BRPI0514537B8 - pyrazole substituted aminoeteroaryl compounds and pharmaceutical composition comprising them - Google Patents

pyrazole substituted aminoeteroaryl compounds and pharmaceutical composition comprising them

Info

Publication number
BRPI0514537B8
BRPI0514537B8 BRPI0514537A BRPI0514537A BRPI0514537B8 BR PI0514537 B8 BRPI0514537 B8 BR PI0514537B8 BR PI0514537 A BRPI0514537 A BR PI0514537A BR PI0514537 A BRPI0514537 A BR PI0514537A BR PI0514537 B8 BRPI0514537 B8 BR PI0514537B8
Authority
BR
Brazil
Prior art keywords
compounds
aminoeteroaryl
pharmaceutical composition
pyrazole substituted
protein kinase
Prior art date
Application number
BRPI0514537A
Other languages
Portuguese (pt)
Inventor
Shen Hong
Jialun Meng Jerry
Jean Cui Jingrong
Andrew Funk Lee
Jia Lei
Alan Pairish Mason
Bich Tran-Dube Michelle
David Nambu Mitchell
Kung Pei-Pei
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35677463&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0514537(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of BRPI0514537A publication Critical patent/BRPI0514537A/en
Publication of BRPI0514537B1 publication Critical patent/BRPI0514537B1/en
Publication of BRPI0514537B8 publication Critical patent/BRPI0514537B8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

compostos de aninoeteroarila substituídos com pirazol como inibidores de proteína quinase. são fornecidos compostos de fórmula i, assim como métodos para sua síntese e uso. os compostos preferidos são potentes inibidores de c-met proteína quinase, e são úteis no tratamento de distúrbios de crescimento anormal da célula, tais como cânceres.pyrazole substituted aninoheteroaryl compounds as protein kinase inhibitors. compounds of formula I are provided, as well as methods for their synthesis and use. preferred compounds are potent c-met protein kinase inhibitors, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

BRPI0514537A 2004-08-26 2005-08-15 pyrazole substituted aminoeteroaryl compounds and pharmaceutical composition comprising them BRPI0514537B8 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US60524404P 2004-08-26 2004-08-26
US60/605,244 2004-08-26
US69080305P 2005-06-14 2005-06-14
US60/690,803 2005-06-14
PCT/IB2005/002695 WO2006021881A2 (en) 2004-08-26 2005-08-15 Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors

Publications (3)

Publication Number Publication Date
BRPI0514537A BRPI0514537A (en) 2008-06-17
BRPI0514537B1 BRPI0514537B1 (en) 2020-05-12
BRPI0514537B8 true BRPI0514537B8 (en) 2021-05-25

Family

ID=35677463

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514537A BRPI0514537B8 (en) 2004-08-26 2005-08-15 pyrazole substituted aminoeteroaryl compounds and pharmaceutical composition comprising them

Country Status (44)

Country Link
US (1) US20060128724A1 (en)
EP (1) EP1784396B8 (en)
JP (1) JP4167295B2 (en)
KR (1) KR100869393B1 (en)
CN (1) CN101018780B (en)
AP (1) AP2332A (en)
AR (1) AR050529A1 (en)
AT (1) ATE492544T1 (en)
AU (1) AU2005276132B2 (en)
BR (1) BRPI0514537B8 (en)
CA (1) CA2577937C (en)
CR (2) CR8938A (en)
CY (1) CY1111138T1 (en)
DE (1) DE602005025499D1 (en)
DK (1) DK1784396T3 (en)
EA (1) EA011725B1 (en)
EC (1) ECSP077278A (en)
ES (1) ES2355923T3 (en)
GE (1) GEP20094845B (en)
GT (1) GT200500226A (en)
HK (1) HK1105415A1 (en)
HN (1) HN2005000477A (en)
HR (1) HRP20110116T1 (en)
IL (1) IL181045A0 (en)
MA (1) MA28827B1 (en)
ME (1) ME01309B (en)
MX (1) MX2007002310A (en)
MY (1) MY139942A (en)
NI (1) NI200700058A (en)
NL (1) NL1029809C2 (en)
NO (1) NO338656B1 (en)
NZ (1) NZ552946A (en)
PA (1) PA8643201A1 (en)
PE (1) PE20060651A1 (en)
PL (1) PL1784396T3 (en)
PT (1) PT1784396E (en)
RS (1) RS51601B (en)
SI (1) SI1784396T1 (en)
SV (1) SV2006002208A (en)
TN (1) TNSN07071A1 (en)
TW (1) TWI300411B (en)
UY (1) UY29080A1 (en)
WO (1) WO2006021881A2 (en)
ZA (1) ZA200701281B (en)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS53118B (en) * 2003-02-26 2014-06-30 Sugen Inc. Aminoheteroaryl compounds as protein kinase inhibitors
KR100859891B1 (en) * 2004-08-26 2008-09-23 화이자 인코포레이티드 Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
US20070072908A1 (en) * 2005-06-08 2007-03-29 Japan Tobacco Inc. Heterocyclic compounds
PT1959955E (en) * 2005-12-05 2011-01-04 Pfizer Prod Inc Method of treating abnormal cell growth
CA2632283C (en) * 2005-12-05 2011-06-21 Pfizer Products Inc. Polymorphs of a c-met/hgfr inhibitor
BRPI0717320A2 (en) 2006-10-23 2013-10-22 Sgx Pharmaceuticals Inc Bicyclic triazols as protein kinase modulators
GB0621607D0 (en) * 2006-10-31 2006-12-06 Chroma Therapeutics Ltd Inhibitors of c-Met
UY30779A1 (en) 2006-12-14 2008-07-31 Bayer Schering Pharma Ag USED DIHYDROPIRIDINE DERIVATIVES AS INHIBITORS OF PROTEIN QUINASE
CA2675755C (en) 2007-01-19 2015-10-06 Xcovery, Inc. Pyridine and pyridazine derivatives as kinase inhibitors
EP2851091B1 (en) 2007-04-13 2017-12-27 Dana-Farber Cancer Institute, Inc. Methods for treating cancer resistant to ERBB therapeutics
US8263585B2 (en) 2007-05-04 2012-09-11 Novartis Ag Organic compounds
DE102007026341A1 (en) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
KR101586503B1 (en) 2007-09-13 2016-01-18 코덱시스, 인코포레이티드 Ketoreductase polypeptides for the reduction of acetophenones
KR20100089090A (en) 2007-10-25 2010-08-11 아스트라제네카 아베 Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders
JP2011511005A (en) 2008-02-04 2011-04-07 オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド 2-aminopyridine kinase inhibitor
AR070317A1 (en) 2008-02-06 2010-03-31 Osi Pharm Inc FURO (3,2-C) PIRIDINE AND HAVING (3,2-C) PIRIDINES
US8268834B2 (en) * 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
JPWO2009131173A1 (en) 2008-04-23 2011-08-18 協和発酵キリン株式会社 2-Aminoquinazoline derivatives
KR101034351B1 (en) * 2008-05-14 2011-05-16 한국화학연구원 Novel benzoxazole-pyridine derivatives or pharmaceutically acceptable salt thereof, preparation method thereof and pharmaceutical composition for the prevention and treatment of abnormal cell growth diseases containing the same as an active ingredient
JP5670325B2 (en) 2008-06-19 2015-02-18 エックスカバリー ホールディング カンパニー エルエルシー Substituted pyridazine carboxamide compounds as kinase inhibitor compounds
EP2356116A1 (en) 2008-11-20 2011-08-17 OSI Pharmaceuticals, Inc. Substituted pyrroloý2,3-b¨-pyridines and-pyrazines
DE102009003975A1 (en) 2009-01-07 2010-07-08 Merck Patent Gmbh Benzothiazolonderivate
WO2010138663A1 (en) * 2009-05-28 2010-12-02 Vertex Pharmaceuticals Incorporated Substituted pyrazole inhibitors of c-met protein kinase
EP3072890B1 (en) 2009-07-07 2018-10-17 MEI Pharma, Inc. Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
DE102009056886A1 (en) 2009-12-03 2011-06-09 Bayer Schering Pharma Aktiengesellschaft cMet inhibitors for the treatment of endometriosis
EP2534156A1 (en) * 2010-02-11 2012-12-19 OSI Pharmaceuticals, LLC 7-aminofuropyridine derivatives
EA201290822A1 (en) * 2010-02-22 2013-03-29 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи TRIAZOLONES AS FATTY ACIDS SYNTHASE INHIBITORS
US20120329826A1 (en) 2010-03-03 2012-12-27 OSI Pharmaceuticals,. LLC Substituted-5-aminopyrrolo/pyrazolopyridines
US8916593B2 (en) 2010-05-04 2014-12-23 Pfizer Inc. Alkoxy-substituted 2-aminopyridines as ALK inhibitors
US8513238B2 (en) * 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
WO2011143646A1 (en) 2010-05-14 2011-11-17 OSI Pharmaceuticals, LLC Fused bicyclic kinase inhibitors
AR081039A1 (en) 2010-05-14 2012-05-30 Osi Pharmaceuticals Llc QUINASA FUSIONED BICYCLE INHIBITORS
EP2571878B1 (en) 2010-05-17 2018-10-17 Incozen Therapeutics Pvt. Ltd. Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b]pyridine compounds as modulators of protein kinases
CN101857594B (en) * 2010-06-18 2013-04-03 南方医科大学 Tetrahydropyridoindole compounds, and preparation method and application thereof
WO2012003338A1 (en) 2010-07-01 2012-01-05 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
AU2011276955B2 (en) * 2010-07-09 2014-11-06 The Walter And Eliza Hall Institute Of Medical Research Protein kinase inhibitors and methods of treatment
CN101967140A (en) * 2010-09-14 2011-02-09 郑州泰基鸿诺药物科技有限公司 Deuterated crizotinib as well as derivant, preparation method and application thereof
ES2610226T3 (en) 2010-10-08 2017-04-26 Xcovery Holding Company Llc 6-Amino-pyridazin-3-yl-carboxamide compounds substituted as protein kinase modulators
US9145390B2 (en) 2011-03-03 2015-09-29 Concert Pharmaceuticals, Inc. Derivatives of pyrazole-substituted amino-heteroaryl compounds
TWI572599B (en) 2011-03-28 2017-03-01 Ｍｅｉ製藥公司 (alpha-substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases
WO2012158658A1 (en) 2011-05-16 2012-11-22 OSI Pharmaceuticals, LLC Fused bicyclic kinase inhibitors
CN102850328B (en) * 2011-07-01 2014-12-24 苏州东南药业股份有限公司 Pyridine chemical, its preparation method, and pharmaceutical composition containing the chemical and application thereof
CN103732588B (en) * 2011-07-27 2016-10-12 南京奥昭生物科技有限公司 Spiro molecules is as kinases inhibitor
CA2842493A1 (en) * 2011-08-02 2013-02-07 James Gail Christensen Crizotinib for use in the treatment of cancer
CN103842353A (en) * 2011-09-21 2014-06-04 苏州韬略生物科技有限公司 Pyridines compounds as inhibitors of kinase
CN103087050A (en) * 2011-10-28 2013-05-08 山东轩竹医药科技有限公司 Aryl kinase inhibitor
GEP201606560B (en) 2012-03-06 2016-10-25 Pfizer Macrocyclic derivatives for the treatment of proliferative diseases
CN103304552B (en) * 2012-03-09 2016-12-28 广东东阳光药业有限公司 Substituted pyridine compounds and using method thereof and purposes
WO2013138210A1 (en) * 2012-03-14 2013-09-19 Ning Xi Substituted cyclic compounds and methods of use
SG10201507714XA (en) 2012-03-16 2015-10-29 Axikin Pharmaceuticals Inc 3,5-diaminopyrazole kinase inhibitors
CN103319468B (en) * 2012-03-21 2016-07-13 广东东阳光药业有限公司 The spiral shell dicyclic compound replaced and using method and purposes
WO2013144191A1 (en) 2012-03-29 2013-10-03 Bayer Intellectual Property Gmbh Substituted 2-amino-3-cyanopyridines as inhibitors of sodium-calcium exchange and use thereof for cardiovascular diseases
WO2013144737A2 (en) 2012-03-30 2013-10-03 Rhizen Pharmaceuticals Sa Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of c-met protein kinases
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
CN103373986B (en) * 2012-04-22 2016-10-05 东南大学 (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine prodrug and preparation method thereof and purposes
KR101582852B1 (en) 2012-05-24 2016-01-07 서울대학교 산학협력단 Therapeutics for the treatment of neurodegenerative diseases mediated by Tau proteins
WO2013181251A1 (en) 2012-05-29 2013-12-05 Ratiopharm Gmbh Crizotinib hydrochloride salt in crystalline
GB201211310D0 (en) * 2012-06-26 2012-08-08 Chroma Therapeutics Ltd CSF-1R kinase inhibitors
WO2014020467A2 (en) 2012-07-30 2014-02-06 Fresenius Kabi Oncology Ltd Process for the preparation of pyrazole substituted aminoheteroaryl compounds
JO3215B1 (en) 2012-08-09 2018-03-08 Phenex Pharmaceuticals Ag Carboxamide or Sulfonamide Substituted Nitrogen-Containing 5-Membered Heterocycles as Modulators for the Orphan Nuclear Receptor RORy
AU2013307383A1 (en) 2012-08-27 2015-03-26 Cemm - Forschungszentrum Fur Molekulare Medizin Gmbh Aminoheteroaryl compounds as MTH1 inhibitors
CN103720691A (en) * 2012-10-11 2014-04-16 韩冰 Compound for treating cerebral palsy and use thereof
WO2014060381A1 (en) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclic compounds as pesticides
US20150299170A1 (en) * 2012-11-21 2015-10-22 Concert Pharmaceuticals, Inc. Fluoro-derivatives of pyrazole-substituted amino-heteroaryl compounds
RU2015131314A (en) * 2013-01-18 2017-02-27 Ф. Хоффманн-Ля Рош Аг 3-SUBSTITUTED PYRAZOLES AND THEIR APPLICATION AS DLK INHIBITORS
CA2899968C (en) * 2013-02-02 2016-12-20 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Substituted 2-aminopyridine protein kinase inhibitor
CN103992307B (en) 2013-02-16 2017-07-14 浙江九洲药物科技有限公司 A kind of preparation method of (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
WO2014139391A1 (en) * 2013-03-11 2014-09-18 Teligene Ltd Substituted pyridine compounds as kinases inhibitors
US9447079B2 (en) 2013-03-14 2016-09-20 Epizyme, Inc. PRMT1 inhibitors and uses thereof
US9365527B2 (en) 2013-03-14 2016-06-14 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
WO2014153214A1 (en) 2013-03-14 2014-09-25 Epizyme, Inc. Arginine methyl transferase inhibtors and uses thereof
US9120757B2 (en) 2013-03-14 2015-09-01 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
US9045455B2 (en) 2013-03-14 2015-06-02 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
US9023883B2 (en) 2013-03-14 2015-05-05 Epizyme, Inc. PRMT1 inhibitors and uses thereof
US9776972B2 (en) 2013-03-14 2017-10-03 Epizyme Inc. Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof
WO2014153235A2 (en) 2013-03-14 2014-09-25 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
BR112015022785A2 (en) 2013-03-14 2017-07-18 Epizyme Inc compound; pharmaceutical composition; packaged pharmaceutical kit or article; method of inhibiting an arginine methyl transferase (rmt); method of modulating gene expression; transcription modulation method; and method of treating an rmt-mediated disorder
CN104059054B (en) * 2013-03-19 2018-11-20 浙江导明医药科技有限公司 Three-level cyclic amine ALK kinase inhibitor for treating cancer
WO2014203177A1 (en) * 2013-06-18 2014-12-24 Shilpa Medicare Limited Amorphous (r) -3- [1- (2, 6-dichloro-3-fluorophenyl) methoxy] -5- [1- (piperidin-4- yl) -1h-pyrazol-4-yl] pyridin-2-amine
CN104230890A (en) * 2013-06-19 2014-12-24 信诺凯（北京）化工有限公司 Pyridine-2-amine derivative as well as preparation method, medicine compositions and application thereof
CN104650049B (en) * 2013-08-28 2018-06-08 广东东阳光药业有限公司 Substituted pyridine compounds and its application method and purposes
KR101598664B1 (en) 2013-09-04 2016-03-02 씨제이헬스케어 주식회사 Protein kinase inhibitors comprising a pyrrolopyridazine derivative
WO2015034729A1 (en) * 2013-09-05 2015-03-12 Calitor Sciences, Llc Substituted pyridine compounds and methods of use
NZ631142A (en) 2013-09-18 2016-03-31 Axikin Pharmaceuticals Inc Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
EP3053923B1 (en) 2013-09-30 2018-04-11 Korea Research Institute of Chemical Technology Triazolopyrazine derivatives as tyrosin kinase inhibitors
MA39776A (en) 2014-03-24 2017-02-01 Hoffmann La Roche Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
WO2015172747A1 (en) * 2014-05-16 2015-11-19 Zhaoyin Wang Spirocyclic molecules as mth1 inhibitors
US10695426B2 (en) 2014-08-25 2020-06-30 Pfizer Inc. Combination of a PD-1 antagonist and an ALK inhibitor for treating cancer
WO2016044576A1 (en) * 2014-09-17 2016-03-24 Epizyme, Inc. Salts, co-crystals, amorphous forms, and crystalline forms of an arginine methyltransferase inhibitor
CN104402868B (en) * 2014-11-04 2016-08-24 郑州泰基鸿诺医药股份有限公司 Deuterated Crizotinib crystal formation and preparation method thereof
JP6864953B2 (en) 2014-12-09 2021-04-28 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Human monoclonal antibody against AXL
CN107250116B (en) 2014-12-23 2020-10-27 艾士盟医疗公司 3, 5-diaminopyrazole kinase inhibitors
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
WO2016145383A1 (en) * 2015-03-11 2016-09-15 Board Of Regents, University Of Texas System Mth1 inhibitors for treating disease
US10259816B2 (en) 2015-04-24 2019-04-16 Guangzhou Maxinovel Pharmaceuticals Co., Ltd. Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical composition and applications thereof
CN106279112A (en) * 2015-06-12 2017-01-04 浙江九洲药业股份有限公司 A kind of Crizotinib intermediate and its preparation method and application
EP3355902B1 (en) 2015-09-30 2022-04-13 Merck Patent GmbH Combination of a pd-1 axis binding antagonist and an alk inhibitor for treating alk-negative cancer
JP7169195B2 (en) 2016-05-20 2022-11-10 バイオヘイブン・ファーマシューティカル・ホールディング・カンパニー・リミテッド Combination of riluzole, riluzole prodrugs or riluzole analogues with immunotherapy to treat cancer
TWI646094B (en) 2016-06-01 2019-01-01 大陸商貝達藥業股份有限公司 Crystal form of inhibitory protein kinase active compound and application thereof
CN106632260B (en) * 2016-09-29 2019-04-26 上海天慈生物谷生物工程有限公司 A kind of preparation method of small molecule kinase inhibitors
CA3063976A1 (en) 2017-05-23 2018-11-29 Mei Pharma, Inc. Combination therapy
SG11202001258UA (en) 2017-08-14 2020-03-30 Mei Pharma Inc Combination therapy
CN110372664A (en) * 2018-04-13 2019-10-25 华东理工大学 Selective JAK2 inhibitor and its application
KR102207608B1 (en) 2019-04-24 2021-01-26 윤종오 Process for producing silicon ion complexes and complexes organicized with carboxylic acid and products using the same

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587458A (en) * 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
EP0625200B1 (en) * 1992-02-06 2005-05-11 Chiron Corporation Biosynthetic binding protein for cancer marker
US5863949A (en) * 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
CA2218503C (en) * 1995-04-20 2001-07-24 Pfizer Inc. Arylsulfonyl hydroxamic acid derivatives
US5747498A (en) * 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
GB9518953D0 (en) * 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
JPH11512750A (en) * 1996-06-27 1999-11-02 ファイザー インク． Derivatives of 2- (2-oxo-ethylidene) -imidazolidin-4-one and their use as farnesyl protein transferase inhibitors
JPH11236333A (en) * 1997-12-30 1999-08-31 Pfizer Prod Inc Imidazolin-4-one derivative as anticancer agent
SK2442001A3 (en) * 1998-08-27 2002-10-08 Pfizer Prod Inc Alkynyl-substituted quinolin-2-ones, pharmaceutical compositions, their use in the treatment and method for producing thereof
JP3494409B2 (en) * 1998-08-27 2004-02-09 ファイザー・プロダクツ・インク Alkynyl-substituted quinolin-2-one derivatives useful as anticancer agents
EP1006113A1 (en) * 1998-12-02 2000-06-07 Pfizer Products Inc. Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth
EE05627B1 (en) * 1998-12-23 2013-02-15 Pfizer Inc. Human monoclonal antibodies to CTLA-4
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
JP3270834B2 (en) * 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク Heteroaromatic bicyclic derivatives useful as anticancer agents
TR200201297T2 (en) * 1999-02-11 2002-06-21 Pfizer Products Inc. Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents.
US6586447B1 (en) * 1999-04-01 2003-07-01 Pfizer Inc 3,3-disubstituted-oxindole derivatives useful as anticancer agents
EP1081137A1 (en) * 1999-08-12 2001-03-07 Pfizer Products Inc. Selective inhibitors of aggrecanase in osteoarthritis treatment
DK1106612T3 (en) * 1999-11-30 2004-05-17 Pfizer Prod Inc Quinoline derivatives useful for inhibiting farnesyl protein transferase
HN2000000266A (en) * 2000-01-21 2001-05-21 Pfizer Prod Inc ANTI-TARGET COMPOUND AND METHOD OF SEPARATION OF ENANTIOMERS USEFUL TO SYNTHEIZE SUCH COMPOUND.
US6844357B2 (en) * 2000-05-01 2005-01-18 Pfizer Inc. Substituted quinolin-2-one derivatives useful as antiproliferative agents
SE0102439D0 (en) * 2001-07-05 2001-07-05 Astrazeneca Ab New compounds
SE0102438D0 (en) * 2001-07-05 2001-07-05 Astrazeneca Ab New compounds
AU2003206109A1 (en) * 2002-02-06 2003-09-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Catechol bioisosteres
JP2005538975A (en) * 2002-07-03 2005-12-22 アステックス テクノロジー リミテッド 3- (Hetero) arylmethoxypyridines and their analogs as p38 MAP kinase inhibitors
AU2003247141A1 (en) * 2002-08-01 2004-02-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem 4-anilido substituted quinazolines and use thereof as inhibitors of epidermal growth factor receptor kinases
SE0203754D0 (en) * 2002-12-17 2002-12-17 Astrazeneca Ab New compounds
DE10307845A1 (en) * 2003-02-25 2004-09-02 Bayer Cropscience Gmbh Heterocyclic amides, processes for their preparation, compositions containing them and their use as pesticides
RS53118B (en) * 2003-02-26 2014-06-30 Sugen Inc. Aminoheteroaryl compounds as protein kinase inhibitors
KR100859891B1 (en) * 2004-08-26 2008-09-23 화이자 인코포레이티드 Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors

Also Published As

Publication number Publication date
EA011725B1 (en) 2009-04-28
NO20071320L (en) 2007-05-29
DE602005025499D1 (en) 2011-02-03
NL1029809A1 (en) 2006-02-28
GT200500226A (en) 2006-04-10
PE20060651A1 (en) 2006-07-19
CR8938A (en) 2007-08-14
CN101018780A (en) 2007-08-15
AR050529A1 (en) 2006-11-01
JP4167295B2 (en) 2008-10-15
AP2332A (en) 2011-12-05
CA2577937C (en) 2010-12-21
ECSP077278A (en) 2007-03-29
NZ552946A (en) 2010-09-30
KR100869393B1 (en) 2008-11-21
UY29080A1 (en) 2006-03-31
PT1784396E (en) 2011-01-27
NO338656B1 (en) 2016-09-26
MY139942A (en) 2009-11-30
PL1784396T3 (en) 2011-05-31
US20060128724A1 (en) 2006-06-15
WO2006021881A2 (en) 2006-03-02
HK1105415A1 (en) 2008-04-03
KR20070038569A (en) 2007-04-10
CN101018780B (en) 2012-01-11
ME01309B (en) 2013-12-20
ATE492544T1 (en) 2011-01-15
IL181045A0 (en) 2007-07-04
DK1784396T3 (en) 2011-02-14
GEP20094845B (en) 2009-11-25
WO2006021881A3 (en) 2006-05-18
NI200700058A (en) 2008-03-07
EA200700321A1 (en) 2007-08-31
AU2005276132A1 (en) 2006-03-02
NL1029809C2 (en) 2006-10-17
MX2007002310A (en) 2007-05-08
BRPI0514537B1 (en) 2020-05-12
AU2005276132B2 (en) 2011-09-29
CR20120421A (en) 2012-09-14
JP2008510788A (en) 2008-04-10
CY1111138T1 (en) 2015-06-11
EP1784396A2 (en) 2007-05-16
BRPI0514537A (en) 2008-06-17
RS51601B (en) 2011-08-31
AP2007003906A0 (en) 2007-02-28
EP1784396B1 (en) 2010-12-22
EP1784396B8 (en) 2011-04-20
MA28827B1 (en) 2007-08-01
TW200621751A (en) 2006-07-01
TNSN07071A1 (en) 2008-06-02
SI1784396T1 (en) 2011-03-31
TWI300411B (en) 2008-09-01
PA8643201A1 (en) 2006-06-02
ZA200701281B (en) 2008-12-31
CA2577937A1 (en) 2006-03-02
SV2006002208A (en) 2006-10-04
HRP20110116T1 (en) 2011-03-31
HN2005000477A (en) 2010-06-09
ES2355923T3 (en) 2011-04-01

Similar Documents

Publication Publication Date Title
BRPI0514537B8 (en) pyrazole substituted aminoeteroaryl compounds and pharmaceutical composition comprising them
BRPI0513915A (en) enantiomerically pure aminoetheroaryl compounds as protein kinase inhibitors
BRPI0514687A (en) amino heteroaryl compounds as protein tyrosine kinase inhibitors
ECSP077271A (en) PIRIMIDINE DERIVATIVES
ECSP077259A (en) PIRIMIDINE DERIVATIVES
BRPI0509369A (en) azaindoles useful as inhibitors of jak and other protein kinases
UY29781A1 (en) DIAZASPIRO SUBSTITUTE COMPOUNDS, PHARMACEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS OR SALTS, PREPARATION METHODS AND USES
ECSP077985A (en) PROTEIN CINASE INHIBITORS DERIVED FROM PIRROL (2,3-B) PIRIDINE
CY1115188T1 (en) POLYCyclic Heteroaryl-Substituted Triazoles Useful as AXL Suspensions
SV2003001148A (en) DERIVATIVES OF BENZAMIDA TIAZOL AND PHARMACEUTICAL COMPOSTIONS TO INHIBIT THE PROLIFERATION OF CELLS, AND METHODS FOR ITS USE REF. NO.0097-01-SV
ECSP056194A (en) DERIVATIVES OF PIRAZOLO-QUINAZOLINA, PROCEDURE FOR ITS PREPARATION AND ITS USE AS QUINASA INHIBITORS
DK1791830T3 (en) Diaminotriazole compounds useful as protein kinase inhibitors
CR9365A (en) COMPOUNDS AND METHODS FOR THE INHIBITION OF THE PROTEIN-CINASA RAF
ATE430747T1 (en) 2-PYRIMIDINYL-PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS
ECSP088145A (en) BICYCLIC DERIVATIVES AS INHIBITORS OF CINASA P38
UY29767A1 (en) BENZOTIAZOLONAS DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND APPLICATIONS
SV2010003559A (en) SOME DERIVATIVES OF 2-PIRAZINONA AND ITS USE AS INHIBITORS OF ELASTASA DE LOS NEUTROFILOS
MX2008001538A (en) 2-aminoaryl pyridines as protein kinases inhibitors.
UY29591A1 (en) AMINOPIRIMIDINS AS KINASE MODULATORS
ECSP066767A (en) DERIVATIVES 1H-TIENO [2,3-C] PIRAZOL USEFUL AS QUINASE INHIBITORS
CR7961A (en) AMINOHETEROARILO COMPOUNDS AS INHIBITORS OF PROTEINQUINASES
BRPI0512986A (en) new hydantoin derivatives
UY28783A1 (en) NEW DERIVATIVES OF 4-BENZIMIDAZOL-2-IL-PIRIDACIN-3-ONA
ECSP045219A (en) DERIVATIVES OF QUINAZOLINONA AND ITS USE AS CB AGONISTS
SE0300457D0 (en) Novel compounds

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/05/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/08/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B25G Requested change of headquarter approved

Owner name: PFIZER INC. (US)