US6001128A - Materials for use in glaucoma filtration devices - Google Patents
Materials for use in glaucoma filtration devices Download PDFInfo
- Publication number
- US6001128A US6001128A US09/086,883 US8688398A US6001128A US 6001128 A US6001128 A US 6001128A US 8688398 A US8688398 A US 8688398A US 6001128 A US6001128 A US 6001128A
- Authority
- US
- United States
- Prior art keywords
- methacrylate
- ethyl
- monomer
- ethyl methacrylate
- nothing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/901—Method of manufacturing prosthetic device
Definitions
- the present invention relates to the field of ophthalmology. More specifically, the invention relates to polymeric materials for use in the manufacture of glaucoma filtration devices.
- elevated intraocular pressure is one of the symptoms associated with the development of glaucoma. Elevations of intraocular pressure can ultimately lead to impairment or loss of normal visual function due to damage to the optic nerve. It is also known that the elevated intraocular pressure is caused by an excess of fluid (i.e., aqueous humor) within the eye. The excess intraocular fluid is believed to result from blockage or impairment of the normal drainage of fluid from the eye via the trabecular meshwork.
- the current drug therapies for treating glaucoma attempt to control intraocular pressure by means of increasing the drainage or "outflow" of aqueous humor from the eye or decreasing the production or "inflow” of aqueous humor by the ciliary processes of the eye.
- patients become refractory to drug therapy.
- the use of drug therapy alone is not sufficient to adequately control intraocular pressure, particularly if there is a severe blockage of the normal passages for the outflow of aqueous humor.
- some patients require surgical intervention to correct the impaired outflow of aqueous humor and thereby normalize or at least control their intraocular pressure.
- the outflow of aqueous humor can be improved by means of intraocular surgical procedures known to those skilled in the art as trabeculectomy procedures. These procedures are collectively referred to herein as "glaucoma filtration surgery.”
- the procedures utilized in glaucoma filtration surgery generally involve the creation of a fistula to promote the drainage of aqueous humor into a surgically prepared filtration bleb.
- filtration devices have been used to shunt aqueous humor via a cannula from the anterior chamber into a dispersing device implanted beneath a surgically created bleb.
- a number of designs for filtration implants are known. See, for example, Prata et al., Ophthalmol. 102:894-904 (1995) which reviews a variety of available filtration implants made from polypropylene, polymethylmethacrylate or silicone materials. See also, Hoskins et al., Ophthalmic Surgery 23:702-707 (1992).
- Wound fibroplasia is a common cause of failure for glaucoma filtration devices.
- the fibroplasia results in encapsulation of the device, limiting aqueous humor outflow.
- There is a need for an improved glaucoma filtration device material which exhibits flexibility, is resistant to bioerosion and tissue adhesion, and does not elicit a significant immune response.
- This invention is directed to glaucoma filtration device materials comprising one or more monomers having the following structure: ##STR2## wherein: X is H or CH 3 ;
- n 0-10;
- Y is nothing, O, or S
- R is nothing, H, or an aliphatic, aromatic or aliphatic/aromatic combination of up to twelve carbon atoms, which can be unsubstituted or substituted with Cl, F, Br, or an alkoxy of up to four carbon atoms;
- cross-linking monomer having two or more ethylenically unsaturated groups.
- the glaucoma filtration device material of the present invention comprises one or more monomers of Formula I: ##STR3## wherein: X is H or CH 3 ;
- n 0-10;
- Y is nothing, O, or S
- R is nothing, H, or an aliphatic, aromatic or aliphatic/aromatic combination of up to twelve carbon atoms, which can be unsubstituted or substituted with Cl, F, Br, or an alkoxy of up to four carbon atoms;
- cross-linking monomer having two or more ethylenically unsaturated groups.
- Suitable monomers of the above formula include, but are not limited to: 2-ethylphenoxy methacrylate; 2-ethylthiophenyl methacrylate; 2-ethylaminophenyl methacrylate; phenyl methacrylate; benzyl methacrylate; 2-phenylethyl methacrylate; 3-phenylpropyl methacrylate; 4-phenylbutyl methacrylate; 4-methylphenyl methacrylate; 4-methylbenzyl methacrylate; 2-2-methylphenylethyl methacrylate; 2-3-methylphenylethyl methacrylate; 2-4-methylphenylethyl methacrylate; 2-(4-propylphenyl)ethyl methacrylate; 2-(4-(1-methylethyl)phenyl)ethyl methacrylate; 2-(4-methoxyphenyl)ethyl methacrylate; 2-(4-cyclohexylpheny
- the copolymerizable cross-linking agent used in the polymers of this invention may be any ethylenically unsaturated compound having more than one unsaturated group.
- Suitable cross-linking agents include, for example: ethylene glycol dimethacrylate; diethylene glycol dimethacrylate; allyl methacrylate; 1,3-propanediol dimethacrylate; allyl methacrylate; 1,6-hexanediol dimethacrylate; 1,4-butanediol dimethacrylate; and the like, including their corresponding acrylates.
- a preferred cross-linking agent is 1,4-butanediol diacrylate (BDDA).
- the glaucoma filtration device materials of the present invention may comprise homopolymers of monomers of Formula (I) or copolymers of two or more different monomers of Formula (I). It will be understood by those skilled in the art, that among polymers of acrylic esters, those made from acrylate monomers tend to have lower glass transition temperatures and to be more flexible than polymers of methacrylate. Accordingly, if a relatively flexible material is desired, the glaucoma drainage device materials of this invention will generally comprise copolymers containing a greater mole percent of acrylate monomers of Formula I, than of methacrylate monomers of Formula I.
- the acrylate monomers constitute from about 60 mole percent to about 95 mole percent of the material, while the methacrylate monomers constitute from about 5 mole percent to about 40 mole percent.
- a copolymer comprising about 60-70 mole percent 2-phenylethyl acrylate (PEA) wherein, in Formula (I), X is H, m is 2, Y is nothing and R is benzene; and about 30-40 mole percent 2-phenylethyl methacrylate (PEMA), wherein, in Formula (I), X is CH 3 , m is 2, Y is nothing and R is benzene.
- PEA 2-phenylethyl acrylate
- PEMA 2-phenylethyl methacrylate
- the proportion of the monomers is preferably chosen to produce a polymer material having a glass transition temperature not greater than about 37° C., which is normal human body temperature. Polymers having glass transition temperatures higher than 37° C. would only be flexible at temperatures above 37° C. It is preferred to use polymers having a glass transition temperature somewhat below normal body temperature and no greater than normal room temperature, e.g., about 20° C.-25° C., in order that the glaucoma filtration devices can be conveniently manipulated at room temperature.
- the glaucoma filtration device materials must exhibit sufficient strength to allow them to be manipulated by the surgeon without fracturing or otherwise suffering significant damage.
- Polymeric materials exhibiting an elongation of at least 150% are preferred. Most preferably, the polymeric materials exhibit an elongation of at least 200%.
- Glaucoma filtration devices made from polymeric materials which break at less than 150% elongation may not endure the distortion which necessarily occurs when they are surgically implanted.
- the polymeric materials of this invention are prepared by generally conventional polymerization methods.
- a mixture of the liquid monomers in the desired proportions together with a conventional thermal free-radical initiator is prepared.
- the mixture can then be introduced into a mold of suitable shape to form the desired glaucoma filtration device.
- Polymerization may be carried out by gentle heating to activate the initiator, for example.
- Typical thermal free radical initiators include peroxides, such as benzophenone peroxide, peroxycarbonates, such as bis-(4-t-butylcyclohexyl) peroxydicarbonate, azonitriles, such as azobisisobutyronitrile, and the like.
- a preferred initiator is bis-(4-t-butylcyclohexyl) peroxydicarbonate (PERK).
- the monomers can be photopolymerized by using a mold which is transparent to actinic radiation of a wavelength capable of initiating polymerization of these acrylic monomers by itself.
- Conventional photoinitiator compounds e.g., a benzophenone-type photoinitiator, can also be introduced to facilitate the polymerization.
- Photosensitizers can be introduced as well to permit the use of longer wavelengths; however, in preparing a polymer which is intended for long residence within the eye, it is generally preferable to keep the number of ingredients in the polymer to a minimum to avoid the presence of materials which might leach from the glaucoma filtration device into the interior of the eye.
- glaucoma filtration devices Many designs of glaucoma filtration devices are known.
- the polymeric materials of the present invention can be used in the manufacture of glaucoma filtration of virtually any design, including, for example, those designs known as the Molteno, Ahmed, Baerveldt, Krupin disk and OptiMed glaucoma implants. See, Prata et al., Ophthalmol. 102:894-904 (1995), the entire contents of which are hereby incorporated by reference. See also, U.S. Pat. No. 5,476,445, which discloses the Baerveldt implant in detail, but with silicone elastomeric materials rather than the acrylic materials of the present invention.
- International Publication No. WO 95135078 which discloses a sclerotomy implant. The entire contents of U.S. Pat. No. 5,476,445 and WO 95/35078 are also incorporated by reference.
- the preferred filtration device material of the present invention comprises a copolymer of about 65 parts by weight PEA, 30 parts by weight PEMA and 3.2 parts by weight BDDA.
- the filtration device materials of the present invention can be molded in, for example, polypropylene molds. After curing the polymeric material, the mold containing the cured material can then be shaped or cut to the desired shape. This shaped mold may then be easily mounted to carry out any contouring operations prior to removing the mold. Shaping operations may be easier to perform if the molded material is first cooled to less than 10° C. and preferably less than 0° C.
- a mixture of 90 mole percent 2-phenylethyl acrylate (PEA), 5 mole percent 2-phenylethyl methacrylate (PEMA), 5 mole percent 1-6 hexanediol dimethacrylate (HDDMA), and 0.1 percent by weight of bis-(4-t-butylcyclohexyl) peroxydicarbonate was degassed and transferred into a film mold made of two glass plates with one layer of a polyethylene terephthalate film on each facing side, with the plates being separated by a silicone gasket of 0.8 mm thickness.
- the mold was designed so that there would be no differential pressure buildup between the inside and the outside of the mold during the polymerization.
- the mold was completely filled by injecting the mixture, e.g., by means of a syringe, into a filling port until the mold was filled and excess monomer mixture was discharged through a vent.
- the filled mold was then heated in an inert environment, for 15 hours at 50° C. At the end of the polymerization period, the mold was opened and the cured sheet of polymer was removed. The material was found to be soft, and foldable, with a glass transition temperature of approximately 12° C.
- the glass transition temperature (Tg) was measured by differential thermal analysis using conventional equipment.
- the ultimate elongation was measured at 20° C. by means of a Mini-Mat elongation instrument manufactured by Polymer Labs, Inc., wherein coupons cut from the 0.8 mm thick sheets where clamped in opposing jaws which were drawn apart until the samples fractured.
- the refractive index at 20° C. was measured with an Abbe refractometer.
- the ratio of loss modulus over storage modulus (Tan) at 37° C. was measured with a Dynamic Mechanical Thermal Analyzer manufactured by Polymer Labs, Inc., wherein a sample of the 0.8 mm thick sheet was vibrated and the ratio of restoring force to exciting force was determined.
- copolymers can be prepared using conventional polymerization procedures. All concentrations are expressed in parts by weight.
- one method of thermally curing the materials of the present invention involves placing them into an air circulating oven for 16 to 18 hours at 65° C., followed by 3 hrs at 100° C.
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Disintegrating Or Milling (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/086,883 US6001128A (en) | 1997-05-29 | 1998-05-29 | Materials for use in glaucoma filtration devices |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4788297P | 1997-05-29 | 1997-05-29 | |
US09/086,883 US6001128A (en) | 1997-05-29 | 1998-05-29 | Materials for use in glaucoma filtration devices |
Publications (1)
Publication Number | Publication Date |
---|---|
US6001128A true US6001128A (en) | 1999-12-14 |
Family
ID=21951541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/086,883 Expired - Lifetime US6001128A (en) | 1997-05-29 | 1998-05-29 | Materials for use in glaucoma filtration devices |
Country Status (11)
Country | Link |
---|---|
US (1) | US6001128A (pt) |
EP (1) | EP0914169B1 (pt) |
JP (1) | JP2000516520A (pt) |
AT (1) | ATE246010T1 (pt) |
AU (1) | AU724458B2 (pt) |
CA (1) | CA2261171A1 (pt) |
DE (1) | DE69816751T2 (pt) |
DK (1) | DK0914169T3 (pt) |
ES (1) | ES2202866T3 (pt) |
PT (1) | PT914169E (pt) |
WO (1) | WO1998053862A2 (pt) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6533768B1 (en) | 2000-04-14 | 2003-03-18 | The Regents Of The University Of California | Device for glaucoma treatment and methods thereof |
US20040260227A1 (en) * | 2002-12-19 | 2004-12-23 | Lisk James R. | Article and method for ocular aqueous drainage |
US20050125003A1 (en) * | 2003-12-05 | 2005-06-09 | Leonard Pinchuk | Glaucoma implant device |
US20070118066A1 (en) * | 2004-12-03 | 2007-05-24 | Leonard Pinchuk | Glaucoma Implant Device |
US20070118065A1 (en) * | 2004-12-03 | 2007-05-24 | Leonard Pinchuk | Glaucoma Implant Device |
US20070123812A1 (en) * | 2004-12-03 | 2007-05-31 | Leonard Pinchuk | Glaucoma Implant Device |
US20070141116A1 (en) * | 2004-12-03 | 2007-06-21 | Leonard Pinchuk | Glaucoma Implant Device |
US20100303804A1 (en) * | 2007-11-23 | 2010-12-02 | Technische Universitat Wien | Composition that can be cured by polymerisation for the production of biodegradable, biocompatible, cross-linkable polymers on the basis of polyvinyl alcohol |
US20110077655A1 (en) * | 2009-09-25 | 2011-03-31 | Fisher Michael A | Vertebral Body Spool Device |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE291045T1 (de) * | 1999-09-07 | 2005-04-15 | Alcon Inc | Material für faltbare ophtalmische und otorhinolaryngologische gegenstände |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4936850A (en) * | 1983-08-30 | 1990-06-26 | Ezekiel Nominees Pty. Ltd. | Intraocular lens implant |
US5066401A (en) * | 1989-07-13 | 1991-11-19 | Akzo N.V. | Flat or capillary membrane based on a homogeneous mixture of polyvinylidene fluoride and a second polymer which can be rendered hydrophilic by chemical reaction |
EP0485197A1 (en) * | 1990-11-07 | 1992-05-13 | Nestle S.A. | Polymers and their use for ophthalmic lenses |
US5171267A (en) * | 1989-08-31 | 1992-12-15 | The Board Of Regents Of The University Of Washington | Surface-modified self-passivating intraocular lenses |
US5236588A (en) * | 1990-10-18 | 1993-08-17 | Dainippon Ink And Chemicals, Inc. | Asymmetric polymer membrane and preparation thereof |
US5282855A (en) * | 1991-11-05 | 1994-02-01 | Alcon Surgical, Inc. | Vaulted intraocular lens having curved slanted haptic |
US5290892A (en) * | 1990-11-07 | 1994-03-01 | Nestle S.A. | Flexible intraocular lenses made from high refractive index polymers |
US5476445A (en) * | 1990-05-31 | 1995-12-19 | Iovision, Inc. | Glaucoma implant with a temporary flow restricting seal |
WO1995035078A1 (fr) * | 1994-06-22 | 1995-12-28 | Chauvin Opsia | Implant de sclerotomie |
US5529690A (en) * | 1990-07-18 | 1996-06-25 | The Australian National University | Formation of porous materials |
US5652014A (en) * | 1991-08-16 | 1997-07-29 | Galin; Miles A. | Medicament coated refractive anterior chamber ocular implant |
-
1998
- 1998-05-29 PT PT98925025T patent/PT914169E/pt unknown
- 1998-05-29 AU AU77064/98A patent/AU724458B2/en not_active Ceased
- 1998-05-29 AT AT98925025T patent/ATE246010T1/de not_active IP Right Cessation
- 1998-05-29 JP JP11500970A patent/JP2000516520A/ja active Pending
- 1998-05-29 US US09/086,883 patent/US6001128A/en not_active Expired - Lifetime
- 1998-05-29 ES ES98925025T patent/ES2202866T3/es not_active Expired - Lifetime
- 1998-05-29 EP EP98925025A patent/EP0914169B1/en not_active Expired - Lifetime
- 1998-05-29 DE DE69816751T patent/DE69816751T2/de not_active Expired - Fee Related
- 1998-05-29 WO PCT/US1998/011008 patent/WO1998053862A2/en active IP Right Grant
- 1998-05-29 CA CA002261171A patent/CA2261171A1/en not_active Abandoned
- 1998-05-29 DK DK98925025T patent/DK0914169T3/da active
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4936850A (en) * | 1983-08-30 | 1990-06-26 | Ezekiel Nominees Pty. Ltd. | Intraocular lens implant |
US5066401A (en) * | 1989-07-13 | 1991-11-19 | Akzo N.V. | Flat or capillary membrane based on a homogeneous mixture of polyvinylidene fluoride and a second polymer which can be rendered hydrophilic by chemical reaction |
US5171267A (en) * | 1989-08-31 | 1992-12-15 | The Board Of Regents Of The University Of Washington | Surface-modified self-passivating intraocular lenses |
US5476445A (en) * | 1990-05-31 | 1995-12-19 | Iovision, Inc. | Glaucoma implant with a temporary flow restricting seal |
US5529690A (en) * | 1990-07-18 | 1996-06-25 | The Australian National University | Formation of porous materials |
US5236588A (en) * | 1990-10-18 | 1993-08-17 | Dainippon Ink And Chemicals, Inc. | Asymmetric polymer membrane and preparation thereof |
EP0485197A1 (en) * | 1990-11-07 | 1992-05-13 | Nestle S.A. | Polymers and their use for ophthalmic lenses |
US5290892A (en) * | 1990-11-07 | 1994-03-01 | Nestle S.A. | Flexible intraocular lenses made from high refractive index polymers |
US5652014A (en) * | 1991-08-16 | 1997-07-29 | Galin; Miles A. | Medicament coated refractive anterior chamber ocular implant |
US5282855A (en) * | 1991-11-05 | 1994-02-01 | Alcon Surgical, Inc. | Vaulted intraocular lens having curved slanted haptic |
WO1995035078A1 (fr) * | 1994-06-22 | 1995-12-28 | Chauvin Opsia | Implant de sclerotomie |
Non-Patent Citations (4)
Title |
---|
Hoskins, et al., "Filtering Seton Implant for Glaucoma: Initial Animal Trial," Ophthalmol, vol. 102, pp. 894-904 (1995). |
Hoskins, et al., Filtering Seton Implant for Glaucoma: Initial Animal Trial, Ophthalmol, vol. 102, pp. 894 904 (1995). * |
Prata, Jr., et al., "In Vitro and In Vivo Flow Characteristics of Glaucoma Drainage Implants," Ophthalmic Surgery, vol. 23, pp. 702-707 (1992). |
Prata, Jr., et al., In Vitro and In Vivo Flow Characteristics of Glaucoma Drainage Implants, Ophthalmic Surgery, vol. 23, pp. 702 707 (1992). * |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6533768B1 (en) | 2000-04-14 | 2003-03-18 | The Regents Of The University Of California | Device for glaucoma treatment and methods thereof |
US7160264B2 (en) | 2002-12-19 | 2007-01-09 | Medtronic-Xomed, Inc. | Article and method for ocular aqueous drainage |
US20040260227A1 (en) * | 2002-12-19 | 2004-12-23 | Lisk James R. | Article and method for ocular aqueous drainage |
US7431709B2 (en) | 2003-12-05 | 2008-10-07 | Innfocus, Llc | Glaucoma implant device |
WO2005055873A3 (en) * | 2003-12-05 | 2007-07-26 | Innfocus Llc | Improved glaucoma implant device |
US20050125003A1 (en) * | 2003-12-05 | 2005-06-09 | Leonard Pinchuk | Glaucoma implant device |
US20070118066A1 (en) * | 2004-12-03 | 2007-05-24 | Leonard Pinchuk | Glaucoma Implant Device |
US20070118065A1 (en) * | 2004-12-03 | 2007-05-24 | Leonard Pinchuk | Glaucoma Implant Device |
US20070123812A1 (en) * | 2004-12-03 | 2007-05-31 | Leonard Pinchuk | Glaucoma Implant Device |
US20070141116A1 (en) * | 2004-12-03 | 2007-06-21 | Leonard Pinchuk | Glaucoma Implant Device |
US7594899B2 (en) | 2004-12-03 | 2009-09-29 | Innfocus, Llc | Glaucoma implant device |
US7837644B2 (en) | 2004-12-03 | 2010-11-23 | Innfocus, Llc | Glaucoma implant device |
US20100303804A1 (en) * | 2007-11-23 | 2010-12-02 | Technische Universitat Wien | Composition that can be cured by polymerisation for the production of biodegradable, biocompatible, cross-linkable polymers on the basis of polyvinyl alcohol |
US8999323B2 (en) * | 2007-11-23 | 2015-04-07 | Technische Universität Wien | Composition that can be cured by polymerisation for the production of biodegradable, biocompatible, cross-linkable polymers on the basis of polyvinyl alcohol |
US20110077655A1 (en) * | 2009-09-25 | 2011-03-31 | Fisher Michael A | Vertebral Body Spool Device |
Also Published As
Publication number | Publication date |
---|---|
JP2000516520A (ja) | 2000-12-12 |
WO1998053862A2 (en) | 1998-12-03 |
DE69816751D1 (de) | 2003-09-04 |
AU724458B2 (en) | 2000-09-21 |
DK0914169T3 (da) | 2003-11-03 |
WO1998053862A3 (en) | 1999-02-25 |
ES2202866T3 (es) | 2004-04-01 |
ATE246010T1 (de) | 2003-08-15 |
EP0914169A3 (en) | 2002-08-28 |
DE69816751T2 (de) | 2004-06-03 |
EP0914169B1 (en) | 2003-07-30 |
CA2261171A1 (en) | 1998-12-03 |
AU7706498A (en) | 1998-12-30 |
PT914169E (pt) | 2003-11-28 |
EP0914169A2 (en) | 1999-05-12 |
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