Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
  • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
  • A01N37/46—N-acyl derivatives
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
  • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
  • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
  • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
  • A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
  • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
  • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
  • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
  • A01N43/10—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with sulfur as the ring hetero atom
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
  • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
  • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
  • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
  • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
  • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
  • A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
  • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
  • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
  • A01N47/20—N-Aryl derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/33—Heterocyclic compounds
  • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
  • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/33—Heterocyclic compounds
  • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
  • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
  • A61P17/04—Antipruritics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P19/00—Drugs for skeletal disorders
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
  • A61P31/04—Antibacterial agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
  • A61P31/12—Antivirals
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
  • A61P31/12—Antivirals
  • A61P31/14—Antivirals for RNA viruses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
  • A61P31/12—Antivirals
  • A61P31/20—Antivirals for DNA viruses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P33/00—Antiparasitic agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P33/00—Antiparasitic agents
  • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
  • A61P33/06—Antimalarials
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P33/00—Antiparasitic agents
  • A61P33/10—Anthelmintics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P33/00—Antiparasitic agents
  • A61P33/10—Anthelmintics
  • A61P33/12—Schistosomicides
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P33/00—Antiparasitic agents
  • A61P33/14—Ectoparasiticides, e.g. scabicides
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
  • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
  • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
  • C07C271/06—Esters of carbamic acids
  • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
  • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
  • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C317/00—Sulfones; Sulfoxides
  • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
  • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
  • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
  • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
  • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
  • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C2601/00—Systems containing only non-condensed rings
  • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
  • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C2601/00—Systems containing only non-condensed rings
  • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
  • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Definitions

• the invention relates to a composition comprising at least one aminobenzamide derivatives or a salt thereof for controlling animal parasites, veterinary pharmaceutical compositions comprising at least one aminobenzamide derivatives or a salt thereof for preventing infection with diseases transmitted through parasites, its use for the preparation of a veterinary pharmaceutical for controlling animal parasites, and a method for preventing infection with diseases transmitted through parasites.
• the infestation of animals, domestic animals, companion animals and agricultural livestock alike, with parasites represents a problem.
• the infested animals are infected with diseases transmitted through parasites, like e.g. lyme disease, a variety of sometimes fatal viral diseases or the immune system of the animals becomes weak due to the infestation, so that the animals become prone to other diseases, like e.g. bacterial infections.
• diseases transmitted through parasites like e.g. lyme disease
• a variety of sometimes fatal viral diseases or the immune system of the animals becomes weak due to the infestation, so that the animals become prone to other diseases, like e.g. bacterial infections.
• costly medicaments have to be administered, and, if the treated animals are agricultural livestock then the food safety is jeopardized.
• the infestation of agricultural livestock with parasites is very often accompanied with a decrease in performance in terms of quality and quantity of produced meat, milk, egg, wool, or fur.
• blood-sucking ectoparasites and ectoparasites causing myiasis are potential transmitters of a broad variety of pathogens besides all other secondary effects of the ectoparasitic infestation as there are blood-loss, irritation, inflammation, secondary bacterial infection, secondary parasiticidal infection (e.g. myiasis) and direct toxicosis (tick paralysis).
• the invention relates to a pharmaceutical composition
• a pharmaceutical composition comprising at least one aminobenzamide derivative of formula (I), or a salt thereof
• aminobenzamides of the formula (I) are defined preferably and most preferably by the following substituents:
• composition as described in the first or second embodiment comprises a compound of formula (I-1) wherein
• aminobenzamides of the formula (I-1) are defined preferably and most preferably by the following substituents:
• composition as described in the first or second embodiment comprises at least one compound of formula (I-2), wherein
• aminobenzamides of the formula (I) are defined preferably and most preferably by the following substituents:
• the pharmaceutical composition comprising the above-mentioned compounds of the formulas (I), (I-1) and (I-2) is preferably a veterinary pharmaceutical composition.
• the present invention further relates to the use of the aminobenzamide derivative as described in any of the first to third embodiment for controlling parasites, preferably animal parasites, most preferred ectoparasites.
• Ectoparasites are in particular arthropods.
• Most preferred groups of arthropods are acari and insects. Surprisingly it was found that the compounds have particular high activity against acari, in particular ticks and mites.
• the present invention further relates to the use of a composition comprising at least one aminobenzamide derivative as described in any of the first to third embodiment for controlling parasites, preferably animal parasites, such as arthropods.
• Arthropods include acari, in particular ticks including hard ticks and soft ticks, mites including scab mites, ear mites, bird mites, harvest mites; arthropods also include insects like flies, lice and fleas in particular fleas for various hosts (e.g. cat fleas, dog fleas etc.), stinging flies, licking flies, parasitic fly larvae, biting lice and sucking lice.
• the present invention further relates to a method for preventing infection with diseases transmitted through parasites, characterized in that a composition comprising at least one aminobenzamide derivative as described in any of the first to third embodiment is administered to the animal enterally, such as orally, topically or parenterally, such as per injection.
• a composition comprising at least one aminobenzamide derivative as described in any of the first to third embodiment is administered to the animal enterally, such as orally, topically or parenterally, such as per injection.
• the preferred route of administration is externally.
• the compounds of the present invention provide excellent activity against animal parasites, particularly against arthropods attacking and/or infesting companion animals or agricultural livestock.
• the compounds and compositions of the invention can be used to control arthropods attacking and/or infesting companion animals and agricultural livestock.
• composition according to the invention optionally comprises further active ingredients and/or auxiliary agents, such as for example developers, surfactants, emulsifiers, solvents, foam formers or anti-foaming agents and fillers.
• auxiliary agents such as for example developers, surfactants, emulsifiers, solvents, foam formers or anti-foaming agents and fillers.
• Examples of further active ingredients which can be used in the present invention are insecticides, bactericides, acaricides, nematicides, fungicides.
• Examples of such active ingredients include organic phosphorous agents, carbonate agents, chemicals of the carboxylate type, chemicals of the chlorinated hydrocarbon type and materials produced from microorganisms.
• active ingredients include, but are not limited to, Acetylcholinesterase (AChE) inhibitors, like carbamates, such as for example alanycarb, aldicarb, aldoxycarb, allyxycarb, aminocarb, bendiocarb, benfuracarb, bufencarb, butacarb, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, cloethocarb, dimetilan, ethiofencarb, fenobucarb, fenothiocarb, formetanate, furathiocarb, isoprocarb, metam-sodium, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, promecarb, propoxur, thiodicarb, thiofanox, trimethacarb, XMC, xylylcarb, and triaza
• Sodium channel modulators/voltage-dependent sodium channel blockers like pyrethroids such as for example acrinathrin, allethrin (d-cis-trans, d-trans), beta-cyfluthrin, bifenthrin, bioallethrin, bioallethrin-S-cyclopentyl-isomer, bioethanomethrin, biopermethrin, bioresmethrin, chlovaporthrin, cis-cypermethrin, cis-resmethrin, cis-permethrin, clocythrin, cycloprothrin, cyfluthrin, cyhalothrin, cypermethrin (alpha-, beta-, theta-, zeta), cyphenothrin, deltamethrin, empenthrin ( 1 R-isomer), esfenvalerate,
• DDT oxadiazines, such as for example indoxacarb.
• Acetylcholine receptor agonists/antagonists like chloronicotinyls, such as for example acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, nithiazine, thiacloprid, thiamethoxam, nicotine, bensultap, cartap.
• chloronicotinyls such as for example acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, nithiazine, thiacloprid, thiamethoxam, nicotine, bensultap, cartap.
• Acetylcholine receptor modulators like Spinosynes, such as for example spinosad.
• GABA controlled chloride channel antagonists like Organochlorine, such as for example camphechlor, chlordane, endosulfan, gamma-HCH, HCH, heptachlor, lindane, methoxychlor; Fiproles, such as for example acetoprole, ethiprole, fipronil, pyrafluprole, pyriprole, and vaniliprole.
• Organochlorine such as for example camphechlor, chlordane, endosulfan, gamma-HCH, HCH, heptachlor, lindane, methoxychlor
• Fiproles such as for example acetoprole, ethiprole, fipronil, pyrafluprole, pyriprole, and vaniliprole.
• Chloride channel activators like Mectins, such as for example avermectin, emamectin, emamectin benzoate, ivermectin, milbemycin, latidectin, lepimectin, selamectin, doramectin, eprinomectin, and moxidectin.
• Mectins such as for example avermectin, emamectin, emamectin benzoate, ivermectin, milbemycin, latidectin, lepimectin, selamectin, doramectin, eprinomectin, and moxidectin.
• Juvenile hormone mimetics like for example diofenolan, epofenonane, fenoxycarb, hydroprene, kinoprene, methoprene, pyriproxifen, and triprene.
• Latrophilin receptor agonists like depsipeptides, referably cyclic depsipetides, in particular 24-membered cyclic depsipeptides, for example emodepside.
• Ecdysone agonists/disruptors like diacylhydrazines, such as for example chromafenozide, halofenozide, methoxyfenozide, tebufenozide.
• Inhibitors of chitin biosynthesis like Benzoylureas, such as for example bistrifluoron, chlofluazuron, diflubenzuron, fluazuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluoron, teflubenzuron, triflumuron; buprofezin; cyromazine.
• Benzoylureas such as for example bistrifluoron, chlofluazuron, diflubenzuron, fluazuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluoron, teflubenzuron, triflumuron; buprofezin; cyromazine.
• Site I electron transport inhibitors like METI's, such as for example fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad; hydramethylnon; dicofol.
• Site II electron transport inhibitors like rotenones.
• Site III electron transport inhibitors like acequinocyl, fluacrypyrim.
• Microbial disruptors of insect intestinal membrane such Bacillus thuringiensis strains.
• Inhibitors of fat synthesis like tetronic acids, such as for example spirodiclofen, spiromesifen; tetramic acids, such as for example spirotetramat (CAS-Reg.-No.: 203313-25-1) and 3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]dec-3-en-4-yl ethyl carbonate (alias: carbonic acid, 3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]dec-3-en-4-yl ethyl ester, CAS-Reg.-No.: 382608-10-8); carboxamides, such as for example flonicamid.
• tetronic acids such as for example spirodiclofen, spiromesifen
• tetramic acids such as for example spirotetramat (CAS-Reg.-No.: 203313-25-1) and
• Octopaminergic agonists such as for example amitraz.
• Inhibitor of magnesium-stimulated ATPase like propargite benzoic acid dicarboxamides, such as for example flubendiamide; Nereistoxin analogous, such as for example thiocyclam hydrogen oxalate, thiosultap-sodium.
• Active ingredients with unknown or non-specific mode of action like fumigants, such as for example aluminium phosphide, methyl bromide, sulphuryl fluoride; feeding inhibitors, such as for example cryolite, flonicamid, pymetrozine; mite growth inhibitors, such as for example clofentezine, etoxazole, hexythiazox; amidoflumet, benclothiaz, benzoximate, bifenazate, bromopropylate, buprofezin, quinomethionate, chlordimeform, chlorobenzilate, chloropicrin, clothiazoben, cycloprene, cyflumetofen, dicyclanil, fenoxacrim, fentrufanil, flubenzimine, flufenerim, flutenzin, gossyplure, hydramethylnone, japonilure, metoxadiazone, petroleum, piperonyl butoxide, potassium
• Examples for parasites against which the compounds or compositions of the invention can be used include, but are not limited to, the above mentioned and, endoparasites, like for example helminths nematodes, trematodes, cestodes, for example such as Acanthocephala, Ascariasis, Cestoda, Clonorchis sinensis , Dracunculiasis, Enterobius vermicularis , Filariasis, Hookworm, Loa loa , Onchocerciasis, Schistosomiasis, Strongyloides stercoralis, Toxocara canis, Trichinella , Whipworm; or protozoa, such as coccidia.
• endoparasites like for example helminths nematodes, trematodes, cestodes, for example such as Acanthocephala, Ascariasis, Cestoda, Clonorchis sinensis , Dracunculiasis
• parasites include but are not limited to parasites from the order of Anoplurida, such as Haematopinus spp., Linognathus spp., Pediculus spp., Phtirus spp., Solenopotes spp., Linognathus setosus, Linognathus vituli, Linognathus ovillus, Linognathus oviformis, Linognathus pedalis, Linognathus stenopsis, Haematopinus asini macrocephalus, Haematopinus eurysternus, Haematopinus suis, Pediculus humanus capitis, Pediculus humanus corporis, Phylloera vastatrix, Phthirus pubis, Solenopotes capillatus;
• Anoplurida such as Haematopinus spp., Linognathus spp., Pediculus spp., Pht
• the compounds of the third embodiment are particularly useful for controlling parasites from the subclass of the Acari (Acarina) and the orders of the Meta- and Mesostigmata, such as Argas spp., Ornithodorus spp., Otobius spp., Ixodes spp., Amblyomma spp., Rhipicephalus (Boophilus) spp Dermacentor spp., Haemaphysalis spp., Hyalomma spp., Dermanyssus spp., the original genus of multi host ticks, namely Rhipicephalus spp., Ornithonyssus spp., Pneumonyssus spp., Raillietia spp., Pneumonyssus spp., Sternostoma spp., Varroa spp., Acarapis spp., Argas persicus, Argas reflexus
• Actinedida Prostigmata
• Acaridida Acaridida
• Acarapis spp. Cheyletiella spp., Ornitrocheyletia spp., Myobia spp., Psorergates spp., Demodex spp., Trombicula spp., Listrophorus spp., Acarus spp., Tyrophagus spp., Caloglyphus spp., Hypodectes spp., Pterolichus spp., Psoroptes spp., Chorioptes spp., Otodectes spp., Sarcoptes spp., Notoedres spp., Knemidocoptes spp., Cytodites spp., Laminosioptes spp., Cheyletiella yasguri, Cheyletiella yasguri, Cheyletiella
• the compounds of the second embodiment are particularly useful for controlling parasites from the subclass of the Acari (Acarina) and the orders of the Meta- and Mesostigmata, with the exception of Ornithodoros spp., Ixodes spp., and Boophilus spp.
• Actinedida Prostigmata
• Acaridida Acaridida
• Acarapis spp. Cheyletiella spp., Ornitrocheyletia spp., Myobia spp., Psorergates spp., Demodex spp., Trombicula spp., Listrophorus spp., Acarus spp., Tyrophagus spp., Caloglyphus spp., Hypodectes spp., Pterolichus spp., Psoroptes spp., Chorioptes spp., Otodectes spp., Sarcoptes spp., Notoedres spp., Knemidocoptes spp., Cytodites spp., Laminosioptes spp., Cheyletiella yasguri, Cheyletiella yasguri, Cheyletiella
• the compounds of embodiment 1, embodiment 2 or embodiment 3 are used for the control of Amblyomma americanum.
• the compounds of embodiment 1, embodiment 2 or embodiment 3 are used for the control of Dermacentor variabilis.
• the compounds of embodiment 1, embodiment 2 or embodiment 3 are used for the control of Dermacentor reticulatus.
• the compounds of embodiment 1, embodiment 2 or embodiment 3 are used for the control of Rhipicephalus sanguineus.
• the compounds of embodiment 1, embodiment 2 or embodiment 3 are used for the control of Rhipicephalus decoloratus.
• ectoparasites are for example bacterial, viral, rickettsial and protozoal vector-borne diseases.
• Examples of viral diseases transmitted through arboviruses are Crimean-Congo Hemorhagic Fever (CCHF), Febrile illness, Papataci fever, Encephalitis, Meningitis, which are caused by Bunyaviridae such as Bunyavirus, Nairovirus or Phlebovirus; Bluetongue, meningoencephalits, Febrile illness, hemorhagic fever, which are caused by Reoviridae, such as Orbivirus, Colitivirus; Febrile illness, rash, enzephalitis, polyarthritis, lymphadenitis, which are caused by Togaviridae, such as Sindbisvirus, Chikungunya Virus; tick-borne meningoencephalitis, Dengue hemorhagic fever, encephalitis, Febrile illness, Yellow fever, which are caused by Flaviviridae, such as Flavivirus (including diverse sub-groups).
• CCHF Crimean-Congo Hemorhagic Fever
• Bunyaviridae such as Bun
• bacterial diseases transmitted through parasites are Rickettsiosis, such as Rocky Mountain spotted fever, tick typhus caused by infection through Rickettsia ssp; Tularemia caused by infection through Francisella tularensis ; Borreliosis or Spirochaetosis, such as Lyme disease, or relapsing fever, caused, by infection through Borrelia ssp.; Ehrllichiosis caused by infection through Ehrlichia ssp.; Plague, caused by infection through Yersinia ssp.
• Rickettsiosis such as Rocky Mountain spotted fever, tick typhus caused by infection through Rickettsia ssp
• Tularemia caused by infection through Francisella tularensis
• Borreliosis or Spirochaetosis such as Lyme disease, or relapsing fever, caused, by infection through Borrelia ssp.
• Ehrllichiosis caused
• Examples of protozoal or rickettsial borne diseases are Babesiosis, such as texas fever, red water disease, Q-fever caused by infection through Babesia ssp.; Theileriosis, such as east coast fever, Mediterranean coast fever, caused by infection through Theileria ssp.; Nagana disease, Sleeping sickness caused by infection through Trypanosoma ssp., Anaplasmosis caused by infection through Anaplasma ssp.; Malaria caused by infection through Plasmodium ssp.; Leishmaniasis caused by infection through Leishmania ssp.
• Babesiosis such as texas fever, red water disease, Q-fever caused by infection through Babesia ssp.
• Theileriosis such as east coast fever, Mediterranean coast fever, caused by infection through Theileria ssp.
• Nagana disease Sleeping sickness caused by infection through Trypanosoma ssp.
• the diseases transmitted through parasites are numerous and are not only limited to the above mentioned. Further diseases caused by animal parasites, in particular ectoparasites, are Myiasis caused by parasites like e.g. Lucilia ssp.; Scabies caused by parasites like e.g.
• mammals include all kind of animals among that also humans, domestic animals, like conventional pet animals, such as for example dogs, cats, cage birds, aquarium fish, less conventional pet animals, such as ferrets, reptiles and exotic birds, all kind of experimental animals, such as rodents like for example, rats and mice, and hamsters and guinea pigs, and agricultural livestock.
• Examples for agricultural livestock are cattle, sheep, goats, horses, pigs, donkeys, camels, buffaloes, rabbits, fur animals such as mink; poultry, like chickens, turkeys, ducks, geese; and other agricultural lifestock like honeybee.
• the compounds or composition according to the invention can be administered in a known manner and in an appropriate preparation form. Preference is given to enteral, parenteral, or external administration.
• the active compounds of formula (I) when used for the treatment of animals can be applied directly.
• they are applied as pharmaceutical compositions which may contain pharmaceutically acceptable excipients and/or auxiliaries which are known in the art.
• the active compounds may be formulated as shampoo or as suitable formulations usable in aerosols, unpressurized sprays, for example pump sprays and atomizer sprays.
• the invention may be carried out in a manner fit to the form of application or administering.
• Suitable forms include aerosols, unpressurized sprays, for example pump sprays and atomizer sprays, automatic misting devices, foggers, foams, gels, vaporizer products with vaporizer platelets made of cellulose or polymer, liquid vaporizers, gel and membrane vaporizers, propeller-driven vaporizers, vaporization systems which do not consume energy (passive vaporization systems).
• the compounds and compositions according to the invention can be applied by way of intramuscular, subcutaneous, intravenous, intraperitoneal injections, implants, or nasal application; by dermal application in the form of, for example, bathing or dipping, spraying, pouring-on and spotting-on, washing, dusting, and with the aid of active-compound-comprising shaped articles such as collars, ear tags, tail tags, limb bands, halters, marking devices and the like.
• the preparation forms for administering the compounds and compositions according to the invention enterally can be tablets, capsules, drinks, drenches, granules, pastes, boluses, feed-through method, and suppositories.
• the compounds and compositions according to the invention can be formulated into usual preparation forms.
• preparation forms include solutions, emulsions, wettable powders, dry flowables, suspensions, dusts, foams, pastes, tablets, granules, aerosols, active compound infiltrated-natural and synthetic products, microcapsules, preparations with a combustor (for example, fumigating and smoking cartridges, cans and coils), ULV (cold mists and warm mists).
• a combustor for example, fumigating and smoking cartridges, cans and coils
• ULV cold mists and warm mists
• Preference is given to powders, emulsions, flowables, homogeneous solutions, emulsion concentrate formulations, WP and suspensions, or suspension concentrate formulations.
• Particularly preferred are methods of application, like pour-ons, spot-ons, sprays, ear-tags and dips with the formulations mentioned herein.
• each of these formulations may be prepared by a known manner per se.
• the compound or composition according to the invention is mixed with developers, such as liquid diluents or carriers, liquid gas diluents or carriers, solid diluents or carriers, and optionally with surfactants, such as anionic, kationic and non-ionic surfactants, such as dioctyl sodium sulfosuccinate and/or dispersants.
• surfactants such as anionic, kationic and non-ionic surfactants, such as dioctyl sodium sulfosuccinate and/or dispersants.
• surfactants such as anionic, kationic and non-ionic surfactants, such as dioctyl sodium sulfosuccinate and/or dispersants.
• surfactants such as anionic, kationic and non-ionic surfactants, such as dioctyl sodium sulfosuccinate and/or dispersants
• liquid diluents or carriers include, but are not limited to, aromatic hydrocarbons, such as xylene, toluene and alkylnaphthalene, chlorinated aromatic or aliphatic hydrocarbons, such as chlorobenzenes, ethylene chlorides and methylene chlorides, aliphatic hydrocarbons, such as cyclohexane, paraffins, such as mineral oil fractions, alcohols, such as for example, benzyl alcohol, isopropanol, ethanol, butanol, glycol and ethers and esters thereof, ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone and cyclohexanone, strong polar solvents, such as dimethylformamide and dimethylsulfoxide, cyclic carbonates, such as ethylene carbonate, propylene carbonate, pyrrolidones, such as N-octylpyrrolidone, N-methylpyrroli
• liquid gas diluents or carriers include, but are not limited to, those which are in a gaseous state at room pressure and liquid under increased pressure, like for example aerosols propellants, such as fron, propane, nitrogen gas, carbon dioxide, and halogenated hydrocarbons.
• solid diluents or carrier examples include, but are not limited to, ground natural minerals, such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and ground synthetic minerals, such as highly dispersed silicic acid, alumina and silicate.
• ground natural minerals such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth
• ground synthetic minerals such as highly dispersed silicic acid, alumina and silicate.
• solid carriers for granules include, but are not limited to, crushed and fractionated rocks, like for example, calcite, marble, pumice, sepiolite and dolomite, synthetic granules of inorganic or organic powders, organic materials, like for example, sawdust, coconut shells, maize cobs and tobacco stalks.
• emulsifiers and/or foam formers include, but are not limited to, nonionic and anionic emulsifiers, like for example, polyoxyethylene fatty acid esters, polyoxyethylene fatty acid alcohol ethers, such as for example, alkylaryl polyglycol ether, alkyl sulfonates, alkyl sulfates and aryl sulfonates and albumin hydrolysates.
• nonionic and anionic emulsifiers like for example, polyoxyethylene fatty acid esters, polyoxyethylene fatty acid alcohol ethers, such as for example, alkylaryl polyglycol ether, alkyl sulfonates, alkyl sulfates and aryl sulfonates and albumin hydrolysates.
• active-compounds comprising shaped articles such as for example collars
• examples of active-compounds comprising shaped articles, such as for example collars include but are not limited o poly vinyl chloride, polyamide, polyamide 6 , polyamide- 6,6 , polyolefins such as high densitiy polyethylene (HDPE), polyethylene, polypropylene and ethylene propylene diene monomer (EPDM).
• HDPE high densitiy polyethylene
• EPDM ethylene propylene diene monomer
• dispersants include, but are not limited to, lignin sulfite waste liquor and methylcellulose.
• Binders are used in preparations, like for example, powders, granules and emulsifiable concentrates.
• binders include, but are not limited to, starches, sugars, cellulose, or modified cellulose such as carboxymethylcellulose, hydroxypropyl cellulose, lactose, or sugar alcohols like xylitol, sorbitol or maltitol, natural or synthetic polymers, such as, gum arabicum, xanthane, polyvinyl alcohol and polyvinyl acetate.
• the colorant examples include, but are not limited to, inorganic pigments, such as iron oxide, titanium oxide and Prussian blue, organic colorants such as Alizarin colorants, azo colorants or metal phthalocyanine colorants, and further, trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum or zinc.
• inorganic pigments such as iron oxide, titanium oxide and Prussian blue
• organic colorants such as Alizarin colorants, azo colorants or metal phthalocyanine colorants
• trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum or zinc.
• the formulation may contain the compound according to the invention from 0.1 to 95% by weight of the total preparation, preferably from 0.5 to 90% by weight, most preferred from 0.8 to 70% by weight.
• mortality in % is determined. 100% means that all eggs are infertile; 0% means that all eggs are fertile.
• test compound Approximately 20-30 ( Lucilia cuprina larvae) are transferred into a test tube containing 1 cm 3 of minced horse meat and 0.5 ml aqueous dilution of test compound.
• mortality in % is determined. 100% means that all the larvae have been killed; 0% means that none of the larvae have been killed.
• a piece or kitchen sponge Prior to the assay, a piece or kitchen sponge is soaked with a mixture of sugar and compound solution and placed into a container. 10 adults ( Musca domestica ) are placed into the container and closed with a perforated lid.
• mortality in % is determined. 100% means that all the flies have been killed; 0% means that none of the flies have been killed.
• mortality in % is determined. 100% means that all eggs are infertile; 0% means that all eggs are fertile.
• Nymphs of the tick Amblyomma hebraeum are placed in perforated plastic beakers and immersed in aqueous compound solution for one minute. Ticks are transferred to a filter paper in a Petri dish and incubated in a climate chamber for 42 days.
• mortality in % is determined. 100% means that all the ticks have been killed; 0% means that none of the ticks have been killed.
• test compounds or compositions were administered in a suitable formulation.

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