US3892534A - Rigidly mounted bubble-type blood oxygenator having flexible flow channels - Google Patents

Rigidly mounted bubble-type blood oxygenator having flexible flow channels Download PDF

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Publication number
US3892534A
US3892534A US430104A US43010474A US3892534A US 3892534 A US3892534 A US 3892534A US 430104 A US430104 A US 430104A US 43010474 A US43010474 A US 43010474A US 3892534 A US3892534 A US 3892534A
Authority
US
United States
Prior art keywords
blood
oxygenator
envelope
flow passage
flexible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US430104A
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English (en)
Inventor
Ronald J Leonard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Co
Original Assignee
Baxter Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AR257073A priority Critical patent/AR207768A1/es
Application filed by Baxter Laboratories Inc filed Critical Baxter Laboratories Inc
Priority to US430104A priority patent/US3892534A/en
Priority to CA210713A priority patent/CA1054473A/en
Priority to IL45835A priority patent/IL45835A/en
Priority to ZA00746517A priority patent/ZA746517B/xx
Priority to BE149565A priority patent/BE821112A/xx
Priority to AU74469/74A priority patent/AU480645B2/en
Priority to IT28766/74A priority patent/IT1025179B/it
Priority to JP12481674A priority patent/JPS5423517B2/ja
Priority to LU71205A priority patent/LU71205A1/xx
Priority to CH1486574A priority patent/CH591247A5/xx
Priority to FR7437036A priority patent/FR2255918B1/fr
Priority to GB48631/74A priority patent/GB1481988A/en
Priority to DE19742458727 priority patent/DE2458727A1/de
Priority to NL7416595A priority patent/NL7416595A/xx
Priority to BR10923/74A priority patent/BR7410923D0/pt
Priority to SE7416391A priority patent/SE405447B/xx
Priority to ES433501A priority patent/ES433501A1/es
Application granted granted Critical
Publication of US3892534A publication Critical patent/US3892534A/en
Assigned to OMNIS SURGICAL INC., A DE CORP. reassignment OMNIS SURGICAL INC., A DE CORP. ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: BAXTER TRAVENOL LABORATORIES, INC.
Assigned to MINNESOTA MINING AND MANUFACTURING COMPANY A CORP OF DELAWARE reassignment MINNESOTA MINING AND MANUFACTURING COMPANY A CORP OF DELAWARE ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: OMNIS SURGICAL INC., A CORP OF DE.
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/32—Oxygenators without membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/32—Oxygenators without membranes
    • A61M1/322—Antifoam; Defoaming
    • A61M1/325—Surfactant coating; Improving wettability
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/03—Heart-lung
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S261/00—Gas and liquid contact apparatus
    • Y10S261/28—Blood oxygenators

Definitions

  • the flexible envelope oxygenators have a significant advantage over the known casing type oxygenators, such as is illustrated in US. Pat. No. 3,488,158, in that the flexible, collapsible blood flow channels of the envelope oxygenators reduce the risk that large amounts of gas can be pumped into a patient's artery, which can have fatal effect.
  • the flexible flow channels collapse flat when not filled with liquid or gas.
  • the pump downstream of an envelope oxygenator is not shut off when the envelope oxygenator empties, little or no gas will be forced into the patient's artery since the flow channels simply collapse under suction of the pump as they empty of blood, functioning as a shut-off valve.
  • flow into the patient's artery terminates as the blood supply is exhausted, despite any continued operation of the downstream, arterial pump.
  • casing-type oxygenators have blood flow passages which are rigid and of unvarying volume. Hence, fatal amounts of gas can easily be pumped into a patient by accident.
  • the invention of this application provides a device which exhibits the safety and effectiveness of flexible, envelope-type oxygenators. yet which also has the convenience of the rigid, casing-type oxygenators. combined with advantages not found in any of the prior oxygenators.
  • a bubble-type blood oxygenator which comprises: a flexible envelope having sealed portions defining in said envelope a flow passage with a blood oxygenating portion and a blood defoaming portion, and which has means for introducing a stream of blood and a stream of oxygen bubbles into one end of said flow passage, and means for removing blood from the other end of said flow passage.
  • a rigid backing is attached to the flexible envelope to carry it in flat, streched-out configuration.
  • the oxygenator of this invention does not need to be tied and stretched on a frame, as have the previous, flexible envelope oxygenators. Instead, it can be simply hung up or stood up for use in a manner similar to the casing-type oxygenators.
  • the oxygenator of this invention possesses the collapsible flow channels which are important for increased safety of operation.
  • the flexible flow passage of the oxygenator can exhibit a restricted capacity to distend with blood by a novel mechanism, in that the presence of the rigid backing prevents at all times the side of the flow passage abutting the backing from distending excessively. Also, as the flow passage begins to distend, the rigid backing causes the flexible envelope to encounter increased tension, which additionally restricts the distension, with the consequent advantages described above.
  • a second feature of the invention relates to the improvement in this general type of oxygenator comprising a tubular blood sampling line which communicates the defoaming portion with a vertically spaced area above the flow passage which area is sealed by a removable seal for maintaining a sterile environment.
  • FIG. I is an elevational view of an oxygenator of this invention with a portion broken away to show the rigid backing behind the flexible envelope portion of the oxygenator.
  • FIG. 2 is an enlarged transverse sectional view taken along Line 22 of FIG. 1.
  • FIG. 3 is an elevational view of the rigid backing of this invention. with a portion broken away to show a second backing layer.
  • an oxygenator of this invention having plastic sheet layers l0, l2 and related parts as shown, which are similar in function to the corresponding parts of the oxygenator disclosed in FIGS. 1 through 4 of U.S. Pat, No. 3,729,377.
  • Sheet layers 10, 12 are sealed together in part by peripheral heat seals 14, 16. Additional heat seals 18, define a flow passage for blood, which includes a blood oxygenating portion 22 and a blood defoaming portion 24.
  • a stream of blood is introduced through entry ports 36, 38, which can be sealed in a sterile manner until use by tear seals 37, which are similar to seal 35.
  • Entry port 36 is connected to a source of venous blood to provide the main stream of blood being circulated, while entry port 38 is provided for the optional recycling of blood as it is removed from an incision site and recycled to the patient.
  • Exit port 40 at the opposite end of the blood flow passage is adapted to connect with tubing for passing the blood back into the patient, and is removably sealed in a manner similar to entry ports 36, 38.
  • Seals 39 and 41 close off the flow passage around the entry and exit ports.
  • Tubular sparger 42 is mounted in the bottom of oxygenating column 22 to provide a wide distribution of fine bubbles of oxygen into the flowing blood in the column.
  • Sparger 42 is a cup-like member generally made of porous plastic and typically having an average pore size of about 90 to I40 microns.
  • the interior of sparger 42 is connected to oxygen line 44 in a conventional manner, which line is sealed between sheets 10 and I2 along seal line 18.
  • Access port 46 is a hole through all layers of the oxygenator, to permit the running of blood lines and the like through the oxygenator in convenient manner.
  • Fluid pressurizable member 59 comprises a pair of plastic sheets heat sealed together to define a pair of interconnected, pressurizable chambers, and is folded about oxygenating portion 22 in the manner described in U.S. Pat. No. 3,729,377 for the purpose of controlling the cross-sectional area of oxygenating portion 22 as desired during the blood oxygenation procedure.
  • Inflation line 80 is provided to add or withdraw pressurizing fluid such as oxygen gas from pressurizable member 59.
  • a rigid backing 82 is provided, which is specifically shown in the present embodiment to be a pair of corrugated sheets 84, 86 similar in structure to each other and generally similar to corrugated material used for making shipping containers.
  • Sheets 84, 86 are preferably made of high density polyethylene or the like, and each comprise a pair of plastic facing layers 88, 90 (FIG. 2) separated by a plurality of generally parallel reinforcing members 92, 94 to space layers 88, 9 and to strengthen the composite structure.
  • Sheets 84, 86 are arranged so that their respective reinforcing members 92, 94 are in angular relation to each other, and generally perpendicular. This provides the complete backing 82 with a high degree of bending resistance so the backing is not easily bent or folded.
  • backing 82 is positioned against plastic sheets l0, 12 as indicated in phantom outline in FIG. 1 to hold sheets 10 and 12 of the envelope oxygenator in stretched-out configuration without the need for tying to a frame, as has been the prior art custom.
  • This can be accomplished by sealing, with heat seals or the like, backing 82 in a second envelope defined by sheet 12 and a third flexible plastic backing sheet 96 (FIG. 2).
  • Sheets l0, l2, and 96 are all heat sealed together along seal lines l4, 16 in the manner of FIG.
  • the envelope oxygenator is permanently secured to backing 82 in stretched-out configuration, to achieve the advantages described above. Also, area 107 can remain unsealed, for ease of manufacture, up to the level of outlet 40, but preferably no higher.
  • oxygenation portion 22 of the blood flow path is not positioned to lie against backing 82, but is laterally spaced therefrom, since its cross sectional area is controlled by the operation of pressurizable member 59.
  • Rigid backing 82 defines an aperture 104 adjacent that portion of the blood defoaming passage 24 which carries the defoaming sponge 26.
  • Aperture 104 passes through both layers 84 and 86, and permits increased distension of the flow passage walls about the defoaming sponge to provide space for it, and allow observation of the defoaming process from both front and back of the oxygenator.
  • Backing 82 also defines other apertures in both layers 84 and 86.
  • Aperture 106 (FIG. 3) is positioned to allow observation of the blood level in the reservoir 28 from both front and back of the oxygenator. while aperture 108 receives outlet port 40.
  • oxygenated blood sampling tube or line 110 extends between the area under seal 35 and the upper end of tortuous passage 28, to permit the sampling of oxygenated blood after filtering for analysis of p0, levels and the like.
  • Tube 110 is affixed at one end by a clip "2 which is heat sealed to the envelope oxygenator along seal line IS.
  • the other, upper end of tube H0 carries a Luer syringe receiving portion 111, and is exposed upon opening seal 35 so that a syringe may be connected to the Luer for collecting a blood sample.
  • the luer-carrying end of tube or line H0 is vertically spaced above the flow passage 24in normal use, to prevent blood from spilling out of the oxygenator through tube 110.
  • a bubble-type blood oxygenator which comprises: a flexible envelope having sealed portions defining in said envelope a flow passage with a blood oxygenating portion and a blood defoaming portion, and which has means for introducing a stream of blood and a stream of oxygen bubbles into one end of said flow passage, and means for removing blood from the other end of said flow passage, the improvement comprising: rigid backing means operatively associated with and carrying and maintaining said envelope in flat, stretched-out configuration, whereby said flow passage, when filled with blood, exhibits reduced outward distension and sagging.
  • said blood defoaming portion comprises an upstream part containing defoaming sponge means, and a second part comprising a tortuous passage for final gas bubble removal from the blood, said rigid backing means defining an aperture adjacent said upstream part to permit increased distension of said flow passage at said upstream part, to provide space for said defoaming sponge means, and allow observation of the defoaming process from both the front and the back of the oxygenator.
  • said rigid backing means comprises a pair of rigid sheets lying against each other, each sheet comprising a pair of facing sheets separated by a plurality of parallel reinforcing members, the reinforcing members of each said rigid sheet defining an angle to the reinforcing members of the other rigid sheet of said pair, whereby said rigid backing means exhibits increased resistance to bend- 7.
  • a bubble-type blood oxygenator which comprises: a flexible envelope having sealed portions defining in said envelope a flow passage with a blood oxygenating portion and a blood defoaming portion, and which has means for introducing a stream of blood and a stream of oxygen bubbles into one end of said flow passage, and means for removing blood from the other end of said flow passage, the improvement comprising: a tubular blood sampling line communicating at one end with said defoaming portion below the level of blood in said defoaming portion in normal use and at its other end with an area which is vertically spaced above said blood level in normal use, said area being sealed from the exterior by removable seal means for maintaining a sterile environment about said other end, and a rigid backing means operatively associated with and carrying and maintaining said envelope in flat, stretched-out configuration, whereby said flow passage, when filled with blood and oxygen, exhibits reduced outward distension and sagging.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)
US430104A 1974-01-02 1974-01-02 Rigidly mounted bubble-type blood oxygenator having flexible flow channels Expired - Lifetime US3892534A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
AR257073A AR207768A1 (es) 1974-01-02 1974-01-01 Un oxigenador sanguineo mejorado
US430104A US3892534A (en) 1974-01-02 1974-01-02 Rigidly mounted bubble-type blood oxygenator having flexible flow channels
CA210713A CA1054473A (en) 1974-01-02 1974-10-03 Rigidly mounted bubble type blood oxygenator having flexible flow channels
IL45835A IL45835A (en) 1974-01-02 1974-10-11 Bubble-type blood oxygenator
ZA00746517A ZA746517B (en) 1974-01-02 1974-10-14 Rigidly mounted bubble type blood oxygenator having flexible flow channels
BE149565A BE821112A (fr) 1974-01-02 1974-10-16 Oxygenateur du type a bulles
AU74469/74A AU480645B2 (en) 1974-01-02 1974-10-18 Rigidly mounted bubble type blood oxygenator having flexible flow channels
IT28766/74A IT1025179B (it) 1974-01-02 1974-10-24 Ossigenatore del sangue del tipo a bolle montato rigidamente presentante canali di flusso flessibili
LU71205A LU71205A1 (de) 1974-01-02 1974-10-29
JP12481674A JPS5423517B2 (de) 1974-01-02 1974-10-29
CH1486574A CH591247A5 (de) 1974-01-02 1974-11-06
FR7437036A FR2255918B1 (de) 1974-01-02 1974-11-08
GB48631/74A GB1481988A (en) 1974-01-02 1974-11-11 Bubble-type blood oxygenator
DE19742458727 DE2458727A1 (de) 1974-01-02 1974-12-12 Vorrichtung zur sauerstoffanreicherung von blut
NL7416595A NL7416595A (nl) 1974-01-02 1974-12-19 Stijf gemonteerde, met bellen werkend bloed- enerator, die flexibele stromingskanalen .
SE7416391A SE405447B (sv) 1974-01-02 1974-12-30 Bubbelblodsyrsettare
BR10923/74A BR7410923D0 (pt) 1974-01-02 1974-12-30 Aperfeicoamento em oxigenador sanguineo do tipo de borbulha mento
ES433501A ES433501A1 (es) 1974-01-02 1975-01-02 Oxigenador de sangre del tipo de burbujas montado rigida- mente y dotado de canales de circulacion flexibles.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US430104A US3892534A (en) 1974-01-02 1974-01-02 Rigidly mounted bubble-type blood oxygenator having flexible flow channels

Publications (1)

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US3892534A true US3892534A (en) 1975-07-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
US430104A Expired - Lifetime US3892534A (en) 1974-01-02 1974-01-02 Rigidly mounted bubble-type blood oxygenator having flexible flow channels

Country Status (17)

Country Link
US (1) US3892534A (de)
JP (1) JPS5423517B2 (de)
AR (1) AR207768A1 (de)
BE (1) BE821112A (de)
BR (1) BR7410923D0 (de)
CA (1) CA1054473A (de)
CH (1) CH591247A5 (de)
DE (1) DE2458727A1 (de)
ES (1) ES433501A1 (de)
FR (1) FR2255918B1 (de)
GB (1) GB1481988A (de)
IL (1) IL45835A (de)
IT (1) IT1025179B (de)
LU (1) LU71205A1 (de)
NL (1) NL7416595A (de)
SE (1) SE405447B (de)
ZA (1) ZA746517B (de)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4108607A (en) * 1975-09-22 1978-08-22 Baxter Travenol Laboratories, Inc. Blood gas simulator
US4268476A (en) * 1975-06-06 1981-05-19 Bentley Laboratories, Inc. Blood oxygenator
US4372914A (en) * 1975-06-06 1983-02-08 Bentley Laboratories, Inc. Blood oxygenator
US4585056A (en) * 1984-04-18 1986-04-29 Norton Company Heat exchanger
US4623518A (en) * 1975-06-06 1986-11-18 Baxter-Travenol Laboratories, Inc. Blood oxygenator
US4637917A (en) * 1983-10-14 1987-01-20 Reed Charles C Bubble oxygenator
US4954317A (en) * 1975-06-06 1990-09-04 Baxter International, Inc. Blood oxygenator
US5049146A (en) * 1989-05-31 1991-09-17 Baxter International, Inc. Blood/gas separator and flow system
US5514335A (en) * 1993-10-25 1996-05-07 Minnesota Mining And Manufacturing Company Blood oxygenation system and reservoir and method of manufacture
US5858015A (en) * 1993-09-29 1999-01-12 Dideco S.P.A. Container for blood
US5871693A (en) * 1996-06-07 1999-02-16 Minnesota Mining And Manufacturing Company Modular blood treatment cartridge
US5935093A (en) * 1997-09-29 1999-08-10 Medtronic, Inc. Softshell reservoir with integrated cardiotomy reservoir
US6050968A (en) * 1997-09-29 2000-04-18 Medtronic, Inc. Two-chambered softshell reservoir
US6113782A (en) * 1998-07-28 2000-09-05 Terumo Cardiovascular Systems Corporation Potting of tubular bundles in housing
US8425486B2 (en) 2008-11-21 2013-04-23 Smisson-Cartledge Biomedical Llc Collapsible fluid reservoir

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3060934A (en) * 1960-03-24 1962-10-30 Claff Clarence Lloyd Membrane-type oxygenator
US3468631A (en) * 1965-06-21 1969-09-23 Bentley Lab Blood oxygenator with heat exchanger
US3502440A (en) * 1967-07-03 1970-03-24 Baxter Laboratories Inc Blood oxygenator
US3545937A (en) * 1966-02-02 1970-12-08 Chirana Z Vdravotnickej Techni Blood oxygenation apparatus
US3729377A (en) * 1971-03-12 1973-04-24 Baxter Laboratories Inc Envelope oxygenator for blood having inflatable portions and process of using same
US3827860A (en) * 1972-06-15 1974-08-06 Sherwood Medical Ind Inc Blood oxygenation device

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2664395A (en) * 1949-08-24 1953-12-29 Marchand John Felix Dialyzer
US2981253A (en) * 1957-07-17 1961-04-25 Univ Minnesota Oxygenator
CA1014443A (en) * 1971-09-08 1977-07-26 Richard A. Dewall Metabolic bubble oxygenator
US3792978A (en) * 1972-05-30 1974-02-19 Sci Med Life Syst Inc Envelope assembly for spool type oxygenator

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3060934A (en) * 1960-03-24 1962-10-30 Claff Clarence Lloyd Membrane-type oxygenator
US3468631A (en) * 1965-06-21 1969-09-23 Bentley Lab Blood oxygenator with heat exchanger
US3545937A (en) * 1966-02-02 1970-12-08 Chirana Z Vdravotnickej Techni Blood oxygenation apparatus
US3502440A (en) * 1967-07-03 1970-03-24 Baxter Laboratories Inc Blood oxygenator
US3729377A (en) * 1971-03-12 1973-04-24 Baxter Laboratories Inc Envelope oxygenator for blood having inflatable portions and process of using same
US3827860A (en) * 1972-06-15 1974-08-06 Sherwood Medical Ind Inc Blood oxygenation device

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268476A (en) * 1975-06-06 1981-05-19 Bentley Laboratories, Inc. Blood oxygenator
US4372914A (en) * 1975-06-06 1983-02-08 Bentley Laboratories, Inc. Blood oxygenator
US4623518A (en) * 1975-06-06 1986-11-18 Baxter-Travenol Laboratories, Inc. Blood oxygenator
US4954317A (en) * 1975-06-06 1990-09-04 Baxter International, Inc. Blood oxygenator
US4108607A (en) * 1975-09-22 1978-08-22 Baxter Travenol Laboratories, Inc. Blood gas simulator
US4637917A (en) * 1983-10-14 1987-01-20 Reed Charles C Bubble oxygenator
US4585056A (en) * 1984-04-18 1986-04-29 Norton Company Heat exchanger
US5049146A (en) * 1989-05-31 1991-09-17 Baxter International, Inc. Blood/gas separator and flow system
US5858015A (en) * 1993-09-29 1999-01-12 Dideco S.P.A. Container for blood
US5514335A (en) * 1993-10-25 1996-05-07 Minnesota Mining And Manufacturing Company Blood oxygenation system and reservoir and method of manufacture
US5753173A (en) * 1993-10-25 1998-05-19 Minnesota Mining And Manufacturing Company Method of manufacturing a blood oxygenation system
US5871693A (en) * 1996-06-07 1999-02-16 Minnesota Mining And Manufacturing Company Modular blood treatment cartridge
US6180058B1 (en) 1996-06-07 2001-01-30 Terumo Cardiovascular Systems Corporation Blood treatment system
US5935093A (en) * 1997-09-29 1999-08-10 Medtronic, Inc. Softshell reservoir with integrated cardiotomy reservoir
US6050968A (en) * 1997-09-29 2000-04-18 Medtronic, Inc. Two-chambered softshell reservoir
US6113782A (en) * 1998-07-28 2000-09-05 Terumo Cardiovascular Systems Corporation Potting of tubular bundles in housing
US8425486B2 (en) 2008-11-21 2013-04-23 Smisson-Cartledge Biomedical Llc Collapsible fluid reservoir

Also Published As

Publication number Publication date
FR2255918B1 (de) 1978-05-05
IL45835A (en) 1977-03-31
BR7410923D0 (pt) 1975-09-02
ES433501A1 (es) 1976-11-16
IT1025179B (it) 1978-08-10
CA1054473A (en) 1979-05-15
SE7416391L (de) 1975-07-03
CH591247A5 (de) 1977-09-15
JPS5098191A (de) 1975-08-04
SE405447B (sv) 1978-12-11
IL45835A0 (en) 1974-12-31
LU71205A1 (de) 1975-04-17
ZA746517B (en) 1975-10-29
DE2458727A1 (de) 1975-07-10
AR207768A1 (es) 1976-10-29
BE821112A (fr) 1975-02-17
NL7416595A (nl) 1975-07-04
GB1481988A (en) 1977-08-03
FR2255918A1 (de) 1975-07-25
JPS5423517B2 (de) 1979-08-14
AU7446974A (en) 1976-04-29

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Legal Events

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AS Assignment

Owner name: OMNIS SURGICAL INC., A DE CORP.

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:BAXTER TRAVENOL LABORATORIES, INC.;REEL/FRAME:004285/0631

Effective date: 19840709

AS Assignment

Owner name: MINNESOTA MINING AND MANUFACTURING COMPANY, 3M CEN

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:OMNIS SURGICAL INC., A CORP OF DE.;REEL/FRAME:004486/0094

Effective date: 19851111