US20040249277A1 - Hollow tube body for medical tool and a catheter into which the hollow tube body is incorporated - Google Patents
Hollow tube body for medical tool and a catheter into which the hollow tube body is incorporated Download PDFInfo
- Publication number
- US20040249277A1 US20040249277A1 US10/776,637 US77663704A US2004249277A1 US 20040249277 A1 US20040249277 A1 US 20040249277A1 US 77663704 A US77663704 A US 77663704A US 2004249277 A1 US2004249277 A1 US 2004249277A1
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- US
- United States
- Prior art keywords
- tube
- layered
- tube body
- catheter
- knife
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0009—Making of catheters or other medical or surgical tubes
- A61M25/0012—Making of catheters or other medical or surgical tubes with embedded structures, e.g. coils, braids, meshes, strands or radiopaque coils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/008—Strength or flexibility characteristics of the catheter tip
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/0069—Tip not integral with tube
Definitions
- the invention relates to a flexible tube body used as a main wire material for a catheter, and particularly concerns to a catheter into which the flexible tube body is incorporated.
- a catheter As a general usage, a catheter is inserted into a tourtous blood vessel or a somatic cavity to be introduced into a diseased area. In this situation, the catheter is manipulated outside a patient's body by pushing, pulling and rotating a handling section of the catheter. During the manipulating process, the catheter advances its leading distal end toward the diseased area to provide it with a necessary treatment.
- the catheter In order to ensure a smooth insertion and treatment for the catheter, it is important to provide the catheter with a high linearity in free state, a pliable flexiblity through its entire length and a good restorability from a bendng deformation. It is also desirable that the catheter has a gradient property represented by a high flexibility at the leading distal end and a reasonable rigidity at a rear portion. At the same time, a high torque transmissibility and good steerability are required for the catheter as mechanical properties so that the leading distal end can precisely respond to manipulating action of the handling section.
- Prior references have been introduced as having a flexible tube for medical tool which can cope with the above mechanical properties.
- the prior references are Laid-open Japanese Patent Application No. 2002-275774 and Japanese Domestic Publication No. 2000-51.3235 in which a group of metallic wires circular in cross section are cylindrically stranded to form a flexible tube structure.
- the present invention has been made with the above drawbacks in mind, it is a main object of the invention to provide a high quality hollow tube body for medical tool and a catheter in which the hollow tube body is incorporated.
- a hollow tube body for medical tool in which a plurality of metallic wires cylindrically stranded to form a flexible tube.
- An inner surface of the flexible tube forms a convex-concave structure represented by the metallic wires formed semi-circular in corss section.
- a leading distal end of the flexible tube is formed into a knife-edge circle configuration to provide a knife-edge circle front.
- a catheter is provided which uses a mono-layered tube in which the hollow tube body is employed at least partly as a main tube.
- a catheter in which a multi-layered tube structure is formed by slidably fitting an upper-layered tube onto a lower-layered tube of a main tube body, and at least one of the upper-layered tube and the lower-layered tube is used as the hollow tube body.
- a drilling (perforative) ability is imparted to a distal end of the flexible tube, while rendering an outer surface of the flexible tube highly smooth. This improves a performance of the catheter when inserting it into the blood vessel and the somatic cavity for the purpose of providing an appropriate treatment.
- the catheter is formed by two-or three-layered tube body.
- the catheter has the multi-layered tube body in which the stranding direction of the metallic wires is opposite among each layer of the tube bodies.
- the rigidity progressively changes from the inner-layered tube to the outer-layered tube.
- the catheter With the catheter formed by the hollow tube body, the catheter is rotated so that the knife-edge circular front advances to serve as a drill so as to perforate or push a hard clot area open when the guide wire, which introduces the catheter, confronts the hard clot area of a completely obstructed region in the blood vessel. This helps smoothly advance the catheter into a true lumen to facilitate the proper treatment against the diseased area. Further, a smooth outer surface of the hollow tube body improves an insertion-slidability against the blood vessel and the somatic cavity so as to produce a catheter of high quality.
- FIG. 1 is a plan view of a hollow tube body for medical tool according to a first embodiment of the invention but partly sectioned;
- FIG. 2 is an enlarged latutidinal cross sectional view of the hollow tube body taken along the line II-II of FIG. 1;
- FIG. 3 is an enlarged longitudinal cross sectional view of a front portion of the hollow tube body taken along the line III-III of FIG. 1;
- FIG. 4 is an explanatory view showing how the hollow tube body is formed
- FIG. 5 is a plan view of a catheter according to a second embodiment of the invention but partly sectioned;
- FIG. 6 is an explanatory view showing how the catheter is manipulated
- FIG. 7 is a plan view of a catheter according to a third embodiment of the invention but partly sectioned;
- FIG. 8 is a plan view of a front portion of a catheter according to a fourth embodiment of the invention but partly sectioned;
- FIG. 9 is an explanatory view showing how the catheter is manipulated
- FIG. 10 is a plan view of a front portion of a catheter according to a fifth embodiment of the invention.
- FIGS. 11 and 12 are explanatory views showing how a catheter is manipulated according to a sixth embodiment of the invention.
- FIG. 13 is a plan view of a hollow tube body according to a seventh embodiment of the invention.
- FIGS. 14 and 15 are explanatory views showing how the hollow tube body is formed
- FIG. 16 is an explanatory view showing how a hollow tube body is formed according to an eighth embodiment of the invention.
- FIG. 17 is a view of a handling section of the catheter.
- a hollow tube body 1 for medical tool is shown according to a first embodiment of the invention.
- the hollow tube body 1 (referred simply to as “tube body” hereinafter) is formed by cylindrically stranding a group of austenitic stainless steel wires 2 along a predetermined circle line to provide a flexible tube which has a certain length (L).
- An inner surface of the tube body 1 forms a convex-concave structure represented by the stainless steel wires 2 generally formed semi-circular in corss section.
- An outer surface of the tube body 1 is rendered smooth cosecutively in the lengthwise direction while the inner surface forms a hollow space 4 in which the convex-concave structure resides.
- a leading distal end of the tube body 1 is formed into a knife-edge circle configuration to provide a knife-edge circle front 3 .
- the knife-edge circle front 3 is outwardly arcuated in cross section, and diametrically decreases progressively as approaching outward.
- the tube body 1 has 8-12 numbers of metallic wires 2 , and measures approx. 0.61 mm in outer diameter (D1) and approx. 0.45 mm in inner diameter (D2).
- the tube body 1 is formed as shown in FIG. 4. Namely, a wire rope R is provided by stranding the metallic wires 2 around an elongated core (not shown). One end of the wire rope R is secured to a rotational chuck 11 of a twisting device 10 . The other end of the wire rope R is secured to a slidable chuck 12 from which a weight 13 is depended. The wire rope R is twisted under the tensile stress caused from the weight 13 .
- a current generating device 14 draws electric currents to the chucks 11 and 12 through an electric wire code 15 so that the wire rope R is heated by its electric resistance to remove the residual stress appeared on the wire rope R during the twisting process. Then, the outer surface of the tube body 1 is smoothly ground so that the metallic wires 2 forms semi-circular in cross section.
- the elongated core is withdrawn from the wire rope R to provide a hollow tube structure.
- FIG. 5 shows a catheter K into which the tube body 1 is incorporated.
- the catheter K has a flexible hollow tube body as a main structure in which a plurality of the metallic wires 2 are stranded according to the method as depicted in FIG. 4.
- the tube body 1 has a front section in the lengthwise direction as an X-zone in which the knife-edge circle front 3 is situated on the leading distal end.
- a rear length portion of the catheter K belongs to a Z-zone, and serves as a diameter-increased portion (denoted at D3 as its diameter) in which the metallic wires 2 forms circular in cross section with its outer surface not ground.
- a middle length portion of the catheter K diametrically increases progressively from its front end (D1) to rear end (D3) to serve as a Y-zone between the front section and the rear length portion.
- the structure is such that the catheter K is flexible in the front portion and rigid in the rear portion as is the necessary property given to the catheter K.
- a connector 5 and a marker M are provided as is well known for those versed in the art.
- the knife-edge circle front 3 is provided by plasma-welding a coil element of the metallic wire 2 , and formed to be outwardly arcuated in cross section by means of grinder or the like. A circumferential surface of the knife-edge circle front 3 is rendered smooth.
- a guide wire C which introduces the catheter K may meet a calcified hard clot area 26 (fibrous cap) of the completely obstructed area 25 .
- the guide wire G is manipulated so that it detours the completely obstructed area 25 to be introduced between the media 22 and the adventitial coat 23 through the intima 21 of the blood vessel 20 .
- the guide wire G meets a hard clot area 26 a again at the other side beyond the completely obstructed area 25 so as to hinder an advancement of the guide wire G.
- the catheter K is advanced from the guide wire G, and rotated to use the knife-edge circle front 3 as a drill to perforate or push the hard clot area 26 a open, thus helping the guide wire G smootly advance into the true lumen.
- Hard clot powder pulverized by the knife-edge circle front 3 is carried away rearward along helical grooves inside the tube body 1 . This eliminates an inconvenience caused due to the fact that the pulverized hard clot powder remains.
- the catheter K is such that its rear end decreases diametrically as approaching the front end portion of the catheter K. This amplifies the rotational force of the front end portion which udergoes the rotational torque from the handling section of the catheter K. This ensures a good drilling function of the knife-edge circle front 3 when the rear end of the catheter K is rotated.
- the smooth outer surface of the front end portion (X-zone) of the catheter K enables a manipulator to readily insert it into the blood vessel and easily rotate it in the blood vessel.
- the group of the metallic wires 2 is twisted under the tensile stress along the lengthwise direction in accordance with the method as shown in FIG. 4. This gives the tube body 1 a high linearity property and a twist-deforming property.
- Each of the metallic wires 2 uniformly slides smoothly without variations to develop no gap between the helical line elements of the tube body 1 , the gap of which often appears on an outer tensile side of a single-wound helical coil tube body when the tube body is bent in the blood vessel with a minimun diameter. This improves an insertability against the blood vessel, a rotation-following ability of the handling section and a torque transmissibility so as to ensure a precise treatment with a high efficiency.
- the knife edge circle front 3 forms an outwardly tapered fashion and facilitates its insertion against the blood vessel.
- FIGS. 7 through 9 shows a third embodiment of the invention.
- a catheter K 1 has a lower-layered tube 1 A provided as a main tube by the tube body 1 identical to that of the catheter K in FIG. 5.
- An upper-layered tube 1 B has the knife-edge circle front 3 at its leading distal end, and is diametrically increased to be slidably fit onto the catheter K of FIG. 5.
- FIG. 8 shows a catheter K 2 according to a fourth embodiment of the invention in which a stranding direction of the lower-layered tube 1 A and that of the upper-layered tube 1 B are mutually opposite by approx. 90 degrees (intersection angle between the lower metallic wires and the upper metallic wires). For this reason, upon perforating the hard clot area 26 a of the completely obstructed area 25 as shown in FIG.
- the lower-layered tube 1 A is manipulated first to provide a small hole on the hard clot area 26 a , and then the upper-layered tube 1 B is manipulated to advance from the lower-layered tube 1 A to diametrically enlarge the small hole, thus easily perforating the hard clot area 26 a with a sufficient-sized hole.
- the blood-dilatation treatment has been implemented with the use of balloon catheters which are replaced in turn from diametrically smaller ones to diametrically larger ones.
- the replacing operation of the balloon catheters is done only by sliding the upper-layered tube 1 B, thus facilitating the blood-dilatation treatment with a high efficiency.
- the metallic wires 2 of the lower-layered tube 1 A and that of the upper-layered tube 1 B come to substantially engage in a point contact with the catheter K 2 in which the stranding direction of the lower-layered tube 1 A and that of the upper-layered tube 1 B are mutually opposite. This improves the slidability of the upper-layered tube 1 B against the lower-layered tube 1 A so as to render the upper-layered tube 1 B easily manipulatable.
- a bending rigidity of the upper-layered tube 1 B may be determined to be greater than that of the lower-layered tube 1 A.
- a hydrophilic polymer e.g., polyvinylpyrrolidone or the like
- FIG. 10 shows a fifth embodiment of the invention in which a catheter K 3 of multi-layered structure is provided.
- an outer tube 1 C is slidably fit onto the upper-layered tube 1 B which is slidably fit onto the lower-layered tube 1 A in the same manner as described at the third embodiment of the invention (referred to FIG. 7).
- the outer tube 1 C is structurally identical to the upper-layered tube 1 B to form a three-layered tube structure.
- FIGS. 11 and 12 show a sixth embodiment of the invention in which a frustocone-shaped chip 8 is provided with the lower-layered tube 1 A of the fifth embodiment of the invention.
- the chip 8 is formed by a metallic (preferably radiopaque) material or a synthetic resin material.
- the chip 8 is diametically decreases progressively as approaching forward.
- a self-expansible stent S is provided between the chip 8 and a front section of the upper-layered tube 1 B.
- the stent S is pushed by the outer tube 1 C to set it in position. Then, the stent S is placed in the diseased area of the blood vessel.
- the outer tube 1 C slides rearward to let the stent S eject in itself so as to set it in the diseased area.
- the knife-edge circle front 3 of the upper-layered tube 1 B may be omitted to improve the sliding performance between the lower-layered tube 1 A, the upper-layered tube 1 B and the outer tube 1 C when the upper-layered tube 1 B is made of a synthetic resin (e.g., polyethylene, fluoro-based plastics or the like).
- the catheter K 3 of the three-layered tube structure enables a manipulator to readily retain the stent S on the diseased area of the blood vessel. This makes it possible for the manipulator to promptly treat the diseased area with a high efficiency, while shortening the time period during which a subject patient suffers so as to significantly ameriorate the curability.
- An inner surface of the outer tube 1 C forms a concave-convex undulation which is consecutively in slidable contact with a zigzag coil line of the stent S. This makes the outer tube 1 C come in a point contact with the stent S, thus enabling the manipulator to appropriately eject the stent S with a smooth operation upon pulling the outer tube 1 C to release the stent S.
- the lower-layered tube 1 A is firstly used to provide a preliminary perforation, then the upper-layered tube 1 B is used to provide a middle-sized perforation, and the outer tube 1 C is finally used to complete a full-sized perforation against the hard clot area 26 a (three-stage perforation). This makes it possible to ensure a full-sized perforation with a precise operation.
- FIGS. 13 through 15 show a seventh embodiment of the invention which provides another method different from the first embodiment of the invention.
- the wire rope R is divided into the X-, Y- and Z-zones in the lengthwise direction.
- a clamp device 14 is mounted on the boundary portion between the X-, Y- and Z-zones, and has a pair of opposed clamp plates 15 which open and close to loosen and tighten the wire rope R as shown in FIGS. 14 and 15.
- the wire rope R is twisted in different turns depending on the X-, Y- and Z-zones. This method renders the metallic wires 2 to be twisted in different turns so as to produce the tube body 1 as shown in FIG. 13.
- the tube body 1 has a bending property which responds in varying hardnesses to the X-, Y- and Z-zones depending on the numbers of twisting turns subjected.
- the tube body 1 is used as a flexible linear wire for medical tool
- the most rigid section of the flexible linear wire corresponds to the handling section residing outside the subject patient
- the softer and more flexible section of the flexible linear wire corresponds to the leading end portion which is introduced into the blood vessel and the somatic cavity.
- FIG. 16 shows an eighth embodiment of the invention in which heating devices 16 A, 16 B and 16 C are provided.
- the wire rope R is set to the heating devices 16 A, 16 B and 16 C in accordance with the lengthwise x-, Y- and Z-zones.
- the wire rope R is heat-treated individually by the heating devices 16 A, 16 B and 16 C. This makes it possible to produce the tube body 1 in which the residual stress is removed in varying degrees depending on the X-, Y- and Z-zones.
- the tube body 1 functions as a highly effective catheter in which the tensile strength and the bending rigidity gradually changes in the lengthwise direction so as to add good mechanical properties needed for the catheter.
- the tube body is provided by winding a metallic wire around a mandrel or using a winding machine (on paragraph 0004 of the Laid-open Japanese Patent Application No. 2002-275774 and on page 1.4 of the Japanese Domestic Publication No. 2000-513235).
- This developes a work hardening layer on one side of the metallic wire to often induce excessive gaps between the helical coil lines of the tube body when the tube body is bend to its minimum diameter, thus losing the rotational maneuverability and the torque transmissibility.
- the method is such that the metallic wires 2 are twisted under the uniform tension to form the work hardening layer equally on an entire surface of the metallic wires 2 .
- FIG. 17 shows handling sections of the catheter K 3 in which the tube body 1 is of two-or three-layered structure (referred to FIG. 10).
- the catheter K 3 has the lower-layered tube 1 A, the upper-layered tube 1 B and the outer tube 1 C, to which the manipulating portions 6 A, 6 B and 6 C are respectively secured in a row.
- the manipulating portions 6 A, 6 B and 6 C are individually pushed, pulled and rotated to enable the manipulator to perforate the hard clot area 26 a and release the stent S.
- the manipulating portions 6 A, 6 B and 6 C may be formed differently from a wing-shaped one provided around respective boss portions.
- a connector 5 which has an injector 7 to introduce contrast media into the blood vessel.
- the catheter K 1 of two-layered structure referred to FIG. 7
- only the manipulating portions 6 A and 6 B are provided in a row.
- the austenitic stainless steel for the present catheter.
- its low thermal conductivity makes it possible to avoid the heat conduction from unnecessarily spreading upon welding the knife-edge circle front 3 and marker M, thus preventing the catheter from deteriorating with a limited amount of electric currents and a shortened period of welding time.
- the tube body for medical tool enhances the performance and function of the catheter which enables the manipulator to perforate the hard clot area and to readily retain the stent in the diseased area so as to significantly improve the curability and the convenience of the subject patient.
- the knife-edge circle front 3 may be formed by welding a discrete a coil or ring line to a front tip coil end of the tube body 1 , otherwise the knife-edge circle front 3 may be integrally provided by press-deforming the front tip coil end of the tube body 1 .
- the front tip coil end of the tube body 1 may be embeded in a plastic ring which serves as the knife-edge circle front 3 .
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- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Media Introduction/Drainage Providing Device (AREA)
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US12/457,379 US8551073B2 (en) | 2003-02-17 | 2009-06-09 | Catheter device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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JP2003-037550 | 2003-02-17 | ||
JP2003037550A JP3971320B2 (ja) | 2003-02-17 | 2003-02-17 | カテーテル |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US12/457,379 Division US8551073B2 (en) | 2003-02-17 | 2009-06-09 | Catheter device |
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US20040249277A1 true US20040249277A1 (en) | 2004-12-09 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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US10/776,637 Abandoned US20040249277A1 (en) | 2003-02-17 | 2004-02-12 | Hollow tube body for medical tool and a catheter into which the hollow tube body is incorporated |
US12/457,379 Active 2026-05-01 US8551073B2 (en) | 2003-02-17 | 2009-06-09 | Catheter device |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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US12/457,379 Active 2026-05-01 US8551073B2 (en) | 2003-02-17 | 2009-06-09 | Catheter device |
Country Status (7)
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US (2) | US20040249277A1 (fr) |
EP (2) | EP1902745A1 (fr) |
JP (1) | JP3971320B2 (fr) |
AT (1) | ATE399034T1 (fr) |
DE (1) | DE602004014548D1 (fr) |
ES (1) | ES2305665T3 (fr) |
HK (1) | HK1068823A1 (fr) |
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US20050222585A1 (en) * | 2004-04-06 | 2005-10-06 | Asahi Intecc Co., Ltd. | Medical equipment |
US20050224471A1 (en) * | 2004-04-08 | 2005-10-13 | Ziyun Chen | Methods and apparatus for delivering laser energy for joining parts |
US20060178653A1 (en) * | 2004-12-21 | 2006-08-10 | Manabu Shimogami | Catheter and method of producing the same |
US20070088230A1 (en) * | 2005-09-06 | 2007-04-19 | Fmd Co., Ltd | Medical instrument and medical equipment for treatment, and rotational handle device |
US20080015508A1 (en) * | 2006-07-07 | 2008-01-17 | Wilson-Cook Medical, Inc. | Telescopic wire guide |
US20080039823A1 (en) * | 2006-02-14 | 2008-02-14 | Asahi Intecc Co. Ltd. | Medical Equipment, Tubular Insertion Device and Tubular Insertion Device Having the Same Medical Equipment |
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US11992238B2 (en) | 2008-02-05 | 2024-05-28 | Boston Scientific Scimed, Inc. | Endovascular device with a tissue piercing distal probe and associated methods |
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Also Published As
Publication number | Publication date |
---|---|
ATE399034T1 (de) | 2008-07-15 |
JP3971320B2 (ja) | 2007-09-05 |
HK1068823A1 (en) | 2005-05-06 |
US20090254107A1 (en) | 2009-10-08 |
EP1454649B8 (fr) | 2008-09-10 |
DE602004014548D1 (de) | 2008-08-07 |
EP1902745A1 (fr) | 2008-03-26 |
ES2305665T3 (es) | 2008-11-01 |
US8551073B2 (en) | 2013-10-08 |
JP2004242973A (ja) | 2004-09-02 |
EP1454649A3 (fr) | 2005-08-17 |
EP1454649A2 (fr) | 2004-09-08 |
EP1454649B1 (fr) | 2008-06-25 |
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