MX2011007455A - Derivados oxadiazol como agonistas de los receptores de esfingosina-1-fosfato 1 (s1p1). - Google Patents

Derivados oxadiazol como agonistas de los receptores de esfingosina-1-fosfato 1 (s1p1).

Info

Publication number
MX2011007455A
MX2011007455A MX2011007455A MX2011007455A MX2011007455A MX 2011007455 A MX2011007455 A MX 2011007455A MX 2011007455 A MX2011007455 A MX 2011007455A MX 2011007455 A MX2011007455 A MX 2011007455A MX 2011007455 A MX2011007455 A MX 2011007455A
Authority
MX
Mexico
Prior art keywords
group
receptor agonists
oxadiazole derivatives
slpl receptor
nitrogen atoms
Prior art date
Application number
MX2011007455A
Other languages
English (en)
Inventor
Nuria Aguilar Izquierdo
Marta Carrascal Riera
Julio Cesar Castro Palomino Laria
Montserrat Erra Sola
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of MX2011007455A publication Critical patent/MX2011007455A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

(ver fórmula (I)) La presente invención se relaciona con nuevos compuestos que tienen la estructura química de la fórmula (I) o las sales farmacéuticamente aceptables o N-óxidos de las mismas, en donde A se selecciona del grupo que consiste de - N-, -O- y -S-; B y C se seleccionan independientemente del grupo que consiste de -N- y -O-, con las condición de que por lo menos dos de A, B y C sean átomos de nitrógeno; G1 se selecciona del grupo que consiste de átomos de nitrógeno y los grupos -CRc-, en donde Rc representa un átomo de hidrógeno, un grupo alquilo C1-4 o un grupo alcoxi C1-4.(ver fórmula (I)).
MX2011007455A 2009-01-19 2010-01-14 Derivados oxadiazol como agonistas de los receptores de esfingosina-1-fosfato 1 (s1p1). MX2011007455A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09382004A EP2210890A1 (en) 2009-01-19 2009-01-19 Oxadiazole derivatives as S1P1 receptor agonists
PCT/EP2010/000158 WO2010081692A1 (en) 2009-01-19 2010-01-14 Oxadiazole derivatives as slpl receptor agonists

Publications (1)

Publication Number Publication Date
MX2011007455A true MX2011007455A (es) 2011-08-03

Family

ID=40568602

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011007455A MX2011007455A (es) 2009-01-19 2010-01-14 Derivados oxadiazol como agonistas de los receptores de esfingosina-1-fosfato 1 (s1p1).

Country Status (17)

Country Link
US (1) US20110274657A1 (es)
EP (2) EP2210890A1 (es)
JP (1) JP2012515182A (es)
KR (1) KR20110110198A (es)
CN (1) CN102282144A (es)
AR (1) AR075022A1 (es)
AU (1) AU2010205825A1 (es)
BR (1) BRPI1005153A2 (es)
CA (1) CA2748394A1 (es)
EA (1) EA201101089A1 (es)
EC (1) ECSP11011200A (es)
IL (1) IL213630A0 (es)
MX (1) MX2011007455A (es)
SG (1) SG172452A1 (es)
TW (1) TW201028407A (es)
UY (1) UY32364A (es)
WO (1) WO2010081692A1 (es)

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Also Published As

Publication number Publication date
AU2010205825A1 (en) 2011-07-07
CN102282144A (zh) 2011-12-14
EA201101089A1 (ru) 2012-02-28
KR20110110198A (ko) 2011-10-06
CA2748394A1 (en) 2010-07-22
TW201028407A (en) 2010-08-01
EP2387571A1 (en) 2011-11-23
WO2010081692A1 (en) 2010-07-22
IL213630A0 (en) 2011-07-31
BRPI1005153A2 (pt) 2019-09-24
UY32364A (es) 2010-02-26
EP2210890A1 (en) 2010-07-28
SG172452A1 (en) 2011-07-28
JP2012515182A (ja) 2012-07-05
ECSP11011200A (es) 2011-08-31
AR075022A1 (es) 2011-03-02
US20110274657A1 (en) 2011-11-10

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