UA99608C2 - PDGFRb-SPECIFIC INHIBITORS - Google Patents
PDGFRb-SPECIFIC INHIBITORSInfo
- Publication number
- UA99608C2 UA99608C2 UAA200910244A UAA200910244A UA99608C2 UA 99608 C2 UA99608 C2 UA 99608C2 UA A200910244 A UAA200910244 A UA A200910244A UA A200910244 A UAA200910244 A UA A200910244A UA 99608 C2 UA99608 C2 UA 99608C2
- Authority
- UA
- Ukraine
- Prior art keywords
- antagonists
- pdgfrb
- specific inhibitors
- pdgfrβ
- specific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fuel Cell (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Заявленное изобретение относится к новым PDGFRβ- специфическим антителам. Антитела применяют для уменьшения или угнетения роста опухолей. Упомянутые антитела могут также вводиться в комбинации с дополнительными противоопухолевыми лекарственными средствами.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92397907P | 2007-04-17 | 2007-04-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA99608C2 true UA99608C2 (en) | 2012-09-10 |
Family
ID=39837443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200910244A UA99608C2 (en) | 2007-04-17 | 2008-04-17 | PDGFRb-SPECIFIC INHIBITORS |
Country Status (14)
Country | Link |
---|---|
US (3) | US7740850B2 (ru) |
EP (1) | EP2139921A2 (ru) |
JP (1) | JP5209702B2 (ru) |
KR (1) | KR101136262B1 (ru) |
CN (1) | CN101707882A (ru) |
AU (1) | AU2008242444B2 (ru) |
BR (1) | BRPI0810374A2 (ru) |
CA (1) | CA2682390A1 (ru) |
EA (1) | EA019595B1 (ru) |
IL (1) | IL200779A0 (ru) |
MX (1) | MX2009011226A (ru) |
NZ (1) | NZ579734A (ru) |
UA (1) | UA99608C2 (ru) |
WO (1) | WO2008130704A2 (ru) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2604280A3 (en) | 2008-03-27 | 2013-10-16 | ZymoGenetics, Inc. | Compositions and methods for inhibiting PDGFRBETA and VEGF-A |
US20120231537A1 (en) * | 2008-04-30 | 2012-09-13 | Gradalis, Inc. | Highly Pure Plasmid DNA Preparations |
JP5693449B2 (ja) * | 2008-04-30 | 2015-04-01 | グラダリス インク.Gradalis, Inc. | 高純度のプラスミドdna調製物及びその調製方法 |
US20110305672A1 (en) | 2008-07-25 | 2011-12-15 | University Of Georgia Research Foundation, Inc. | COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPs), EPICARDIAL PROGENITOR CELLS (EPCs) AND MULTIPOTENT CD56C CELLS (C56Cs) AND METHODS OF PRODUCING AND USING SAME |
EP2379718B2 (en) | 2008-12-16 | 2020-12-30 | Novartis AG | Yeast display systems |
TW201102068A (en) * | 2009-06-02 | 2011-01-16 | Novartis Ag | Treatment of ophthalmologic disorders mediated by alpha-carbonic anhydrase isoforms |
WO2011036305A2 (en) * | 2009-09-28 | 2011-03-31 | Medizinische Universität Wien | New use of pdgfrbeta inhibitors |
WO2011075185A1 (en) | 2009-12-18 | 2011-06-23 | Oligasis | Targeted drug phosphorylcholine polymer conjugates |
EP3798236B1 (en) | 2011-03-15 | 2022-08-10 | X-Body, Inc. | Antibody screening methods |
CN102250249A (zh) * | 2011-06-18 | 2011-11-23 | 常州亚当生物技术有限公司 | 一种抗VEGF/PDGFRbeta双特异性抗体及其应用 |
CN103857700A (zh) | 2011-08-26 | 2014-06-11 | 梅里麦克制药股份有限公司 | 串联fc双特异性抗体 |
EP3712173B1 (en) | 2011-12-05 | 2023-07-12 | X-Body, Inc. | Pdgf receptor beta binding polypeptides |
TWI613215B (zh) | 2012-02-22 | 2018-02-01 | 再生元醫藥公司 | 抗-大-內皮素-1(big-et-1)抗體及其用途 |
JO3405B1 (ar) * | 2013-01-09 | 2019-10-20 | Regeneron Pharma | الأجسام المضادة لمضاد مستقبل عامل النمو المشتق من الصفائح الدموية - بيتا واستخداماتها |
KR20150143458A (ko) | 2013-03-06 | 2015-12-23 | 메리맥 파마슈티컬즈, 인크. | 항-C-MET 탠덤 Fc 이중특이적 항체 |
EP3041513B1 (en) | 2013-09-08 | 2020-08-05 | Kodiak Sciences Inc. | Factor viii zwitterionic polymer conjugates |
US9914769B2 (en) | 2014-07-15 | 2018-03-13 | Kymab Limited | Precision medicine for cholesterol treatment |
DE202014010499U1 (de) | 2013-12-17 | 2015-10-20 | Kymab Limited | Targeting von humaner PCSK9 zur Cholesterinbehandlung |
KR102127408B1 (ko) * | 2014-01-29 | 2020-06-29 | 삼성전자주식회사 | 항 Her3 scFv 단편 및 이를 포함하는 항 c-Met/항 Her3 이중 특이 항체 |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
EP3207128B1 (en) | 2014-10-17 | 2022-07-27 | Kodiak Sciences Inc. | Butyrylcholinesterase zwitterionic polymer conjugates |
JP2018517660A (ja) | 2015-03-20 | 2018-07-05 | ヨハン ウォルフガング ゲーテ−ウニベルジテート フランクフルト アム マイン | 周皮細胞長鎖非コーディングrna |
WO2017106609A2 (en) * | 2015-12-16 | 2017-06-22 | Kadmon Corporation, Llc. | Pdgfr beta antibody |
MX2018005384A (es) | 2015-12-16 | 2018-08-16 | Regeneron Pharma | Composiciones y metodos para fabricar microparticulas de proteina. |
SG11201805420SA (en) | 2015-12-30 | 2018-07-30 | Kodiak Sciences Inc | Antibodies and conjugates thereof |
AU2017348475B2 (en) * | 2016-10-30 | 2024-02-08 | Shanghai Henlius Biotech, Inc. | Anti-PD-L1 antibodies and variants |
WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
WO2018169785A2 (en) * | 2017-03-13 | 2018-09-20 | The Government Of The United States Of America As Represented By The Secretary Of The Army | Therapeutic antibodies to marburg virus |
CN109021104B (zh) * | 2017-06-12 | 2022-08-12 | 上海睿智化学研究有限公司 | 一种抗人血小板衍生生长因子β受体的抗体及其应用 |
US11795221B2 (en) | 2018-02-28 | 2023-10-24 | WuXi Biologics Ireland Limited | Monoclonal antibody against human LAG-3, method for preparing the same, and use thereof |
DE102018204828A1 (de) | 2018-03-29 | 2019-10-02 | Ford Global Technologies, Llc | Verhinderung von Glatteis durch Abwasser von Kraftfahrzeugen |
US11773155B2 (en) | 2018-08-09 | 2023-10-03 | Beijing Wisdomab Biotechnology Co., Ltd | Bispecific antibody against rabies virus, and application thereof |
WO2020071881A1 (ko) * | 2018-10-05 | 2020-04-09 | 서울대학교산학협력단 | Pdgf 수용체에 대한 항체 및 이의 용도 |
CN114786731A (zh) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
KR20220140551A (ko) * | 2020-02-07 | 2022-10-18 | 바이오리온 테크놀러지스 비.브이. | 혈소판 유래 성장 인자 수용체(pdgfr) 항체, 이의 컨쥬게이트, 조성물 및 용도 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
JPH06507543A (ja) | 1991-01-31 | 1994-09-01 | コア セラピューティクス,インコーポレイティド | ヒト血小板由来成長因子レセプターポリペプチドの細胞外領域ドメイン |
US20020009443A1 (en) * | 1991-12-02 | 2002-01-24 | Vanitha Ramakrishman | Inhibitory immunoglobulin polypeptides to human pdgf beta receptor |
PT1696031E (pt) | 1991-12-02 | 2010-06-25 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
US5817310A (en) * | 1991-12-02 | 1998-10-06 | Cor Therapeutics, Inc. | Inhibitory immunoglobulin polypeptides to human PDGF beta receptor |
US5620687A (en) | 1993-02-25 | 1997-04-15 | Zymogenetics, Inc. | Inhibition of intimal hyperplasia using antibodies to PDGF beta receptors |
US5976534A (en) | 1993-02-25 | 1999-11-02 | Zymogenetics, Inc. | Inhibition of intimal hyperplasia using antibodies to PDGF receptors and heparin |
US5840299A (en) * | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
US6811779B2 (en) * | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
US5882644A (en) | 1996-03-22 | 1999-03-16 | Protein Design Labs, Inc. | Monoclonal antibodies specific for the platelet derived growth factor β receptor and methods of use thereof |
US6259971B1 (en) * | 1997-06-30 | 2001-07-10 | Compaq Computer Corporation | Portable fuel-cell-powered system with ultrasonic atomization of H2O by-product |
US7740841B1 (en) | 2000-01-28 | 2010-06-22 | Sunnybrook Health Science Center | Therapeutic method for reducing angiogenesis |
US20020103345A1 (en) | 2000-05-24 | 2002-08-01 | Zhenping Zhu | Bispecific immunoglobulin-like antigen binding proteins and method of production |
US7413823B2 (en) * | 2000-09-22 | 2008-08-19 | Siemens Aktiengesellschaft | Method for monitoring the discharge of media out of fuel cell, and a fuel cell system |
EP1313161A1 (en) * | 2001-11-15 | 2003-05-21 | Ballard Power Systems AG | Fuel cell system and method for operating the same |
US7582726B2 (en) * | 2003-11-10 | 2009-09-01 | Ghc Research Development Corporation | VEGF receptor antagonists |
EP1786918A4 (en) | 2004-07-17 | 2009-02-11 | Imclone Systems Inc | NEW BISPECIFIC ANTIBODY TETRAVALENT |
WO2008011216A2 (en) | 2006-05-16 | 2008-01-24 | Pro-Pharmaceuticals, Inc. | Galactose-pronged polysaccharides in a formulation for antifibrotic therapies |
-
2008
- 2008-04-17 WO PCT/US2008/005137 patent/WO2008130704A2/en active Application Filing
- 2008-04-17 CN CN200880012257A patent/CN101707882A/zh active Pending
- 2008-04-17 EP EP08743156A patent/EP2139921A2/en not_active Withdrawn
- 2008-04-17 NZ NZ579734A patent/NZ579734A/en not_active IP Right Cessation
- 2008-04-17 KR KR1020097021652A patent/KR101136262B1/ko not_active IP Right Cessation
- 2008-04-17 CA CA002682390A patent/CA2682390A1/en not_active Abandoned
- 2008-04-17 AU AU2008242444A patent/AU2008242444B2/en not_active Ceased
- 2008-04-17 UA UAA200910244A patent/UA99608C2/ru unknown
- 2008-04-17 MX MX2009011226A patent/MX2009011226A/es active IP Right Grant
- 2008-04-17 US US12/148,482 patent/US7740850B2/en not_active Expired - Fee Related
- 2008-04-17 JP JP2010504124A patent/JP5209702B2/ja not_active Expired - Fee Related
- 2008-04-17 EA EA200970953A patent/EA019595B1/ru not_active IP Right Cessation
- 2008-04-17 BR BRPI0810374-7A2A patent/BRPI0810374A2/pt not_active IP Right Cessation
- 2008-06-25 US US12/674,350 patent/US20110207005A1/en not_active Abandoned
-
2009
- 2009-09-07 IL IL200779A patent/IL200779A0/en unknown
-
2010
- 2010-04-21 US US12/764,121 patent/US20100221267A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2008130704A3 (en) | 2008-12-24 |
EA019595B1 (ru) | 2014-04-30 |
US7740850B2 (en) | 2010-06-22 |
WO2008130704A2 (en) | 2008-10-30 |
AU2008242444A1 (en) | 2008-10-30 |
US20100221267A1 (en) | 2010-09-02 |
EP2139921A2 (en) | 2010-01-06 |
IL200779A0 (en) | 2010-05-17 |
CA2682390A1 (en) | 2008-10-30 |
AU2008242444B2 (en) | 2013-05-02 |
US20110207005A1 (en) | 2011-08-25 |
JP5209702B2 (ja) | 2013-06-12 |
BRPI0810374A2 (pt) | 2014-10-29 |
MX2009011226A (es) | 2010-04-01 |
KR20090130382A (ko) | 2009-12-23 |
US20090053241A1 (en) | 2009-02-26 |
CN101707882A (zh) | 2010-05-12 |
JP2010524466A (ja) | 2010-07-22 |
NZ579734A (en) | 2012-01-12 |
KR101136262B1 (ko) | 2012-07-05 |
EA200970953A1 (ru) | 2010-10-29 |
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