UA99602C2 - Антитело, специфически связывающееся с jam-a, способное ингибировать пролиферацию опухолевых клеток - Google Patents
Антитело, специфически связывающееся с jam-a, способное ингибировать пролиферацию опухолевых клетокInfo
- Publication number
- UA99602C2 UA99602C2 UAA200906473A UAA200906473A UA99602C2 UA 99602 C2 UA99602 C2 UA 99602C2 UA A200906473 A UAA200906473 A UA A200906473A UA A200906473 A UAA200906473 A UA A200906473A UA 99602 C2 UA99602 C2 UA 99602C2
- Authority
- UA
- Ukraine
- Prior art keywords
- jam
- proliferation
- antibody
- inhibiting
- tumor cells
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Изобретение относится к антителу или его функциональному фрагменту, специфически связывающемуся с JAM-A (антитела, обозначенного как 6F4), способному ингибировать пролиферацию опухолевых клеток in vitro и/или in vivo, нуклеиновой кислоты, кодирующей его, вектору, клетке-хозяину, способу получения антитела, мышиной гибридоме, продуцирующей антитело, депонированной в CNCM под номером I-3646, а также к гуманизированному антителу, полученному из исходного мышиного антитела. Изобретение также относится к композиции, содержащей данное антитело, и применению антитела для изготовления лекарства для профилактики или лечения заболевания, связанного с пролиферацией клеток.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0610329A FR2909092B1 (fr) | 2006-11-24 | 2006-11-24 | Nouveaux anticorps anti-proliferation |
Publications (1)
Publication Number | Publication Date |
---|---|
UA99602C2 true UA99602C2 (ru) | 2012-09-10 |
Family
ID=37903981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200906473A UA99602C2 (ru) | 2006-11-24 | 2007-11-23 | Антитело, специфически связывающееся с jam-a, способное ингибировать пролиферацию опухолевых клеток |
Country Status (28)
Country | Link |
---|---|
US (2) | US8071730B2 (ru) |
EP (1) | EP2074148A1 (ru) |
JP (1) | JP2010509931A (ru) |
KR (1) | KR20090088878A (ru) |
CN (1) | CN101535344B (ru) |
AU (1) | AU2007324509B2 (ru) |
BR (1) | BRPI0719323A2 (ru) |
CA (1) | CA2670039A1 (ru) |
CL (1) | CL2007003357A1 (ru) |
CR (1) | CR10788A (ru) |
CU (1) | CU23792A3 (ru) |
EC (1) | ECSP099341A (ru) |
FR (1) | FR2909092B1 (ru) |
GE (1) | GEP20125629B (ru) |
GT (1) | GT200900126A (ru) |
HK (1) | HK1132752A1 (ru) |
IL (1) | IL198744A0 (ru) |
MA (1) | MA30891B1 (ru) |
MX (1) | MX2009005293A (ru) |
NI (1) | NI200900079A (ru) |
NO (1) | NO20092360L (ru) |
NZ (1) | NZ576174A (ru) |
RU (1) | RU2451689C2 (ru) |
SA (1) | SA07280637B1 (ru) |
TN (1) | TN2009000194A1 (ru) |
TW (1) | TW200829602A (ru) |
UA (1) | UA99602C2 (ru) |
WO (1) | WO2008062063A1 (ru) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JOP20080381B1 (ar) | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
US8187601B2 (en) | 2008-07-01 | 2012-05-29 | Aveo Pharmaceuticals, Inc. | Fibroblast growth factor receptor 3 (FGFR3) binding proteins |
JP2013509191A (ja) * | 2009-10-30 | 2013-03-14 | メルク・シャープ・エンド・ドーム・コーポレイション | Ax1およびax189pcsk9アンタゴニストおよびバリアント |
EA201390472A1 (ru) * | 2010-10-29 | 2014-02-28 | Иммьюноджен, Инк. | Новые молекулы, связывающиеся с egfr, и их иммуноконъюгаты |
EP2455403A1 (en) | 2010-11-23 | 2012-05-23 | Pierre Fabre Medicament | Homogeneous humanized antibodies against JAM-A that inhibit proliferation |
US20130287790A1 (en) * | 2012-03-30 | 2013-10-31 | The Board Of Trustees Of The Leland Standford Junior University | Use of jam-a in diagnosing and treating leukemia |
MY181648A (en) | 2012-08-24 | 2020-12-30 | Univ California | Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis |
KR20150097304A (ko) | 2014-02-18 | 2015-08-26 | 삼성전자주식회사 | 항 EGFR DARPin을 포함하는 EGFR/HER2 이중 특이 항체 |
BR112018067522A2 (pt) | 2016-03-01 | 2019-02-05 | Univ Of Rijeka Faculty Of Medicine | anticorpos específicos para receptor de poliovírus humano (pvr) |
CA3029003A1 (en) | 2016-06-27 | 2018-01-04 | The Regents Of The University Of California | Cancer treatment combinations |
CN109789197A (zh) * | 2016-08-03 | 2019-05-21 | 奈斯科尔公司 | 用于调节lair信号转导的组合物和方法 |
CN109022366A (zh) * | 2018-08-16 | 2018-12-18 | 江南大学 | 一株分泌抗左旋咪唑单克隆抗体的杂交瘤细胞株及其应用 |
CN114740108B (zh) * | 2022-03-28 | 2023-07-14 | 天津键凯科技有限公司 | 一种聚合物修饰抗体类药物的修饰度的测定方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9604470D0 (sv) * | 1996-12-04 | 1996-12-04 | Tamas Bartfai Konsulting Ab | Transmembrane component of tight junction |
US6235883B1 (en) * | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
US20030171568A1 (en) * | 1998-09-16 | 2003-09-11 | Avi Ashkenazi | Use of A33 antigens and JAM-IT |
ES2364266T3 (es) * | 1998-04-03 | 2011-08-30 | Chugai Seiyaku Kabushiki Kaisha | Anticuerpo humanizado hacia el factor tisular humano (tf) y procedimiento para construir el anticuerpo humanizado. |
EP2292761A1 (en) * | 1999-03-11 | 2011-03-09 | Merck Serono S.A. | Vascular adhesion molecules and modulation of their function |
WO2005060457A2 (en) * | 2003-12-04 | 2005-07-07 | Pdl Biopharma, Inc. | Treatment of inflammatory bowel diseases with anti-ip-10 antibodies |
WO2006008076A2 (en) * | 2004-07-16 | 2006-01-26 | Universita Degli Studi Di Milano | Methods and agents stimulating the immune response |
EP1888639A1 (en) * | 2005-05-12 | 2008-02-20 | Oncotherapy Science, Inc. | Methods for damaging cells using effector function of anti-dsc2 antibody |
US7981628B2 (en) * | 2006-04-28 | 2011-07-19 | Oregon Health & Science University | Monoclonal antibodies and their use |
-
2006
- 2006-11-24 FR FR0610329A patent/FR2909092B1/fr not_active Expired - Fee Related
-
2007
- 2007-11-23 KR KR1020097009675A patent/KR20090088878A/ko not_active Application Discontinuation
- 2007-11-23 WO PCT/EP2007/062760 patent/WO2008062063A1/en active Application Filing
- 2007-11-23 EP EP07847306A patent/EP2074148A1/en not_active Withdrawn
- 2007-11-23 NZ NZ576174A patent/NZ576174A/en not_active IP Right Cessation
- 2007-11-23 BR BRPI0719323-8A patent/BRPI0719323A2/pt not_active IP Right Cessation
- 2007-11-23 JP JP2009537651A patent/JP2010509931A/ja not_active Ceased
- 2007-11-23 CN CN2007800405398A patent/CN101535344B/zh not_active Expired - Fee Related
- 2007-11-23 UA UAA200906473A patent/UA99602C2/ru unknown
- 2007-11-23 MX MX2009005293A patent/MX2009005293A/es active IP Right Grant
- 2007-11-23 RU RU2009123409/10A patent/RU2451689C2/ru not_active IP Right Cessation
- 2007-11-23 CL CL200703357A patent/CL2007003357A1/es unknown
- 2007-11-23 CA CA002670039A patent/CA2670039A1/en not_active Abandoned
- 2007-11-23 AU AU2007324509A patent/AU2007324509B2/en not_active Ceased
- 2007-11-23 GE GEAP200711322A patent/GEP20125629B/en unknown
- 2007-11-24 SA SA07280637A patent/SA07280637B1/ar unknown
- 2007-11-26 TW TW096144763A patent/TW200829602A/zh unknown
-
2008
- 2008-05-22 US US12/125,726 patent/US8071730B2/en not_active Expired - Fee Related
-
2009
- 2009-05-06 NI NI200900079A patent/NI200900079A/es unknown
- 2009-05-08 CR CR10788A patent/CR10788A/es unknown
- 2009-05-14 MA MA31875A patent/MA30891B1/fr unknown
- 2009-05-14 IL IL198744A patent/IL198744A0/en unknown
- 2009-05-14 CU CU20090082A patent/CU23792A3/es not_active IP Right Cessation
- 2009-05-14 GT GT200900126A patent/GT200900126A/es unknown
- 2009-05-18 TN TNP2009000194A patent/TN2009000194A1/fr unknown
- 2009-05-18 EC EC2009009341A patent/ECSP099341A/es unknown
- 2009-06-19 NO NO20092360A patent/NO20092360L/no not_active Application Discontinuation
-
2010
- 2010-01-12 HK HK10100290.5A patent/HK1132752A1/xx not_active IP Right Cessation
-
2011
- 2011-12-05 US US13/310,840 patent/US20120156191A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN101535344A (zh) | 2009-09-16 |
US20120156191A1 (en) | 2012-06-21 |
MA30891B1 (fr) | 2009-11-02 |
FR2909092B1 (fr) | 2012-10-19 |
CL2007003357A1 (es) | 2008-04-04 |
BRPI0719323A2 (pt) | 2014-02-04 |
RU2009123409A (ru) | 2010-12-27 |
GEP20125629B (en) | 2012-09-10 |
CN101535344B (zh) | 2013-10-16 |
TN2009000194A1 (en) | 2010-10-18 |
MX2009005293A (es) | 2009-08-07 |
NI200900079A (es) | 2010-11-10 |
FR2909092A1 (fr) | 2008-05-30 |
IL198744A0 (en) | 2010-02-17 |
CU23792A3 (es) | 2012-03-15 |
NZ576174A (en) | 2012-03-30 |
EP2074148A1 (en) | 2009-07-01 |
WO2008062063A1 (en) | 2008-05-29 |
US20100092455A1 (en) | 2010-04-15 |
TW200829602A (en) | 2008-07-16 |
SA07280637B1 (ar) | 2012-04-11 |
CR10788A (es) | 2009-06-23 |
ECSP099341A (es) | 2009-06-30 |
US8071730B2 (en) | 2011-12-06 |
JP2010509931A (ja) | 2010-04-02 |
RU2451689C2 (ru) | 2012-05-27 |
AU2007324509B2 (en) | 2013-01-17 |
NO20092360L (no) | 2009-08-11 |
CA2670039A1 (en) | 2008-05-29 |
GT200900126A (es) | 2011-09-02 |
HK1132752A1 (en) | 2010-03-05 |
AU2007324509A1 (en) | 2008-05-29 |
KR20090088878A (ko) | 2009-08-20 |
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