US20070093697A1 - Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature - Google Patents
Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature Download PDFInfo
- Publication number
- US20070093697A1 US20070093697A1 US11/332,796 US33279606A US2007093697A1 US 20070093697 A1 US20070093697 A1 US 20070093697A1 US 33279606 A US33279606 A US 33279606A US 2007093697 A1 US2007093697 A1 US 2007093697A1
- Authority
- US
- United States
- Prior art keywords
- substance
- measurable substance
- bypassing
- shunting
- measurable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/281—Instillation other than by gravity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/285—Catheters therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/32—Oxygenators without membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M25/003—Multi-lumen catheters with stationary elements characterized by features relating to least one lumen located at the distal part of the catheter, e.g. filters, plugs or valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0094—Heating or cooling appliances for medical or therapeutic treatment of the human body using a remote control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
- A61F2007/126—Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M2025/0034—Multi-lumen catheters with stationary elements characterized by elements which are assembled, connected or fused, e.g. splittable tubes, outer sheaths creating lumina or separate cores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M2025/0037—Multi-lumen catheters with stationary elements characterized by lumina being arranged side-by-side
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/007—Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
Definitions
- a patent foramen ovale is a defect in the septum (wall) between the two upper (atrial) chambers of the heart. Specifically, the defect is an incomplete closure of the atrial septum that results in the creation of a flap or a valve-like opening in the atrial septal wall (see illustration).
- a PFO is frequent in everyone before birth but seals shut in about 80% of people.
- the flap When a person with this defect creates pressure inside his or her chest—such as when coughing, sneezing, or straining during a bowel movement—the flap can open, and blood can flow in either direction directly between the right and left atrium. When blood moves directly from the right atrium to the left atrium, this blood bypasses the filtering system of the lungs. If debris is present in the blood, such as small blood clots, it can pass through the left atrium and lodge in the brain, causing a stroke, or another organ, such as the heart, eyes, or kidneys.
- PFOs are not uncommon and usually cause no symptoms at all.
- One in five people have a PFO but less than 1% have a stroke or other cause to have the PFO closed.
- a PFO is congenital, meaning it is a defect that is inborn or exists at birth. Stated another way, the defect is an abnormality, not a disease.
- the septum between the two atrium of the heart developed normally before birth but the flap did not seal completely after birth.
- the present invention provides a rapid, economical test for the detection of a right to left shunt applicable to the population at large due to its safety and noninvasiveness.
- the intended procedure involves gaining access to the circulatory system, injecting a measurable substance, ideally during prolonged and/or repeated Valsalva maneuvers, and then rapidly and repeatedly, ideally continuously, assaying for the substance. Through the determination of the appearance of a small amount of the substance prior to the subsequent high concentrations generated by the remainder of the bolus, one may safely diagnose a meaningful communication between the right and left heart, or other right to left shunt bypassing the lungs.
- the device may consist of one or two access sites (arterial or venous), a pump or syringe for delivering the substance and a discrete and repeatable sampling or measuring mechanism linked to a timer.
- the sampling mechanism alternatively, could be a continuous mechanism and the diagnosis of a PFO could be based on the qualitative or quantitative appearance of the substance at key time points.
- the delivery of the substance and the acquisition of samples will be completely automated and the device will consist of an indicator panel to signal the beginning and the end of the required Valsalva.
- the substance may be any substance which is safe for use in the bloodstream and easily detectable and may be assayed for externally via blood sampling or may be assayed for via an intravascular sensor, in the instances where such a sensor may be miniaturized enough to be placed on a catheter.
- Possible substances include, but are not limited to: ammonia, ethanol, indocyanine green, lithium, radiolabled plasma or any other indicator capable of being injected and rapidly detected.
- the ideal embodiment of the device involving a single access site will consist of a dual-lumen catheter where the sampling port is proximal to the site of substance delivery and the two lumens do not communicate. In this way, the delivery will not interfere with the sampling for the substance.
- a substance can be used which is completely, or nearly completely, removed from the bloodstream by the lungs.
- a simple assay for the substance can then be used and any blood concentration above a certain threshold can be considered diagnostic of a communication between the right and left heart.
- Either embodiment may involve one or two points of access, most likely a venous and/or arterial access.
- the device may consist of a controlled source of oxygen delivered to the patient during which arterial blood gases or pulse oximetry is performed.
- the corresponding decrease or increase in arterial or venous oxygen can then be used to measure shunt fraction, or percent of the blood that is not being passed through the lungs. This will allow for the quick, easy determination of the amount of blood that is being shunted from right to left.
- This device and method will create a PFO screening test that can be widely applicable to all patients due to the ease and inexpensiveness of the test.
- the device could provide an economical, minimally invasive test for any right to left shunt, including PFOs, ventricular septal defects, atrial septal defects, patent ductus arteriosus, arteriovenous malformation in the pulmonary bed and any other condition allowing blood to bypass the capillary bed of the lungs.
- FIGS. 1 A-B A frontal view of an example of an access catheter FIG. 1A and the logic controller FIG. 1B .
- FIGS. 2 A-C Frontal views of the access catheter FIGS. 2 A-B in action delivering the measurable substance FIG. 2A and then acquiring the appearance data FIG. 2B with all functions controlled, and the data analyzed, by the logic controller FIG. 2C .
- FIGS. 3 A-B Frontal views of the system attached to the patient while delivering, and recording the appearance of, the measurable substance.
- FIG. 3A illustrates the system utilizing a single access site utilizing a multi-function catheter.
- FIG. 4 Frontal view of the system in which injection is not required due to use of oxygen at varying concentrations of inhalation as the measurable substance.
- FIGS. 1 A-B A frontal view of an example of an access catheter FIG. 1A and the logic controller FIG. 1B .
- the needle 1 is shown with two ports, an intake port 3 and an outflow port 4 .
- the logic controller 2 is shown with the tubing ports 6 and other controls 5 .
- FIGS. 2 A-C Frontal views of the access catheter FIGS. 2 A-B in action delivering the measurable substance FIG. 2A and then acquiring the appearance data FIG. 2B with all functions controlled, and the data analyzed, by the logic controller FIG. 2C .
- the logic controller is shown with possible graphical data analyzer 7 and controls 8 .
- Controls 8 include start button, time indicator and possible indicator to begin Valsalva maneuver, etc.
- FIGS. 3 A-B Frontal views of the system attached to the patient while delivering, and recording the appearance of, the measurable substance.
- FIG. 3A illustrates the system utilizing a single access site 9 utilizing a multi-function catheter 1 .
- FIG. 3B illustrates the multi-catheter system.
- FIG. 4 Frontal view of the system in which injection is not required due to use of oxygen at varying concentrations of inhalation as the measurable substance.
- the logic controller 10 is used to analyze the fluctuation in oxygen concentration while the oxygen delivery system 11 controls the oxygen levels.
- the oxygen delivery system 11 and the logic controller 12 are integrated to allow for automated delivery of pulmonary oxygen and recording of blood oxygen levels.
- the blood oxygen levels can be recorded using pulse oximetry, arterial blood gases, venous blood gases, etc.
Abstract
The present invention provides a rapid, economical test for the detection of a right to left shunt applicable to the population at large due to its safety and noninvasiveness. The intended procedure involves gaining access to the circulatory system, injecting a measurable substance, ideally during prolonged and/or repeated Valsalva maneuvers, and then rapidly and repeatedly, ideally continuously, assaying for the substance. Through the determination of the appearance of a small amount of the substance prior to the subsequent high concentrations generated by the remainder of the bolus, one may safely diagnose a meaningful communication between the right and left heart, or other right to left shunt bypassing the lungs.
Description
- This application claims priority to U.S. Provisional Patent Application Ser. No. 60/613,205, filed Sep. 27, 2004, U.S. Provisional Patent Application Ser. No. 60/643,145, filed Jan. 12, 2005 and U.S. Provisional Patent Application Ser. No. 60/728,785, filed Oct. 21, 2005. The relevant disclosures of the applications cited in this paragraph is hereby incorporated by reference.
- A patent foramen ovale (PFO) is a defect in the septum (wall) between the two upper (atrial) chambers of the heart. Specifically, the defect is an incomplete closure of the atrial septum that results in the creation of a flap or a valve-like opening in the atrial septal wall (see illustration). A PFO is frequent in everyone before birth but seals shut in about 80% of people.
- When a person with this defect creates pressure inside his or her chest—such as when coughing, sneezing, or straining during a bowel movement—the flap can open, and blood can flow in either direction directly between the right and left atrium. When blood moves directly from the right atrium to the left atrium, this blood bypasses the filtering system of the lungs. If debris is present in the blood, such as small blood clots, it can pass through the left atrium and lodge in the brain, causing a stroke, or another organ, such as the heart, eyes, or kidneys.
- PFOs are not uncommon and usually cause no symptoms at all. One in five people have a PFO but less than 1% have a stroke or other cause to have the PFO closed. A PFO is congenital, meaning it is a defect that is inborn or exists at birth. Stated another way, the defect is an abnormality, not a disease. The septum between the two atrium of the heart developed normally before birth but the flap did not seal completely after birth.
- While there is a plethora of prior art surrounding the closure of PFOs including, among others, US Pat. App. Nos. 20050080406, 20050216054, 20050209636, 20050192654, 20050192627, 20050187568, 20030225421 and U.S. Pat. Nos. 5,846,261, 5,718,725, little work has been done to assist in the diagnosis of PFOs. The ideal procedure would be accurate and inexpensive as the optimal use of such a technology would allow for the screening of patients for PFOs, or other right to left shunts, prior to the onset of stroke or migraine symptoms. Currently, diagnosis of a PFO is accomplished through the use of an air-filled contrast agent and ultrasound, either Transesophageal or Transthoracic. This procedure is both expensive and involves risks associated with contrast usage, namely if there is a communication between the right and left heart bypassing the lungs, said air-filled contrast agent will instead become trapped in the cerebral or peripheral vasculature, potentially resulting in morbidity or mortality.
- The present invention provides a rapid, economical test for the detection of a right to left shunt applicable to the population at large due to its safety and noninvasiveness. The intended procedure involves gaining access to the circulatory system, injecting a measurable substance, ideally during prolonged and/or repeated Valsalva maneuvers, and then rapidly and repeatedly, ideally continuously, assaying for the substance. Through the determination of the appearance of a small amount of the substance prior to the subsequent high concentrations generated by the remainder of the bolus, one may safely diagnose a meaningful communication between the right and left heart, or other right to left shunt bypassing the lungs.
- The device may consist of one or two access sites (arterial or venous), a pump or syringe for delivering the substance and a discrete and repeatable sampling or measuring mechanism linked to a timer. The sampling mechanism, alternatively, could be a continuous mechanism and the diagnosis of a PFO could be based on the qualitative or quantitative appearance of the substance at key time points. In the preferred embodiment, the delivery of the substance and the acquisition of samples will be completely automated and the device will consist of an indicator panel to signal the beginning and the end of the required Valsalva. The substance may be any substance which is safe for use in the bloodstream and easily detectable and may be assayed for externally via blood sampling or may be assayed for via an intravascular sensor, in the instances where such a sensor may be miniaturized enough to be placed on a catheter. Possible substances include, but are not limited to: ammonia, ethanol, indocyanine green, lithium, radiolabled plasma or any other indicator capable of being injected and rapidly detected.
- Due to the requirement for sensitivity in measuring the substance, the ideal embodiment of the device involving a single access site will consist of a dual-lumen catheter where the sampling port is proximal to the site of substance delivery and the two lumens do not communicate. In this way, the delivery will not interfere with the sampling for the substance.
- Alternatively, a substance can be used which is completely, or nearly completely, removed from the bloodstream by the lungs. A simple assay for the substance can then be used and any blood concentration above a certain threshold can be considered diagnostic of a communication between the right and left heart. Either embodiment may involve one or two points of access, most likely a venous and/or arterial access.
- In yet another embodiment, the device may consist of a controlled source of oxygen delivered to the patient during which arterial blood gases or pulse oximetry is performed. By varying the oxygen level that is inhaled, the corresponding decrease or increase in arterial or venous oxygen can then be used to measure shunt fraction, or percent of the blood that is not being passed through the lungs. This will allow for the quick, easy determination of the amount of blood that is being shunted from right to left.
- This device and method will create a PFO screening test that can be widely applicable to all patients due to the ease and inexpensiveness of the test. In addition the device could provide an economical, minimally invasive test for any right to left shunt, including PFOs, ventricular septal defects, atrial septal defects, patent ductus arteriosus, arteriovenous malformation in the pulmonary bed and any other condition allowing blood to bypass the capillary bed of the lungs.
- FIGS. 1A-B—A frontal view of an example of an access catheter
FIG. 1A and the logic controllerFIG. 1B . - FIGS. 2A-C—Frontal views of the access catheter FIGS. 2A-B in action delivering the measurable substance
FIG. 2A and then acquiring the appearance dataFIG. 2B with all functions controlled, and the data analyzed, by the logic controllerFIG. 2C . - FIGS. 3A-B—Frontal views of the system attached to the patient while delivering, and recording the appearance of, the measurable substance.
FIG. 3A illustrates the system utilizing a single access site utilizing a multi-function catheter. -
FIG. 4 —Frontal view of the system in which injection is not required due to use of oxygen at varying concentrations of inhalation as the measurable substance. - FIGS. 1A-B—A frontal view of an example of an access catheter
FIG. 1A and the logic controllerFIG. 1B . The needle 1 is shown with two ports, anintake port 3 and anoutflow port 4. Thelogic controller 2 is shown with thetubing ports 6 andother controls 5. - FIGS. 2A-C—Frontal views of the access catheter FIGS. 2A-B in action delivering the measurable substance
FIG. 2A and then acquiring the appearance dataFIG. 2B with all functions controlled, and the data analyzed, by the logic controllerFIG. 2C . The logic controller is shown with possiblegraphical data analyzer 7 and controls 8.Controls 8 include start button, time indicator and possible indicator to begin Valsalva maneuver, etc. - FIGS. 3A-B—Frontal views of the system attached to the patient while delivering, and recording the appearance of, the measurable substance.
FIG. 3A illustrates the system utilizing asingle access site 9 utilizing a multi-function catheter 1.FIG. 3B illustrates the multi-catheter system. -
FIG. 4 —Frontal view of the system in which injection is not required due to use of oxygen at varying concentrations of inhalation as the measurable substance. Thelogic controller 10 is used to analyze the fluctuation in oxygen concentration while theoxygen delivery system 11 controls the oxygen levels. In the ideal embodiment, theoxygen delivery system 11 and the logic controller 12 are integrated to allow for automated delivery of pulmonary oxygen and recording of blood oxygen levels. The blood oxygen levels can be recorded using pulse oximetry, arterial blood gases, venous blood gases, etc.
Claims (14)
1. A method providing for the detection of cardiovascular shunting and/or bypassing of the pulmonary capillary bed comprising:
Intravascular injection of a measurable substance, and
Assaying for said measurable substance, and
Interpreting the appearance and/or disappearance of the measurable substance to determine if said shunting or bypassing is present
2. The method of claim 1 in which the measurable substance may be ethanol, indocyanine green, lithium, radiolabled plasma, ammonia or any other indicator capable of being injected and rapidly detected
3. The method of claim 1 in which said injection is accomplished by an automated mechanism to provide reliability of infusion
4. The method of claim 1 in which said assaying may be conducted repeatedly or on a continuous basis
5. The method of claim 4 in which the curve associated with said appearance of the substance is use to conduct said interpretation of the presence of shunting or bypassing
6. The method of claim 5 in which abnormal shape of the curve or appearance of measurable substance earlier than anticipated is interpreted as a the presence of shunting or bypassing
7. The method of claim 1 in which said assaying for said measurable substance occurs intravascularly
8. The method of claim 7 in which said intravascular measurement is accomplished at the site of injection of the measurable substance
9. The method of claim 8 in which a single multi-function catheter is used to inject the measurable substance and to assay for said measurable substance
10. The method of claim 1 in which said assaying for said measurable substance occurs external to the patient
11. The method of claim 1 in which injecting the measurable substance, assaying for said measurable substance and interpreting the acquired data may be fully automated
12. A method providing for the detection of cardiovascular shunting and/or bypassing of the pulmonary capillary bed comprising:
Varying concentrations of inhaled oxygen, and
Measurement of blood oxygen content
13. The method of claim 12 in which inhaled oxygen and blood oxygen are used to directly measure cardiovascular shunting and/or bypassing of the pulmonary capillary bed
14. The method of claim 12 in which inhaled oxygen and blood gas measurements may be coordinated via a single instrument
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/332,796 US20070093697A1 (en) | 2005-10-21 | 2006-01-17 | Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72878505P | 2005-10-21 | 2005-10-21 | |
US11/332,796 US20070093697A1 (en) | 2005-10-21 | 2006-01-17 | Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature |
Publications (1)
Publication Number | Publication Date |
---|---|
US20070093697A1 true US20070093697A1 (en) | 2007-04-26 |
Family
ID=37963393
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/332,796 Abandoned US20070093697A1 (en) | 2005-10-21 | 2006-01-17 | Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature |
US11/552,090 Active 2033-02-28 US8672884B2 (en) | 2005-10-21 | 2006-10-23 | Method and apparatus for peritoneal hypothermia and/or resuscitation |
US14/161,297 Abandoned US20140135878A1 (en) | 2005-10-21 | 2014-01-22 | Method and Apparatus for Peritoneal Hypothermia and/or Resuscitation |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/552,090 Active 2033-02-28 US8672884B2 (en) | 2005-10-21 | 2006-10-23 | Method and apparatus for peritoneal hypothermia and/or resuscitation |
US14/161,297 Abandoned US20140135878A1 (en) | 2005-10-21 | 2014-01-22 | Method and Apparatus for Peritoneal Hypothermia and/or Resuscitation |
Country Status (7)
Country | Link |
---|---|
US (3) | US20070093697A1 (en) |
EP (1) | EP1971378A4 (en) |
JP (1) | JP2009512504A (en) |
AU (1) | AU2006304877C1 (en) |
BR (1) | BRPI0619309A2 (en) |
CA (1) | CA2626795A1 (en) |
WO (1) | WO2007048068A2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100016731A1 (en) * | 2008-07-15 | 2010-01-21 | Cardiox Corporation | Hemodynamic Detection of Circulatory Anomalies |
US20110245662A1 (en) * | 2010-04-06 | 2011-10-06 | Eggers Philip E | Hemodynamic Detection of Circulatory Anomalies |
CN111345850A (en) * | 2020-03-10 | 2020-06-30 | 苏州大学附属第一医院 | Method for evaluating induced thoracic negative pressure by right-left shunt |
Families Citing this family (189)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5990921A (en) * | 1982-11-16 | 1984-05-25 | Matsushita Electronics Corp | Method and apparatus for manufacturing semiconductor device |
US6673098B1 (en) * | 1998-08-24 | 2004-01-06 | Radiant Medical, Inc. | Disposable cassette for intravascular heat exchange catheter |
CA2411569A1 (en) * | 2002-11-12 | 2004-05-12 | Ross E. Mantle | Medical device for the extravascular recirculation of fluid in body cavities at controlled temperature and pressure |
EP1667595B1 (en) | 2003-09-12 | 2014-01-01 | Vessix Vascular, Inc. | System for selectable eccentric remodeling and/or ablation of atherosclerotic material |
EP4197447A1 (en) * | 2004-08-16 | 2023-06-21 | Corindus, Inc. | Image-guided navigation for catheter-based interventions |
US8920414B2 (en) | 2004-09-10 | 2014-12-30 | Vessix Vascular, Inc. | Tuned RF energy and electrical tissue characterization for selective treatment of target tissues |
US9713730B2 (en) | 2004-09-10 | 2017-07-25 | Boston Scientific Scimed, Inc. | Apparatus and method for treatment of in-stent restenosis |
US8396548B2 (en) | 2008-11-14 | 2013-03-12 | Vessix Vascular, Inc. | Selective drug delivery in a lumen |
US7699799B2 (en) * | 2005-08-26 | 2010-04-20 | Ceeben Systems, Inc. | Ultrasonic material removal system for cardiopulmonary bypass and other applications |
US20070051409A1 (en) | 2005-09-02 | 2007-03-08 | Belmont Instrument Corporation | Pressure responsive fluid flow control valves |
WO2007036925A1 (en) * | 2005-09-29 | 2007-04-05 | Corindus Ltd. | Methods and apparatuses for treatment of hollow organs |
US20180311071A1 (en) * | 2005-10-21 | 2018-11-01 | Daniel R. BURNETT | Method and apparatus for peritoneal oxygenation |
US8019435B2 (en) | 2006-05-02 | 2011-09-13 | Boston Scientific Scimed, Inc. | Control of arterial smooth muscle tone |
US8926550B2 (en) | 2006-08-31 | 2015-01-06 | Fresenius Medical Care Holdings, Inc. | Data communication system for peritoneal dialysis machine |
CA2666660C (en) | 2006-10-18 | 2015-06-02 | Minnow Medical, Inc. | Inducing desirable temperature effects on body tissue |
AU2007310991B2 (en) | 2006-10-18 | 2013-06-20 | Boston Scientific Scimed, Inc. | System for inducing desirable temperature effects on body tissue |
US10124141B2 (en) * | 2007-01-23 | 2018-11-13 | Fisher & Paykel Healthcare Limited | Humidification apparatus having RFID tag sensor at patient end of gas pathway |
US8100880B2 (en) * | 2007-04-05 | 2012-01-24 | Velomedix, Inc. | Automated therapy system and method |
US20080249467A1 (en) * | 2007-04-05 | 2008-10-09 | Daniel Rogers Burnett | Device and Method for Safe Access to a Body Cavity |
KR100857188B1 (en) * | 2007-05-15 | 2008-09-05 | 한국화학연구원 | Apparatus for controlling drug infusion and method using the same |
US8330579B2 (en) * | 2007-07-05 | 2012-12-11 | Baxter International Inc. | Radio-frequency auto-identification system for dialysis systems |
WO2009009367A2 (en) * | 2007-07-06 | 2009-01-15 | Allievion Medical, Inc. | Constrained fluid delivery device |
JP5410423B2 (en) * | 2007-07-09 | 2014-02-05 | ベロメディックス,インク | Hypothermia apparatus and method |
US8828068B2 (en) * | 2007-07-17 | 2014-09-09 | Cardiac Pacemakers, Inc. | Systems and methods for local vasoactive response using temperature modulation |
US7819835B2 (en) | 2007-08-07 | 2010-10-26 | Belmont Instrument Corporation | Hyperthermia, system, method and components |
US11000407B2 (en) | 2007-08-07 | 2021-05-11 | Belmont Instrument, Llc | Hyperthermia, system, method, and components |
WO2009023797A1 (en) * | 2007-08-14 | 2009-02-19 | Innercool Therapies, Inc. | Methods and systems for inducing therapeutic hypothermia in a pre-hospital, field, or ambulance setting |
US20090125014A1 (en) * | 2007-11-14 | 2009-05-14 | Bouthillier Robert J | Thermal Ablation System |
JP5397705B2 (en) * | 2007-12-03 | 2014-01-22 | グリッピングハート・アクチボラゲット | State machine user interface system and verification interface system |
US9348975B2 (en) * | 2008-05-02 | 2016-05-24 | Baxter International Inc. | Optimizing therapy outcomes for peritoneal dialysis |
US8882700B2 (en) | 2008-05-02 | 2014-11-11 | Baxter International Inc. | Smart patient transfer set for peritoneal dialysis |
EP2282803B1 (en) * | 2008-05-06 | 2015-07-01 | Corindus Inc. | Catheter system |
US8713026B2 (en) * | 2008-06-13 | 2014-04-29 | Sandisk Technologies Inc. | Method for playing digital media files with a digital media player using a plurality of playlists |
DE102008031662A1 (en) | 2008-07-04 | 2010-01-07 | Fresenius Medical Care Deutschland Gmbh | Device for peritoneal dialysis |
US8057679B2 (en) | 2008-07-09 | 2011-11-15 | Baxter International Inc. | Dialysis system having trending and alert generation |
WO2010025338A1 (en) * | 2008-08-29 | 2010-03-04 | Corindus Ltd. | Catheter control system and graphical user interface |
WO2010025336A1 (en) * | 2008-08-29 | 2010-03-04 | Corindus Ltd. | Catheter simulation and assistance system |
DE102008045878A1 (en) * | 2008-09-06 | 2010-03-11 | Robert Prof. Bauernschmitt | Hose e.g. intravascular hose, or tubular medical device for use with heart-lung machine and extracorporal blood circulation set, has sensor determining parameters of patient, and device arranged in lumen and connected with sensor |
US20100121159A1 (en) * | 2008-11-07 | 2010-05-13 | Daniel Rogers Burnett | Devices and Methods for Monitoring Core Temperature and an Intraperitoneal Parameter |
WO2010056745A1 (en) | 2008-11-17 | 2010-05-20 | Minnow Medical, Inc. | Selective accumulation of energy with or without knowledge of tissue topography |
WO2010068783A1 (en) * | 2008-12-12 | 2010-06-17 | Corindus Inc. | Remote catheter procedure system |
US8377012B2 (en) * | 2009-01-30 | 2013-02-19 | Baxter International Inc. | Transfer sets for therapy optimization |
US20100204765A1 (en) * | 2009-02-06 | 2010-08-12 | Hall Gregory W | Method and Apparatus for Inducing Therapeutic Hypothermia |
US9301871B2 (en) | 2009-02-26 | 2016-04-05 | Advanced Cooling Therapy, Inc. | Devices and methods for controlling patient temperature |
US9622909B2 (en) * | 2009-02-26 | 2017-04-18 | Advanced Cooling Therapy, Inc. | Devices and methods for controlling patient temperature |
WO2010107916A1 (en) | 2009-03-18 | 2010-09-23 | Corindus Inc. | Remote catheter system with steerable catheter |
US8632511B2 (en) * | 2009-05-06 | 2014-01-21 | Alcon Research, Ltd. | Multiple thermal sensors in a multiple processor environment for temperature control in a drug delivery device |
US8282829B2 (en) | 2009-05-20 | 2012-10-09 | Baxter International Inc. | System and method for automated data collection of twenty-four hour ultrafiltration and other patient parameters using wired or wireless technology |
US20100312174A1 (en) * | 2009-06-06 | 2010-12-09 | Hoffman Josef C A | Peritoneal Dialysis System |
DE102009039953A1 (en) * | 2009-08-28 | 2011-03-03 | Bernd Beck | Measurement data converter for a patient monitoring system |
US9962229B2 (en) | 2009-10-12 | 2018-05-08 | Corindus, Inc. | System and method for navigating a guide wire |
EP2488245B1 (en) | 2009-10-12 | 2019-02-20 | Corindus, Inc. | Catheter system with percutaneous device movement algorithm |
US9020827B2 (en) | 2009-10-16 | 2015-04-28 | Baxter International Inc. | Peritoneal dialysis optimized using a patient hand-held scanning device |
US8998854B2 (en) * | 2010-01-28 | 2015-04-07 | Warsaw Orthopedic, Inc. | Catheter devices and drainage systems for delivering therapeutic agents |
WO2011100692A1 (en) * | 2010-02-15 | 2011-08-18 | The General Hospital Corporation | Methods and devices for selective disruption of visceral fat by controlled cooling |
DE102010011465A1 (en) | 2010-03-15 | 2011-09-15 | Fresenius Medical Care Deutschland Gmbh | System for performing a blood treatment |
AU2011238925B2 (en) | 2010-04-09 | 2016-06-16 | Vessix Vascular, Inc. | Power generating and control apparatus for the treatment of tissue |
US9192790B2 (en) | 2010-04-14 | 2015-11-24 | Boston Scientific Scimed, Inc. | Focused ultrasonic renal denervation |
US9265913B2 (en) | 2010-09-22 | 2016-02-23 | Vital 5, Llc | Catheter assembly |
DE102010022201A1 (en) * | 2010-05-20 | 2011-11-24 | Fresenius Medical Care Deutschland Gmbh | Medical treatment arrangement |
US8473067B2 (en) | 2010-06-11 | 2013-06-25 | Boston Scientific Scimed, Inc. | Renal denervation and stimulation employing wireless vascular energy transfer arrangement |
WO2012006625A2 (en) * | 2010-07-09 | 2012-01-12 | Velomedix, Inc. | Method and apparatus for pressure measurement |
US9463062B2 (en) | 2010-07-30 | 2016-10-11 | Boston Scientific Scimed, Inc. | Cooled conductive balloon RF catheter for renal nerve ablation |
US9155589B2 (en) | 2010-07-30 | 2015-10-13 | Boston Scientific Scimed, Inc. | Sequential activation RF electrode set for renal nerve ablation |
US9408661B2 (en) | 2010-07-30 | 2016-08-09 | Patrick A. Haverkost | RF electrodes on multiple flexible wires for renal nerve ablation |
US9358365B2 (en) | 2010-07-30 | 2016-06-07 | Boston Scientific Scimed, Inc. | Precision electrode movement control for renal nerve ablation |
US9084609B2 (en) | 2010-07-30 | 2015-07-21 | Boston Scientific Scime, Inc. | Spiral balloon catheter for renal nerve ablation |
US9833293B2 (en) | 2010-09-17 | 2017-12-05 | Corindus, Inc. | Robotic catheter system |
US9446224B2 (en) | 2010-09-22 | 2016-09-20 | Vital 5, L.L.C. | Barrier catheter |
TWI556849B (en) | 2010-10-21 | 2016-11-11 | 美敦力阿福盧森堡公司 | Catheter apparatus for renal neuromodulation |
US8974451B2 (en) | 2010-10-25 | 2015-03-10 | Boston Scientific Scimed, Inc. | Renal nerve ablation using conductive fluid jet and RF energy |
US9220558B2 (en) | 2010-10-27 | 2015-12-29 | Boston Scientific Scimed, Inc. | RF renal denervation catheter with multiple independent electrodes |
US9028485B2 (en) | 2010-11-15 | 2015-05-12 | Boston Scientific Scimed, Inc. | Self-expanding cooling electrode for renal nerve ablation |
US9089350B2 (en) | 2010-11-16 | 2015-07-28 | Boston Scientific Scimed, Inc. | Renal denervation catheter with RF electrode and integral contrast dye injection arrangement |
US9668811B2 (en) | 2010-11-16 | 2017-06-06 | Boston Scientific Scimed, Inc. | Minimally invasive access for renal nerve ablation |
US9326751B2 (en) | 2010-11-17 | 2016-05-03 | Boston Scientific Scimed, Inc. | Catheter guidance of external energy for renal denervation |
US9060761B2 (en) | 2010-11-18 | 2015-06-23 | Boston Scientific Scime, Inc. | Catheter-focused magnetic field induced renal nerve ablation |
US9023034B2 (en) | 2010-11-22 | 2015-05-05 | Boston Scientific Scimed, Inc. | Renal ablation electrode with force-activatable conduction apparatus |
US9192435B2 (en) | 2010-11-22 | 2015-11-24 | Boston Scientific Scimed, Inc. | Renal denervation catheter with cooled RF electrode |
US20120157993A1 (en) | 2010-12-15 | 2012-06-21 | Jenson Mark L | Bipolar Off-Wall Electrode Device for Renal Nerve Ablation |
WO2012100095A1 (en) | 2011-01-19 | 2012-07-26 | Boston Scientific Scimed, Inc. | Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury |
US9655555B2 (en) * | 2011-03-07 | 2017-05-23 | Potrero Medical, Inc. | Sensing foley catheter |
AU2012230767A1 (en) | 2011-03-23 | 2013-10-31 | Nxstage Medical, Inc. | Peritoneal dialysis systems, devices, and methods |
US9861733B2 (en) | 2012-03-23 | 2018-01-09 | Nxstage Medical Inc. | Peritoneal dialysis systems, devices, and methods |
WO2012133356A1 (en) * | 2011-03-29 | 2012-10-04 | オリンパスメディカルシステムズ株式会社 | Insufflation device |
EP2514453B1 (en) * | 2011-04-19 | 2013-11-27 | Matthias Roth | Apparatus for controlling a body temperature |
CA2874443A1 (en) * | 2011-05-13 | 2012-11-22 | Vascular Technology Inc. | Remotely controlled suction/irrigation for surgery |
US20120330225A1 (en) * | 2011-06-27 | 2012-12-27 | Fresenius Medical Care Holdings, Inc. | Active Catheter |
US9579030B2 (en) | 2011-07-20 | 2017-02-28 | Boston Scientific Scimed, Inc. | Percutaneous devices and methods to visualize, target and ablate nerves |
EP2734264B1 (en) | 2011-07-22 | 2018-11-21 | Boston Scientific Scimed, Inc. | Nerve modulation system with a nerve modulation element positionable in a helical guide |
WO2013036540A1 (en) * | 2011-09-05 | 2013-03-14 | Thermocure, Inc. | Gastric, cutaneous, or peritoneal delivery of frozen mist to induce therapeutic hyperthermia |
USD679804S1 (en) | 2011-09-22 | 2013-04-09 | Vital 5, Llc | Catheter |
US20130079596A1 (en) * | 2011-09-23 | 2013-03-28 | Todd Edward Smith | Dynamic surgical fluid sensing |
WO2013055826A1 (en) | 2011-10-10 | 2013-04-18 | Boston Scientific Scimed, Inc. | Medical devices including ablation electrodes |
US9420955B2 (en) | 2011-10-11 | 2016-08-23 | Boston Scientific Scimed, Inc. | Intravascular temperature monitoring system and method |
EP2765940B1 (en) | 2011-10-11 | 2015-08-26 | Boston Scientific Scimed, Inc. | Off-wall electrode device for nerve modulation |
US9364284B2 (en) | 2011-10-12 | 2016-06-14 | Boston Scientific Scimed, Inc. | Method of making an off-wall spacer cage |
US9079000B2 (en) | 2011-10-18 | 2015-07-14 | Boston Scientific Scimed, Inc. | Integrated crossing balloon catheter |
EP2768563B1 (en) | 2011-10-18 | 2016-11-09 | Boston Scientific Scimed, Inc. | Deflectable medical devices |
US9186449B2 (en) * | 2011-11-01 | 2015-11-17 | Fresenius Medical Care Holdings, Inc. | Dialysis machine support assemblies and related systems and methods |
EP3366250A1 (en) | 2011-11-08 | 2018-08-29 | Boston Scientific Scimed, Inc. | Ostial renal nerve ablation |
WO2013074813A1 (en) | 2011-11-15 | 2013-05-23 | Boston Scientific Scimed, Inc. | Device and methods for renal nerve modulation monitoring |
US9119632B2 (en) | 2011-11-21 | 2015-09-01 | Boston Scientific Scimed, Inc. | Deflectable renal nerve ablation catheter |
US9168352B2 (en) | 2011-12-19 | 2015-10-27 | Cardiacassist, Inc. | Dual lumen cannula |
US9265969B2 (en) | 2011-12-21 | 2016-02-23 | Cardiac Pacemakers, Inc. | Methods for modulating cell function |
US9037259B2 (en) | 2011-12-23 | 2015-05-19 | Vessix Vascular, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
WO2013101452A1 (en) | 2011-12-28 | 2013-07-04 | Boston Scientific Scimed, Inc. | Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements |
US9050106B2 (en) | 2011-12-29 | 2015-06-09 | Boston Scientific Scimed, Inc. | Off-wall electrode device and methods for nerve modulation |
US9539389B2 (en) * | 2012-02-08 | 2017-01-10 | Stmicroelectronics, Inc. | Wireless flow sensor using present flow rate data |
WO2013158076A2 (en) | 2012-04-17 | 2013-10-24 | Empire Technology Development Llc | Heat treatment device |
WO2013169927A1 (en) | 2012-05-08 | 2013-11-14 | Boston Scientific Scimed, Inc. | Renal nerve modulation devices |
US10321946B2 (en) | 2012-08-24 | 2019-06-18 | Boston Scientific Scimed, Inc. | Renal nerve modulation devices with weeping RF ablation balloons |
US9173696B2 (en) | 2012-09-17 | 2015-11-03 | Boston Scientific Scimed, Inc. | Self-positioning electrode system and method for renal nerve modulation |
WO2014047411A1 (en) | 2012-09-21 | 2014-03-27 | Boston Scientific Scimed, Inc. | System for nerve modulation and innocuous thermal gradient nerve block |
US10549127B2 (en) | 2012-09-21 | 2020-02-04 | Boston Scientific Scimed, Inc. | Self-cooling ultrasound ablation catheter |
JP6074051B2 (en) | 2012-10-10 | 2017-02-01 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | Intravascular neuromodulation system and medical device |
US9044575B2 (en) | 2012-10-22 | 2015-06-02 | Medtronic Adrian Luxembourg S.a.r.l. | Catheters with enhanced flexibility and associated devices, systems, and methods |
GB2510321B (en) * | 2012-11-12 | 2018-01-31 | Biosurgical S L | Agitation apparatus |
US9956033B2 (en) | 2013-03-11 | 2018-05-01 | Boston Scientific Scimed, Inc. | Medical devices for modulating nerves |
WO2014143571A1 (en) | 2013-03-11 | 2014-09-18 | Boston Scientific Scimed, Inc. | Medical devices for modulating nerves |
US9808311B2 (en) | 2013-03-13 | 2017-11-07 | Boston Scientific Scimed, Inc. | Deflectable medical devices |
US10543037B2 (en) | 2013-03-15 | 2020-01-28 | Medtronic Ardian Luxembourg S.A.R.L. | Controlled neuromodulation systems and methods of use |
US9549783B2 (en) * | 2013-03-15 | 2017-01-24 | Corindus, Inc. | Catheter system with magnetic coupling |
US10265122B2 (en) | 2013-03-15 | 2019-04-23 | Boston Scientific Scimed, Inc. | Nerve ablation devices and related methods of use |
EP2967734B1 (en) | 2013-03-15 | 2019-05-15 | Boston Scientific Scimed, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
EP2967725B1 (en) | 2013-03-15 | 2019-12-11 | Boston Scientific Scimed, Inc. | Control unit for detecting electrical leakage between electrode pads and system comprising such a control unit |
US10548663B2 (en) | 2013-05-18 | 2020-02-04 | Medtronic Ardian Luxembourg S.A.R.L. | Neuromodulation catheters with shafts for enhanced flexibility and control and associated devices, systems, and methods |
CN105473091B (en) | 2013-06-21 | 2020-01-21 | 波士顿科学国际有限公司 | Renal denervation balloon catheter with co-movable electrode supports |
EP3010436A1 (en) | 2013-06-21 | 2016-04-27 | Boston Scientific Scimed, Inc. | Medical devices for renal nerve ablation having rotatable shafts |
US9707036B2 (en) | 2013-06-25 | 2017-07-18 | Boston Scientific Scimed, Inc. | Devices and methods for nerve modulation using localized indifferent electrodes |
WO2015002787A1 (en) | 2013-07-01 | 2015-01-08 | Boston Scientific Scimed, Inc. | Medical devices for renal nerve ablation |
EP3019105B1 (en) | 2013-07-11 | 2017-09-13 | Boston Scientific Scimed, Inc. | Devices for nerve modulation |
EP3019106A1 (en) | 2013-07-11 | 2016-05-18 | Boston Scientific Scimed, Inc. | Medical device with stretchable electrode assemblies |
US9925001B2 (en) | 2013-07-19 | 2018-03-27 | Boston Scientific Scimed, Inc. | Spiral bipolar electrode renal denervation balloon |
WO2015013301A1 (en) | 2013-07-22 | 2015-01-29 | Boston Scientific Scimed, Inc. | Renal nerve ablation catheter having twist balloon |
JP2016527959A (en) | 2013-07-22 | 2016-09-15 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | Renal nerve ablation medical device |
CN105473093B (en) | 2013-08-22 | 2019-02-05 | 波士顿科学国际有限公司 | Flexible circuit with the improved adhesion strength to renal nerve modulation sacculus |
US10188400B2 (en) * | 2013-08-27 | 2019-01-29 | University Of South Florida | Intraluminal occluding catheter |
CN105555218B (en) | 2013-09-04 | 2019-01-15 | 波士顿科学国际有限公司 | With radio frequency (RF) foley's tube rinsed with cooling capacity |
WO2015038947A1 (en) | 2013-09-13 | 2015-03-19 | Boston Scientific Scimed, Inc. | Ablation balloon with vapor deposited cover layer |
EP3057488B1 (en) | 2013-10-14 | 2018-05-16 | Boston Scientific Scimed, Inc. | High resolution cardiac mapping electrode array catheter |
US11246654B2 (en) | 2013-10-14 | 2022-02-15 | Boston Scientific Scimed, Inc. | Flexible renal nerve ablation devices and related methods of use and manufacture |
WO2015057584A1 (en) | 2013-10-15 | 2015-04-23 | Boston Scientific Scimed, Inc. | Medical device balloon |
US9770606B2 (en) | 2013-10-15 | 2017-09-26 | Boston Scientific Scimed, Inc. | Ultrasound ablation catheter with cooling infusion and centering basket |
JP6259099B2 (en) | 2013-10-18 | 2018-01-10 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | Balloon catheter comprising a conductive wire with flexibility, and related uses and manufacturing methods |
JP2016534842A (en) | 2013-10-25 | 2016-11-10 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | Embedded thermocouples in denervation flex circuits |
US20150148595A1 (en) * | 2013-11-25 | 2015-05-28 | Avent, Inc. | Method of Placing a Drainage Catheter System |
CN105899157B (en) | 2014-01-06 | 2019-08-09 | 波士顿科学国际有限公司 | Tear-proof flexible circuit assembly |
EP4253024A3 (en) | 2014-01-27 | 2023-12-27 | Medtronic Ireland Manufacturing Unlimited Company | Neuromodulation catheters having jacketed neuromodulation elements and related devices |
JP6325121B2 (en) | 2014-02-04 | 2018-05-16 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | Alternative placement of temperature sensors on bipolar electrodes |
US11000679B2 (en) | 2014-02-04 | 2021-05-11 | Boston Scientific Scimed, Inc. | Balloon protection and rewrapping devices and related methods of use |
EP2932945A1 (en) * | 2014-04-17 | 2015-10-21 | seiratherm GmbH | Apparatus, system and method for controlling a temperature of a patient |
US10736690B2 (en) | 2014-04-24 | 2020-08-11 | Medtronic Ardian Luxembourg S.A.R.L. | Neuromodulation catheters and associated systems and methods |
US9775978B2 (en) | 2014-07-25 | 2017-10-03 | Warsaw Orthopedic, Inc. | Drug delivery device and methods having a retaining member |
US10080877B2 (en) | 2014-07-25 | 2018-09-25 | Warsaw Orthopedic, Inc. | Drug delivery device and methods having a drug cartridge |
US11471401B2 (en) | 2014-08-28 | 2022-10-18 | The General Hospital Corporation | Injectable slurries and methods of manufacturing the same |
US11504322B2 (en) | 2014-08-28 | 2022-11-22 | The General Hospital Corporation | Injectable slurries and methods of manufacturing the same |
US20170274011A1 (en) | 2014-08-28 | 2017-09-28 | The General Hospital Corporation | Injectable slurries and methods of manufacturing and using the same |
FR3027509B1 (en) * | 2014-10-28 | 2021-05-14 | Herritech | ANIMAL VAGINAL PENETRATION ASSISTANT APPARATUS INCLUDING A VISION SYSTEM, ESPECIALLY FOR LOCALIZING THE UTERAL NECK |
WO2016090270A1 (en) | 2014-12-05 | 2016-06-09 | Corindus, Inc. | System and method for navigating a guide wire |
AU2016262467B2 (en) * | 2015-05-11 | 2020-09-10 | Alcyone Therapeutics, Inc. | Drug delivery systems and methods |
US20180289890A1 (en) | 2015-09-30 | 2018-10-11 | SEIRATHERM GmbH | Volume adjustment infusion system and method |
CN108136115A (en) | 2015-09-30 | 2018-06-08 | 塞拉瑟姆有限责任公司 | Shiver with cold adjusts transfusion system and method |
WO2017055450A1 (en) | 2015-09-30 | 2017-04-06 | SEIRATHERM GmbH | Intracranial pressure adjustment infusion system and method |
US10076650B2 (en) | 2015-11-23 | 2018-09-18 | Warsaw Orthopedic, Inc. | Enhanced stylet for drug depot injector |
KR20180122642A (en) | 2016-02-26 | 2018-11-13 | 더 제너럴 하스피탈 코포레이션 | System and method for manufacture and delivery of medical ice slurry |
USD802755S1 (en) | 2016-06-23 | 2017-11-14 | Warsaw Orthopedic, Inc. | Drug pellet cartridge |
AU2017355364A1 (en) | 2016-11-02 | 2019-05-23 | Miraki Innovation Think Tank Llc | Devices and methods for slurry generation |
US10434261B2 (en) | 2016-11-08 | 2019-10-08 | Warsaw Orthopedic, Inc. | Drug pellet delivery system and method |
US11324673B2 (en) | 2016-11-18 | 2022-05-10 | Miraki Innovation Think Tank Llc | Cosmetic appearance of skin |
US10507292B2 (en) | 2016-11-30 | 2019-12-17 | Belmont Instrument, Llc | Rapid infuser with vacuum release valve |
US10137257B2 (en) | 2016-11-30 | 2018-11-27 | Belmont Instrument, Llc | Slack-time heating system for blood and fluid warming |
US10485936B2 (en) | 2016-11-30 | 2019-11-26 | Belmont Instrument, Llc | Rapid infuser with advantageous flow path for blood and fluid warming |
DK3382238T3 (en) * | 2017-03-31 | 2021-03-15 | Gemue Gebr Mueller Appbau Gmbh & Co Kg | Membrane and method of manufacturing the membrane |
JP7085762B2 (en) | 2017-04-05 | 2022-06-17 | ミラキ イノベーション シンク タンク エルエルシー | Cold slurry confinement |
AU2018250270A1 (en) | 2017-04-05 | 2019-10-31 | Miraki Innovation Think Tank Llc | Point of delivery cold slurry generation |
CN107252381B (en) * | 2017-06-02 | 2018-09-28 | 侯晓彤 | A kind of cooling device of Myocardium protecting device |
US11179516B2 (en) | 2017-06-22 | 2021-11-23 | Baxter International Inc. | Systems and methods for incorporating patient pressure into medical fluid delivery |
US20190000501A1 (en) * | 2017-07-03 | 2019-01-03 | Bryan Nowroozi | Systems, devices and methods for accessing a body |
US10570362B2 (en) * | 2017-07-12 | 2020-02-25 | Deka Products Limited Partnership | System and method for transferring tissue |
US10500342B2 (en) | 2017-08-21 | 2019-12-10 | Miraki Innovation Think Tank Llc | Cold slurry syringe |
WO2019046853A1 (en) * | 2017-09-02 | 2019-03-07 | Biocrede Inc. | Medical device with integrated biosensor |
US11872337B2 (en) | 2018-02-28 | 2024-01-16 | Nxstage Medical, Inc. | Fluid preparation and treatment devices methods and systems |
ES2902356T3 (en) * | 2019-01-22 | 2022-03-28 | Eight Medical Int B V | A flushing catheter with temperature sensor and manufacturing method thereof |
JP2023537466A (en) | 2020-07-10 | 2023-09-01 | シー チェンジ サージカル エルエルシー | injectable slush feed supply |
US20220133134A1 (en) * | 2020-11-04 | 2022-05-05 | Kotl, Llc | Imaging and pressure sensing apparatus and probes with a slidable sheath |
JPWO2022181126A1 (en) * | 2021-02-26 | 2022-09-01 | ||
US11241330B1 (en) | 2021-04-02 | 2022-02-08 | Brixton Biosciences, Inc. | Apparatus for creation of injectable slurry |
DE102021112959A1 (en) | 2021-05-19 | 2022-11-24 | Semiflow Medical GmbH | System and method to support lung function |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5230343A (en) * | 1990-06-14 | 1993-07-27 | Triton Technology, Inc. | Colored microspheres for measuring and tracing fluid mixing and flow |
US5595181A (en) * | 1994-03-24 | 1997-01-21 | Hubbard; A. Robert | System for providing cardiac output and shunt quantitation |
US6503203B1 (en) * | 2001-01-16 | 2003-01-07 | Koninklijke Philips Electronics N.V. | Automated ultrasound system for performing imaging studies utilizing ultrasound contrast agents |
US6939302B2 (en) * | 1999-03-12 | 2005-09-06 | Medrad, Inc. | Apparatus and method for controlling contrast enhanced imaging procedures |
US20060002856A1 (en) * | 2001-09-20 | 2006-01-05 | Bastiaan Driehuys | Methods for in vivo evaluation of physiological conditions and/or organ or system function including methods to evaluate cardiopulmonary disorders such as chronic heart failure using polarized 129Xe |
US20080015434A1 (en) * | 2001-05-22 | 2008-01-17 | Alfred E. Mann Institute For Biomedical Engineering At The University Of S. California | Measurement of Cardiac Output and Blood Volume by Non-Invasive Detection of Indicator Dilution for Hemodialysis |
US20080146945A1 (en) * | 2005-02-18 | 2008-06-19 | Pfeiffer Ulrich J | Device for Determining Cardiopulmonary Volumes and Flows of a Living Being |
US7409240B1 (en) * | 2004-02-09 | 2008-08-05 | Bishop Harry A | System and method for imaging myocardial infarction |
US20100016731A1 (en) * | 2008-07-15 | 2010-01-21 | Cardiox Corporation | Hemodynamic Detection of Circulatory Anomalies |
Family Cites Families (189)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2078786A (en) | 1934-12-17 | 1937-04-27 | Wood Glen Mason | Applicator and control means therefor |
US3042042A (en) | 1958-03-14 | 1962-07-03 | Blanck Joachim Hillard | Stomach pump |
US3459188A (en) * | 1965-07-26 | 1969-08-05 | American Hospital Supply Corp | Paracentesis stylet catheter |
US3505988A (en) * | 1967-04-11 | 1970-04-14 | Norman Deane | Prosthesis for chronic access to the peritoneum |
US3698396A (en) * | 1970-12-04 | 1972-10-17 | Abbott Lab | Catheter assembly for peritoneal cavity insertion |
US3927980A (en) | 1973-08-22 | 1975-12-23 | Baxter Laboratories Inc | Oxygen overpressure protection system for membrane-type blood oxygenators |
US4356826A (en) | 1979-05-09 | 1982-11-02 | Olympus Optical Co., Ltd. | Stabbing apparatus for diagnosis of living body |
US4445500A (en) | 1982-03-03 | 1984-05-01 | Thomas Jefferson University | Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders |
US4657532A (en) * | 1985-07-19 | 1987-04-14 | Thomas Jefferson University | Intra-peritoneal perfusion of oxygenated fluorocarbon |
US4413633A (en) | 1981-06-01 | 1983-11-08 | Yanda Roman L | Method and apparatus for monitoring body conditions |
US4450841A (en) | 1982-03-03 | 1984-05-29 | Thomas Jefferson University | Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders |
US4535773A (en) | 1982-03-26 | 1985-08-20 | Inbae Yoon | Safety puncturing instrument and method |
US4883459A (en) | 1983-07-29 | 1989-11-28 | Reynaldo Calderon | Retrograde perfusion |
US4497324A (en) | 1983-10-03 | 1985-02-05 | American Hospital Supply Corporation | Temperature monitoring catheter |
US4770652A (en) * | 1985-02-12 | 1988-09-13 | Mahurkar Sakharam D | Method and apparatus for using dual-lumen catheters for extracorporeal treatment |
IL78756A0 (en) | 1986-05-12 | 1986-08-31 | Biodan Medical Systems Ltd | Catheter and probe |
US4904237A (en) | 1988-05-16 | 1990-02-27 | Janese Woodrow W | Apparatus for the exchange of cerebrospinal fluid and a method of treating brain and spinal cord injuries |
US5249585A (en) | 1988-07-28 | 1993-10-05 | Bsd Medical Corporation | Urethral inserted applicator for prostate hyperthermia |
US5141493A (en) | 1990-01-26 | 1992-08-25 | Sarcos Group | Peritoneal dialysis system |
US5395342A (en) * | 1990-07-26 | 1995-03-07 | Yoon; Inbae | Endoscopic portal |
US5584804A (en) | 1990-10-10 | 1996-12-17 | Life Resuscitation Technologies, Inc. | Brain resuscitation and organ preservation device and method for performing the same |
US5149321A (en) | 1990-10-10 | 1992-09-22 | Klatz Ronald M | Brain resuscitation device and method for performing the same |
US5112267A (en) | 1990-12-21 | 1992-05-12 | Dexter C. Liu | Toy vehicle with movable body component |
US5122267A (en) * | 1991-01-24 | 1992-06-16 | Oceanic Systems, Inc. | Foam fractionation filter |
US5693017A (en) * | 1991-02-14 | 1997-12-02 | Wayne State University | Apparatus and method of delivery of gas-supersaturated solutions to a delivery site |
JPH0538327A (en) * | 1991-04-23 | 1993-02-19 | Olympus Optical Co Ltd | Medical equipment |
US5245367A (en) | 1991-11-12 | 1993-09-14 | David Miller | Annular mask contact lenses |
WO1993013718A1 (en) * | 1992-01-21 | 1993-07-22 | Valleylab, Inc. | Electrosurgical control for a trocar |
WO1993020876A1 (en) | 1992-04-14 | 1993-10-28 | Du-Med B.V. | Electronic catheter displacement sensor |
AU659261B2 (en) | 1992-06-19 | 1995-05-11 | Conmed Corporation | Electrosurgical trocar assembly |
FR2693179B1 (en) | 1992-07-03 | 1994-10-14 | Martin Sa | Sheet retainer for a stacking magazine. |
US5282962A (en) | 1992-07-17 | 1994-02-01 | Chen Chi Der | Protein skimmer and power head thereof |
US5354277A (en) | 1992-09-04 | 1994-10-11 | Biocontrol Technology, Inc. | Specialized perfusion protocol for whole-body hyperthermia |
US6620188B1 (en) | 1998-08-24 | 2003-09-16 | Radiant Medical, Inc. | Methods and apparatus for regional and whole body temperature modification |
US6346074B1 (en) | 1993-02-22 | 2002-02-12 | Heartport, Inc. | Devices for less invasive intracardiac interventions |
EP0617913B1 (en) * | 1993-03-26 | 2001-11-21 | Edwards Lifesciences Corporation | Intracranial pressure monitor and drainage catheter assembly |
US5352206A (en) * | 1993-03-31 | 1994-10-04 | Laparomed Corporation | Trocar system having penetration indicator |
CA2159981A1 (en) * | 1993-04-09 | 1994-10-27 | Charles C. Hart | Surgical trocar with cutoff circuit |
JP3387602B2 (en) * | 1993-12-27 | 2003-03-17 | テルモ株式会社 | Intraperitoneal indwelling catheter |
US5478329A (en) | 1994-05-06 | 1995-12-26 | Ternamian; Artin M. | Trocarless rotational entry cannula |
US5569292A (en) * | 1995-02-01 | 1996-10-29 | Ethicon Endo-Surgery, Inc. | Surgical penetration instrument with transparent blades and tip cover |
US5554280A (en) | 1995-05-15 | 1996-09-10 | Loehr; Gary | Filter system |
US5562821A (en) | 1995-07-21 | 1996-10-08 | Commonwealth Of Puerto Rico | Foam fractionator |
US5730720A (en) * | 1995-08-18 | 1998-03-24 | Ip Scientific, Inc. | Perfusion hyperthermia treatment system and method |
US5755756A (en) | 1995-09-15 | 1998-05-26 | Freedman, Jr.; Robert J. | Hypothermia-inducing resuscitation unit |
US5665227A (en) | 1995-11-29 | 1997-09-09 | Watt; Ronald | Dual-flow protein skimmer |
US6066163A (en) | 1996-02-02 | 2000-05-23 | John; Michael Sasha | Adaptive brain stimulation method and system |
US5758643A (en) | 1996-07-29 | 1998-06-02 | Via Medical Corporation | Method and apparatus for monitoring blood chemistry |
AU5091198A (en) | 1996-10-22 | 1998-05-15 | Hemocleanse, Inc. | Continuous flow-through peritoneal dialysis (cfpd) method with control of intraperitoneal pressure |
US6019729A (en) | 1996-11-15 | 2000-02-01 | Kabushiki Kaisha Tokai-Rika-Denki-Seisakusho | Sensor mechanism-equipped catheter |
ATE307536T1 (en) | 1997-04-01 | 2005-11-15 | Axel Muntermann | DEVICE FOR DETECTING CATHETER TISSUE CONTACT AND INTERACTIONS WITH TISSUE DURING CATHETER ABLATION |
US6030358A (en) | 1997-08-08 | 2000-02-29 | Odland; Rick Matthew | Microcatheter and method for site specific therapy |
JPH11221229A (en) | 1997-09-24 | 1999-08-17 | Eclipse Surgical Technol Inc | Catheter |
JP3342021B2 (en) * | 1997-10-17 | 2002-11-05 | サーコン コーポレーション | Medical device system that penetrates tissue |
US5916153A (en) | 1997-10-27 | 1999-06-29 | Rhea, Jr.; W. Gardner | Multifunction catheter |
CA2318600C (en) | 1998-01-23 | 2007-11-13 | Hemotherm, Inc. | Apparatuses and processes for hyperthermia |
US7749215B1 (en) * | 1998-02-05 | 2010-07-06 | Biosense, Inc. | Intracardiac cell delivery and cell transplantation |
US6149624A (en) | 1998-02-05 | 2000-11-21 | Mcshane; Richard Houston | Apparatus and method for the rapid induction of hypothermic brain preservation |
US6458150B1 (en) | 1999-02-19 | 2002-10-01 | Alsius Corporation | Method and apparatus for patient temperature control |
US6716236B1 (en) | 1998-04-21 | 2004-04-06 | Alsius Corporation | Intravascular catheter with heat exchange element having inner inflation element and methods of use |
US6368304B1 (en) | 1999-02-19 | 2002-04-09 | Alsius Corporation | Central venous catheter with heat exchange membrane |
US6126684A (en) | 1998-04-21 | 2000-10-03 | The Regents Of The University Of California | Indwelling heat exchange catheter and method of using same |
US6581403B2 (en) | 2001-09-25 | 2003-06-24 | Alsius Corporation | Heating/cooling system for indwelling heat exchange catheter |
US6149670A (en) | 1999-03-11 | 2000-11-21 | Alsius Corporation | Method and system for treating cardiac arrest using hypothermia |
US6645234B2 (en) | 1998-04-21 | 2003-11-11 | Alsius Corporation | Cardiovascular guiding catheter with heat exchange properties and methods of use |
US6530946B1 (en) | 1998-04-21 | 2003-03-11 | Alsius Corporation | Indwelling heat exchange heat pipe catheter and method of using same |
US6419643B1 (en) | 1998-04-21 | 2002-07-16 | Alsius Corporation | Central venous catheter with heat exchange properties |
US6682551B1 (en) | 1999-03-11 | 2004-01-27 | Alsius Corporation | Method and system for treating cardiac arrest using hypothermia |
US6338727B1 (en) | 1998-08-13 | 2002-01-15 | Alsius Corporation | Indwelling heat exchange catheter and method of using same |
US7255709B2 (en) | 1998-04-21 | 2007-08-14 | Alsius Corporation | Intravascular heat exchange catheter with temperature sensor |
US6520933B1 (en) | 1998-04-21 | 2003-02-18 | Alsius Corporation | Central venous line cooling catheter having a spiral-shaped heat exchange member |
US7287398B2 (en) * | 2001-09-25 | 2007-10-30 | Alsius Corporation | Heating/cooling system for indwelling heat exchange catheter |
US6056766A (en) * | 1998-06-09 | 2000-05-02 | Thompson; Ronald J. | Stabilized trocar, and method of using same |
US6175688B1 (en) | 1998-07-10 | 2001-01-16 | Belmont Instrument Corporation | Wearable intravenous fluid heater |
US6450990B1 (en) | 1998-08-13 | 2002-09-17 | Alsius Corporation | Catheter with multiple heating/cooling fibers employing fiber spreading features |
US6610083B2 (en) | 1998-08-24 | 2003-08-26 | Radiant Medical, Inc. | Multiple lumen heat exchange catheters |
US6620189B1 (en) * | 2000-02-28 | 2003-09-16 | Radiant Medical, Inc. | Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter |
CA2340749A1 (en) | 1998-09-11 | 2000-03-23 | Medivance Inc. | Method and apparatus for providing localized heating of the preoptic anterior hypothalamus |
US6117076A (en) | 1998-09-21 | 2000-09-12 | Belmont Instruments Corporation | Patient monitoring system and method |
US6146411A (en) * | 1998-12-24 | 2000-11-14 | Alsius Corporation | Cooling system for indwelling heat exchange catheter |
US6375674B1 (en) | 1999-01-04 | 2002-04-23 | Medivance, Inc. | Cooling/heating pad and system |
US6197045B1 (en) | 1999-01-04 | 2001-03-06 | Medivance Incorporated | Cooling/heating pad and system |
US6743218B2 (en) | 1999-01-15 | 2004-06-01 | Cathlogic, Inc. | Retractable catheter systems and associated methods |
US6436295B2 (en) | 1999-02-11 | 2002-08-20 | Jason Kim | Protein skimmer |
US6719724B1 (en) | 1999-02-19 | 2004-04-13 | Alsius Corporation | Central venous line catheter having multiple heat exchange elements and multiple infusion lumens |
US6405080B1 (en) | 1999-03-11 | 2002-06-11 | Alsius Corporation | Method and system for treating cardiac arrest |
US6582398B1 (en) | 1999-02-19 | 2003-06-24 | Alsius Corporation | Method of managing patient temperature with a heat exchange catheter |
US6585692B1 (en) | 1999-02-19 | 2003-07-01 | Alsius Corporation | Method and system for patient temperature management and central venous access |
US6554797B1 (en) | 1999-02-19 | 2003-04-29 | Alsius Corporation | Method and system for patient temperature management and central venous access |
DE69902509T2 (en) | 1999-02-19 | 2003-03-27 | Alsius Corp | Central venous catheter with temperature control system |
US6299599B1 (en) | 1999-02-19 | 2001-10-09 | Alsius Corporation | Dual balloon central venous line catheter temperature control system |
US6254567B1 (en) | 1999-02-26 | 2001-07-03 | Nxstage Medical, Inc. | Flow-through peritoneal dialysis systems and methods with on-line dialysis solution regeneration |
US6217552B1 (en) | 1999-03-01 | 2001-04-17 | Coaxia, Inc. | Medical device for selective intrathecal spinal cooling in aortic surgery and spinal trauma |
US6019783A (en) | 1999-03-02 | 2000-02-01 | Alsius Corporation | Cooling system for therapeutic catheter |
US6460544B1 (en) | 1999-03-11 | 2002-10-08 | Alsius Corporation | Method and apparatus for establishing and maintaining therapeutic hypothemia |
US6290717B1 (en) | 1999-03-31 | 2001-09-18 | Alsius Corporation | Temperature probe and interconnect cable for hypothermia catheter temperature feedback |
US6579496B1 (en) | 1999-05-25 | 2003-06-17 | Viacirq, Inc. | Apparatus for implementing hyperthermia |
EP1187590B1 (en) | 1999-05-25 | 2014-08-13 | Viacirq, Inc. | Hyperthermia method and apparatus |
US6165207A (en) | 1999-05-27 | 2000-12-26 | Alsius Corporation | Method of selectively shaping hollow fibers of heat exchange catheter |
AU5302400A (en) | 1999-05-27 | 2000-12-18 | Alsius Corporation | Apparatus and method for advancing cooling catheter |
US6436071B1 (en) * | 1999-06-08 | 2002-08-20 | The Trustees Of Columbia University In The City Of New York | Intravascular systems for corporeal cooling |
AU6342400A (en) | 1999-07-08 | 2001-01-30 | Alsius Corporation | Operational enhancements for using cooling catheters |
JP2001029459A (en) * | 1999-07-19 | 2001-02-06 | Tomio Ota | Liquid supply system |
US6287326B1 (en) | 1999-08-02 | 2001-09-11 | Alsius Corporation | Catheter with coiled multi-lumen heat transfer extension |
US7422601B2 (en) | 1999-08-02 | 2008-09-09 | University Of Chicago Office Of Technology Transfer | Method for inducing hypothermia |
US6231594B1 (en) | 1999-08-11 | 2001-05-15 | Radiant Medical, Inc. | Method of controlling body temperature while reducing shivering |
AU6637500A (en) * | 1999-08-13 | 2001-03-13 | Johns Hopkins University, The | Device and method for rapid chest tube insertion |
US6685724B1 (en) * | 1999-08-24 | 2004-02-03 | The Penn State Research Foundation | Laparoscopic surgical instrument and method |
WO2001017471A1 (en) | 1999-09-03 | 2001-03-15 | Alsius Corporation | Method and system for treating high intracranial pressure using hypothermia |
US6447474B1 (en) | 1999-09-15 | 2002-09-10 | Alsius Corporation | Automatic fever abatement system |
US20050154370A1 (en) | 1999-10-29 | 2005-07-14 | Medtronic, Inc. | Methods and systems for providing therapies into the pericardial space |
GB9926980D0 (en) | 1999-11-15 | 2000-01-12 | Medivance Instr Limited | Improved pneumatic device |
AU4512701A (en) | 1999-12-03 | 2001-06-12 | Neuron Therapeutics, Inc. | Method and apparatus for closed recirculation of synthetic cerebrospinal fluid |
AU4713601A (en) | 1999-12-07 | 2001-06-18 | Alsius Corporation | Method and system for treating stroke using hypothermia |
CA2389028A1 (en) * | 1999-12-08 | 2001-06-14 | James A. Filice | Catheter with stylet lumen |
US6347633B1 (en) | 2000-01-14 | 2002-02-19 | First Circle Medical, Inc. | Treatment of hepatitis C using hyperthermia |
US6497676B1 (en) | 2000-02-10 | 2002-12-24 | Baxter International | Method and apparatus for monitoring and controlling peritoneal dialysis therapy |
US6648906B2 (en) * | 2000-04-06 | 2003-11-18 | Innercool Therapies, Inc. | Method and apparatus for regulating patient temperature by irrigating the bladder with a fluid |
US6638265B1 (en) * | 2000-06-08 | 2003-10-28 | Artin M. Ternamian | Laparoscopy cannula adapter and assembly |
WO2002026176A1 (en) | 2000-09-28 | 2002-04-04 | Alsius Corporation | Method of using a central venous line catheter |
US6819950B2 (en) | 2000-10-06 | 2004-11-16 | Alexander K. Mills | Method for noninvasive continuous determination of physiologic characteristics |
US6530945B1 (en) | 2000-11-28 | 2003-03-11 | Alsius Corporation | System and method for controlling patient temperature |
US6699268B2 (en) | 2000-12-15 | 2004-03-02 | Alsius Corporation | Radio frequency patient heating system |
US6602243B2 (en) | 2000-12-15 | 2003-08-05 | Alsius Corporation | Foley catheter having redundant temperature sensors and method |
US6529775B2 (en) | 2001-01-16 | 2003-03-04 | Alsius Corporation | System and method employing indwelling RF catheter for systemic patient warming by application of dielectric heating |
WO2002058606A1 (en) | 2001-01-24 | 2002-08-01 | Alsius Corporation | Central venous catheter with heat exchange properties |
US6451045B1 (en) | 2001-02-22 | 2002-09-17 | Alsius Corporation | Heat exchange catheter having a helically wrapped heat exchanger |
US6641602B2 (en) | 2001-04-13 | 2003-11-04 | Alsius Corporation | Method and device including a colo-rectal heat exchanger |
US6641603B2 (en) | 2001-04-13 | 2003-11-04 | Alsius Corporation | Heat exchange catheter having helically wound reinforcement |
US6709448B2 (en) | 2001-04-13 | 2004-03-23 | Alsius Corporation | Open core heat exchange catheter, system and method |
US6461379B1 (en) | 2001-04-30 | 2002-10-08 | Medivance, Incorporated | Localized bodily cooling/heating apparatus and method |
US6706060B2 (en) | 2001-06-05 | 2004-03-16 | Alsius Corporation | Heat exchange catheter |
US6733517B1 (en) | 2001-06-13 | 2004-05-11 | Alsius Corporation | Angling introducer sheath for catheter having temperature control system |
US7455666B2 (en) * | 2001-07-13 | 2008-11-25 | Board Of Regents, The University Of Texas System | Methods and apparatuses for navigating the subarachnoid space |
US6676409B2 (en) | 2001-08-01 | 2004-01-13 | Medivance Instruments Limited | Dental tool |
JP2004538087A (en) * | 2001-08-15 | 2004-12-24 | インナークール セラピーズ, インコーポレイテッド | Patient temperature control system and method using temperature planning algorithm |
US6911014B2 (en) * | 2001-10-05 | 2005-06-28 | Medical Components, Inc. | Continuous flow peritoneal dialysis catheter |
US6818012B2 (en) | 2001-10-11 | 2004-11-16 | Medivance, Incorporated | Patient temperature control system with fluid temperature response |
US6660027B2 (en) | 2001-10-11 | 2003-12-09 | Medivance Incorporated | Patient temperature control system with fluid preconditioning |
US6699267B2 (en) | 2001-10-11 | 2004-03-02 | Medivance Incorporated | Patient temperature control system with fluid temperature response |
US6807444B2 (en) | 2001-11-05 | 2004-10-19 | Hosheng Tu | Apparatus and methods for monitoring tissue impedance |
US6572640B1 (en) | 2001-11-21 | 2003-06-03 | Alsius Corporation | Method and apparatus for cardiopulmonary bypass patient temperature control |
EP1453524A2 (en) | 2001-12-04 | 2004-09-08 | Minnesota High-Tech Resources, LLC | Breathable gas mixtures to change body temperature |
WO2003059218A1 (en) | 2002-01-09 | 2003-07-24 | Alsius Corporation | Method and system for therapeutic hypothermia |
US6648905B2 (en) | 2002-02-27 | 2003-11-18 | Medivance Incorporated | Enhanced medical thermal energy exchange pad |
US6799063B2 (en) | 2002-02-27 | 2004-09-28 | Medivance Incorporated | Temperature control pads with integral electrodes |
US6669715B2 (en) | 2002-02-27 | 2003-12-30 | Medivance Incorporated | Medical thermal energy exchange pad |
US6692518B2 (en) | 2002-02-27 | 2004-02-17 | Medivance Incorporated | Patient temperature control system |
US6704590B2 (en) | 2002-04-05 | 2004-03-09 | Cardiac Pacemakers, Inc. | Doppler guiding catheter using sensed blood turbulence levels |
US6685733B1 (en) | 2002-04-10 | 2004-02-03 | Radiant Medical, Inc. | Methods and systems for reducing substance-induced renal damage |
WO2003089031A1 (en) * | 2002-04-19 | 2003-10-30 | Neuron Therapeutics | Subarachnoid spinal catheter for transporting cerebrospinal fluid |
US7144407B1 (en) | 2002-05-30 | 2006-12-05 | Alsius Corporation | Cardiovascular intra aortic balloon pump catheter with heat exchange function and methods of use |
US20030225393A1 (en) * | 2002-05-31 | 2003-12-04 | Kimberly-Clark Worldwide, Inc. | Low profile transpyloric jejunostomy system and method to enable |
US6852099B2 (en) * | 2002-06-04 | 2005-02-08 | Baxter International Inc. | Device for controllably applying liquids to body surfaces |
US6878156B1 (en) | 2002-07-26 | 2005-04-12 | Alsius Corporation | Portable cooler for heat exchange catheter |
US6802855B2 (en) | 2002-08-08 | 2004-10-12 | Medivance Incorporated | Patient temperature control system connector apparatus |
US6827728B2 (en) | 2002-08-08 | 2004-12-07 | Medivance Incorporated | Patient temperature control system |
US6749625B2 (en) | 2002-08-30 | 2004-06-15 | Alsius Corporation | Intravascular temperature control catheter |
US6796995B2 (en) | 2002-08-30 | 2004-09-28 | Alsius Corporation | Intravascular temperature control catheter |
AU2003301255A1 (en) | 2002-10-15 | 2004-05-04 | Medtronic Inc. | Screening techniques for management of a nervous system disorder |
US20040087606A1 (en) | 2002-11-01 | 2004-05-06 | Voorhees Marc E. | Shivering suppression during cooling to lower body temperature |
CA2411569A1 (en) * | 2002-11-12 | 2004-05-12 | Ross E. Mantle | Medical device for the extravascular recirculation of fluid in body cavities at controlled temperature and pressure |
US20040122353A1 (en) | 2002-12-19 | 2004-06-24 | Medtronic Minimed, Inc. | Relay device for transferring information between a sensor system and a fluid delivery system |
US7278984B2 (en) | 2002-12-31 | 2007-10-09 | Alsius Corporation | System and method for controlling rate of heat exchange with patient |
US7097657B2 (en) | 2003-02-18 | 2006-08-29 | Alsius Corporation | Dual IV bag arrangement for intravascular temperature control catheter cooling circuit |
WO2004080274A2 (en) * | 2003-03-06 | 2004-09-23 | Erblan Surgical, Inc. | Insufflator and method of use |
US6893454B2 (en) | 2003-04-28 | 2005-05-17 | Alsius Corporation | Intrarectal heat exchange catheter |
US7836881B2 (en) | 2003-04-28 | 2010-11-23 | Advanced Circulatory Systems, Inc. | Ventilator and methods for treating head trauma and low blood circulation |
US7001418B2 (en) | 2003-04-30 | 2006-02-21 | Alsius Corporation | Intravascular heat exchange catheter with insulated coolant tubes |
JP4291039B2 (en) * | 2003-05-12 | 2009-07-08 | オリンパス株式会社 | Ultrasonic trocar puncture system |
US6921198B2 (en) | 2003-06-12 | 2005-07-26 | Medivance Incorporated | Patient temperature repeating system and method |
US20050033391A1 (en) | 2003-08-06 | 2005-02-10 | Alsius Corporation | System and method for treating cardiac arrest and myocardial infarction |
CA2536810A1 (en) | 2003-08-25 | 2005-04-28 | Medivance Incorporated | Active body cooling with vasodilation to reduce body temperature |
US7270639B2 (en) | 2003-10-14 | 2007-09-18 | Zoll Circulation, Inc. | Temperature regulation system for automatic chest compression housing |
JP4832763B2 (en) * | 2004-01-20 | 2011-12-07 | エシコン・エンド−サージェリィ・インコーポレイテッド | Access medical device and medical procedure execution method |
US7318834B2 (en) | 2004-02-09 | 2008-01-15 | Philip Chidi Njemanze | Apparatus and method for hypothermia and rewarming by altering the temperature of the cerebrospinal fluid in the brain |
US20060064146A1 (en) | 2004-09-17 | 2006-03-23 | Collins Kenneth A | Heating/cooling system for indwelling heat exchange catheter |
US6981945B1 (en) | 2004-11-12 | 2006-01-03 | Artann Laboratories, Inc. | Colonoscope handgrip with force and torque monitor |
US20060190066A1 (en) | 2005-02-23 | 2006-08-24 | Worthen William J | System and method for bringing hypothermia rapidly onboard |
US7070612B1 (en) | 2005-02-23 | 2006-07-04 | Alsius Corporation | System and method for bringing hypothermia rapidly onboard |
US7425216B2 (en) | 2005-03-01 | 2008-09-16 | Alsius Corporation | System and method for treating cardiac arrest and myocardial infarction |
EP3187157A1 (en) | 2005-04-27 | 2017-07-05 | ZOLL Circulation, Inc. | Apparatus & method for providing enhanced heat transfer from a body |
US20060276864A1 (en) | 2005-06-03 | 2006-12-07 | Alsius Corporation | Systems and methods for sensing patient temperature in temperature management system |
US7181927B2 (en) | 2005-07-01 | 2007-02-27 | Alsius Corporation | Primary heat exchanger for patient temperature control |
US7699799B2 (en) | 2005-08-26 | 2010-04-20 | Ceeben Systems, Inc. | Ultrasonic material removal system for cardiopulmonary bypass and other applications |
US20070051409A1 (en) | 2005-09-02 | 2007-03-08 | Belmont Instrument Corporation | Pressure responsive fluid flow control valves |
US20080190066A1 (en) * | 2007-02-14 | 2008-08-14 | Rajewski David E | Mobile compartment system |
US8100880B2 (en) | 2007-04-05 | 2012-01-24 | Velomedix, Inc. | Automated therapy system and method |
US20080249467A1 (en) | 2007-04-05 | 2008-10-09 | Daniel Rogers Burnett | Device and Method for Safe Access to a Body Cavity |
-
2006
- 2006-01-17 US US11/332,796 patent/US20070093697A1/en not_active Abandoned
- 2006-10-23 CA CA002626795A patent/CA2626795A1/en not_active Abandoned
- 2006-10-23 AU AU2006304877A patent/AU2006304877C1/en not_active Ceased
- 2006-10-23 WO PCT/US2006/041515 patent/WO2007048068A2/en active Application Filing
- 2006-10-23 US US11/552,090 patent/US8672884B2/en active Active
- 2006-10-23 JP JP2008536617A patent/JP2009512504A/en not_active Ceased
- 2006-10-23 EP EP06817349.1A patent/EP1971378A4/en not_active Withdrawn
- 2006-10-23 BR BRPI0619309-9A patent/BRPI0619309A2/en not_active IP Right Cessation
-
2014
- 2014-01-22 US US14/161,297 patent/US20140135878A1/en not_active Abandoned
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5230343A (en) * | 1990-06-14 | 1993-07-27 | Triton Technology, Inc. | Colored microspheres for measuring and tracing fluid mixing and flow |
US5595181A (en) * | 1994-03-24 | 1997-01-21 | Hubbard; A. Robert | System for providing cardiac output and shunt quantitation |
US6939302B2 (en) * | 1999-03-12 | 2005-09-06 | Medrad, Inc. | Apparatus and method for controlling contrast enhanced imaging procedures |
US6503203B1 (en) * | 2001-01-16 | 2003-01-07 | Koninklijke Philips Electronics N.V. | Automated ultrasound system for performing imaging studies utilizing ultrasound contrast agents |
US20080015434A1 (en) * | 2001-05-22 | 2008-01-17 | Alfred E. Mann Institute For Biomedical Engineering At The University Of S. California | Measurement of Cardiac Output and Blood Volume by Non-Invasive Detection of Indicator Dilution for Hemodialysis |
US20060002856A1 (en) * | 2001-09-20 | 2006-01-05 | Bastiaan Driehuys | Methods for in vivo evaluation of physiological conditions and/or organ or system function including methods to evaluate cardiopulmonary disorders such as chronic heart failure using polarized 129Xe |
US7409240B1 (en) * | 2004-02-09 | 2008-08-05 | Bishop Harry A | System and method for imaging myocardial infarction |
US20080146945A1 (en) * | 2005-02-18 | 2008-06-19 | Pfeiffer Ulrich J | Device for Determining Cardiopulmonary Volumes and Flows of a Living Being |
US20100016731A1 (en) * | 2008-07-15 | 2010-01-21 | Cardiox Corporation | Hemodynamic Detection of Circulatory Anomalies |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100016731A1 (en) * | 2008-07-15 | 2010-01-21 | Cardiox Corporation | Hemodynamic Detection of Circulatory Anomalies |
WO2010009193A2 (en) * | 2008-07-15 | 2010-01-21 | Cardiox Corporation | Hemodynamic detection of circulatory anomalies |
WO2010009193A3 (en) * | 2008-07-15 | 2010-04-15 | Cardiox Corporation | Hemodynamic detection of circulatory anomalies |
US20140128733A1 (en) * | 2008-07-15 | 2014-05-08 | Cardiox Corporation | Systems and methods for hemodynamic detection of circulatory anomalies |
US20110245662A1 (en) * | 2010-04-06 | 2011-10-06 | Eggers Philip E | Hemodynamic Detection of Circulatory Anomalies |
EP2555671A4 (en) * | 2010-04-06 | 2016-02-17 | Cardiox Corp | System for improved hemodynamic detection of circulatory anomalies |
CN111345850A (en) * | 2020-03-10 | 2020-06-30 | 苏州大学附属第一医院 | Method for evaluating induced thoracic negative pressure by right-left shunt |
Also Published As
Publication number | Publication date |
---|---|
EP1971378A2 (en) | 2008-09-24 |
AU2006304877B2 (en) | 2013-01-17 |
WO2007048068A2 (en) | 2007-04-26 |
US8672884B2 (en) | 2014-03-18 |
JP2009512504A (en) | 2009-03-26 |
US20070106247A1 (en) | 2007-05-10 |
EP1971378A4 (en) | 2013-10-02 |
AU2006304877A1 (en) | 2007-04-26 |
US20140135878A1 (en) | 2014-05-15 |
AU2006304877C1 (en) | 2013-08-15 |
BRPI0619309A2 (en) | 2012-10-02 |
CA2626795A1 (en) | 2007-04-26 |
WO2007048068A3 (en) | 2007-07-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20070093697A1 (en) | Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature | |
US10383546B2 (en) | Oral end tidal carbon dioxide method for diagnosing pulmonary arterial hypertension | |
US7445601B2 (en) | Non-invasive device and method for the diagnosis of pulmonary vascular occlusions | |
US7344497B2 (en) | Non-invasive device and method for measuring the cardiac output of a patient | |
KR20120087127A (en) | Device for treating an individual suffering from cardiac insufficiency, cardiac arrest, circulatory arrest or stroke | |
US20230211060A1 (en) | Method and apparatus for assessing cardiac output in veno-arterial extracorporeal blood oxygenation | |
EP3914316B1 (en) | Apparatus for assessing cardiac output in veno-venous extracorporeal blood oxygenation | |
US20070123775A1 (en) | Method and device for monitoring infusions | |
US8323194B2 (en) | Detection of bubbles during hemodynamic monitoring when performing automated measurement of blood constituents | |
JP2009106788A (en) | Polarized 129xe contrast agent for in vivo evaluation of respiratory organ disorder or cardiopulmonary disorder such as chronic heart failure | |
US20130317378A1 (en) | Assessment of Pulmonary Blood Flow and Systemic Blood Flow in a Single Ventricle Patient | |
Palágyi et al. | Monitoring microcirculatory blood flow with a new sublingual tonometer in a porcine model of hemorrhagic shock | |
AU2002329991A1 (en) | Methods for in vivo evaluation of a physiological structure or function using polarized 129Xe | |
US7291502B2 (en) | Method for performing a non-invasive blood gas test | |
Giraud et al. | Hemodynamic Monitoring in the ICU | |
KR101666106B1 (en) | Apparatus and method of monitoring body fluid distribution, and apparatus and method of measuring plasma volume | |
David Hillis et al. | Measurements of left‐to‐right intracardiac shunting in adults: Oximetric versus indicator dilution techniques | |
Buise et al. | Reflectance spectrophotometry and tissue oxygenation in experimental and clinical practice | |
Maynar et al. | Lithium dilution cardiac output and arterial pulse power analysis | |
Pardy et al. | Comparison of pulmonary artery pressures and mixed venous oxygen tension with other indices in acute haemorrhage: an experimental study | |
Keidan et al. | Carbon Dioxide Elimination After Sodium Bicarbonate Administration as a Novel Method to Assess Cardiac Output: A Pilot Study | |
JP2022179416A (en) | Catheter with blood O2/CO2 concentration measurement | |
Thomas et al. | Assessing oxygenation in the transport environment | |
Tsai et al. | Spontaneous variability of arterial oxygenation in critically ill mechanically ventilated patients | |
Ceriana et al. | Noninvasive cardiac output assessment during heart surgery |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: THERANOVA, LLC, CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BURNETT, DANIEL ROGERS;MANGRUM, SHANE;REEL/FRAME:022847/0761;SIGNING DATES FROM 20090603 TO 20090605 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |