20110110198A (ko) 2011-10-06
SG172452A1 (en) 2011-07-28
ECSP11011200A (es) 2011-08-31
CN102282144A (zh) 2011-12-14
BRPI1005153A2 (pt) 2019-09-24

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