UY30524A1 - Anticuerpos dirigidos a avb(beta)6 y sus usos - Google Patents

Anticuerpos dirigidos a avb(beta)6 y sus usos

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Publication number
UY30524A1
UY30524A1 UY30524A UY30524A UY30524A1 UY 30524 A1 UY30524 A1 UY 30524A1 UY 30524 A UY30524 A UY 30524A UY 30524 A UY30524 A UY 30524A UY 30524 A1 UY30524 A1 UY 30524A1
Authority
UY
Uruguay
Prior art keywords
beta
sequences
inclusive
antigen
alpha
Prior art date
Application number
UY30524A
Other languages
English (en)
Inventor
Simon Thomas Barry
Avril Alfred
Vahe Bedian
Ian Foltz
Julie Rinkenberger
Original Assignee
Astrazeneca Ab
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Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY30524A1 publication Critical patent/UY30524A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere

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Abstract

Se describen agentes de union dirigidos, anticuerpos de este tipo dirigidos al antígeno a(alfa) VB(Beta)6 y usos de dichos agentes. En particular, se describen anticuerpos monoclonales completamente humanos dirigidos al antígeno a(alfa)VB(Beta)6. Se describen secuencias de nucleotidos que codifican, y secuencias de aminoácios que comprenden, moléculas de inmunoglobulina de cadena pesada y liviana, en particular secuencias que se corresponden con secuencias contiguas de cadena pesada y liviana que abarcan las regiones estructurales (FR) y/o las regiones determinantes de la complementariedad (CDR), específicamente desde la FR1 hasta la FR4 inclusive, o desde la CDR1 hasta la CDR3 inclusive. Se describen asimismo hibridomas u otras íneas celulares que expresan dichas moléculas de inmunoglobulina y dichos anticuerpos monoclonales.
UY30524A 2006-08-03 2007-08-03 Anticuerpos dirigidos a avb(beta)6 y sus usos UY30524A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83555906P 2006-08-03 2006-08-03

Publications (1)

Publication Number Publication Date
UY30524A1 true UY30524A1 (es) 2008-02-29

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Application Number Title Priority Date Filing Date
UY30524A UY30524A1 (es) 2006-08-03 2007-08-03 Anticuerpos dirigidos a avb(beta)6 y sus usos

Country Status (18)

Country Link
US (4) US20080057063A1 (es)
EP (1) EP2064244B1 (es)
JP (2) JP5362563B2 (es)
KR (1) KR20090039739A (es)
CN (2) CN103524619B (es)
AR (1) AR062213A1 (es)
AU (1) AU2007348941B2 (es)
BR (1) BRPI0715141A2 (es)
CA (1) CA2658612C (es)
ES (1) ES2746925T3 (es)
IL (1) IL196848A0 (es)
MX (1) MX2009001293A (es)
NO (1) NO20090877L (es)
RU (1) RU2009107277A (es)
TW (1) TW200815474A (es)
UY (1) UY30524A1 (es)
WO (1) WO2008112004A2 (es)
ZA (1) ZA200900395B (es)

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CN101553505A (zh) 2009-10-07
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