US3314429A - Gelatin capsule with dispenser - Google Patents

Gelatin capsule with dispenser Download PDF

Info

Publication number
US3314429A
US3314429A US396188A US39618864A US3314429A US 3314429 A US3314429 A US 3314429A US 396188 A US396188 A US 396188A US 39618864 A US39618864 A US 39618864A US 3314429 A US3314429 A US 3314429A
Authority
US
United States
Prior art keywords
cannula
capsule
needle
tube
vessel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US396188A
Inventor
Norman J Boehm
Charles C Cochran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Catalent Pharma Solutions Inc
Original Assignee
Catalent Pharma Solutions Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Catalent Pharma Solutions Inc filed Critical Catalent Pharma Solutions Inc
Priority to US396188A priority Critical patent/US3314429A/en
Priority to DE19651486663 priority patent/DE1486663A1/en
Priority to GB37001/65A priority patent/GB1122787A/en
Application granted granted Critical
Publication of US3314429A publication Critical patent/US3314429A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D35/00—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
    • B65D35/24—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with auxiliary devices
    • B65D35/36—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with auxiliary devices for applying contents to surfaces
    • B65D35/38—Nozzles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages

Definitions

  • This invention relates to tube-type capsules for holding fluid medicaments and the like and in particular to an improved technique for extracting the fluid from such capsules.
  • Tube-type capsules of e.g. gelatin are well known in the art and are used to hold salves, adhesives, oils and other fluid materials. Such capsules terminate in an end, which may be of reduced diameter, to provide a neck and the enclosed fluid normally is released by puncturing or snipping off the tip of the neck. Such capsules are advantageous for dispensing the fluid in desired quantities by squeezing the body to expel liquid from the opening in the neck.
  • fluids as a ribbon through an aperture as e.g. ointments or creams. It is also desirable to be able to insert medicaments internally into animals, as well as externally. For example, in treating mastitis in cows where medication must be inserted into an infected udder in which case it is necessary to provide the normally stubbed-nose capsule with means to apply the medicament through the teat.
  • Another object is to provide an extension or cannula of this type which includes means for puncturing the end of the capsule as the cannula is being affixed to the capsule, or after cannula has been aflixed.
  • FIG. 1 is a side view, partially in section, of a conventional tube-type capsule containing liquid
  • FIG. 2 is a sectional axial view of a cannular extension for the capsule
  • FIG. 3 is a side view, partly in section, of a puncture rod adapted to fit within the extension of FIG. 2;
  • FIG. 4 is a side View of the capsule, extension and puncture rod in assembled relation
  • FIG. 5 is a view like FIG. 4 broken away to show the puncture rod fully extended into the cannula and through the neck of the capsule;
  • FIG. 6 is an enlarged sectional View of a cannula having an integrally molded puncture needle in the base thereof.
  • a cannula of plastic or other suitable material is attached to the neck portion 1 of a tube capsule 4 by properly deforming the neck.
  • Polyethylene is a particularly good material from which to mold the cannula as it is cheap, easily molded and of the proper hardness to deform properly the capsule neck.
  • polystyrenee, cellulose acetate or other plastic materials are also suitable.
  • the cannula has a nozzle or tip 3 and a large base portion 2 which is internally threaded and of such internal diameter as to engage snugly the smooth-surfaced neck 1 of the capsule 4 when twisted thereon.
  • the capsule material e.g.
  • plasticized gelatin must be sufficiently soft and pliable so that it readily deforms to mate closely with the threads of the base. In this way the cannula is firmly secured to the capsule to prevent removal by axial stress and leakage of fluid.
  • a suitable gelatin composition contains by weight from about 27 to 36% gelatin, about 47 to 25% glycerin and the balance water. This material possesses the property of cold flow and thus deforms upon application of pressure without heat.
  • a suitable tool may take the form of a hollow metal needle 6 with pointed end 7 slidably disposed in the opening 5 in the cannula tip 3.
  • the needle also may be made of rigid plastic such as polystyrene and if desired may be integrally formed with the cannula rather than as a separate part.
  • the needle 6 When it is desired to expel the contents of the capsule 4, the needle 6 is pushed down to pierce the end of capsule neck 1, thus providing a passage from the interior of the capsule into the cannula through the needle.
  • the capsule contents may be expelled through the needle within the cannula by squeezing the capsule 4, when the parts fll'fi assembled as shown in FIG. 5.
  • the needle If integrally formed, the needle will extend only from the inner end of the cannula as indicated at 8 in FIG. 6. Since the needle 8 does not move with respect to the base, it will pierce the capsule only as the cannula is screwed on to the capsule, just prior to use.
  • the capsule contains medicament which must be used under sterile conditions
  • the capsule and the cannula-needle device 3, 6 are sterilized and packed in a sterile package. Care must be taken in iercing to apply pressure to the needle 6 with sterile means since the medicament flows through the needle. When adhesive or other non-sterile materials are being handled this is not necessary, of course.
  • the tool may be of any cross-sectional shape as long as it is sufficiently pointed to puncture the capsule easily.
  • An alternative means for puncturing the capsule is a solid pointed rod or needle which may replace the hollow 6 in the cannula.
  • the rod may be inserted in the capsule at the time of assemblage of the parts and may remain in such position as a seal or plug until later withdrawal for release of fluid contents of the capsule.
  • the opening formed by the solid needle will remain open after the needle is removed. It should be pointed out however, that piercing the capsule and immediately removing the needle does not permit free flow from the capsule because the gelatin closes again. After the needle has been in the gelatin for some time, the gelatin takes a set and will remain open when the needle is removed.
  • Still another alternative is to use a hollow puncture die into which a slug of capsule material lodges upon puncture. The slug is removed upon withdrawal of the tube thus providing free flow to the cannula.
  • Cannula extensions of the type described may be used with any size capsules as long as there is sufficient neck length and diameter to provide a proper seal with threads of the cannula base.
  • the capsule may be of substantially uniform diameter provided of course the diameter is slightly smaller than the base of the cannula so that the cannula will fit. In other words a capsule with a neck is not necessary for purposes of the invention.
  • a dispensing device to be used with medication filled capsules for treatment of mastitis and the like comprising, in combination;
  • a vessel part of which is a smooth surfaced cylindrical shaped portion of cold flow deformable material
  • an elongated cannula constructed of a. material harder than said deformable material, said cannula having an enlarged internally threaded base end and a tip end, said base end being screwed onto and forming threads on said vessel at said smooth surfaced portion in fluid tight relationship,

Description

United States Patent Ofilice 3,314,429 Patented Apr. 18, 1967 3,314,429 GELATIN CAPSULE WITH DISPENSER Norman J. Boehm, Grosse Pointe Woods, and Charles C. Cochran, Hamtramck, Micln, assignors to R. P. Scherer Corporation, Detroit, Mich.
Filed Sept. 14, 1964, Ser. No. 396,188 2 Claims. (Cl. 128-232) This invention relates to tube-type capsules for holding fluid medicaments and the like and in particular to an improved technique for extracting the fluid from such capsules.
Tube-type capsules of e.g. gelatin are well known in the art and are used to hold salves, adhesives, oils and other fluid materials. Such capsules terminate in an end, which may be of reduced diameter, to provide a neck and the enclosed fluid normally is released by puncturing or snipping off the tip of the neck. Such capsules are advantageous for dispensing the fluid in desired quantities by squeezing the body to expel liquid from the opening in the neck.
It is often desirable to release fluids as a ribbon through an aperture as e.g. ointments or creams. It is also desirable to be able to insert medicaments internally into animals, as well as externally. For example, in treating mastitis in cows where medication must be inserted into an infected udder in which case it is necessary to provide the normally stubbed-nose capsule with means to apply the medicament through the teat.
It is thus an object of this invention to provide an inexpensive, safe and reliable device for releasing fluid from a tube capsule through an elongated discharge passage.
It is a further object of this invention to provide a combination tube-type capsule and extension which is free of leakage at the juncture of the capsule and extension in which the extension is held secure from inadvertent axial removal from the capsule.
Another object is to provide an extension or cannula of this type which includes means for puncturing the end of the capsule as the cannula is being affixed to the capsule, or after cannula has been aflixed.
In the drawing:
FIG. 1 is a side view, partially in section, of a conventional tube-type capsule containing liquid;
FIG. 2 is a sectional axial view of a cannular extension for the capsule;
FIG. 3 is a side view, partly in section, of a puncture rod adapted to fit within the extension of FIG. 2;
FIG. 4 is a side View of the capsule, extension and puncture rod in assembled relation;
FIG. 5 is a view like FIG. 4 broken away to show the puncture rod fully extended into the cannula and through the neck of the capsule; and
FIG. 6 is an enlarged sectional View of a cannula having an integrally molded puncture needle in the base thereof.
In accordance with our invention a cannula of plastic or other suitable material is attached to the neck portion 1 of a tube capsule 4 by properly deforming the neck. Polyethylene is a particularly good material from which to mold the cannula as it is cheap, easily molded and of the proper hardness to deform properly the capsule neck. However, polystyrenee, cellulose acetate or other plastic materials are also suitable. The cannula has a nozzle or tip 3 and a large base portion 2 which is internally threaded and of such internal diameter as to engage snugly the smooth-surfaced neck 1 of the capsule 4 when twisted thereon. The capsule material, e.g. plasticized gelatin, must be sufficiently soft and pliable so that it readily deforms to mate closely with the threads of the base. In this way the cannula is firmly secured to the capsule to prevent removal by axial stress and leakage of fluid. A suitable gelatin composition contains by weight from about 27 to 36% gelatin, about 47 to 25% glycerin and the balance water. This material possesses the property of cold flow and thus deforms upon application of pressure without heat.
Prior to inserting the capsule into the cannula base it may be unctured at the neck tip to permit later discharge of fluid through the cannula. However, because of difficulty in preventing fluid seepage prior to securing the extension when the capsule is prepunctured, we have found it more convenient to puncture the capsule after mating with the extension by providing in the cannula opening a needlelike puncture tool. A suitable tool may take the form of a hollow metal needle 6 with pointed end 7 slidably disposed in the opening 5 in the cannula tip 3. The needle also may be made of rigid plastic such as polystyrene and if desired may be integrally formed with the cannula rather than as a separate part. When it is desired to expel the contents of the capsule 4, the needle 6 is pushed down to pierce the end of capsule neck 1, thus providing a passage from the interior of the capsule into the cannula through the needle. The capsule contents may be expelled through the needle within the cannula by squeezing the capsule 4, when the parts fll'fi assembled as shown in FIG. 5. If integrally formed, the needle will extend only from the inner end of the cannula as indicated at 8 in FIG. 6. Since the needle 8 does not move with respect to the base, it will pierce the capsule only as the cannula is screwed on to the capsule, just prior to use.
When the capsule contains medicament which must be used under sterile conditions, the capsule and the cannula-needle device 3, 6 are sterilized and packed in a sterile package. Care must be taken in iercing to apply pressure to the needle 6 with sterile means since the medicament flows through the needle. When adhesive or other non-sterile materials are being handled this is not necessary, of course.
The tool may be of any cross-sectional shape as long as it is sufficiently pointed to puncture the capsule easily. An alternative means for puncturing the capsule is a solid pointed rod or needle which may replace the hollow 6 in the cannula. The rod may be inserted in the capsule at the time of assemblage of the parts and may remain in such position as a seal or plug until later withdrawal for release of fluid contents of the capsule.
Because of the cold flow properties of the gelatin, the opening formed by the solid needle will remain open after the needle is removed. It should be pointed out however, that piercing the capsule and immediately removing the needle does not permit free flow from the capsule because the gelatin closes again. After the needle has been in the gelatin for some time, the gelatin takes a set and will remain open when the needle is removed.
Still another alternative is to use a hollow puncture die into which a slug of capsule material lodges upon puncture. The slug is removed upon withdrawal of the tube thus providing free flow to the cannula.
Cannula extensions of the type described may be used with any size capsules as long as there is sufficient neck length and diameter to provide a proper seal with threads of the cannula base. The capsule may be of substantially uniform diameter provided of course the diameter is slightly smaller than the base of the cannula so that the cannula will fit. In other words a capsule with a neck is not necessary for purposes of the invention.
We claim:
1. A dispensing device to be used with medication filled capsules for treatment of mastitis and the like comprising, in combination;
a vessel part of which is a smooth surfaced cylindrical shaped portion of cold flow deformable material,
an elongated cannula constructed of a. material harder than said deformable material, said cannula having an enlarged internally threaded base end and a tip end, said base end being screwed onto and forming threads on said vessel at said smooth surfaced portion in fluid tight relationship,
a separate and removable pointed needle, shaped to conform to and slidably mounted in the tube of said cannula with said pointed end extending into said base end of said cannula, said needle extending the length of said tube and protruding from said tip end References Cited by the Examiner UNITED STATES PATENTS Pittenger 128272 Saffir 128-272 Barradas 128216 Marchand 128-216 X Gonshery 167-83 RICHARD A. GAUDET, Primary Examiner.
G. E. MCNEILL, Assistant Examiner.

Claims (1)

1. A DISPENSING DEVICE TO BE USED WITH MEDICATION FILLED CAPSULES FOR TREATMENT OF MASTITIS AND THE LIKE COMPRISING, IN COMBINATION; A VESSEL PART OF WHICH IS A SMOOTH SURFACED CYLINDRICAL SHAPED PORTION OF COLD FLOW DEFORMABLE MATERIAL, AN ELONGATED CANNULA CONSTRUCTED OF A MATERIAL HARDER THAN SAID DEFORMABLE MATERIAL, SAID CANNULA HAVING AN ENLARGED INTERNALLY THREADED BASE END AND A TIP END, SAID BASE END BEING SCREWED ONTO AND FORMING THREADS ON SAID VESSEL AT SAID SMOOTH SURFACED PORTION IN FLUID TIGHT RELATIONSHIP, A SEPARATE AND REMOVABLE POINTED NEEDLE, SHAPED TO CONFORM TO AND SLIDABLY MOUNTED IN THE TUBE OF SAID CANNULA WITH SAID POINTED END EXTENDING INTO SAID BASE END OF SAID CANNULA, SAID NEEDLE EXTENDING THE LENGTH OF SAID TUBE AND PROTRUDING FROM SAID TIP END SO THAT IT MAY BE MANUALLY DISPLACED TO PIERCE SAID VESSEL AND THEN REMOVED FROM SAID CANNULA.
US396188A 1964-09-14 1964-09-14 Gelatin capsule with dispenser Expired - Lifetime US3314429A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US396188A US3314429A (en) 1964-09-14 1964-09-14 Gelatin capsule with dispenser
DE19651486663 DE1486663A1 (en) 1964-09-14 1965-08-27 Gelatin capsule with dispenser
GB37001/65A GB1122787A (en) 1964-09-14 1965-08-27 Device comprising a deformable capsule and a cannula

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US396188A US3314429A (en) 1964-09-14 1964-09-14 Gelatin capsule with dispenser

Publications (1)

Publication Number Publication Date
US3314429A true US3314429A (en) 1967-04-18

Family

ID=23566218

Family Applications (1)

Application Number Title Priority Date Filing Date
US396188A Expired - Lifetime US3314429A (en) 1964-09-14 1964-09-14 Gelatin capsule with dispenser

Country Status (3)

Country Link
US (1) US3314429A (en)
DE (1) DE1486663A1 (en)
GB (1) GB1122787A (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3480014A (en) * 1966-09-15 1969-11-25 American Cyanamid Co Method for ointment storage and dispensing
US3905370A (en) * 1974-03-28 1975-09-16 Int Paper Co Disposable douche product
US3995772A (en) * 1975-07-07 1976-12-07 Liautaud James P Non-pressurized fluid product dispenser
US4152378A (en) * 1977-03-14 1979-05-01 Baxter Travenol Laboratories, Inc. Container closure having automatic opening means
US4361149A (en) * 1977-08-27 1982-11-30 Bunder Glas Gmbh Injection syringe
US4994029A (en) * 1989-09-12 1991-02-19 David Bull Laboratories Pty. Ltd. Syringe mixer and injector device
US5480064A (en) * 1995-01-04 1996-01-02 Yan; Yi-Tsung Dispensing syringe for a fluid glue
US6213349B1 (en) * 1999-08-23 2001-04-10 Yi-Tsung Yan Cap structure of a glue container
US20100210565A1 (en) * 1999-11-08 2010-08-19 Rasor Julia S Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces
US20110040240A1 (en) * 1999-07-12 2011-02-17 Capnia, Inc. Methods for treating rhinitis and conjunctivitis
JP2016060492A (en) * 2014-09-12 2016-04-25 ユニ・チャーム株式会社 Fluid container

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2021982B (en) * 1978-06-05 1982-12-22 Beckman Instruments Inc Integral one piece centrifuge tube
GB8405244D0 (en) * 1984-02-29 1984-04-04 Edwards J I Hypodermic instruments
US4886495A (en) * 1987-07-08 1989-12-12 Duoject Medical Systems Inc. Vial-based prefilled syringe system for one or two component medicaments
GB2210268A (en) * 1987-02-25 1989-06-07 Duoject Inc Syringe system
US5364369A (en) * 1987-07-08 1994-11-15 Reynolds David L Syringe
ZA886656B (en) * 1987-09-16 1990-05-30 Colgate Palmolive Co Device for treatment of gum disease
US5462317A (en) * 1994-03-23 1995-10-31 Keller; Wilhelm A. Adapter for a mixing or dispensing device
DE19805007A1 (en) * 1998-02-07 1999-08-12 Krupp Berco Bautechnik Gmbh Device for attaching a lubricant reservoir to a lubricant delivery unit

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2176041A (en) * 1936-06-25 1939-10-10 Sharp & Dohme Inc 1929 Container for lyophilic biologically active substances
US2628615A (en) * 1949-12-28 1953-02-17 Jacob A Saffir Hypodermic injection device
US2677373A (en) * 1952-05-19 1954-05-04 P M Ind Inc Plastic injection device
US2768623A (en) * 1954-12-29 1956-10-30 John F Marchand Container for liquids, and more particularly to a container which incorporates therein the function of a syringe
US3239420A (en) * 1962-10-11 1966-03-08 Vitamix Pharmaceuticals Inc Gelatin composition

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2176041A (en) * 1936-06-25 1939-10-10 Sharp & Dohme Inc 1929 Container for lyophilic biologically active substances
US2628615A (en) * 1949-12-28 1953-02-17 Jacob A Saffir Hypodermic injection device
US2677373A (en) * 1952-05-19 1954-05-04 P M Ind Inc Plastic injection device
US2768623A (en) * 1954-12-29 1956-10-30 John F Marchand Container for liquids, and more particularly to a container which incorporates therein the function of a syringe
US3239420A (en) * 1962-10-11 1966-03-08 Vitamix Pharmaceuticals Inc Gelatin composition

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3480014A (en) * 1966-09-15 1969-11-25 American Cyanamid Co Method for ointment storage and dispensing
US3905370A (en) * 1974-03-28 1975-09-16 Int Paper Co Disposable douche product
US3995772A (en) * 1975-07-07 1976-12-07 Liautaud James P Non-pressurized fluid product dispenser
US4152378A (en) * 1977-03-14 1979-05-01 Baxter Travenol Laboratories, Inc. Container closure having automatic opening means
US4361149A (en) * 1977-08-27 1982-11-30 Bunder Glas Gmbh Injection syringe
US4994029A (en) * 1989-09-12 1991-02-19 David Bull Laboratories Pty. Ltd. Syringe mixer and injector device
US5480064A (en) * 1995-01-04 1996-01-02 Yan; Yi-Tsung Dispensing syringe for a fluid glue
US20110040240A1 (en) * 1999-07-12 2011-02-17 Capnia, Inc. Methods for treating rhinitis and conjunctivitis
US6213349B1 (en) * 1999-08-23 2001-04-10 Yi-Tsung Yan Cap structure of a glue container
US20100210565A1 (en) * 1999-11-08 2010-08-19 Rasor Julia S Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces
JP2016060492A (en) * 2014-09-12 2016-04-25 ユニ・チャーム株式会社 Fluid container
US20170197762A1 (en) * 2014-09-12 2017-07-13 Unicharm Corporation Fluid container
US10093459B2 (en) * 2014-09-12 2018-10-09 Unicharm Corporation Fluid container

Also Published As

Publication number Publication date
DE1486663A1 (en) 1969-06-12
GB1122787A (en) 1968-08-07

Similar Documents

Publication Publication Date Title
US3314429A (en) Gelatin capsule with dispenser
US3938520A (en) Transfer unit having a dual channel transfer member
US2764979A (en) Medicament dispensing unit
US3376866A (en) Medicament injector with attached vial
US3739779A (en) Hypodermic syringe and needle construction
US3330281A (en) Combination syringe and vial mixing container
US3411503A (en) Collapsible mixing syringe with extrusion casing
US4741737A (en) Prefilled ampoule-syringe
US5454805A (en) Medicine vial link for needleless syringes
US2699167A (en) Hypodermic injector
US3506008A (en) Medical applicator
US3945382A (en) Device for introduction of liquid medication into a flexible bag
US4664656A (en) Injection syringe
US3108591A (en) Syringe
PT100362A (en) DEVICE FOR THE ADMINISTRATION OF MEDICINES, IN PARTICULAR MEDICATIONS WITH TWO COMPONENTS
US3482572A (en) Apparatus for the infusion of liquids into a body
US3737973A (en) Method and device for assembling a stopper to a syringe barrel
US2681654A (en) Venoclysis equipment
US2693189A (en) Venoclysis equipment
US4453935A (en) Disposable container-applicator with leak-proof cover
US5413564A (en) Predetermined dosage hypodermic syringe system
US3089489A (en) Aspirating type hypodermic syringes
US20080249462A1 (en) Disposable Dispensers for Personal Use
US3244173A (en) Syringe
US3380449A (en) Cartridge with burstable seal