US20140048171A1 - Device for the preparation of containment units of biological liquids - Google Patents
Device for the preparation of containment units of biological liquids Download PDFInfo
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- US20140048171A1 US20140048171A1 US14/004,995 US201214004995A US2014048171A1 US 20140048171 A1 US20140048171 A1 US 20140048171A1 US 201214004995 A US201214004995 A US 201214004995A US 2014048171 A1 US2014048171 A1 US 2014048171A1
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- Prior art keywords
- gap
- containment units
- containment
- units
- outlet
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0231—Multiple bag systems for separating or storing blood components with gas separating means, e.g. air outlet through microporous membrane or gas bag
Definitions
- the present invention relates to a device for the preparation of containment units of biological liquids.
- devices of known type having means for the connection of a syringe containing the biological liquid and a plurality of containment units to be filled.
- connection means define a transit channel for the biological liquid having an inlet gap, connectable to the syringe containing the biological liquid, and a plurality of outlet gaps, associable with the units to be filled.
- These devices also comprise at least a mouth for expelling the air contained in the containment units, and aspired by means of a syringe.
- the containment units generally used with these devices of known type are of the soft or flexible type, i.e., deformable to such an extent as to make their opposite sides coincide with one another, so that by applying a suitable vacuum, they can be emptied of the air contained inside them, thereby making subsequent filling easier.
- Another problem still of devices of known type consists in the fact that they do not allow the easy preparation of a high number of containment units, e.g., more than twenty units, due to the ensuing difficulty in handling same.
- the devices of known type cannot therefore be used with semi-rigid containment units, i.e., deformable but not enough to cause their collapse, although preferable to soft bags inasmuch as they permit controlling the dispensing of the biological liquid towards the outside in a more precise and easier way.
- the semi-rigid units are not used with the aforementioned devices of known type inasmuch as they cannot be completely emptied of the air contained inside them, and which therefore prevents them from being completely filled.
- the biological liquid introduced into the transit channel by the syringe manages to return up towards the semi-rigid containment units only along a section of the channel itself due to the presence of air which prevents it from moving any further forward.
- the devices of known type for filling containment units of biological liquids such as stem cells, platelet concentrates, serum eye drops, plasma, etc. . . . , have a range of application limited only to the use of flexible containment units, which are however to be considered worse than the semi-rigid type inasmuch as they do not permit the controlled dispensing of the biological liquid itself.
- the main aim of the present invention is to provide a device for the preparation of containment units of biological liquids which is considerably more simple to make and use than the known devices.
- one object of the present invention is to provide a device which allows to fill a plurality of containment units in a considerably quicker way than the known devices.
- One object of the present invention is to provide a device which has a greater flexibility of use, meaning that it can be used indifferently for filling flexible, semi-rigid or rigid containment units.
- Another object of the present invention is to provide a device for the preparation of containment units of biological liquids which allows overcoming the mentioned drawbacks of the state of the art within the ambit of a simple, rational, easy and effective to use as well as low cost solution.
- the present device for the preparation of containment units of biological liquids, characterised by the fact that it comprises a main body which defines at least a filling channel, having at least an inlet gap of a biological liquid and at least an air outlet gap, and which comprises a plurality of containment units arranged in succession to one another and defining respective containment chambers positioned along said filling channel and placed in between said inlet gap and said outlet gap.
- FIG. 1 is a plan view from above of a device according to the invention in a first embodiment
- FIG. 2 is a transversal section of the device of FIG. 1 ;
- FIG. 3 is a plan view from above of a device according to the invention in a second embodiment
- FIG. 4 is a plan view from above of a device according to the invention in a third embodiment.
- a device for the preparation of containment units of biological liquids such as stem cells, platelet concentrates, serum eye drops, plasma, etc. . . .
- the device 1 comprises at least one main body 2 which defines at least a filling channel 3 having an inlet gap 3 a, connectable to a syringe containing a biological liquid, and at least an outlet gap 3 b for air expulsion.
- the body 2 comprises a plurality of containment units 4 , arranged in succession to one another, which define respective containment chambers 5 positioned along the channel 3 and placed in between the inlet gap 3 a and the outlet gap 3 b.
- the chambers 5 communicate therefore with the filling channel 3 . More in particular, the chambers 5 communicate with the inlet gap 3 a and outlet gap 3 b.
- the inlet gap 3 a and the outlet gap 3 b are arranged in correspondence to the opposite extremity sections of the body 2 .
- the inlet gap 3 a and the outlet gap 3 b are therefore arranged on opposite sides with respect to the containment units 4 .
- the units 4 can be of the soft, semi-rigid or rigid type.
- the units 4 are of the semi-rigid type. More in particular, the units 4 are elastically deformable, and so they naturally tend to return to an idle configuration wherein the walls delimiting the relative chambers 5 are at a distance from one another.
- the body 2 comprises, in correspondence to the inlet gap 3 a, a connection of the luer lock type.
- the device 1 comprises a filtering device 6 of hydrophobic type associated with the body 2 in correspondence to the outlet gap 3 b.
- the body 2 comprises at least an intermediate tubular element 7 a placed in between each pair of consecutive containment units 4 and at least two extremal tubular elements 7 b associated with the first and last of the units 4 respectively and defining the inlet gap 3 a and the outlet gap 3 b.
- Each tubular element 7 a and 7 b therefore defines a corresponding section of the filling channel 3 .
- each unit 4 has two openings 8 , arranged on opposite sides, each of which is associated with a respective intermediate or extremal tubular element 7 a and 7 b.
- the units 4 are made separately with respect to the tubular elements 7 a and 7 b and are associated integral with the latter in correspondence to their extremal portions.
- At least one of the tubular elements 7 a and 7 b comprises a first and a second portion 9 a and 9 b associated integral the one with the other and crossed by the filling channel 3 .
- the first portion 9 a is separable from the second portion 9 b so as to interrupt the filling channel 3 and define an outlet mouth for the biological liquid on the second portion itself.
- the first portion 9 a comprises closing means 10 for closing the outlet mouth so defined on the second portion 9 b.
- the first portion 9 a is removable by tearing off from the second portion 9 b and separation means 11 are provided for separating the portions 9 a and 9 b.
- the separation means 11 comprise two pairs of fins, of which one pair is associated with the first portion 9 a and the other pair is associated with the second portion 9 b, suitable for being gripped by an operator to facilitate the reciprocal rotation of the portions 9 a and 9 b.
- the units 4 have bigger section than the tubular elements 7 a and 7 b.
- the channel 3 also comprises at least an additional mouth 12 associable with an additional syringe, e.g., for the introduction of substances for activating the biological liquid.
- the additional mouth 12 is arranged on the opposite side of the outlet gap 3 b with respect to the containment units 4 . More in detail, the additional mouth 12 is defined on the extremal tubular element 7 b which also defines the inlet gap 3 a.
- the device 1 comprises at least one valve element 13 associated with the body 2 and which can be operated to place selectively in communication the containment chambers 5 with the inlet gap 3 a or with the additional mouth 12 .
- the additional mouth 12 is defined on at least one intermediate tubular element 7 a.
- the channel 3 comprises a plurality of additional mouths 12 defined on each intermediate tubular element 7 a and on at least one extremal tubular element 7 b.
- the device 1 also comprises at least one elastically deformable valve body arranged in correspondence to each additional mouth 12 ; such valve body, not visible in detail in the figures, is suitable for opening by effect of the insertion of the additional syringe needle and for closing automatically following the removal of the latter.
- the channel 3 also comprises one additional gap 14 suitable for allowing air to come out in the event of two or more syringes being used for filling the units 4 .
- the additional gap 14 is arranged on the opposite side of the outlet gap 3 b with respect to the units 4 .
- the additional gap 14 is defined along the extremal tubular element 7 b which also defines the inlet gap 3 a.
- the additional gap 14 is distinct from the inlet gap 3 a, the outlet gap 3 b and the additional mouth 12 .
- the device 1 then comprises a further filtering device 15 , this too of the hydrophobic and breathable type, associated with the body 2 and fitted in the additional gap 14 .
- the device 1 comprises a further valve element 16 associated with the body 2 in correspondence to the additional gap 14 and which can be operated to place selectively in communication the inlet gap 3 a with the additional gap 14 or with the chambers 5 .
- the operation of the present invention is the following.
- a syringe is introduced containing a biological liquid inside the inlet gap 3 a and the biological liquid is injected along the channel 3 by pressing the piston of the syringe itself.
- the biological liquid injected this way runs along the entire channel 3 and gradually fills the containment chambers 5 which it crosses.
- the relative syringe is introduced into the additional mouth 12 thus injecting its contents along the channel 3 .
- each intermediate tubular element 7 a and one extremal tubular element 7 b is provided with a relevant additional mouth 12 , and so the activation substances can also be injected inside the chambers 5 after each chamber 5 has been closed.
- each unit 4 are closed by means of a welding long each tubular element 7 a and 7 b. At this point, each unit 4 can be separated from the others and managed independently.
- each tubular element 7 a and 7 b is suitably done in correspondence to the relative first portion 9 a, in such a way that this can then be detached from the corresponding second portion 9 b to close it.
- the positioning of the containment units in series along an open channel allows automatically expelling the air inside the channel itself by effect of the introduction of the biological liquid.
- the device according to the invention is therefore easy to make and use, inasmuch as it is made up of considerably fewer components compared to known devices and requires only the execution of the injection phase of the biological liquid inside the filling channel.
- the device according to the invention can be used with any type of containment units, meaning both with soft containment units and with semi-rigid or rigid ones. Such device therefore has a flexible range of use.
- the device according to the invention allows filling any number of containment units in a very easy way, without this affecting at all the structural complexity of same or its ease of handling.
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Veterinary Medicine (AREA)
- Mechanical Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- External Artificial Organs (AREA)
- Supply Of Fluid Materials To The Packaging Location (AREA)
- Packages (AREA)
- Basic Packing Technique (AREA)
Abstract
The device (1) for the preparation of containment units (4) of biological liquids includes a main body (2) which defines at least a filling channel (3), having at least an inlet gap (3 a) of a biological liquid and at least an air outlet gap (3 b), and includes a plurality of containment units (4) arranged in succession to one another and defining respective containment chambers (5) positioned along the filling channel (3) and placed in between the inlet gap (3 a) and the outlet gap (3 b).
Description
- The present invention relates to a device for the preparation of containment units of biological liquids.
- Generally speaking, to fill containment units of biological liquids such as stem cells, platelet concentrates, serum eye drops, plasma, etc. . . . , devices of known type are used having means for the connection of a syringe containing the biological liquid and a plurality of containment units to be filled.
- More in particular, these connection means define a transit channel for the biological liquid having an inlet gap, connectable to the syringe containing the biological liquid, and a plurality of outlet gaps, associable with the units to be filled.
- These devices also comprise at least a mouth for expelling the air contained in the containment units, and aspired by means of a syringe. In fact, the containment units generally used with these devices of known type are of the soft or flexible type, i.e., deformable to such an extent as to make their opposite sides coincide with one another, so that by applying a suitable vacuum, they can be emptied of the air contained inside them, thereby making subsequent filling easier.
- Some of these devices of known type are described by DE 19934491 and by EP 1930033.
- These devices of known type do however have a number of drawbacks.
- They are in fact complicated to make and assemble, also due to the high number of parts making them up.
- Another drawback of these known devices consists in the fact that they take a long time to prepare. These long preparation times are due at least in part to the carrying out of the air aspiration and biological liquid filling phases, which may even have to be repeated several times in order to eliminate as much air as possible, and to the handling of the devices themselves aimed at facilitating the movement of the air bubbles towards the outlet mouth.
- Another problem still of devices of known type consists in the fact that they do not allow the easy preparation of a high number of containment units, e.g., more than twenty units, due to the ensuing difficulty in handling same.
- Furthermore, the larger the number of containment units to be filled, the greater the dimensions must be of the connecting elements placed between the syringe and the containment units themselves, hence the biological liquid which remains inside such connecting elements and which is wasted increases along with the increase in the number of units to be filled.
- Another drawback of known devices consists in the fact that they can only be used with containment units of a soft or flexible type, i.e., whose walls are deformable until they coincide with one another.
- The devices of known type cannot therefore be used with semi-rigid containment units, i.e., deformable but not enough to cause their collapse, although preferable to soft bags inasmuch as they permit controlling the dispensing of the biological liquid towards the outside in a more precise and easier way.
- More in detail, the semi-rigid units are not used with the aforementioned devices of known type inasmuch as they cannot be completely emptied of the air contained inside them, and which therefore prevents them from being completely filled. The biological liquid introduced into the transit channel by the syringe manages to return up towards the semi-rigid containment units only along a section of the channel itself due to the presence of air which prevents it from moving any further forward.
- It therefore follows that the devices of known type for filling containment units of biological liquids, such as stem cells, platelet concentrates, serum eye drops, plasma, etc. . . . , have a range of application limited only to the use of flexible containment units, which are however to be considered worse than the semi-rigid type inasmuch as they do not permit the controlled dispensing of the biological liquid itself.
- The main aim of the present invention is to provide a device for the preparation of containment units of biological liquids which is considerably more simple to make and use than the known devices.
- Within this aim, one object of the present invention is to provide a device which allows to fill a plurality of containment units in a considerably quicker way than the known devices.
- One object of the present invention is to provide a device which has a greater flexibility of use, meaning that it can be used indifferently for filling flexible, semi-rigid or rigid containment units.
- Another object of the present invention is to provide a device for the preparation of containment units of biological liquids which allows overcoming the mentioned drawbacks of the state of the art within the ambit of a simple, rational, easy and effective to use as well as low cost solution.
- The above objects are achieved by the present device for the preparation of containment units of biological liquids, characterised by the fact that it comprises a main body which defines at least a filling channel, having at least an inlet gap of a biological liquid and at least an air outlet gap, and which comprises a plurality of containment units arranged in succession to one another and defining respective containment chambers positioned along said filling channel and placed in between said inlet gap and said outlet gap.
- Other characteristics and advantages of the present invention will become more evident from the description of a preferred, but not sole, embodiment of a device for the preparation of containment units of biological liquids, illustrated purely as an example but not limited to the annexed drawings in which:
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FIG. 1 is a plan view from above of a device according to the invention in a first embodiment; -
FIG. 2 is a transversal section of the device ofFIG. 1 ; -
FIG. 3 is a plan view from above of a device according to the invention in a second embodiment; -
FIG. 4 is a plan view from above of a device according to the invention in a third embodiment. - With particular reference to such figures, globally indicated by 1 is a device for the preparation of containment units of biological liquids, such as stem cells, platelet concentrates, serum eye drops, plasma, etc. . . .
- According to the invention, the
device 1 comprises at least onemain body 2 which defines at least a fillingchannel 3 having aninlet gap 3 a, connectable to a syringe containing a biological liquid, and at least anoutlet gap 3 b for air expulsion. - Moreover, the
body 2 comprises a plurality ofcontainment units 4, arranged in succession to one another, which definerespective containment chambers 5 positioned along thechannel 3 and placed in between theinlet gap 3 a and theoutlet gap 3 b. - The
chambers 5 communicate therefore with the fillingchannel 3. More in particular, thechambers 5 communicate with theinlet gap 3 a andoutlet gap 3 b. - More in detail, the
inlet gap 3 a and theoutlet gap 3 b are arranged in correspondence to the opposite extremity sections of thebody 2. Theinlet gap 3 a and theoutlet gap 3 b are therefore arranged on opposite sides with respect to thecontainment units 4. - The
units 4 can be of the soft, semi-rigid or rigid type. - Preferably, the
units 4 are of the semi-rigid type. More in particular, theunits 4 are elastically deformable, and so they naturally tend to return to an idle configuration wherein the walls delimiting therelative chambers 5 are at a distance from one another. - The
body 2 comprises, in correspondence to theinlet gap 3 a, a connection of the luer lock type. - Furthermore, the
device 1 comprises afiltering device 6 of hydrophobic type associated with thebody 2 in correspondence to theoutlet gap 3 b. - Advantageously, the
body 2 comprises at least an intermediatetubular element 7 a placed in between each pair ofconsecutive containment units 4 and at least two extremaltubular elements 7 b associated with the first and last of theunits 4 respectively and defining theinlet gap 3 a and theoutlet gap 3 b. Eachtubular element filling channel 3. - More in particular, each
unit 4 has two openings 8, arranged on opposite sides, each of which is associated with a respective intermediate or extremaltubular element - Preferably, the
units 4 are made separately with respect to thetubular elements - Different embodiments cannot be ruled wherein the
units 4 are made in a single body piece with thetubular elements - In the second embodiment shown in the
FIG. 3 , at least one of thetubular elements second portion filling channel 3. More in particular, thefirst portion 9 a is separable from thesecond portion 9 b so as to interrupt thefilling channel 3 and define an outlet mouth for the biological liquid on the second portion itself. Suitably, thefirst portion 9 a comprises closing means 10 for closing the outlet mouth so defined on thesecond portion 9 b. - Preferably, the
first portion 9 a is removable by tearing off from thesecond portion 9 b and separation means 11 are provided for separating theportions first portion 9 a and the other pair is associated with thesecond portion 9 b, suitable for being gripped by an operator to facilitate the reciprocal rotation of theportions - Suitably, the
units 4 have bigger section than thetubular elements - Advantageously, the
channel 3 also comprises at least anadditional mouth 12 associable with an additional syringe, e.g., for the introduction of substances for activating the biological liquid. - In the first and in the second embodiments shown in the
FIGS. 1 , 2 and 3, theadditional mouth 12 is arranged on the opposite side of theoutlet gap 3 b with respect to thecontainment units 4. More in detail, theadditional mouth 12 is defined on the extremaltubular element 7 b which also defines theinlet gap 3 a. In these embodiments, thedevice 1 comprises at least onevalve element 13 associated with thebody 2 and which can be operated to place selectively in communication thecontainment chambers 5 with theinlet gap 3 a or with theadditional mouth 12. - In the third embodiment shown in
FIG. 4 , instead, theadditional mouth 12 is defined on at least one intermediatetubular element 7 a. More in particular, in this embodiment, thechannel 3 comprises a plurality ofadditional mouths 12 defined on each intermediatetubular element 7 a and on at least one extremaltubular element 7 b. Preferably, thedevice 1 also comprises at least one elastically deformable valve body arranged in correspondence to eachadditional mouth 12; such valve body, not visible in detail in the figures, is suitable for opening by effect of the insertion of the additional syringe needle and for closing automatically following the removal of the latter. - Advantageously, as shown in
FIG. 2 , thechannel 3 also comprises one additional gap 14 suitable for allowing air to come out in the event of two or more syringes being used for filling theunits 4. Suitably, the additional gap 14 is arranged on the opposite side of theoutlet gap 3 b with respect to theunits 4. - More in particular, the additional gap 14 is defined along the extremal
tubular element 7 b which also defines theinlet gap 3 a. - In the embodiment shown in
FIG. 2 , the additional gap 14 is distinct from theinlet gap 3 a, theoutlet gap 3 b and theadditional mouth 12. - The
device 1 then comprises a further filtering device 15, this too of the hydrophobic and breathable type, associated with thebody 2 and fitted in the additional gap 14. - Furthermore, the
device 1 comprises a further valve element 16 associated with thebody 2 in correspondence to the additional gap 14 and which can be operated to place selectively in communication theinlet gap 3 a with the additional gap 14 or with thechambers 5. - The operation of the present invention is the following.
- Initially, a syringe is introduced containing a biological liquid inside the
inlet gap 3 a and the biological liquid is injected along thechannel 3 by pressing the piston of the syringe itself. - The biological liquid injected this way runs along the
entire channel 3 and gradually fills thecontainment chambers 5 which it crosses. - Before injecting the biological liquid along the
channel 3, there is air inside thechambers 5 and thetubular elements outlet gap 3 b, and consequently as the biological liquid moves forward inside thechannel 3, the air initially present along the filling channel itself escapes outside thebody 2. - If it then becomes necessary to introduce one or more activating substances, such as autologous and homologous thrombin and batroxobin in the case of platelet concentrates, inside the
units 4, the relative syringe is introduced into theadditional mouth 12 thus injecting its contents along thechannel 3. - In the first and in the second embodiment shown in the
FIGS. 1 , 2 and 3, there is just oneadditional mouth 12 and, therefore, the activation substance must be injected in thechambers 5 before these are closed. - In the third embodiment shown in
FIG. 4 , on the other hand, each intermediatetubular element 7 a and one extremaltubular element 7 b is provided with a relevantadditional mouth 12, and so the activation substances can also be injected inside thechambers 5 after eachchamber 5 has been closed. - Once all the
units 4 have been filled with biological liquid, these are closed and isolated the one from the other. - More in particular, in the embodiments described above, the
units 4 are closed by means of a welding long eachtubular element unit 4 can be separated from the others and managed independently. - As regards the second embodiment described and shown in
FIG. 3 , the closing of eachtubular element first portion 9 a, in such a way that this can then be detached from the correspondingsecond portion 9 b to close it. - It has in point of fact been ascertained how the described invention achieves the proposed objects and in particular the fact is underlined that it allows preparing a plurality of containment units of biological liquids in a considerably more simple and practical way compared to devices of known type.
- In fact, the positioning of the containment units in series along an open channel allows automatically expelling the air inside the channel itself by effect of the introduction of the biological liquid.
- The device according to the invention is therefore easy to make and use, inasmuch as it is made up of considerably fewer components compared to known devices and requires only the execution of the injection phase of the biological liquid inside the filling channel.
- Again, the device according to the invention can be used with any type of containment units, meaning both with soft containment units and with semi-rigid or rigid ones. Such device therefore has a flexible range of use.
- Furthermore, the device according to the invention allows filling any number of containment units in a very easy way, without this affecting at all the structural complexity of same or its ease of handling.
Claims (16)
1-15. (canceled)
16. Device (1) for the preparation of containment units (4) of biological liquids, comprising a main body (2) which defines at least a filling channel (3), having at least an inlet gap (3 a) of a biological liquid and at least an air outlet gap (3 b), and which comprises a plurality of containment units (4) arranged in succession to one another and defining respective containment chambers (5), wherein said containment chambers (5) are positioned along said filling channel (3) and placed in between said inlet gap (3 a) and said outlet gap (3 b).
17. Device (1) according to claim 16 , wherein said inlet gap (3 a) and said outlet gap (3 b) are arranged on opposite sides of said filling channel (3).
18. Device (1) according to claim 16 , wherein said main body (2) comprises at least an intermediate tubular element (7 a) placed in between each pair of consecutive containment units (4) and comprises at least two extremal tubular elements (7 b) associated with the first and last of said containment units (4) and defining said inlet gap (3 a) and said outlet gap (3 b) respectively.
19. Device (1) according to claim 18 , wherein said containment units (4) have bigger section than said tubular elements (7 a, 7 b).
20. Device (1) according to claim 16 , wherein said device (1) comprises at least a hydrophobic air filtering device (6) associated with said outlet gap (3 b).
21. Device (1) according to claim 18 , wherein each of said containment units (4) has two openings (8) for the flow of biological liquid, each of said openings (8) being associated with a respective tubular element (7 a, 7 b).
22. Device (1) according to claim 16 , wherein said filling channel (3) comprises at least an additional mouth (12) distinct from said inlet gap (3 a) and from said outlet gap (3 b).
23. Device (1) according to claim 22 , wherein said additional mouth (12) is arranged opposite said outlet gap (3 b) with respect to said containment units (4).
24. Device (1) according to claim 22 , wherein said main body (2) comprises at least an intermediate tubular element (7 a) placed in between each pair of consecutive containment units (4) and comprises at least two extremal tubular elements (7 b) associated with the first and last of said containment units (4) and defining said inlet gap (3 a) and said outlet gap (3 b) respectively, said additional mouth (12) being defined at least on said intermediate tubular element (7 a).
25. Device (1) according to claim 16 , wherein said filling channel (3) comprises at least an additional gap (14) for air outlet.
26. Device (1) according to claim 25 , wherein said additional gap (14) is arranged opposite said outlet gap (3 b) with respect to said containment units (4).
27. Device (1) according to claim 18 , wherein at least one of said tubular elements (7 a, 7 b) comprises a first and a second portion (9 a, 9 b) integrally associated with each other and crossed by said filling channel (3), said first portion (9 a) being separable from said second portion (9 b) interrupting said filling channel (3) in such a way as to define an outlet mouth of the biological liquid on the second portion itself and comprising closing means (10) of said outlet mouth.
28. Device (1) according to claim 27 , wherein said first portion (9 a) can be removed by tearing off from said second portion (9 b), separation means (11) being provided for the separation of said portions.
29. Device (1) according to claim 16 , wherein said containment units (4) are of the semi-rigid type.
30. Device (1) according to claim 29 , wherein said containment units (4) are elastically deformable and have an idle configuration in which their walls that delimit respective containment chambers (5) are at a distance from one another.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMO2011A000058 | 2011-03-16 | ||
IT000058A ITMO20110058A1 (en) | 2011-03-16 | 2011-03-16 | DEVICE FOR THE PREPARATION OF BIOLOGICAL LIQUIDS CONTAINMENT UNIT |
PCT/IB2012/000508 WO2012123810A1 (en) | 2011-03-16 | 2012-03-15 | Device for the preparation of containment units of biological liquids |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/IB2012/000508 A-371-Of-International WO2012123810A1 (en) | 2011-03-16 | 2012-03-15 | Device for the preparation of containment units of biological liquids |
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Application Number | Title | Priority Date | Filing Date |
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US16/216,945 Continuation US10745153B2 (en) | 2011-03-16 | 2018-12-11 | Method for the preparation of containment units of biological liquids |
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US20140048171A1 true US20140048171A1 (en) | 2014-02-20 |
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Application Number | Title | Priority Date | Filing Date |
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US14/004,995 Abandoned US20140048171A1 (en) | 2011-03-16 | 2012-03-15 | Device for the preparation of containment units of biological liquids |
US16/216,945 Active 2032-06-01 US10745153B2 (en) | 2011-03-16 | 2018-12-11 | Method for the preparation of containment units of biological liquids |
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US16/216,945 Active 2032-06-01 US10745153B2 (en) | 2011-03-16 | 2018-12-11 | Method for the preparation of containment units of biological liquids |
Country Status (7)
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US (2) | US20140048171A1 (en) |
EP (1) | EP2686032B1 (en) |
DK (1) | DK2686032T3 (en) |
ES (1) | ES2542782T3 (en) |
IT (1) | ITMO20110058A1 (en) |
RU (1) | RU2603053C2 (en) |
WO (1) | WO2012123810A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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ITMO20130001A1 (en) * | 2013-01-09 | 2014-07-10 | Biomed Device Srl | METHOD FOR FILLING CONTAINERS WITH FRESH AUTOLOGOUS HEMOCOMPONENTS |
ITMO20140360A1 (en) * | 2014-12-16 | 2016-06-16 | Biomed Device S R L | METHOD FOR FILLING CONTAINERS WITH FRESH BLOOD COMPONENTS |
KR101663925B1 (en) * | 2016-03-03 | 2016-10-07 | 김경원 | an auto injector hand piece with air filter device |
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Also Published As
Publication number | Publication date |
---|---|
RU2603053C2 (en) | 2016-11-20 |
WO2012123810A1 (en) | 2012-09-20 |
EP2686032B1 (en) | 2015-04-29 |
EP2686032A1 (en) | 2014-01-22 |
ITMO20110058A1 (en) | 2012-09-17 |
ES2542782T3 (en) | 2015-08-11 |
DK2686032T3 (en) | 2015-07-27 |
US10745153B2 (en) | 2020-08-18 |
US20190127090A1 (en) | 2019-05-02 |
RU2013146112A (en) | 2015-04-27 |
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