US108034A - Improvement in putting up medicines - Google Patents
Improvement in putting up medicines Download PDFInfo
- Publication number
- US108034A US108034A US108034DA US108034A US 108034 A US108034 A US 108034A US 108034D A US108034D A US 108034DA US 108034 A US108034 A US 108034A
- Authority
- US
- United States
- Prior art keywords
- medicines
- putting
- slate
- improvement
- tablets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title description 38
- 229940079593 drugs Drugs 0.000 title description 28
- 239000010454 slate Substances 0.000 description 16
- BQJCRHHNABKAKU-KBQPJGBKSA-N Morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 6
- 229960005181 morphine Drugs 0.000 description 6
- 229930014694 morphine Natural products 0.000 description 6
- 229930006677 A03BA01 - Atropine Natural products 0.000 description 2
- RKUNBYITZUJHSG-SPUOUPEWSA-N Atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 2
- 229960000396 Atropine Drugs 0.000 description 2
- 239000001828 Gelatine Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Definitions
- My invention has for its object the putting up of medicines in such a way that they can be taken with the greatest ease by the most delicate patients, while the doses are made equal with the most absolute certainty. Their bulk is so reduced that any quantity of various medicines may be carried by physicians withoutinconvenience, who thus may at once dispense the medicines they prescribe.
- I compound my improved medicines in tablets containing a large number of doses, and out these up into smaller tablets containing the number of doses prescribed.
- I dissolve eighty grains of the finest, purest, and whitest gelatine in eight ounces distilled water at a proper degree of heat, preferably 63 Celsius. of morphine, thoroughly mixed in thirty-six drops of chemically-pure glycerine. Stir'the whole carefully, and then pour it evenly over the slate.
- This slate may be of any desired size; but I prefer making it siX inches by twelve and one-half, sothat when the same is perfectly polished and divided into squares of one-half inch, by means of double parallel lines engraved into the slate to the depth of about half a line, the slate will contain three hundred squares of perfectly equal size.
- this slatein its frameA which may be constructed of wood, metal, or any other suitable material, and extends above the surface of the slate.
- the slate is made detachable from the frame
- gelatinous tablet thus prepared easily loosens from the slate, and is then out between the parallel lines which have been formed on the same by the indented lines on the slate into smaller tablets of twelve or any other. desired number of squares, each square containing exactly one-fourth of a grain of sulphuric morphine, as shown in Fig. 3.
- Fig. 4 I have shown a tablet which is intended for medicines which are applied to the eyes, or other very tender parts of the body, in very small dosesas, for instance,
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
in the several figures.
FREDERIG KRAUS, or CINCINNATI, onIo;
IMPROVEMENT llN PUTTING UP MEDICINES.
Specification forming part of LettersPatent No. 108,034, dated October 4, 1870.
To all whom iii may concern.-
Be it known that I, FREDERIG KRAUS, of
Cincinnati, in the county of Hamilton and companying drawing, which makes part of this specification, and in which Figures 1 and2represent the slates on which my improved medicines are" prepared, and Figs. 3 and 4 represent specimens of my improved-medicine.
Like letters of reference indicate like parts The nature of my invention consists in putting up medicines in gelatinous tablets divided by indented lines into parts of equal size, each partbeing made to contain the desired dose of medicine, so that each tablet contains any desired number of equal doses; also,
. in the slates on which these medicines are prepared;
My invention has for its object the putting up of medicines in such a way that they can be taken with the greatest ease by the most delicate patients, while the doses are made equal with the most absolute certainty. Their bulk is so reduced that any quantity of various medicines may be carried by physicians withoutinconvenience, who thus may at once dispense the medicines they prescribe.
Druggists who preparemedicines in this manner in various doses are saved a great deal of trouble in compounding prescriptions, and the medicines can be safely kept without danger of spoiling.
I compound my improved medicines in tablets containing a large number of doses, and out these up into smaller tablets containing the number of doses prescribed.
Any kind of medicine which can be dissolved can be put up in this way; and I will now proceed to describe the preparation of sulphuric morphine as an'example.
I dissolve eighty grains of the finest, purest, and whitest gelatine in eight ounces distilled water at a proper degree of heat, preferably 63 Celsius. of morphine, thoroughly mixed in thirty-six drops of chemically-pure glycerine. Stir'the whole carefully, and then pour it evenly over the slate. I
This slate may be of any desired size; but I prefer making it siX inches by twelve and one-half, sothat when the same is perfectly polished and divided into squares of one-half inch, by means of double parallel lines engraved into the slate to the depth of about half a line, the slate will contain three hundred squares of perfectly equal size. In Fig. l I have shown this slatein its frameA, which may be constructed of wood, metal, or any other suitable material, and extends above the surface of the slate.
- The slate is made detachable from the frame,
so that different slates, being divided into larger or smaller squares, maybe used, accorddust, and allow the solution to dry at a temperature of about 40 to 45 Celsius. The
gelatinous tablet thus prepared easily loosens from the slate, and is then out between the parallel lines which have been formed on the same by the indented lines on the slate into smaller tablets of twelve or any other. desired number of squares, each square containing exactly one-fourth of a grain of sulphuric morphine, as shown in Fig. 3.
In Fig. 4 I have shown a tablet which is intended for medicines which are applied to the eyes, or other very tender parts of the body, in very small dosesas, for instance,
sulphuric atropine, which isapplied to the that the whole dose can be applied directly to the diseased portion of the eye, on' which it remains by reason of its gelatmouscharacter,
To this I add seventy-five grains and it cannot, on account of its fineness, irritate the most delicate part.
In traveling these medicine-tablets can be easily carried, and any person knowing the dose required can purchase these medicines and take them with perfect safety.
Having thus described my invention, what I claim as new, and desire to secure by Letters Patent, is
1. The method of preparing medicines in the manner substantially herein described.
2. Medicines or drugs put up in gelatinous tablets, which are divided into equal doses,in the manner substantially as herein described.
3. lhe slates shown in Figs. 1 and 2, for preparing gelatinous medicine tablets, substantially as herein described.
FBEDERIO KRAUS.
Vitnesses:
J. JAUMANN, J. A. KEY.
Publications (1)
Publication Number | Publication Date |
---|---|
US108034A true US108034A (en) | 1870-10-04 |
Family
ID=2177508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US108034D Expired - Lifetime US108034A (en) | Improvement in putting up medicines |
Country Status (1)
Country | Link |
---|---|
US (1) | US108034A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3863633A (en) * | 1971-06-04 | 1975-02-04 | Pharmacia Ab | Composition containing a substance showing a topical effect on the eye, and a method of preparing the same |
US4179497A (en) * | 1973-12-17 | 1979-12-18 | Merck & Co., Inc. | Solid state ophthalmic medication |
US4265875A (en) * | 1976-07-23 | 1981-05-05 | Inveresk Research International | Controlled release suppositories |
-
0
- US US108034D patent/US108034A/en not_active Expired - Lifetime
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3863633A (en) * | 1971-06-04 | 1975-02-04 | Pharmacia Ab | Composition containing a substance showing a topical effect on the eye, and a method of preparing the same |
US4179497A (en) * | 1973-12-17 | 1979-12-18 | Merck & Co., Inc. | Solid state ophthalmic medication |
US4265875A (en) * | 1976-07-23 | 1981-05-05 | Inveresk Research International | Controlled release suppositories |
US4292300A (en) * | 1976-07-23 | 1981-09-29 | Inveresk Research International | Controlled release suppositories |
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