US20070185460A1 - Intradermal injection device - Google Patents
Intradermal injection device Download PDFInfo
- Publication number
- US20070185460A1 US20070185460A1 US10/569,618 US56961804A US2007185460A1 US 20070185460 A1 US20070185460 A1 US 20070185460A1 US 56961804 A US56961804 A US 56961804A US 2007185460 A1 US2007185460 A1 US 2007185460A1
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- US
- United States
- Prior art keywords
- protrusion
- holder
- channel
- proximal
- needle cannula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M5/343—Connection of needle cannula to needle hub, or directly to syringe nozzle without a needle hub
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
- A61M2005/3107—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle for needles
- A61M2005/311—Plugs, i.e. sealing rods or stylets closing the bore of needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M5/349—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub using adhesive bond or glues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
- A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
Definitions
- the present invention relates to an intradermal injection device.
- Drug substances may be delivered into a patient's body via injection into the muscle, subcutaneous tissue, or into the epidermis and dermis (also referred to as an intradermal injection).
- the efficacy of a particular drug substance may change when the drug is delivered intradermally. In some cases, intradermal delivery may be more beneficial to the patient.
- intradermal delivery may be more beneficial to the patient.
- the skin thickness both between individuals and within the same individual at different sites of the body.
- the outer skin layer epidermis has a thickness of ranging from 50 to 200 microns
- the dermis, the inner and thicker layer of the skin has a thickness ranging from 1.5 to 3.5 mm.
- a needle cannula that penetrates the skin deeper than about 3 mm has a potential of passing through the dermis layer of the skin, thus making the injection into the subcutaneous region, which may result in an insufficient immune response, especially where the substance to be delivered intradermally has not been indicated for subcutaneous injection.
- the needle cannula may penetrate the skin at too shallow a depth to deliver the substance and result in what is commonly known in the art as a “wet injection” due to reflux of the substance from the injection site.
- the standard procedure for making an intradermal injection is difficult to perform, and successful administration of an intradermal injection using that procedure depends upon experience and technique of the person using the injection device.
- the Mantoux procedure requires that the user of the injection device stretch the skin, orient the needle bevel to face upwardly, and insert a 26 gauge short bevel needle cannula to deliver a volume of 0.5 ml or less of the drug substance into the skin of the patient.
- the needle cannula must be maintained at an angle varying from around 10° to 15° with respect to the patient's skin to form a blister or wheal in which the drug substance is deposited or otherwise contained.
- an intradermal needle assembly has been developed for use with a prefillable container having a reservoir capable of storing a drug substance for injection into the skin of a patient.
- a needle cannula is supported by the prefillable container and has a forward tip extending away from the container.
- the intradermal needle assembly includes a limiter that is securable to the prefillable container and which surrounds the needle cannula and provides a generally flat skin engaging surface extending in a plane generally perpendicular to an axis of the needle cannula.
- the flat skin engaging surface is adapted to be received against the skin of the patient during administration of the intradermal injection.
- the needle forward tip extends beyond the skin engaging surface a distance of approximately 0.5 to 3 mm. Therefore, the limiter limits penetration of the needle into the dermis layer of the skin of the patient so that the drug substance is injected into the dermis layer of the patient.
- the present invention is directed to an intradermal injection device comprising a unitary body having an open distal end and a proximal end having a skin engaging surface defined thereon; a reservoir defined between the proximal and distal ends for accommodating a drug substance; and a channel defined at the proximal end of the unitary body and extending through, and distally from, the skin engaging surface to the reservoir.
- the device comprises a needle cannula having a sharpened proximal end and a distal end.
- the needle cannula is secured in the channel with the distal end being in communication with the reservoir and the proximal end of the needle cannula extending from the skin engaging surface a distance in the range of about 0.5 mm to 3.0 mm such that the skin engaging surface limits penetration of the proximal end of the needle cannula to the dermis layer of the skin of a patient.
- a protrusion is provided on the proximal end of the body of the device which extends proximally from a first surface portion.
- the protrusion is annular and circumscribes the channel. The protrusion aides in the injection process by providing a good interface between the device and the patient's skin, limiting leakage from the injection site during the injection process.
- a holder for a medicament comprising the unitary body is provided to which a needle cannula may be affixed.
- a needle cannula is “staked” or directly affixed to an injection body or holder for a medicament to form an intradermal injection device, without the use of a separate limiter.
- the subject invention is particularly well-suited to be used as a glass prefillable intradermal syringe, although other applications are possible.
- distal shall refer to a part or direction located away or furthest from a patient
- whole proximal shall refer to a part or direction towards or located nearest to a patient.
- a drug substance is used herein in an illustrative, non-limiting manner to refer to any substance injectable into the body of a patient for any purpose.
- Reference to a patient may be to any being, human or animal.
- FIG. 1 is a side partial cross-sectional view of an intradermal injection device constructed in accordance with an embodiment of the present invention
- FIG. 2 is an enlarged partial view of Section 2 in FIG. 1 ;
- FIG. 3 is a top view of the intradermal injection device depicted in FIG. 2 , as viewed from line 3 - 3 ;
- FIG. 4 is an elevational side view of a body of an intradermal injection device, constructed in accordance with an embodiment of the present invention
- FIG. 5 is an enlarged partial view of Section 5 in FIG. 4 ;
- FIG. 6 is a partial side view of a body of an intradermal injection device having a protrusion extending therefrom constructed in accordance with an embodiment of the present invention
- FIG. 7 is a top view of the intradermal injection device depicted in FIG. 6 , as viewed from line 7 - 7 ;
- FIG. 8 is a cross-sectional view taken from line 8 - 8 of FIG. 7 without the needle cannula or adhesive being shown; and, FIGS. 9 a - 9 b depict various cross-sections which may be used alternatively to the cross-section shown in FIG. 8 .
- FIGS. 1-3 depict an intradermal injection device 100 constructed in accordance with an embodiment of the present invention.
- the injection device 100 is preferably a syringe comprised of a body 10 having a barrel 20 , an open distal end 40 with a flange 22 , a proximal end 30 , and a reservoir 24 defined therebetween.
- a drug substance may be placed in the reservoir 24 before the injection device 100 is provided to the end user.
- the injection device 100 also includes a plunger 80 slidingly and sealingly provided within the reservoir 24 , and a plunger rod 90 secured to the plunger 80 to facilitate movement of the plunger 80 within the reservoir 24 to effect expulsion of the drug substance therefrom.
- the body 10 narrows near the proximal end 30 to form a neck 28 that supports a limiter 50 defined at the proximal end 30 of the body 10 .
- the neck 28 is preferably tapered, particularly to converge in a distal to proximal direction.
- a first transition 32 may be provided to accommodate a gradual change in the outer diameter between the barrel 20 and the neck 28
- a second transition 34 may be provided to accommodate a gradual change in outer diameter between the neck 28 and limiter 50 .
- the transitions 32 , 34 may be chamfered, radiused, or otherwise softened to avoid forming sharp, e.g., right angle, transitions between the various elements.
- the limiter 50 defines a skin engaging surface 52 at its proximal end that contacts the skin of a patient during use of the injection device 100 .
- the limiter 50 and skin engaging surface 52 are unitarily formed with the body 10 .
- the skin engaging surface 52 may be formed flat or with any known configuration, including, but not limited to, those surface configurations disclosed in copending Appl. No. [Attorney Reference No. 102-530 (P-5612)], the entire disclosure of which is incorporated herein by reference.
- the limiter 50 preferably has a cylindrical shape and defines an outer diameter d which is less than or equal to 11 mm, more preferably less than or equal to 5.5 mm.
- Outer perimeter 54 formed at the intersection of the skin engaging surface 52 and side surface 56 of the limiter 50 , is preferably chamfered, radiused or otherwise softened to avoid defining a sharp transition between the skin engaging surface 52 and the side surface 56 .
- a channel 26 extends through the skin engaging surface 52 and in a distal direction into communication with the reservoir 24 .
- the channel 26 preferably has a central longitudinal axis which is generally perpendicular to a plane defined by the skin engaging surface 52 .
- the channel 26 may have a constant diameter, or it may have a diameter varying in size from one approximately matched to the outer diameter of a needle cannula, and increasing to a size greater than the outer diameter of the needle cannula. In either case, a portion of the channel 26 preferably has a diameter sized and shaped to accommodate a needle cannula, as described in more detail below.
- channel 26 For a varying diameter channel 26 , it is preferred that the end of the channel 26 nearest the skin engaging surface 52 have a larger diameter than other portions of the channel 26 to receive an adhesive for securing the needle cannula in the channel 26 . Also, for a varying diameter configuration, the cross-sectional profile of the channel 26 may be tapered, stepped, or any other configuration that permits variation in the diameter of the channel 26 . In a preferred embodiment, such as is depicted in FIG. 2 , channel 26 has a first part 126 located near the skin engaging surface 52 , and a second part 226 , located near the reservoir 24 .
- the first part 126 has a diameter greater than that of the second part 226 ; the diameter of the second part 226 being preferably selected to be approximately the same as the outer diameter of the needle cannula provided as part of the inventive injection device 100 .
- the outer diameter of the various gauges of needle cannula is well known in the art and the second part 226 may be sized accordingly.
- the channel 26 may optionally include a third part 336 provided adjacent the reservoir 24 to provide an at least partial transition between a bottom surface 124 of the reservoir 24 and the second part 226 of the channel 26 . A similar transition may be provided between the first and second parts 126 , 226 of the channel 26 .
- the body 10 which can act as a holder for medicament, can be provided alone.
- the body 10 in combination with a needle cannula 70 forms the injection device 100 .
- the needle cannula 70 is supported at the proximal end 30 of the body 10 in the channel 26 and includes a distal end 74 located in or near the reservoir 24 and a forward tip 72 , preferably sharpened, that extends a predetermined distance d 2 from the skin engaging surface 52 .
- distance d 2 ranges from approximately 0.5 mm to 3 mm.
- the distance d 2 is preferably measured from a plane defined by coplanar portions of the skin engaging surface 52 (whether or not the skin engaging surface 52 is flat), more preferably, the distance d 2 is measured from proximal most portions of the skin engaging surface 52 .
- the coplanar portions may be disposed continuously or discontinuously about the needle cannula 70 .
- the skin engaging surface 52 is formed to engage a patient's skin such that a uniform ring of pressure is generated about the needle cannula 70 during injection. The ring of pressure assists in reduction in fluid leakage from the injection site during the injection process.
- the distal end 74 is in fluid communication with the reservoir 24 , and the needle cannula 70 provides a fluid path from the reservoir 24 through which the drug substance may be expelled from the injection device 100 and injected into the intradermal region in a patient's skin.
- a central axis of the needle cannula 70 is arranged at a predetermined angle with respect to a plane defined by the skin engaging surface 52 , particularly the plane from which the distance d 2 is measured as described above. In a preferred embodiment, that predetermined angle is approximately 90°. Other angular relationships are also contemplated by, and within the scope and spirit of, the present invention.
- the angular relationship between the needle cannula central axis 76 and plane of the skin engaging surface 52 may be defined by variation on the placement of the needle cannula 70 in the channel 26 , variation in the orientation of the skin engaging surface 52 , or variation of both.
- the needle cannula 70 is secured to the body 10 and within the channel 26 using a suitable adhesive 60 (see, e.g., FIG. 3 ), particularly where the body 10 is formed of glass.
- the adhesive 60 is heat or ultraviolet curable.
- the amount of adhesive 60 used to secure the needle cannula 70 within the channel 26 is controlled so as to ensure that the flatness of the skin engaging surface 52 is not affected by the adhesive 60 .
- the amount of adhesive 60 provided does not completely fill the first part 126 of the channel 26 , but instead, is recessed with regard to the skin engaging surface 52 , e.g. by forming a generally concave surface.
- the first part 126 of the channel 26 conveniently provides a pocket for the adhesive 60 and it is not necessary to apply the adhesive 60 to other portions of the channel 26 .
- the needle cannula 70 can be directly secured in the channel 26 using any known technique, such as being insert molded with the body 10 being formed of plastic.
- the plunger rod 90 is connected at one end to the plunger 80 and having, at its other end, a thumb pad 92 that may be depressed by a user to cause movement of the plunger 80 within the reservoir 24 to expel the drug substance therefrom.
- a thumb pad 92 that may be depressed by a user to cause movement of the plunger 80 within the reservoir 24 to expel the drug substance therefrom.
- the plunger 80 may come into contact with the bottom surface 124 of the reservoir 24 .
- the plunger 80 may be forced onto the distal end 74 of the needle cannula 70 to sealingly engage the needle cannula 70 . With this arrangement, the plunger 80 may thus seal the needle cannula 70 and prevent additional drug substance or other material from exiting the needle cannula 70 (either into the patient's skin or elsewhere).
- the body 10 of the inventive intradermal delivery device 100 be at least partially made from glass, preferably wholly, although other suitable materials that may be now known or hereafter developed may be used, including plastic. Although the inventive intradermal delivery device 100 may be used in various applications, it is particularly well-suited as a glass prefillable intradermal syringe.
- a drug substance is provided into the reservoir 24 and the plunger 80 is placed in the open distal end 40 of the barrel 20 .
- the device 100 will be provided to a point-of-use with the drug substance and the plunger 80 being in the barrel 20 ready for use.
- the plunger 80 is prepared and the drug substance is charged into the barrel by aspiration or other known methods at the point of use.
- the inventive injection device 100 is preferably oriented in a generally perpendicular relationship with respect to the injection site.
- the central axis 76 of the needle cannula 70 is generally perpendicular to a plane defined by the patient's skin at the injection site.
- Deviations from generally perpendicular typically will not adversely impact the use and efficiency of the inventive injection device 100 .
- the forward tip 72 of the needle cannula 70 is caused to pierce the patient's skin until the skin engaging surface 52 contacts the patient's skin.
- the length of the needle cannula 70 extending beyond the skin engaging surface 52 and the skin engaging surface 52 itself serve to limit the depth of penetration of the forward tip 72 of the needle cannula to the intradermal space of the patient's skin.
- the health care provider administering the injection depresses the thumb pad 92 to cause the plunger 80 to move in a distal to proximal direction in the reservoir 24 thus causing expulsion of the drug substance therefrom.
- each injection device 100 may be filled with a predetermined dose of a particular drug substance intended for administration in a single dose.
- the plunger 80 may be forced to sealingly engage the distal end 74 of the needle cannula 70 and prevent further expulsion of drug substance or other material through and from the needle cannula 70 .
- the inventive injection device 100 may also include a safety component that shields the forward tip 72 of the needle cannula 70 to reduce the possibility of accidental needle-stick injury from occurring after use of the device 100 .
- the safety component may cover the forward tip 72 before use and/or after use, and preferably locks in place after use to prevent inadvertent exposure to the forward tip 72 after use of the device 100 .
- the safety component may comprise a holder for the body 10 , a shield to cover the forward tip 72 of the needle cannula 70 , other components that facilitate manual or assisted activation, or variations and combinations thereof.
- a protrusion 300 is provided to extend proximally from the proximal end of the body 10 .
- the skin engaging surface 52 may be formed with various configurations.
- the skin engaging surface 52 is defined on a free proximal end 302 of the protrusion.
- a first surface portion 304 is also defined on the proximal end 30 of the body 10 .
- the first surface portion 304 is flat, annular, and circumscribes the protrusion 300 .
- the protrusion 300 is preferably annular and circumscribes the channel 26 . More preferably, the protrusion 300 bounds to channel 26 , particularly the first part 126 .
- the protrusion 300 may be formed with various cross-sectional shapes.
- the protrusion is formed with a rectangular cross-section, particularly a square cross-section.
- the height h may be in the range of 0.2 mm to 0.5 mm and the width w of the free proximal end 302 , and thus the skin engaging surface 52 , may be in the range of 0.2 mm to 0.5 mm.
- the height h and width w are generally equal.
- the protrusion 300 may have a trapezoidal cross-section with a height h in the range of 0.5 mm to 1.0 mm, a width w of the free proximal end 302 in the range of 0.35 mm to 0.6 mm, and a side surface 306 disposed at an angle a relative to the first surface portion 304 , the angle a being in the range of 30-45 degrees.
- Other polygonal shapes are possible.
- portions of the protrusion 302 may be formed arcuately as shown in FIG. 9 b.
- the channel 26 As indicated above, it is preferred to bound the channel 26 with the protrusion 300 .
- the body 10 being formed of glass, and as will be appreciated by those skilled in the art, the transition between the skin engaging surface 52 and the channel 26 shown in the embodiment of FIGS. 1-5 is difficult to achieve. In particular, a pin or other element used to form the channel 26 easily disrupts the transition and consistency in formation may be difficult to achieve.
- the protrusion 300 With forming the body 10 of glass, it has been found that the protrusion 300 allows for easier and more consistent formation of the channel 26 and surrounding portions.
- the protrusion 300 (ring) is added to compensate for the radius which normally forms between the tip and the channel during the glass forming process. The result is a sharper corner.
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US10/569,618 US20070185460A1 (en) | 2003-08-28 | 2004-01-30 | Intradermal injection device |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US49850803P | 2003-08-28 | 2003-08-28 | |
US10/569,618 US20070185460A1 (en) | 2003-08-28 | 2004-01-30 | Intradermal injection device |
PCT/US2004/002783 WO2005025641A2 (en) | 2003-08-28 | 2004-01-30 | Intradermal injection device |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/US2004/002783 A-371-Of-International WO2005025641A2 (en) | 2003-08-28 | 2004-01-30 | Intradermal injection device |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US14/568,526 Continuation US9682198B2 (en) | 2003-08-28 | 2014-12-12 | Intradermal injection device |
Publications (1)
Publication Number | Publication Date |
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US20070185460A1 true US20070185460A1 (en) | 2007-08-09 |
Family
ID=34312171
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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US10/569,618 Abandoned US20070185460A1 (en) | 2003-08-28 | 2004-01-30 | Intradermal injection device |
US14/568,526 Expired - Lifetime US9682198B2 (en) | 2003-08-28 | 2014-12-12 | Intradermal injection device |
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Application Number | Title | Priority Date | Filing Date |
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US14/568,526 Expired - Lifetime US9682198B2 (en) | 2003-08-28 | 2014-12-12 | Intradermal injection device |
Country Status (10)
Country | Link |
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US (2) | US20070185460A1 (pt) |
EP (2) | EP3354308B1 (pt) |
JP (1) | JP4746545B2 (pt) |
CN (1) | CN100509072C (pt) |
AU (1) | AU2004271893B2 (pt) |
BR (1) | BRPI0414021B1 (pt) |
CA (1) | CA2536681C (pt) |
MX (1) | MXPA06002047A (pt) |
WO (1) | WO2005025641A2 (pt) |
ZA (1) | ZA200602318B (pt) |
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US20100270702A1 (en) * | 2008-01-15 | 2010-10-28 | West Pharmaceutical Services, Inc. | Collet mechanism and method of molding cannula to a syringe barrel |
US20110166520A1 (en) * | 2008-09-30 | 2011-07-07 | Terumo Kabushiki Kaisha | Injection needle and drug injection device |
US20110224606A1 (en) * | 2010-03-10 | 2011-09-15 | Shibaji Shome | Method and apparatus for remote ischemic conditioning during revascularization |
US20130138047A1 (en) * | 2010-09-29 | 2013-05-30 | Terumo Kabushiki Kaisha | Syringe with needle |
US20130216975A1 (en) * | 2012-02-22 | 2013-08-22 | Transcodent GmbH & Co. KG | Dispensing Container for Dental Compound |
USD689188S1 (en) | 2012-07-19 | 2013-09-03 | West Pharmaceutical Services, Inc. | Syringe plunger rod |
USD693002S1 (en) | 2011-09-21 | 2013-11-05 | West Pharmaceutical Services, Inc. | Hub for medical container |
US8721603B2 (en) | 2008-01-15 | 2014-05-13 | West Pharmaceutical Services, Inc. | Syringe with co-molded hub and cannula |
US9445838B2 (en) | 2009-03-03 | 2016-09-20 | Bection, Dickinson And Company | Pen needle assembly for delivering drug solutions |
WO2017058755A1 (en) * | 2015-09-28 | 2017-04-06 | Tuttlenumbnow Llc | Systems and methods for bending a needle |
US20170312453A1 (en) * | 2015-01-20 | 2017-11-02 | Terumo Kabushiki Kaisha | Injection needle assembly and injector provided therewith for injecting drug solution into upper layer of skin |
EP3714925A1 (en) | 2012-04-09 | 2020-09-30 | Becton, Dickinson and Company | Injection mechanism utilizing a vial |
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WO2003022330A2 (en) | 2001-09-12 | 2003-03-20 | Becton, Dickinson And Company | Microneedle-based pen device for drug delivery and method for using same |
US9486581B2 (en) | 2002-09-11 | 2016-11-08 | Becton, Dickinson And Company | Injector device with force lock-out and injection rate limiting mechanisms |
US7645264B2 (en) | 2005-04-11 | 2010-01-12 | Becton, Dickinson And Company | Injection device with secondary reservoir |
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US10384379B2 (en) | 2010-09-29 | 2019-08-20 | Terumo Kabushiki Kaisha | Syringe with needle |
US20180178423A1 (en) * | 2010-09-29 | 2018-06-28 | Terumo Kabushiki Kaisha | Syringe with needle |
US20130138047A1 (en) * | 2010-09-29 | 2013-05-30 | Terumo Kabushiki Kaisha | Syringe with needle |
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US20170312453A1 (en) * | 2015-01-20 | 2017-11-02 | Terumo Kabushiki Kaisha | Injection needle assembly and injector provided therewith for injecting drug solution into upper layer of skin |
US10413680B2 (en) * | 2015-01-20 | 2019-09-17 | Terumo Kabushiki Kaisha | Injection needle assembly and injector provided therewith for injecting drug solution into upper layer of skin |
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Also Published As
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US20150100022A1 (en) | 2015-04-09 |
AU2004271893B2 (en) | 2010-07-29 |
JP2007503866A (ja) | 2007-03-01 |
EP1660149A4 (en) | 2009-01-14 |
AU2004271893A1 (en) | 2005-03-24 |
EP3354308A1 (en) | 2018-08-01 |
EP3354308B1 (en) | 2020-11-11 |
ZA200602318B (en) | 2007-09-26 |
US9682198B2 (en) | 2017-06-20 |
JP4746545B2 (ja) | 2011-08-10 |
BRPI0414021A (pt) | 2006-10-24 |
EP1660149A2 (en) | 2006-05-31 |
WO2005025641A3 (en) | 2006-04-13 |
WO2005025641A2 (en) | 2005-03-24 |
EP1660149B1 (en) | 2018-03-07 |
CN1859937A (zh) | 2006-11-08 |
BRPI0414021B1 (pt) | 2023-09-26 |
CA2536681A1 (en) | 2005-03-24 |
CA2536681C (en) | 2011-07-05 |
MXPA06002047A (es) | 2006-05-25 |
CN100509072C (zh) | 2009-07-08 |
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