US1987146A - Syringe equipment - Google Patents

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US1987146A
US1987146A US509956A US50995631A US1987146A US 1987146 A US1987146 A US 1987146A US 509956 A US509956 A US 509956A US 50995631 A US50995631 A US 50995631A US 1987146 A US1987146 A US 1987146A
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plunger
vial
syringe
container
ring
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George N Hein
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle

Definitions

  • This invention relates tosyringe equipment for liquids and particularly. for a type of syringe wherein a container or. .vial for theliquid maybe provided in pack'a'geform'. soadaptedlthat the 5 package is utilized'as'the barrel ofQthe syringe when in operative use.
  • a syringe having a chambered barrellportion, a piston with a piston head snugly fitting'andreciprocable in the barrel and a perforated injection needle or cannula mounted at a discharge end of the syringe structure.
  • the structural parts may be termed as permanent, and it is necessary to transfer: the liquid, or a pellet to be dissolved with liquid, from a separate container to the syringe-barrel. This transfer exposes the liquid tothe atmosphereand, in case of pellets,to actual handling,- and the possibility of co ntarnination of theinjection fluid; also the syringe barrel may not be as carefully sterilized as is desirable.
  • each p e er b o din s p f r a s e inls ,t ion', ,an'dfthe co fainer may be used asfja barrel 1 ror .;,tne jsyringefa 'rid discarded "when emptied by its. us so" as r to' avoid any possibility of contain; inat of the contentsQbyjexposure to atmos;
  • prgvme means whereby, an injection he mounteddirejctly tosuchfi Syringe qr yat one open r end, and a frangible opposite 'end; and .towhich.[aninjectionneedle may be attached; tpfiproyide a slidabler closure member mrqneenewmcii may be use'das a plunger head v 76 provide such; a syringe-forming barreland container which has a slidable closure Iwhichdhas teeththereon whereby.
  • a ntainer barrellli v I i :2 r ' is a sectioned longitudinal transverse
  • Fig 3 is ajsectio ed longitudinal transverseview "of ferrule 01' truncated conical shell.
  • v Fig. fl is-a sectioned longitudinal transverse 'Iview'Lof-Tassembly of'devices of Figs. 1, '2 and 3, @but gwithiferrule threaded to receive a needle base.
  • Fig. Q5. is a' sectioned. longitudinal transverse sectioned mass l t th I View. a: plungerhaving aserrated end portion.
  • Fig.l7 is a sectionedlongitudinalviewgof. modij fertil. formof container barrel having alfrangible end.v internal cavity .to .,be ,fra'ctiiredby, a needle "end and having at its other enda puncturable lclosur'e cork; 's'o' that the, container may also be ⁇ usedin inverted, types-of syringes.
  • Fig. 9 is a sectioned longitudinal transverse view of suitable needle for use in device shown in Fig. 8.
  • Fig. 10 is a longitudinal transverse section of a frame support for a plunger adapted for use with a container.
  • I'have' provided a ferrule 6,101 any suitable material, such as cell'u1oid,-brass, or moulded block tin, which is mountedon -the extension portion "4' between the.”scoreiineidandthe end'3 of the cylindrical bodytthe score'line rer-, .erably being located “closely adjacent the router end of the'ierrule.
  • Thetype-' ot""ferrule*shown .inFig, 3 is o'irshape siibstantiallyicorresponding to the so-calledflzueritip, and adapts: the "container to use with the'typeot syringe trameihaving aLuer sleeve. (The terrcludefs maybe adhered to the extension by suitable "adhesive, "such as shellac or'sealing wax,”as'"indicated by stippling at'f'l.
  • 'A'suitable closure member 8 is jprovided for the open' end '2, preferably 'orres'ilientmaterlal such as cork orsort vulcanizedrdbber, arid-has:suug
  • Theclosuremember in my preferred form is provided -witha clrcumierentialside wallhavingagroovemtherein, the "e'dgespf which snugly an d 'slidablyfilt”the inner container body wall, as, at 11, andproviding an" inner' face 12' and 'outertace 13.
  • Thi's' iorm decreases the .frictional res'istanceagairistFthe barrel walls andwhen'pressedby plunger9 against the contents of the barrel;theedgeslrare more readily expan'dedto" make ta"1eak,-pr06f fpacking gland.
  • ing portion 18 formed integrdlly with the irangi- 10 ble end of 'the container.
  • the advantage of this .f.orm (Fig. '7) is that the container is adaptable If it is rdesiredratortnse a plunger of the type of Fig. 5, a
  • Fig. 7 is mounted to the franl5 *g'iblee'ndby-means of threads 19 with an end of ithemeedle-adapted toiracture the inward extension on the score line 5.
  • the container of Fig. isdesired to be used with an inverted type of syringe, the end 3 isnotfractured, but the .op- 20 posite end Zoifthecorita'iiieriis fltte'd'over atubular piston having "a: needle” to puncture the clo sure'f8 throughza recess 20 "and npon'pressure of the.
  • closure cork 8' serves as'a piston head to expelthe container -'contentsthrough'the 25 "of'the'injection.
  • Ina-socket -23 mayhave; provided at thebase ef-itswecessa gasket or 'ggland 25 whereby a tight leak-#proof *joint isprovide'd for the' base -ze-of ail-(injection 1 needle.
  • aniannular riug zii preiferablyPhaving*a bevelled internal surface -29; is prcwlded-withop- -positelydispose'd" trunnions 30 mounted openings 3 1 of arms or ayoke 32, which may 1 have mounted thereon *and exteridingradiany there- 5 ⁇ from "finger- -grip "bars' -33.
  • the bevelled ring 28* is: pivoted 5 v "on" trunnions 30, so ⁇ that "the 'radial -axis or *the ring is substantially pe pendicular to the axis of 'the yokey -as shown in dotted-lines in Fig. 10,
  • this structure is that "when theplunger is not 'inserted in the vial which is supported at its "15 plunger-receiving end, the gravitational force will tip the vial and its ring holder to a position where the radial axis of the ring and the vial are substantially perpendicular to the axis of opening 34 and plunger 35, so that a vial may be removed or a new one inserted, or the vial refilled, without the yoke or plunger interfering with such operations.
  • the arms of the yoke 32 are therefore suiiiciently long so that asthe vial and ring swing on the pivotal axis of the ring the radius of the ring will not permit interference or contact with the retracted plunger head or yoke arms, and yet the arms are sufliciently short so that the plunger-receiving end of the vial will be in close proximity to the lower plunger end so that the plunger may readily enter and align the vial when the syringe is positioned vertically and the axis of ring and vial swing on the pivots into substantial axial alignment with the axis of opening 34 and plunger 35.
  • Syringe equipment for mounting tubular syringe vials which have one end outwardly flared and adapted to receive internally therein a plunger, comprising a member adapted to externally engage the outwardly flared portion of the vial and thereby support the body of the vial adjacent said plunger-receiving end said member being free of means to engage thevial at the discharge end and limit the length of a vial which may be supported in said member, a plunger support member pivotally mounted to said vial supporting member and having an opening at its radially central portion and a plunger member slidably mounted in said opening of the plunger support member, the pivotal axis of the vial supporting member being angular to the longitudinal axis of the plunger, and the distance from the central opening of the plunger support member to the pivotal axis of the vial support member being greater than the radius of the opening of the vial supporting member and sufficiently short so that when a vial is placed in said vial support member with the plunger-receiving end
  • Syringe equipment including the combination of a tubular syringe vial which has one end adapted to receive internally thereina plunger and which has an outwardly flared bead at said end, a ring member having an opening through which the vial body may be inserted, said ring member being adapted for externally engaging and thereby supporting the body of the vial adjacent said outwardly flared plunger-receiving end, a yoke pivotally mounted to said ring member, said yoke having an opening at its radially central portion, and a plunger member slidably mounted in the opening of said yoke, the pivotal axis of the ring being angular to the longitudinal axis of the plunger, and the arms of said yoke be- 7 so that when a vial is placed in said ring memher with the plunger-receiving end held by said ring member, the ring may swing on its pivotal axis and hold the plunger receiving end of the vial closely adjacent to the

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Description

Jan. 8, 1935. G. N. HEIN 1,987,146
SYRINGE EQUIPMENT Filed Jan. 20, 1931 g INVENTOR. BY 9 A TTORNEY Patented Jan. 8, 1935 H n VSYRINGE'EQUIPMENT' ffGeorgeN. Heimi an is V Application January 20, 193 1".
V This invention relates tosyringe equipment for liquids and particularly. for a type of syringe wherein a container or. .vial for theliquid maybe provided in pack'a'geform'. soadaptedlthat the 5 package is utilized'as'the barrel ofQthe syringe when in operative use.
Heretofore, it has been the mostusually followed practice to provide a syringe having a chambered barrellportion, a piston with a piston head snugly fitting'andreciprocable in the barrel and a perforated injection needle or cannula mounted at a discharge end of the syringe structure. In this type of syringe the structural parts may be termed as permanent, and it is necessary to transfer: the liquid, or a pellet to be dissolved with liquid, from a separate container to the syringe-barrel. This transfer exposes the liquid tothe atmosphereand, in case of pellets,to actual handling,- and the possibility of co ntarnination of theinjection fluid; also the syringe barrel may not be as carefully sterilized as is desirable.
The medical and dental professions particularly have for many years been endeavoring to ,find a; typeofsyringe which was efficient, and sufficiently cheap in construction,so that a sin .gle injection quantity of liquid could beinia ed in a syringe-container barrel direct bytheinanufacturerrand that single injection quantityused direct frornthecontainer, without measurement, and ,wi hcut av n -r 5. a r. t el u to an independent I syringe structure sincefrequently,
itis necessary to work so rapidly that a nioperatorcannot stop in an-operation to measure the u d; -n9 1: 0eshe a W r T Y on an s- ..srstant; even assuming an assistant available.
r;-In1the"syringeart therehas heretofore been I u edv .0. :m year a ta ered,- i hu e dfi "syringe barrel in the form of. a tubular truncated ;cone,gand known in the trade asa Luer-tin-iwhich ,is usuallyrmade integrally with a syringe barrel,
eth re ba r l be l ss m a w p ma- ;teri al tiphas been in use for so long a time that it has become standardized and manufacturers of syringe frames and needles have-frequently constructed their implements Witht.
sleeve adapted. to closely lit. and form ,a leakproof joint with la barrel .provided with a Luer tip, which structure is known in the art "as a Luer sleeve I An objectof this inventicnis to provideafsyringe-formingoutfit'wherein-the liquid may be placed within a container at a manufacturing plant, and put up inpackage form, wherein the package containsa plurality. of containers each p e er b o din s p f r a s e inls ,t ion', ,an'dfthe co fainer may be used asfja barrel 1 ror .;,tne jsyringefa 'rid discarded "when emptied by its. us so" as r to' avoid any possibility of contain; inat of the contentsQbyjexposure to atmos;
prgvme means whereby, an injection he mounteddirejctly tosuchfi Syringe qr yat one open r end, and a frangible opposite 'end; and .towhich.[aninjectionneedle may be attached; tpfiproyide a slidabler closure member mrqneenewmcii may be use'das a plunger head v 76 provide such; a syringe-forming barreland container which has a slidable closure Iwhichdhas teeththereon whereby. the closure r l mber ma .b.a ;1a11y'rotat 1 i ie m ia ti ien endemcient ranie, to support 'a' ingeyialisofthatthe ea'dilyf removed and replaced; l r v I v bo ve;- ne'n tioned an'dbthe'r objects in View; the invention consists in the novel'c'onstruction and combination of ,parts hereinafter described,[illustrated in the accompanying I drawsthe barrel and .iilgland pointedout in the .claiinshereto append- ,ed'; it being: understood; that various changes in V I oportion, .size'andfjminor'detailsi of ."constructi Withinthescope of the claims may be. resorted. to withfout' departing from the spirit pr sacrificing any or Y thefl o iiiorebcl arly cornbrehendjthe inv'e'n lon, QIrQe'f" ence i'sdirected to the accompanying,,drawmg: whriyin;
a ntainer barrellli v I i :2 r 'is a sectioned longitudinal transverse Fig 3 is ajsectio ed longitudinal transverseview "of ferrule 01' truncated conical shell.
, v Fig. fl is-a sectioned longitudinal transverse 'Iview'Lof-Tassembly of'devices of Figs. 1, '2 and 3, @but gwithiferrule threaded to receive a needle base. Fig. Q5. is a' sectioned. longitudinal transverse sectioned mass l t th I View. a: plungerhaving aserrated end portion.
i Fig. Sis an end {view .of plunger, disclosing serratedend prtin..,.,;j .I 1, Fig.l7 is a sectionedlongitudinalviewgof. modij fled. formof container barrel having alfrangible end.v internal cavity .to .,be ,fra'ctiiredby, a needle "end and having at its other enda puncturable lclosur'e cork; 's'o' that the, container may also be {usedin inverted, types-of syringes.
i -.2 (a weighe l n i l t an i nt view of modification of container barrel and threaded socket to receive needle.
Fig. 9 is a sectioned longitudinal transverse view of suitable needle for use in device shown in Fig. 8.
Fig. 10 is a longitudinal transverse section of a frame support for a plunger adapted for use with a container.
Referring to .the...drawing,.in which like reference charactersi indicate correspondin gz parts in the several views, 1 represents, generally, a container. body forming a syringe vial preferablyof tubular cylindrical construction and of any suit able frangible material, such as $18.55;.M'1Ubber or the like, having an end opening 2,.fornied therein and having its opposite-'end=3*normallyclosed by a frangible portiomQ'preIerablyiot-leeper diameter than the cylindrical portion of the body, and preferably being a tubular cone lilre st'ructure, .which is,,provided. intermediate. its length with ascore' line. or breaking .point 5.: Wherrthe containeris made.dtglassthisextension is formed byblowing or'd-rawing theslass; aproce'dure well known theglass making art;lbut'it"cannot be entirely depended .upontogproduce:mathematicallypreciseside walls whichwould'iform' atight joint with a syringe. sleeve of "the. aforesaid "Luer type, :nor' isifit' suitably adapted togpositively .enage 'a nee'dle so that the needle will ndtbeblown on. by pressure. I'have' provided a ferrule 6,101 any suitable material, such as cell'u1oid,-brass, or moulded block tin, which is mountedon -the extension portion "4' between the."scoreiineidandthe end'3 of the cylindrical bodytthe score'line rer-, .erably being located "closely adjacent the router end of the'ierrule. Thetype-' ot""ferrule*shown .inFig, 3 is o'irshape siibstantiallyicorresponding to the so-calledflzueritip, and adapts: the "container to use with the'typeot syringe trameihaving aLuer sleeve. (The terriilefs maybe adhered to the extension by suitable "adhesive, "such as shellac or'sealing wax,"as'"indicated by stippling at'f'l.
'A'suitable closure member 8:is jprovided for the open' end '2, preferably 'orres'ilientmaterlal such as cork orsort vulcanizedrdbber, arid-has:suug
slidable "'flt with the innerfside' walls or the fractured on the'score'line5. "Theclosuremember in my preferred form is provided -witha clrcumierentialside wallhavingagroovemtherein, the "e'dgespf which snugly an d 'slidablyfilt"the inner container body wall, as, at 11, andproviding an" inner' face 12' and 'outertace 13. Thi's' iorm decreases the .frictional res'istanceagairistFthe barrel walls andwhen'pressedby plunger9 against the contents of the barrel;theedgeslrare more readily expan'dedto" make ta"1eak,-pr06f fpacking gland.
'fbe axially rotate.d,"the-latter ieatnrwbeing to break any seal which may .be intentionally formed, as by1a-wax"wash'toi=insure* the contents or thdcontainer"against contamination or-evapfor use with syringes of several types.
ing portion 18 formed integrdlly with the irangi- 10 ble end of 'the container. "The advantage of this .f.orm (Fig. '7) is that the container is adaptable If it is rdesiredratortnse a plunger of the type of Fig. 5, a
needle, as shownin Fig. 7, is mounted to the franl5 *g'iblee'ndby-means of threads 19 with an end of ithemeedle-adapted toiracture the inward extension on the score line 5. It'the container of Fig. isdesired to be used with an inverted type of syringe, the end 3 isnotfractured, but the .op- 20 posite end Zoifthecorita'iiieriis fltte'd'over atubular piston having "a: needle" to puncture the clo sure'f8 throughza recess 20 "and npon'pressure of the. container the closure cork 8' serves as'a piston head to expelthe container -'contentsthrough'the 25 "of'the'injection. '"In" Fig.-4'and-Fig. dare shown m'eansto positively 'hold the injection'needlerin engagement at" the discharge end ot'thepontain- "er, comprising in -Figs 4= an exte'mal threading of the ferrule- 6, as 'at"21;-arid*in Fig.--'8an" internal threadingyas at22, '01 a socket 23' whichf-is 7 pro- "35 vided with *a cdllar24 cementedtothe-"extension :point 4" by suitable adhesive cement. Ina-socket -23 mayhave; provided at thebase ef-itswecessa gasket or 'ggland 25 whereby a tight leak-#proof *joint isprovide'd for the' base -ze-of ail-(injection 1 needle.
"If "desired, a needle having a "strainer *2 7 inter- "mediate the fracturableportionof the container 'andthecannula ofthe needleniaybe usedto eliminate=any possibility-of fineIragments o'1"the -45 fractured container-being 'carried into "the "inf jection stream. "This syringe equipment mayalso --be' adapted to "a- 'suitable type of holding frameeither-wither withoutfinger grip bar's, one -;pre-' ferred' embodiment *belng' illustrated in Fig. 10,
wherein aniannular riug zii preiferablyPhaving*a bevelled internal surface -29; is prcwlded-withop- -positelydispose'd" trunnions 30 mounted openings =3 1 of arms or ayoke 32, which may 1 have mounted thereon *and exteridingradiany there- 5 {from "finger- -grip "bars' -33. *Concentrimwithfthe longitudinal :airis-dI-{the "yoke --at its-upper endiis -an openinga'i' through-which is slidably disposed c-a -plunger 35, provided "with a recessed *heaid' 36'adapte'd'to engage the'proj ection" -14 "of closure 1 cork 8- in piston forming relation. "This plunger headmay also' be provided {with teeth or similar typeand for similar purposegas teeth l'l of- Figi '5.
- To place' -a container-in or remove a container from the holden the bevelled ring 28* is: pivoted 5 v "on" trunnions 30, so{ that "the 'radial -axis or *the ring is substantially pe pendicular to the axis of 'the yokey -as shown in dotted-lines in Fig. 10,
whereupon the container may be inserted or removed; free or 'obstructiomby the yokeor plunger "70 head. When a container is "within the annular ring,' the-bea'd or outward flare 37" seats upon-the "internal 'bevel oi? the annular ring. The purpose -of' this structure is that "when theplunger is not 'inserted in the vial which is supported at its "15 plunger-receiving end, the gravitational force will tip the vial and its ring holder to a position where the radial axis of the ring and the vial are substantially perpendicular to the axis of opening 34 and plunger 35, so that a vial may be removed or a new one inserted, or the vial refilled, without the yoke or plunger interfering with such operations. The arms of the yoke 32 are therefore suiiiciently long so that asthe vial and ring swing on the pivotal axis of the ring the radius of the ring will not permit interference or contact with the retracted plunger head or yoke arms, and yet the arms are sufliciently short so that the plunger-receiving end of the vial will be in close proximity to the lower plunger end so that the plunger may readily enter and align the vial when the syringe is positioned vertically and the axis of ring and vial swing on the pivots into substantial axial alignment with the axis of opening 34 and plunger 35.
I claim:-
1. Syringe equipment for mounting tubular syringe vials which have one end outwardly flared and adapted to receive internally therein a plunger, comprising a member adapted to externally engage the outwardly flared portion of the vial and thereby support the body of the vial adjacent said plunger-receiving end said member being free of means to engage thevial at the discharge end and limit the length of a vial which may be supported in said member, a plunger support member pivotally mounted to said vial supporting member and having an opening at its radially central portion and a plunger member slidably mounted in said opening of the plunger support member, the pivotal axis of the vial supporting member being angular to the longitudinal axis of the plunger, and the distance from the central opening of the plunger support member to the pivotal axis of the vial support member being greater than the radius of the opening of the vial supporting member and sufficiently short so that when a vial is placed in said vial support member with the plunger-receiving end held by said member, the vial may swing on the pivotal axis of the vial support member and hold the plunger-receiving end of the vial closely adjacent the end of the plunger with the radial axis of the vial supporting member angular to the axis of the plunger.
2. Syringe equipment including the combination of a tubular syringe vial which has one end adapted to receive internally thereina plunger and which has an outwardly flared bead at said end, a ring member having an opening through which the vial body may be inserted, said ring member being adapted for externally engaging and thereby supporting the body of the vial adjacent said outwardly flared plunger-receiving end, a yoke pivotally mounted to said ring member, said yoke having an opening at its radially central portion, and a plunger member slidably mounted in the opening of said yoke, the pivotal axis of the ring being angular to the longitudinal axis of the plunger, and the arms of said yoke be- 7 so that when a vial is placed in said ring memher with the plunger-receiving end held by said ring member, the ring may swing on its pivotal axis and hold the plunger receiving end of the vial closely adjacent to the end of the plunger with the radial axis of the ring angular to the axis or the plunger.
GEORGE N. HEIN.
US509956A 1931-01-20 1931-01-20 Syringe equipment Expired - Lifetime US1987146A (en)

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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2542814A (en) * 1946-10-17 1951-02-20 Sterling Drug Inc Hypodermic syringe
US2574964A (en) * 1949-06-24 1951-11-13 Eisenstark Julius Syringe
US2666434A (en) * 1950-11-17 1954-01-19 Robert W Ogle Disposable syringe
US2670121A (en) * 1951-01-31 1954-02-23 Scherer Corp R P Flexible follower for metal ampoules
US2671580A (en) * 1951-10-25 1954-03-09 Marlin R Henson Embalmer's cosmetic wax dispensing instrument
US2672867A (en) * 1951-10-31 1954-03-23 American Home Prod Hypodermic syringe
US2711171A (en) * 1953-10-14 1955-06-21 Becton Dickinson Co Hypodermic syringe
US2778360A (en) * 1955-05-09 1957-01-22 Pfizer & Co C Hypodermic syringe
US3498295A (en) * 1967-05-17 1970-03-03 Bio Neering Inc Cartridge for use in multiple injection device
US3788524A (en) * 1971-12-22 1974-01-29 Cutter Lab Additive container
US4291695A (en) * 1976-04-05 1981-09-29 Duphar International Research B.V. Disposable injection syringe
US5019053A (en) * 1989-10-23 1991-05-28 Gte Products Corporation Hypodermic syringe
DE102015107631A1 (en) * 2015-05-15 2016-11-17 Gerresheimer Regensburg Gmbh Syringe with closure

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2542814A (en) * 1946-10-17 1951-02-20 Sterling Drug Inc Hypodermic syringe
US2574964A (en) * 1949-06-24 1951-11-13 Eisenstark Julius Syringe
US2666434A (en) * 1950-11-17 1954-01-19 Robert W Ogle Disposable syringe
US2670121A (en) * 1951-01-31 1954-02-23 Scherer Corp R P Flexible follower for metal ampoules
US2671580A (en) * 1951-10-25 1954-03-09 Marlin R Henson Embalmer's cosmetic wax dispensing instrument
US2672867A (en) * 1951-10-31 1954-03-23 American Home Prod Hypodermic syringe
US2711171A (en) * 1953-10-14 1955-06-21 Becton Dickinson Co Hypodermic syringe
US2778360A (en) * 1955-05-09 1957-01-22 Pfizer & Co C Hypodermic syringe
US3498295A (en) * 1967-05-17 1970-03-03 Bio Neering Inc Cartridge for use in multiple injection device
US3788524A (en) * 1971-12-22 1974-01-29 Cutter Lab Additive container
US4291695A (en) * 1976-04-05 1981-09-29 Duphar International Research B.V. Disposable injection syringe
US5019053A (en) * 1989-10-23 1991-05-28 Gte Products Corporation Hypodermic syringe
DE102015107631A1 (en) * 2015-05-15 2016-11-17 Gerresheimer Regensburg Gmbh Syringe with closure

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