UA95488C2 - Концентрированный раствор метотрексата для подкожного введения - Google Patents
Концентрированный раствор метотрексата для подкожного введенияInfo
- Publication number
- UA95488C2 UA95488C2 UAA200901346A UAA200901346A UA95488C2 UA 95488 C2 UA95488 C2 UA 95488C2 UA A200901346 A UAA200901346 A UA A200901346A UA A200901346 A UAA200901346 A UA A200901346A UA 95488 C2 UA95488 C2 UA 95488C2
- Authority
- UA
- Ukraine
- Prior art keywords
- concentrated
- ready
- carpule
- methotrexate solution
- subcutaneous introduction
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Описаны концентрированные растворы метотрексата, пригодные для применения активного вещества при производстве лекарственного средства, которое вводят подкожно, для лечения воспалительных аутоиммунных заболеваний. Метотрексат добавляют к фармацевтически приемлемому растворителю при концентрации 50 мг/мл. Данное изобретение также относится к готовому шприцу и карпуле, содержащей такой фармацевтический раствор, а также к ручке-иньектору, которая содержит такую карпулу и/или готовый шприц.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006033837A DE102006033837A1 (de) | 2006-07-21 | 2006-07-21 | Konzentrierte Methotrexat-Lösungen |
Publications (1)
Publication Number | Publication Date |
---|---|
UA95488C2 true UA95488C2 (ru) | 2011-08-10 |
Family
ID=38640096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200901346A UA95488C2 (ru) | 2006-07-21 | 2007-07-20 | Концентрированный раствор метотрексата для подкожного введения |
Country Status (22)
Country | Link |
---|---|
US (7) | US8664231B2 (ru) |
EP (2) | EP2046332B1 (ru) |
JP (1) | JP5683810B2 (ru) |
KR (1) | KR101260554B1 (ru) |
AT (2) | ATE491455T1 (ru) |
AU (1) | AU2007276387B2 (ru) |
BR (1) | BRPI0715433A2 (ru) |
CA (2) | CA2869671A1 (ru) |
CY (1) | CY1111159T1 (ru) |
DE (3) | DE102006033837A1 (ru) |
DK (1) | DK2046332T3 (ru) |
ES (1) | ES2355399T3 (ru) |
HR (1) | HRP20110148T1 (ru) |
ME (1) | ME01940B (ru) |
MX (1) | MX2009000812A (ru) |
PL (1) | PL2046332T3 (ru) |
PT (1) | PT2046332E (ru) |
RS (1) | RS51688B (ru) |
RU (1) | RU2403044C1 (ru) |
SI (1) | SI2046332T1 (ru) |
UA (1) | UA95488C2 (ru) |
WO (1) | WO2008009476A2 (ru) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20040103930A (ko) | 2002-02-11 | 2004-12-09 | 앤태어스 파머, 인코퍼레이티드 | 피내 주사기 |
ES2716135T5 (es) | 2005-01-24 | 2023-06-15 | Antares Pharma Inc | Inyector de chorro asistido por aguja con jeringa precargada |
WO2007131025A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Injector with adjustable dosing |
US8251947B2 (en) | 2006-05-03 | 2012-08-28 | Antares Pharma, Inc. | Two-stage reconstituting injector |
DE102006033837A1 (de) * | 2006-07-21 | 2008-01-31 | Medac Gesellschaft für klinische Spezialpräparate m.b.H | Konzentrierte Methotrexat-Lösungen |
CN101605547A (zh) * | 2006-11-21 | 2009-12-16 | 卡罗拜奥斯制药公司 | 使用gm-csf拮抗剂治疗慢性炎症疾病的方法 |
US8814834B2 (en) | 2008-03-10 | 2014-08-26 | Antares Pharma, Inc. | Injector safety device |
ES2738539T3 (es) | 2008-08-05 | 2020-01-23 | Antares Pharma Inc | Inyector de dosis múltiples |
JP5732039B2 (ja) | 2009-03-20 | 2015-06-10 | アンタレス・ファーマ・インコーポレーテッド | 危険有害性薬剤の注入システム |
US9770414B2 (en) | 2010-05-13 | 2017-09-26 | Pacira Pharmaceuticals, Inc. | Sustained release formulation of methotrexate as a disease-modifying antirheumatic drug (DMARD) and an anti-cancer agent |
US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
GB201200192D0 (en) | 2012-01-06 | 2012-02-22 | Rosemont Pharmaceuticals Ltd | Methotrexate composition |
PT2822618T (pt) | 2012-03-06 | 2024-03-04 | Antares Pharma Inc | Seringa pré-cheia com característica de força de rutura |
JP6457383B2 (ja) | 2012-04-06 | 2019-01-23 | アンタレス・ファーマ・インコーポレーテッド | テストステロン組成物の針支援式ジェット注入投与 |
WO2013169800A1 (en) | 2012-05-07 | 2013-11-14 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
EP2950856B1 (en) | 2013-01-29 | 2023-10-11 | Sanofi-Aventis Deutschland GmbH | Electronic module and drug delivery device |
EP4349383A3 (en) | 2013-02-11 | 2024-06-19 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
CA2905031C (en) | 2013-03-11 | 2018-01-23 | Hans PFLAUMER | Dosage injector with pinion system |
WO2014165136A1 (en) * | 2013-03-12 | 2014-10-09 | Antares Pharma, Inc. | Constant volume prefilled syringes and kits thereof |
WO2015147018A1 (ja) * | 2014-03-28 | 2015-10-01 | テルモ株式会社 | 炎症性自己免疫疾患治療用の注射用水性製剤 |
US20150297600A1 (en) * | 2014-04-16 | 2015-10-22 | Antares Pharma, Inc. | Method Of Achieving Increased Systemic Availability of Methotrexate |
WO2015183213A1 (en) | 2014-05-28 | 2015-12-03 | Onko İlaç Sanayi̇ Ve Ti̇caret A. Ş. | Pharmaceutical dosage forms containing n-[4-[[(2,4-diamino-6-pteridinyl)methyl] methylamino] benzoyl]-l- glutamic acid and n-[4-[[(2-amino-3,4- dihydro -4-oxo-6- pteridinyl) methyl] methyl amino] benzoyl]-l-glutamic acid |
JP2017066073A (ja) * | 2015-09-29 | 2017-04-06 | テルモ株式会社 | 炎症性自己免疫疾患治療用の注射用水性製剤およびその保存方法 |
KR102095284B1 (ko) | 2017-05-11 | 2020-04-01 | (주)케어젠 | 메토트렉세이트와 펩타이드의 결합체 |
GB2591681A (en) * | 2018-08-29 | 2021-08-04 | Ftf Pharma Private Ltd | Methotrexate pharmaceutical composition |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4357971A (en) * | 1980-09-19 | 1982-11-09 | Cyberon Corporation | Syringe gauging, loading and injection apparatus |
US5279586A (en) * | 1992-02-04 | 1994-01-18 | Becton, Dickinson And Company | Reusable medication delivery pen |
EP0768902B1 (en) * | 1992-11-19 | 1998-07-15 | Tebro S.A. | Disposable auto-injector for prefilled syringes |
US5593671A (en) | 1994-07-01 | 1997-01-14 | American Cyanamid Company | Method of attenuating lung capillary leak in a mammal |
US5542934A (en) * | 1995-06-02 | 1996-08-06 | Silver; Richard M. | Multiple carpule hypodermic syringe |
US6544504B1 (en) | 1999-07-28 | 2003-04-08 | Schering Corporation | Combined use of interleukin 10 and methotrexate for immuno-modulatory therapy |
CA2439852A1 (en) * | 2001-03-02 | 2002-09-12 | Christine Dingivan | Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphav beta3 antagonists |
US20040176381A1 (en) * | 2003-03-06 | 2004-09-09 | Walsh Michael J. | Methotrexate compliance packaging |
US20050153969A1 (en) * | 2004-01-13 | 2005-07-14 | Iomed, Inc. | Methods for treating neoplastic, angiogenic, fibroblastic, and/or immunosuppressive ocular irregularities via administration of methotrexate based medicaments, and ocular iontophoretic devices for delivering methotrexate based medicament |
DE102006033837A1 (de) | 2006-07-21 | 2008-01-31 | Medac Gesellschaft für klinische Spezialpräparate m.b.H | Konzentrierte Methotrexat-Lösungen |
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2006
- 2006-07-21 DE DE102006033837A patent/DE102006033837A1/de active Pending
-
2007
- 2007-07-20 RS RS20110010A patent/RS51688B/en unknown
- 2007-07-20 DE DE502007005972T patent/DE502007005972D1/de active Active
- 2007-07-20 MX MX2009000812A patent/MX2009000812A/es active IP Right Grant
- 2007-07-20 RU RU2009106053/15A patent/RU2403044C1/ru active
- 2007-07-20 UA UAA200901346A patent/UA95488C2/ru unknown
- 2007-07-20 KR KR1020097003655A patent/KR101260554B1/ko active IP Right Grant
- 2007-07-20 EP EP07786239A patent/EP2046332B1/de active Active
- 2007-07-20 US US12/374,528 patent/US8664231B2/en active Active
- 2007-07-20 SI SI200730475T patent/SI2046332T1/sl unknown
- 2007-07-20 WO PCT/EP2007/006491 patent/WO2008009476A2/de active Application Filing
- 2007-07-20 PL PL07786239T patent/PL2046332T3/pl unknown
- 2007-07-20 BR BRPI0715433-0A patent/BRPI0715433A2/pt not_active Application Discontinuation
- 2007-07-20 AU AU2007276387A patent/AU2007276387B2/en active Active
- 2007-07-20 JP JP2009521153A patent/JP5683810B2/ja active Active
- 2007-07-20 CA CA2869671A patent/CA2869671A1/en not_active Abandoned
- 2007-07-20 DE DE202007019703.9U patent/DE202007019703U1/de not_active Expired - Lifetime
- 2007-07-20 AT AT07786239T patent/ATE491455T1/de active
- 2007-07-20 AT ATGM50122/2015U patent/AT14872U1/de not_active IP Right Cessation
- 2007-07-20 EP EP10194145A patent/EP2292235A3/de not_active Withdrawn
- 2007-07-20 ES ES07786239T patent/ES2355399T3/es active Active
- 2007-07-20 DK DK07786239.9T patent/DK2046332T3/da active
- 2007-07-20 CA CA2659662A patent/CA2659662C/en active Active
- 2007-07-20 ME MEP-2011-207A patent/ME01940B/me unknown
- 2007-07-20 PT PT07786239T patent/PT2046332E/pt unknown
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2011
- 2011-02-03 CY CY20111100118T patent/CY1111159T1/el unknown
- 2011-02-28 HR HR20110148T patent/HRP20110148T1/hr unknown
-
2014
- 2014-02-07 US US14/175,357 patent/US20140155405A1/en not_active Abandoned
- 2014-03-03 US US14/195,117 patent/US20140179703A1/en not_active Abandoned
-
2015
- 2015-03-02 US US14/635,542 patent/US20150164902A1/en not_active Abandoned
-
2017
- 2017-05-11 US US15/592,882 patent/US20170246172A1/en not_active Abandoned
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2018
- 2018-10-05 US US16/152,463 patent/US10610531B2/en active Active
-
2020
- 2020-02-25 US US16/800,584 patent/US11944629B2/en active Active
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