US20120071555A1 - Compositions of abscisic acid for animal health - Google Patents

Compositions of abscisic acid for animal health Download PDF

Info

Publication number: US20120071555A1
Authority: US; United States
Prior art keywords: aba; animal; compositions; offspring; feed
Prior art date: 2010-09-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

US13/236,444

Other languages

English (en)

Inventor

Maria Pilar Herrero

Warren E. Shafer

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Valent BioSciences LLC

Original Assignee

Valent BioSciences LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-09-17

Filing date

2011-09-19

Publication date

2012-03-22

2011-09-19 Application filed by Valent BioSciences LLC filed Critical Valent BioSciences LLC

2011-09-19 Priority to US13/236,444 priority Critical patent/US20120071555A1/en

2011-11-18 Assigned to VALENT BIOSCIENCES CORPORATION reassignment VALENT BIOSCIENCES CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HERRERO, MARIA PILAR, SHAFER, WARREN E.

2012-03-22 Publication of US20120071555A1 publication Critical patent/US20120071555A1/en

2014-08-20 Priority to US14/463,987 priority patent/US9591867B2/en

2017-02-02 Priority to US15/423,068 priority patent/US10238613B2/en

2019-08-15 Priority to US16/541,385 priority patent/USRE48854E1/en

2021-10-06 Priority to US17/495,128 priority patent/US20220023243A1/en

Status Abandoned legal-status Critical Current

Links

241001465754 Metazoa Species 0.000 title claims abstract description 51
239000000203 mixture Substances 0.000 title abstract description 60
JLIDBLDQVAYHNE-YKALOCIXSA-N abscisic acid group Chemical group C\C(\C=C\[C@@]1(O)C(C)=CC(=O)CC1(C)C)=C\C(O)=O JLIDBLDQVAYHNE-YKALOCIXSA-N 0.000 title abstract description 40
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229940093471 ethyl oleate Drugs 0.000 description 1
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239000003925 fat Substances 0.000 description 1
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238000003898 horticulture Methods 0.000 description 1
BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
239000000017 hydrogel Substances 0.000 description 1
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230000005847 immunogenicity Effects 0.000 description 1
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230000005764 inhibitory process Effects 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
208000019423 liver disease Diseases 0.000 description 1
244000144972 livestock Species 0.000 description 1
241000238565 lobster Species 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000000391 magnesium silicate Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
229940099273 magnesium trisilicate Drugs 0.000 description 1
229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
235000019793 magnesium trisilicate Nutrition 0.000 description 1
230000007758 mating behavior Effects 0.000 description 1
230000007721 medicinal effect Effects 0.000 description 1
239000002609 medium Substances 0.000 description 1
229910021645 metal ion Inorganic materials 0.000 description 1
239000004530 micro-emulsion Substances 0.000 description 1
244000005700 microbiome Species 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
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238000012986 modification Methods 0.000 description 1
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239000012457 nonaqueous media Substances 0.000 description 1
239000000346 nonvolatile oil Substances 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
150000002895 organic esters Chemical class 0.000 description 1
230000008520 organization Effects 0.000 description 1
239000006179 pH buffering agent Substances 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
230000032696 parturition Effects 0.000 description 1
229940112824 paste Drugs 0.000 description 1
239000006072 paste Substances 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
239000003375 plant hormone Substances 0.000 description 1
239000002798 polar solvent Substances 0.000 description 1
229920001987 poloxamine Polymers 0.000 description 1
229920000747 poly(lactic acid) Polymers 0.000 description 1
239000004626 polylactic acid Substances 0.000 description 1
108010026466 polyproline Proteins 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
229940116317 potato starch Drugs 0.000 description 1
238000002203 pretreatment Methods 0.000 description 1
230000008569 process Effects 0.000 description 1
229940002612 prodrug Drugs 0.000 description 1
239000000651 prodrug Substances 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
239000011253 protective coating Substances 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
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238000004064 recycling Methods 0.000 description 1
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230000027272 reproductive process Effects 0.000 description 1
235000019515 salmon Nutrition 0.000 description 1
231100000438 skin toxicity Toxicity 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
229940001584 sodium metabisulfite Drugs 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
235000014347 soups Nutrition 0.000 description 1
239000004455 soybean meal Substances 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
230000000920 spermatogeneic effect Effects 0.000 description 1
239000007921 spray Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000008107 starch Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
230000007666 subchronic toxicity Effects 0.000 description 1
231100000195 subchronic toxicity Toxicity 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000002600 sunflower oil Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
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239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000001839 systemic circulation Effects 0.000 description 1
239000000454 talc Substances 0.000 description 1
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235000021195 test diet Nutrition 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
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150000003626 triacylglycerols Chemical class 0.000 description 1
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UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/50—Feeding-stuffs specially adapted for particular animals for rodents
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

compositions of the present invention may be formulated for an intranasal, intravenous, transdermal or opthalmic administration. It is within a skill in the art to formulate the compositions for such administration.
Feed is conventionally prepared in a large bin or mixer in which the feed ingredients are added in descending weight order according to their prevalence in the ultimate feed mixture. Thus, cracked or ground grain would be the primary ingredient. Minor ingredients are then added. Micro-ingredients are added last. These include vitamins, drugs, growth promoters, antibiotics, and, in the present case, ABA. Thus, ABA can be one of the micro-ingredients and is added to the feed in the final blending step. The feed is blended for conventional time periods.

US13/236,444 2010-09-17 2011-09-19 Compositions of abscisic acid for animal health Abandoned US20120071555A1 (en)

Priority Applications (5)

Application Number	Priority Date	Filing Date	Title
US13/236,444 US20120071555A1 (en)	2010-09-17	2011-09-19	Compositions of abscisic acid for animal health
US14/463,987 US9591867B2 (en)	2010-09-17	2014-08-20	Compositions of abscisic acid for animal health
US15/423,068 US10238613B2 (en)	2010-09-17	2017-02-02	Compositions of abscisic acid for animal health
US16/541,385 USRE48854E1 (en)	2010-09-17	2019-08-15	Compositions of abscisic acid for animal health
US17/495,128 US20220023243A1 (en)	2010-09-17	2021-10-06	Compositions of abscisic acid for animal health

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US38402010P	2010-09-17	2010-09-17
US13/236,444 US20120071555A1 (en)	2010-09-17	2011-09-19	Compositions of abscisic acid for animal health

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
US14/463,987 Division US9591867B2 (en)	2010-09-17	2014-08-20	Compositions of abscisic acid for animal health

Publications (1)

Publication Number	Publication Date
US20120071555A1 true US20120071555A1 (en)	2012-03-22

Family

ID=45818303

Family Applications (9)

Application Number	Title	Priority Date	Filing Date
US13/236,462 Active 2032-02-06 US8536224B2 (en)	2010-09-17	2011-09-19	Pharmaceutical and nutraceutical compositions of abscisic acid
US13/236,444 Abandoned US20120071555A1 (en)	2010-09-17	2011-09-19	Compositions of abscisic acid for animal health
US13/236,472 Abandoned US20120071557A1 (en)	2010-09-17	2011-09-19	Animal feed compositions of abscisic acid
US14/014,665 Active US8729122B2 (en)	2010-09-17	2013-08-30	Pharmaceutical and nutraceutical compositions of abscisic acid
US14/463,987 Active US9591867B2 (en)	2010-09-17	2014-08-20	Compositions of abscisic acid for animal health
US14/717,110 Abandoned US20150250209A1 (en)	2010-09-17	2015-05-20	Animal feed compositions of abscisic acid
US15/423,068 Ceased US10238613B2 (en)	2010-09-17	2017-02-02	Compositions of abscisic acid for animal health
US16/541,385 Active USRE48854E1 (en)	2010-09-17	2019-08-15	Compositions of abscisic acid for animal health
US17/495,128 Abandoned US20220023243A1 (en)	2010-09-17	2021-10-06	Compositions of abscisic acid for animal health

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
US13/236,462 Active 2032-02-06 US8536224B2 (en)	2010-09-17	2011-09-19	Pharmaceutical and nutraceutical compositions of abscisic acid

Family Applications After (7)

Application Number	Title	Priority Date	Filing Date
US13/236,472 Abandoned US20120071557A1 (en)	2010-09-17	2011-09-19	Animal feed compositions of abscisic acid
US14/014,665 Active US8729122B2 (en)	2010-09-17	2013-08-30	Pharmaceutical and nutraceutical compositions of abscisic acid
US14/463,987 Active US9591867B2 (en)	2010-09-17	2014-08-20	Compositions of abscisic acid for animal health
US14/717,110 Abandoned US20150250209A1 (en)	2010-09-17	2015-05-20	Animal feed compositions of abscisic acid
US15/423,068 Ceased US10238613B2 (en)	2010-09-17	2017-02-02	Compositions of abscisic acid for animal health
US16/541,385 Active USRE48854E1 (en)	2010-09-17	2019-08-15	Compositions of abscisic acid for animal health
US17/495,128 Abandoned US20220023243A1 (en)	2010-09-17	2021-10-06	Compositions of abscisic acid for animal health

Country Status (10)

Country	Link
US (9)	US8536224B2 (fr)
EP (5)	EP2616060B1 (fr)
JP (8)	JP5898206B2 (fr)
CN (6)	CN105878224A (fr)
BR (4)	BR122019010112B1 (fr)
CA (2)	CA3047772C (fr)
DK (1)	DK2616059T3 (fr)
ES (2)	ES2545866T3 (fr)
MX (7)	MX340751B (fr)
WO (3)	WO2012037561A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20220369630A1 (en) *	2021-05-06	2022-11-24	Stoller Enterprises, Inc.	Stable S-(+)-Abscisic Acid Nonaqueous Liquid Solutions

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX340751B (es) *	2010-09-17	2016-07-22	Valent Biosciences Corp	Composiciones de alimento para animales de acido abscisico.
AU2015204644B2 (en)	2014-01-10	2018-06-28	Valent Biosciences Corporation	(S)-3'-methyl-abscisic acid and esters thereof
WO2016007587A2 (fr)	2014-07-08	2016-01-14	Valent Biosciences Corporation	Dérivés d'acide abscissique substituées en 3'
ES2834574T3 (es)	2014-07-17	2021-06-17	Nutravis S R L	Un nuevo tratamiento para mejorar el uso del azúcar dietético con fines energéticos
EP4265122A1 (fr)	2020-12-16	2023-10-25	Sumitomo Chemical Company, Limited	Aliment pour porcs mélangé de l'acide abscissique
WO2022131287A1 (fr)	2020-12-16	2022-06-23	住友化学株式会社	Aliment pour bétail
TW202245613A (zh)	2021-02-17	2022-12-01	日商住友化學股份有限公司	家畜用飼料
US20240139124A1 (en)	2021-02-17	2024-05-02	Sumitomo Chemical Company, Limited	Livestock Feed
CN116782772A (zh)	2021-02-17	2023-09-19	住友化学株式会社	家畜用饲料
TW202304315A (zh)	2021-04-07	2023-02-01	日商住友化學股份有限公司	家畜用飼料

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1182508A (en)	1914-09-05	1916-05-09	Underwood Typewriter Co	Automatic type-writer operator.
US1184608A (en)	1915-06-07	1916-05-23	Berger Specialty Mfg Company Inc	Bottle-holder.
US3958025A (en) *	1972-10-06	1976-05-18	Livingston Virginia W C	Abscisic acid tablets and process
US4209530A (en)	1978-07-28	1980-06-24	Endowment And Research Foundation At Montana State University	Insect control compositions employing abscisic acid
US4434180A (en)	1978-07-28	1984-02-28	Visscher Saralee N	Insect control methods with abscisic acid
US5834473A (en) *	1993-04-29	1998-11-10	Cultor, Ltd.	Method for treating coccidiosis
EP0714305B1 (fr) *	1993-08-27	2001-12-19	Vetrepharm, Inc.	Composition et procede servant a stimuler les capacites de reproduction
JP2001181632A (ja) *	1999-10-14	2001-07-03	Nisshin Oil Mills Ltd:The	抗酸化剤
IT1320180B1 (it) *	2000-12-29	2003-11-26	Hunza Di Marazzita Maria Carme	Preparazioni nutrizionali e terapeutiche dotate di attivita'antiossidante ed in grado di controllare gli eccessi ponderali e
US7718699B1 (en)	2005-03-04	2010-05-18	Broyles Robert H	Abscissic acid and derivatives thereof for the treatment of diseases
CN100426996C (zh) *	2004-08-02	2008-10-22	阳麈苇	脱落酸抗癌保健饮料
CN1748674A (zh) *	2004-09-14	2006-03-22	中国科学院成都生物研究所	天然脱落酸用于制备肿瘤细胞“分化诱导剂”药物的新用途
JP2006232807A (ja) *	2005-01-27	2006-09-07	Toyobo Co Ltd	西洋わさび抽出物を含む抗酸化剤
CN1686174A (zh) *	2005-04-18	2005-10-26	杨奇彪	防治恶性肿瘤的抑瘤素配方
EP1714674A1 (fr) *	2005-04-21	2006-10-25	Desol BV	Procédé pour l'amélioration de la fertilité chez les animaux
EP1714673A1 (fr) *	2005-04-21	2006-10-25	Desol BV	Procédé pour allonger la période de la mobilité des poissons
US8389024B2 (en) *	2005-06-22	2013-03-05	Gonzalo Romero M.	Abscisic acid against cancer
US20060292215A1 (en)	2005-06-22	2006-12-28	Gonzalo Romero M	Abscisic acid against cancer
ITTO20050708A1 (it)	2005-10-07	2007-04-08	Univ Degli Studi Genova	Fluridone come agente anti-infiammatorio
US7741367B2 (en) *	2006-02-08	2010-06-22	Virginia Tech Intellectual Properties, Inc.	Method of using abscisic acid to treat diseases and disorders
US8367727B2 (en) *	2006-02-08	2013-02-05	Virginia Tech Intellectual Properties, Inc.	Method of using abscisic acid to treat diseases and disorders
JP2008074725A (ja) *	2006-09-19	2008-04-03	Noevir Co Ltd	保湿剤、アルギナーゼ活性促進剤、細胞賦活剤、コラーゲン産生促進剤、ヒアルロン酸産生促進剤、抗酸化剤、及び中性脂肪蓄積抑制剤
JP2009000045A (ja) *	2007-06-21	2009-01-08	Unitika Ltd	飼料配合剤
JP5268086B2 (ja) *	2007-10-02	2013-08-21	国立大学法人岩手大学	冬虫夏草の培養方法及び冬虫夏草を有効成分とする免疫賦活剤、がん細胞増殖抑制剤、抗炎症剤、又は抗酸化剤
US8320308B2 (en)	2007-11-07	2012-11-27	Stmicroelectronics, Inc.	Parallel data services and spectrum sensing with cognitive channel switching in a wireless area network
US9063122B2 (en) *	2008-10-17	2015-06-23	Alfredo Gallegos	Biomodulators for treatment or prevention of disease
JP5451281B2 (ja)	2009-09-16	2014-03-26	ピーエスフォールクスコエスエイアールエル	センスアンプ回路及びそれを備えた半導体装置
US8993624B2 (en) *	2010-05-26	2015-03-31	Virginia Tech Intellectual Properties, Inc.	Method of preventing and treating inflammatory diseases and disorders with abscisic acid
MX340751B (es) *	2010-09-17	2016-07-22	Valent Biosciences Corp	Composiciones de alimento para animales de acido abscisico.

2011
- 2011-09-19 MX MX2014005078A patent/MX340751B/es unknown
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- 2011-09-19 EP EP11826087.6A patent/EP2616059B1/fr active Active
- 2011-09-19 US US13/236,462 patent/US8536224B2/en active Active
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- 2011-09-19 EP EP17173027.8A patent/EP3228311A3/fr not_active Withdrawn
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- 2011-09-19 CN CN201610225684.4A patent/CN105878224A/zh active Pending
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- 2011-09-19 DK DK11826087.6T patent/DK2616059T3/en active
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- 2011-09-19 US US13/236,444 patent/US20120071555A1/en not_active Abandoned
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- 2011-09-19 CN CN201910591925.0A patent/CN111494353A/zh active Pending
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- 2011-09-19 CN CN201610086156.5A patent/CN105640929A/zh active Pending
- 2011-09-19 EP EP19195737.2A patent/EP3598970A1/fr active Pending
2013
- 2013-08-30 US US14/014,665 patent/US8729122B2/en active Active
2014
- 2014-08-20 US US14/463,987 patent/US9591867B2/en active Active
2015
- 2015-05-20 US US14/717,110 patent/US20150250209A1/en not_active Abandoned
2016
- 2016-03-03 JP JP2016041232A patent/JP2016166188A/ja active Pending
2017
- 2017-02-02 US US15/423,068 patent/US10238613B2/en not_active Ceased
- 2017-07-14 JP JP2017138029A patent/JP2017222688A/ja active Pending
2018
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2019
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2021
- 2021-02-10 JP JP2021019584A patent/JP7217763B2/ja active Active
- 2021-10-06 US US17/495,128 patent/US20220023243A1/en not_active Abandoned
2022
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20220369630A1 (en) *	2021-05-06	2022-11-24	Stoller Enterprises, Inc.	Stable S-(+)-Abscisic Acid Nonaqueous Liquid Solutions
US20220369632A1 (en) *	2021-05-06	2022-11-24	Stoller Enterprises, Inc.	Stable S-(+)-Abscisic Acid Nonaqueous Liquid Solutions
US20220369631A1 (en) *	2021-05-06	2022-11-24	Stoller Enterprises, Inc.	Stable S-(+)-Abscisic Acid Nonaqueous Liquid Solutions
US11589582B2 (en) *	2021-05-06	2023-02-28	Stoller Enterprises, Inc	Stable S-(+)-abscisic acid nonaqueous liquid solutions
US11606954B2 (en) *	2021-05-06	2023-03-21	Stoller Enterprises, Inc.	Stable S-(+)-abscisic acid nonaqueous liquid solutions
US11617368B2 (en)	2021-05-06	2023-04-04	Stoller Enterprises, Inc.	Stable S-(+)-abscisic acid nonaqueous liquid solutions

Also Published As

Publication number	Publication date
US9591867B2 (en)	2017-03-14
CA2809641A1 (fr)	2012-03-22
JP5898206B2 (ja)	2016-04-06
MX340147B (es)	2016-06-28
BR122019010112B1 (pt)	2021-12-21
US20170143651A1 (en)	2017-05-25
CN103179963A (zh)	2013-06-26
CN103179964A (zh)	2013-06-26
JP6602440B2 (ja)	2019-11-06
BR112013005914B1 (pt)	2020-10-06
US20220023243A1 (en)	2022-01-27
MX2013002948A (es)	2013-05-09
EP3228311A2 (fr)	2017-10-11
EP2616059A4 (fr)	2014-03-26
EP2616058A1 (fr)	2013-07-24
BR112013005912B1 (pt)	2021-07-13
CN103179965A (zh)	2013-06-26
WO2012037562A2 (fr)	2012-03-22
US20120071557A1 (en)	2012-03-22
EP2616058B1 (fr)	2015-08-12
MX340752B (es)	2016-07-22
US20150250209A1 (en)	2015-09-10
CN103179963B (zh)	2016-07-06
DK2616059T3 (en)	2017-10-23
JP2017222688A (ja)	2017-12-21
BR112013005912A2 (pt)	2016-05-17
WO2012037562A3 (fr)	2012-08-02
EP2616060B1 (fr)	2015-08-12
US20120071556A1 (en)	2012-03-22
EP3228311A3 (fr)	2018-01-10
BR112013005915B1 (pt)	2021-10-05
CN105878224A (zh)	2016-08-24
US8729122B2 (en)	2014-05-20
JP2021075557A (ja)	2021-05-20
MX340983B (es)	2016-08-01
CA3047772C (fr)	2021-07-20
JP7217763B2 (ja)	2023-02-03
WO2012037563A1 (fr)	2012-03-22
EP2616059B1 (fr)	2017-07-05
CA3047772A1 (fr)	2012-03-22
CN111494353A (zh)	2020-08-07
US10238613B2 (en)	2019-03-26
EP2616059A2 (fr)	2013-07-24
ES2545867T9 (es)	2017-02-17
ES2545867T3 (es)	2015-09-16
JP2020019782A (ja)	2020-02-06
EP2616058A4 (fr)	2013-10-09
ES2545866T3 (es)	2015-09-16
EP2616060A1 (fr)	2013-07-24
JP2013542925A (ja)	2013-11-28
JP2019163315A (ja)	2019-09-26
CN103179964B (zh)	2015-12-02
MX2013002947A (es)	2013-05-09
US20130345308A1 (en)	2013-12-26
JP2016166188A (ja)	2016-09-15
JP2023012490A (ja)	2023-01-25
JP2019031557A (ja)	2019-02-28
EP3598970A1 (fr)	2020-01-29
US8536224B2 (en)	2013-09-17
USRE48854E1 (en)	2021-12-21
BR112013005914A2 (pt)	2016-05-17
MX2013002949A (es)	2013-05-09
MX340751B (es)	2016-07-22
CA2809641C (fr)	2019-09-10
EP2616060A4 (fr)	2013-10-09
WO2012037561A1 (fr)	2012-03-22
CN105640929A (zh)	2016-06-08
US20140364501A1 (en)	2014-12-11
BR112013005915A2 (pt)	2016-05-17

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2011-11-18

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Owner name: VALENT BIOSCIENCES CORPORATION, ILLINOIS

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2015-01-12

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