US3818894A - Laryngeal implant - Google Patents
Laryngeal implant Download PDFInfo
- Publication number
- US3818894A US3818894A US00215126A US21512672A US3818894A US 3818894 A US3818894 A US 3818894A US 00215126 A US00215126 A US 00215126A US 21512672 A US21512672 A US 21512672A US 3818894 A US3818894 A US 3818894A
- Authority
- US
- United States
- Prior art keywords
- implant
- tip
- implant according
- group
- hydrophilic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/20—Epiglottis; Larynxes; Tracheae combined with larynxes or for use therewith
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
Definitions
- the implant is made from water-swellable and physiologically inert material, such as a synthetic cross-linked hydrophilic gel, and has in a dry state, when it is ready for use in an operation, the shape of a straight or bent stick provided with a sharp, pointed tip.
- physiologically inert material such as a synthetic cross-linked hydrophilic gel
- the implant body except the tip may contain physiologically inert plasticizers.
- the aforementioned materials such as paraffin and the others move inside the vocal cords over a period of time and eventu- O ally escape into the space below the glottis.
- the crushed cartilage on the other hand, is absorbed in the course of time, so that the success of all the aforesaid operations is only temporary and the shape of the vocal cords after the operation cannot be determined in advance.
- the implant accordingto the invention overcomes all above mentioned disadvantages comprises a physiologically inert material which swells in water and has in the dry state, as prepared for the operation, the shape of a straight or bent elongated body, such as a stick provided with a sharp, pointed tip.
- Hydrophilic material with a linear swelling capacity from 10 to 45 percent may be used as an inert material swelling in water.
- the implant may contain dyestuffs, pigments or contrast substances.
- the implant according to the invention has preferably the same length in a dry state as after equilibrium swelling in water. Its modulus of elasticity may be decreased, except with respect to the tip, by adding water or another physiologically inert plasticizer.
- glycol methacrylate or glycol acrylate, respectively to include not only simple ethyleneglycol, but also diethyleneglycol, triethyleneglycol, propyleneglycol, butyleneglycol and the like, that is, an arbitrary hydrophilic aliphatic diol.
- Glycerol monomethacrylate or .acrylate may be also used.
- the elongated body such as a stick is prepared in the dry state from the physiologically inert material swelling in water, preferably from a synthetic cross-linked hydrophilic gel, and this stick is provided with a sharp, pointed tip before or after drying.
- the stick is advantageously made from a material which contains a physiologically inert plasticizer or is impregnated with the plasticizer, and wherein the tip or the part used for making the tip is freed from the plasticizer by extraction.
- the stick can be also swollen in water, the clamped in such a way to be unable to shrink lengthwise, dried and provided with the tip, or the dried stick can be heated above the glasstransition temperature, stretched in this state, cooled and provided with the tip.
- the implant according-to the invention may be prepared also in any manner such that the body has an una pointed tip. In this case the implant returns into the original uneven or combined shape after being swollen, due to its shape memory.
- the characteristic glassy hard state of hydrophilic polymers in their dry condition is necessary only in the region of the stabbing tip for introduction of the implant into tissue.
- the remaining part of the implant need not to be in the glassy hard state.
- the body of the implant has to be sufficiently rigid to enable its introduction. into tissue by overcoming the resistance of the opening tissue.
- the modulus of elasticity of theimplant body is generally sufficiently high when above about kg/cm However, a modulus about 1,000 kg/cm is especially advantageous.
- the hydrophilic materials show considerable decrease of brittleness when their modulus of elasticity in the dry state is reduced from the usual value of 20,000 50,000 kg/cm to 5,000 kg/cm
- the required reduction of modulus and thus also the high toughness of the implant body can be achieved by introduction of a small amount of a convenient plasticizer into the three dimensional network of the hydrophillic polymer.
- This can even be water, in the simpliest case, which may be absorbed for instance from aqueous solutions of sodium chloride.
- the amount of water in the gel decreases with the increase of the-concentration of the salt in water, since it is in equilibrium with this solution.
- sparingly cross-linked glycol methacrylate gel softens by long soaking in a 15 percent solution of salt in such a way that its elasticity modulus is then about 500 kglcm Under these circumstances the tip is also softened. Therefore, it is necessary to dry the sharp end of the implant before application and to preserve the absorbed water in the residual material of the implant, for instance, by wrapping the implant in an aluminium foil and drying of the uncovered tip only.
- the implant can be made so that it has a different hardness in its individual parts so that it has relatively long-term stability. For example,
- glycerol may be absorbed by the gel along with water from dilute solutions of glycerol at elevated temperature, and will remain in the gel permanently after drying. Subsequently, all of the glycerol may be extracted from the tip by dipping the tip into water so that it leashes out from the tip leaving the presence of glycerol limited to the remaining parts of the implant. The required effect is obtained at low concentrations of glycerol, such as at 0.2 2%. The glycerol remains localized in the implant, in the slightly swollen state, for a long time and its migration into the non-plasticized tip does not take place.
- the implant can be prepared in this condition in a sterilized package, ready for instant use without any special preparation before use by the consumer.
- plasticizers which are absorbed by the gel and are physiologically unobjectionable in small amounts, such as diacetin, triethyleneglycol, butanedioll ,3,urethane acetoin, diethyl tartrate, N,N'-dilactyl urea, lactamide and the like.
- plasticizers which are absorbed by the gel and are physiologically unobjectionable in small amounts, such as diacetin, triethyleneglycol, butanedioll ,3,urethane acetoin, diethyl tartrate, N,N'-dilactyl urea, lactamide and the like. These compounds may be introduced into the gel either from aqueous solutions or from solutions in other volatile solvents which heavily swell the gel and thus open the gel structure for the rapid diffusion of plasticizers.
- the same solvents are convenient for the reverse washing of plasticizers from the tip of the implant.
- the procedure can be also employed, where the tip is protected from the softening action of the solutions by coating, e.g. with paraffin, or where only other parts of the implant are dipped into the solutions.
- the operation comprises insertion of the implant into the predetermined place of the vocal cord by direct laryngoscopy methods using a multiple magnifying surgical microscope, preferably after a very small incision in the mucous membrane at the upper surface of vocal cord is made.
- the implant is used in a dry state and is of almost glassy hardness. The implant swells in the tissue for several minutes, increases its volume as it has been 'predeterminedly designed to do and thus increases the mass of the atrophied vocal cord, shifting its edge more to, the center and thereby contracting, or liquidating the slot between cords occuring hitherto at voice formation. This improves the voice in the objectively evident way and removes hoarseness and subjective difficulties, mainly the voice tiredness.
- the implant can be employed in similar way for the treatment of paralysis of the recurrent nerve, when the afficted vocal cord is slack and excavated and the opposite vocal cord is unable to compensate for the disturbance formed by drawing across middle line.
- the purpose of the implant is similar as in the case of atrophy of the vocal cords and it has to level the excavation by taking up the slack vocal cord, to improve the closure of glottis and to improve the voice and subjective difficulties of the patient.
- the application of the implant according to the invention has the distinct advantage in that the patient can speak within several minutes at the operation, while with other methods total vocal inactivity is required usually for from 3 to 7 days.
- the implant can be used for surgical treatment in other regions which are afflicted with atrophy, such as with atrophy of nasal mucous membrane and the like.
- EXAMPLE 1 A mixture consisting of parts of hydroxyethyl methacrylate containing 0.2 of ethylene dimethacrylate, 15 parts of 0.25 aqueous solution of ammonium persulfate and 15 parts of 0.25 aqueous solution of sodium disulfite is charged by a pipette into a plurality of thin-walled 30 cm long glass capillary tubes having a inner diameter 0.8 to 2.5 mm which are placed horizontally. Polymeriz mixture is sucked into the whole length of the tubes by capillarity. The polymerization takes place at ambient temperature and is completed within 8 hours.
- the several gel sticks are then isolated either by breaking the capillary tubes and careful separation of the crushed glass, or, in more convenient way, by dissolving the glass in cold 20 hydrofluoric acid.
- the sticks are thoroughly washed in water and then the ends cut off to remove any portions not perfectly polymerized due to diffusing oxygen. Thereafter, one end of each stick, preferably in semi-dry state, is cut with a sharp knife in a fairly oblique angle to form a shape similar to the tip of an injection needle.
- the stick deforms in the course of further drying but the original shape was recovered and release of internal stress obtained by heating the stick above the softening point, i.e., to C.
- the sticks were thereafter either laid loose on stretched knitted fabric made from terylene monofilament or suspended in boiling xylene. Fine files and abrasive paper are used for forming the finish and sterilization is carried out in an ethylene oxide atmosphere.
- water-swelling gels can be prepared from other neutral monomers, such as from N- methyl methacrylamide, acrylamide or vinylpyrrolidone in the presence of suitable cross-linking agents, such as methylene-bis-acrylamide.
- monomers containing ionizable groups in their molecule can be employed (such as methacrylic acid) which, present in slightly cross-linked gels, when employed in the amount of upto several percent substantial increase of swelling capacity in neutral aqueous solutions.
- methacrylic acid ionizable groups in their molecule
- EXAMPLE 2 The monomer mixture as described in Example 1 is charged into a 3 m long thin-walled silicone rubber tube having an inner diameter of 1.2 mm. The opposite end of the tube is sealed and lml more mixture is pressed into the tube by a syringe so that the tube expands and is able to compensate precisely for the polymerization contraction. Then the other end is sealed, the tube is inserted into a wider glass tube, which is freed from all oxygen by a stream of nitrogen and sealed. After polymerization is completed, the silicone tube is split by two lengthwise cuts and the casted rod is released. It is quite regular, intact and free of contraction bubbles.
- the rod may be, after cutting to pieces and washing in water, impregnated with plasticizers, such as by heating in a 3 aqueous solution of glycerol. if a rod is dried in the lengthwise fixed position, it is obtained in stretched state and by swelling under physiological condition only gets wider but not longer. To finish the implant, the tip is formed, freed from the plasticizer by dipping in water, and, after final drying, is sharpened with fine emery.
- plasticizers such as by heating in a 3 aqueous solution of glycerol.
- EXAMPLE 3 A mixture consisting of 30 parts of acrylonitrile, 70 parts of nitric acid (density 1.5) and 0. 1 parts of ammonium persulfate was charged into similar capillary tubes, as those which are described in Example 1. The capillary tubes were inerted into a pressure vessel, air was replaced by nitrogen and the pressure of nitrogen was increased to 3 atm. After five days the capillary tubes were removed from the pressure vessel and heated for hours to 45 C. Further working was analogous to Example 1.
- a larynreal implant for surgical purposes for use in the surgical treatment of vocal cords comprising a .6 body of hydrophilic polymeric crosslinked gel material having the form of a rod-like needle with a sharp, pointed tip in the dry state in which it is applied, said implant being swellable after implantation in the vocal cord to help improve closure of glottis.
- hydrophilic polymeric crosslinked material is an insoluble, hydrophilic gel having a linear swelling capacity in the region from 10 to 45 percent.
- hydrophilic material is a copolymer selected from the group of glycol methecrylate and acrylate containing up to 2 weight percent of a material selected from the group consisting of glycol dimethacrylate and diacrylate and up to 3 weight percent of material selected from the group consisting of methacrylic acid or acrylic acid.
- the implant according to claim 1 which has approximately the same length in a dry state as after equilibrium swelling in water.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CS469A CS151338B1 (de) | 1971-01-22 | 1971-01-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
US3818894A true US3818894A (en) | 1974-06-25 |
Family
ID=5336824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US00215126A Expired - Lifetime US3818894A (en) | 1971-01-22 | 1972-01-03 | Laryngeal implant |
Country Status (8)
Country | Link |
---|---|
US (1) | US3818894A (de) |
JP (1) | JPS5029596B1 (de) |
CS (1) | CS151338B1 (de) |
DE (1) | DE2201861A1 (de) |
FR (1) | FR2122952A5 (de) |
GB (1) | GB1334691A (de) |
IT (1) | IT948034B (de) |
NL (1) | NL7200661A (de) |
Cited By (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3948271A (en) * | 1972-11-07 | 1976-04-06 | Taichiro Akiyama | Drain for the eardrum and apparatus for introducing the same |
NL7801015A (en) * | 1978-01-27 | 1979-07-31 | Medline Ab | Swellable material used to block body ducts - is used esp. to block oviducts as a contraceptive and pref. comprises acrylic! copolymer hydrogel |
US4298002A (en) * | 1979-09-10 | 1981-11-03 | National Patent Development Corporation | Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation |
US4509504A (en) * | 1978-01-18 | 1985-04-09 | Medline Ab | Occlusion of body channels |
US5197982A (en) * | 1991-10-15 | 1993-03-30 | Goldsmith Iii Manning M | Adjustable prosthetic device for vocal cord and method |
AU650646B2 (en) * | 1990-04-20 | 1994-06-30 | Ent, L.L.C | Phonosurgery devices |
US6161034A (en) * | 1999-02-02 | 2000-12-12 | Senorx, Inc. | Methods and chemical preparations for time-limited marking of biopsy sites |
US20020058882A1 (en) * | 1998-06-22 | 2002-05-16 | Artemis Medical, Incorporated | Biopsy localization method and device |
US6497706B1 (en) | 1998-03-03 | 2002-12-24 | Senorx, Inc. | Biopsy device and method of use |
US6540695B1 (en) | 1998-04-08 | 2003-04-01 | Senorx, Inc. | Biopsy anchor device with cutter |
US6544185B2 (en) | 2000-10-23 | 2003-04-08 | Valentino Montegrande | Ultrasound imaging marker and method of use |
US6638234B2 (en) | 1998-03-03 | 2003-10-28 | Senorx, Inc. | Sentinel node location and biopsy |
US6654629B2 (en) | 2002-01-23 | 2003-11-25 | Valentino Montegrande | Implantable biomarker and method of use |
US6662041B2 (en) | 1999-02-02 | 2003-12-09 | Senorx, Inc. | Imageable biopsy site marker |
US20030233101A1 (en) * | 2002-06-17 | 2003-12-18 | Senorx, Inc. | Plugged tip delivery tube for marker placement |
US6679851B2 (en) | 1998-09-01 | 2004-01-20 | Senorx, Inc. | Tissue accessing and anchoring device and method |
US6725083B1 (en) | 1999-02-02 | 2004-04-20 | Senorx, Inc. | Tissue site markers for in VIVO imaging |
US6758848B2 (en) | 1998-03-03 | 2004-07-06 | Senorx, Inc. | Apparatus and method for accessing a body site |
US20040204660A1 (en) * | 1998-06-22 | 2004-10-14 | Artemis Medical, Inc. | Biopsy localization method and device |
US20040236212A1 (en) * | 2003-05-23 | 2004-11-25 | Senorx, Inc. | Fibrous marker and intracorporeal delivery thereof |
US20040236211A1 (en) * | 2003-05-23 | 2004-11-25 | Senorx, Inc. | Marker or filler forming fluid |
US6862470B2 (en) | 1999-02-02 | 2005-03-01 | Senorx, Inc. | Cavity-filling biopsy site markers |
US6875182B2 (en) | 1998-03-03 | 2005-04-05 | Senorx, Inc. | Electrosurgical specimen-collection system |
US20050113855A1 (en) * | 2003-08-11 | 2005-05-26 | Kennedy Kenneth C.Ii | Surgical implant |
US20050119562A1 (en) * | 2003-05-23 | 2005-06-02 | Senorx, Inc. | Fibrous marker formed of synthetic polymer strands |
US20060173280A1 (en) * | 2003-11-17 | 2006-08-03 | Inrad, Inc. | Multi Mode Imaging Marker |
US20060241411A1 (en) * | 2005-04-20 | 2006-10-26 | Inrad, Inc. | Marking device with retracable cannula |
US20070038146A1 (en) * | 2005-08-05 | 2007-02-15 | Quick Richard L | Biopsy device with fluid delivery to tissue specimens |
US20080039819A1 (en) * | 2006-08-04 | 2008-02-14 | Senorx, Inc. | Marker formed of starch or other suitable polysaccharide |
US20080102439A1 (en) * | 2006-10-27 | 2008-05-01 | Bin Tian | Biological tissue for surgical implantation |
US20080188931A1 (en) * | 2006-11-01 | 2008-08-07 | Seoul National University Hospital | Cricoid wedge implant |
US20080254298A1 (en) * | 2006-02-23 | 2008-10-16 | Meadwestvaco Corporation | Method for treating a substrate |
US20090030309A1 (en) * | 2007-07-26 | 2009-01-29 | Senorx, Inc. | Deployment of polysaccharide markers |
US20090112118A1 (en) * | 2005-08-05 | 2009-04-30 | Senorx, Inc. | Biopsy device with fluid delivery to tissue specimens |
US20090171198A1 (en) * | 2006-08-04 | 2009-07-02 | Jones Michael L | Powdered marker |
US20090204021A1 (en) * | 2004-12-16 | 2009-08-13 | Senorx, Inc. | Apparatus and method for accessing a body site |
US20100010341A1 (en) * | 2006-12-18 | 2010-01-14 | Talpade Dnyanesh A | Biopsy Marker with In Situ-Generated Imaging Properties |
US20100030072A1 (en) * | 2006-12-12 | 2010-02-04 | Casanova R Michael | Multiple Imaging Mode Tissue Marker |
US20100082102A1 (en) * | 2008-09-23 | 2010-04-01 | Senorx, Inc. | Porous bioabsorbable implant |
US20100298698A1 (en) * | 2000-11-20 | 2010-11-25 | Senorx, Inc. | Tissue site markers for in vivo imaging |
US20100298696A1 (en) * | 2003-11-17 | 2010-11-25 | Bard Peripheral Vascular, Inc. | Self-contained, self-piercing, side-expelling marking apparatus |
US20100331668A1 (en) * | 2008-01-31 | 2010-12-30 | Ranpura Himanshu M | Biopsy Tissue Marker |
US20110028836A1 (en) * | 2008-12-30 | 2011-02-03 | Himanshu Ranpura | Marker delivery device for tissue marker placement |
US20110082547A1 (en) * | 1997-10-10 | 2011-04-07 | Senorx, Inc. | Tissue marking implant |
US20110166448A1 (en) * | 1999-02-02 | 2011-07-07 | Jones Michael L | Marker delivery device with releasable plug |
US20110184449A1 (en) * | 2006-08-04 | 2011-07-28 | Senorx, Inc. | Marker delivery device with obturator |
US20110184280A1 (en) * | 1999-02-02 | 2011-07-28 | Jones Michael L | Intracorporeal marker and marker delivery device |
US20110214398A1 (en) * | 2010-03-05 | 2011-09-08 | Edwards Lifesciences Corporation | Dry Prosthetic Heart Valve Packaging System |
US8343071B2 (en) | 2004-12-16 | 2013-01-01 | Senorx, Inc. | Biopsy device with aperture orientation and improved tip |
US8437834B2 (en) | 2006-10-23 | 2013-05-07 | C. R. Bard, Inc. | Breast marker |
US8486028B2 (en) | 2005-10-07 | 2013-07-16 | Bard Peripheral Vascular, Inc. | Tissue marking apparatus having drug-eluting tissue marker |
US8579931B2 (en) | 1999-06-17 | 2013-11-12 | Bard Peripheral Vascular, Inc. | Apparatus for the percutaneous marking of a lesion |
US8641640B2 (en) | 2005-05-23 | 2014-02-04 | Senorx, Inc. | Tissue cutting member for a biopsy device |
US8668737B2 (en) | 1997-10-10 | 2014-03-11 | Senorx, Inc. | Tissue marking implant |
USD715442S1 (en) | 2013-09-24 | 2014-10-14 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
USD715942S1 (en) | 2013-09-24 | 2014-10-21 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
USD716450S1 (en) | 2013-09-24 | 2014-10-28 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
USD716451S1 (en) | 2013-09-24 | 2014-10-28 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
US9408592B2 (en) | 2003-12-23 | 2016-08-09 | Senorx, Inc. | Biopsy device with aperture orientation and improved tip |
US9498317B2 (en) | 2010-12-16 | 2016-11-22 | Edwards Lifesciences Corporation | Prosthetic heart valve delivery systems and packaging |
US9820824B2 (en) | 1999-02-02 | 2017-11-21 | Senorx, Inc. | Deployment of polysaccharide markers for treating a site within a patent |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS542892U (de) * | 1977-06-09 | 1979-01-10 | ||
US5344453A (en) * | 1991-05-30 | 1994-09-06 | Boston Medical Products, Inc. | Thyroplasty implant |
US5201765A (en) * | 1991-09-20 | 1993-04-13 | Xomed-Treace Inc. | Vocal cord medialization prosthesis |
JP5224318B2 (ja) * | 2007-06-29 | 2013-07-03 | 財団法人ヒューマンサイエンス振興財団 | 声帯補強具ならびに声帯萎縮防止用電極およびこれを備えた声帯萎縮防止装置 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3220960A (en) * | 1960-12-21 | 1965-11-30 | Wichterle Otto | Cross-linked hydrophilic polymers and articles made therefrom |
US3505988A (en) * | 1967-04-11 | 1970-04-14 | Norman Deane | Prosthesis for chronic access to the peritoneum |
US3520949A (en) * | 1966-07-26 | 1970-07-21 | Nat Patent Dev Corp | Hydrophilic polymers,articles and methods of making same |
US3524447A (en) * | 1964-04-06 | 1970-08-18 | Sterilon Corp | Method of making a rigid tipped polyvinyl catheter |
US3707150A (en) * | 1970-11-05 | 1972-12-26 | William W Montgomery | Laryngeal keel |
-
1971
- 1971-01-22 CS CS469A patent/CS151338B1/cs unknown
-
1972
- 1972-01-03 US US00215126A patent/US3818894A/en not_active Expired - Lifetime
- 1972-01-11 GB GB126272A patent/GB1334691A/en not_active Expired
- 1972-01-15 DE DE19722201861 patent/DE2201861A1/de active Pending
- 1972-01-17 NL NL7200661A patent/NL7200661A/xx unknown
- 1972-01-19 IT IT19569/72A patent/IT948034B/it active
- 1972-01-19 FR FR7201684A patent/FR2122952A5/fr not_active Expired
- 1972-01-21 JP JP47007757A patent/JPS5029596B1/ja active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3220960A (en) * | 1960-12-21 | 1965-11-30 | Wichterle Otto | Cross-linked hydrophilic polymers and articles made therefrom |
US3524447A (en) * | 1964-04-06 | 1970-08-18 | Sterilon Corp | Method of making a rigid tipped polyvinyl catheter |
US3520949A (en) * | 1966-07-26 | 1970-07-21 | Nat Patent Dev Corp | Hydrophilic polymers,articles and methods of making same |
US3505988A (en) * | 1967-04-11 | 1970-04-14 | Norman Deane | Prosthesis for chronic access to the peritoneum |
US3707150A (en) * | 1970-11-05 | 1972-12-26 | William W Montgomery | Laryngeal keel |
Cited By (174)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3948271A (en) * | 1972-11-07 | 1976-04-06 | Taichiro Akiyama | Drain for the eardrum and apparatus for introducing the same |
US4509504A (en) * | 1978-01-18 | 1985-04-09 | Medline Ab | Occlusion of body channels |
NL7801015A (en) * | 1978-01-27 | 1979-07-31 | Medline Ab | Swellable material used to block body ducts - is used esp. to block oviducts as a contraceptive and pref. comprises acrylic! copolymer hydrogel |
US4298002A (en) * | 1979-09-10 | 1981-11-03 | National Patent Development Corporation | Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation |
AU650646B2 (en) * | 1990-04-20 | 1994-06-30 | Ent, L.L.C | Phonosurgery devices |
US5549673A (en) * | 1990-04-20 | 1996-08-27 | Smith & Nephew Richards Inc. | Phonosurgery implant instruments and a system and method of implantation |
US5197982A (en) * | 1991-10-15 | 1993-03-30 | Goldsmith Iii Manning M | Adjustable prosthetic device for vocal cord and method |
US20110082547A1 (en) * | 1997-10-10 | 2011-04-07 | Senorx, Inc. | Tissue marking implant |
US8157862B2 (en) | 1997-10-10 | 2012-04-17 | Senorx, Inc. | Tissue marking implant |
US9039763B2 (en) | 1997-10-10 | 2015-05-26 | Senorx, Inc. | Tissue marking implant |
US8668737B2 (en) | 1997-10-10 | 2014-03-11 | Senorx, Inc. | Tissue marking implant |
US8147487B2 (en) | 1998-03-03 | 2012-04-03 | Senorx, Inc. | Apparatus and method for accessing a body site |
US6758848B2 (en) | 1998-03-03 | 2004-07-06 | Senorx, Inc. | Apparatus and method for accessing a body site |
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Also Published As
Publication number | Publication date |
---|---|
JPS5029596B1 (de) | 1975-09-25 |
NL7200661A (de) | 1972-07-25 |
GB1334691A (en) | 1973-10-24 |
FR2122952A5 (de) | 1972-09-01 |
CS151338B1 (de) | 1973-10-19 |
IT948034B (it) | 1973-05-30 |
DE2201861A1 (de) | 1972-08-10 |
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