UA89976C2 - Применение цианиновых красителей для диагностики пролиферативных болезней - Google Patents

Применение цианиновых красителей для диагностики пролиферативных болезней

Info

Publication number
UA89976C2
UA89976C2 UAA200708556A UAA200708556A UA89976C2 UA 89976 C2 UA89976 C2 UA 89976C2 UA A200708556 A UAA200708556 A UA A200708556A UA A200708556 A UAA200708556 A UA A200708556A UA 89976 C2 UA89976 C2 UA 89976C2
Authority
UA
Ukraine
Prior art keywords
diagnosis
proliferative diseases
cyanine dyes
administration
less
Prior art date
Application number
UAA200708556A
Other languages
English (en)
Ukrainian (uk)
Inventor
Кай Лиха
Мартин Пессель
Мальте Банер
Михаэль Ширнер
Original Assignee
Байер Шеринг Фарма Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34933224&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA89976(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Байер Шеринг Фарма Акциенгезельшафт filed Critical Байер Шеринг Фарма Акциенгезельшафт
Publication of UA89976C2 publication Critical patent/UA89976C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Данное изобретение касается применения цианинового красителя SF64 для диагностики пролиферативных заболеваний при введении в количестве меньше 5 мг/кг массы тела.
UAA200708556A 2005-01-07 2006-01-05 Применение цианиновых красителей для диагностики пролиферативных болезней UA89976C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05000276A EP1679082A1 (en) 2005-01-07 2005-01-07 Use of cyanine dyes for the diagnosis of proliferative diseases

Publications (1)

Publication Number Publication Date
UA89976C2 true UA89976C2 (ru) 2010-03-25

Family

ID=34933224

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200708556A UA89976C2 (ru) 2005-01-07 2006-01-05 Применение цианиновых красителей для диагностики пролиферативных болезней

Country Status (23)

Country Link
EP (2) EP1679082A1 (ru)
JP (1) JP5578765B2 (ru)
KR (1) KR20070092270A (ru)
CN (1) CN101128218A (ru)
AR (1) AR052190A1 (ru)
AU (1) AU2006204496A1 (ru)
BR (1) BRPI0606411A2 (ru)
CA (1) CA2594390C (ru)
CR (1) CR9232A (ru)
DO (1) DOP2006000005A (ru)
GT (1) GT200600001A (ru)
IL (1) IL182499A0 (ru)
MX (1) MX2007008300A (ru)
NO (1) NO20074036L (ru)
NZ (1) NZ554917A (ru)
PA (1) PA8659101A1 (ru)
PE (2) PE20060872A1 (ru)
RU (1) RU2007129919A (ru)
TW (1) TW200635612A (ru)
UA (1) UA89976C2 (ru)
UY (1) UY29323A1 (ru)
WO (1) WO2006072580A1 (ru)
ZA (1) ZA200706533B (ru)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1619501B1 (en) * 2004-07-22 2007-09-26 Bayer Schering Pharma Aktiengesellschaft Use of cyanine dyes for the diagnosis of disease associated with angiogenesis
EP1679082A1 (en) * 2005-01-07 2006-07-12 Schering AG Use of cyanine dyes for the diagnosis of proliferative diseases
EP1743658A1 (en) * 2005-07-14 2007-01-17 Schering Aktiengesellschaft Optical imaging of rheumatoid arthritis
US20100119457A1 (en) * 2007-03-30 2010-05-13 Helmut Lenz Composition of labeled and non-labeled monoclonal antibodies
WO2009012109A2 (en) 2007-07-13 2009-01-22 Emory University Cyanine-containing compounds for cancer imaging and treatment
GB0803477D0 (en) 2008-02-26 2008-04-02 Ge Healthcare As Therapy selection method
CN105288645A (zh) * 2008-06-13 2016-02-03 西塞医疗中心 用于癌症靶向治疗的小分子配体-药物轭合物
GB0814960D0 (en) * 2008-08-15 2008-09-24 Ge Healthcare As Method for detecting dysplasia
WO2011003996A1 (en) 2009-07-09 2011-01-13 F. Hoffmann-La Roche Ag In vivo tumor vasculature imaging
CN102548466A (zh) 2009-07-28 2012-07-04 霍夫曼-拉罗奇有限公司 非侵入性体内光学成像方法
JP2011046662A (ja) 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
WO2011025950A2 (en) 2009-08-28 2011-03-03 Visen Medical, Inc. Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique
JP2011046663A (ja) * 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
JP5945226B2 (ja) 2009-09-22 2016-07-05 ビセン メディカル， インコーポレイテッド 拡散媒質の仮想屈折率整合のためのシステムおよび方法
MX2012012736A (es) 2010-05-07 2013-02-26 Hoffmann La Roche Metodo de diagnostico para la deteccion de celulas ex vivo.
EP2683290B1 (en) 2011-03-07 2018-11-07 F.Hoffmann-La Roche Ag Methods for in vivo testing of therapeutic antibodies
JP6385060B2 (ja) 2011-03-07 2018-09-05 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 治療的に活性な抗体のインビボにおける選択
KR101373108B1 (ko) 2012-01-20 2014-03-27 이화여자대학교 산학협력단 폴리메틴 체인에 메조-반응작용기를 갖는 신규한 시아닌 유도체 및 이의 제조방법
CN102608051B (zh) * 2012-02-21 2015-04-08 中国科学院化学研究所 用于诊断白血病的试剂盒
CN102706787B (zh) * 2012-05-24 2015-04-08 中国科学院化学研究所 菁染料的新用途
CN102703569B (zh) * 2012-05-24 2014-04-09 中国科学院化学研究所 菁染料的新用途
US10743768B2 (en) 2012-10-15 2020-08-18 Visen Medical, Inc. Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources
EP2849743B1 (en) 2012-10-26 2019-09-25 Canon Kabushiki Kaisha Cancer cell inhibitory drug and cancer stem-cell detection probe
WO2014092958A1 (en) * 2012-12-10 2014-06-19 Molecular Targeting Technologies, Inc. Compositions and methods of diagnosing ocular diseases
AU2014373656B2 (en) 2013-12-31 2019-12-05 Cornell University Systems, methods, and apparatus for multichannel imaging of fluorescent sources in real time
RU2565645C1 (ru) * 2014-09-05 2015-10-20 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ рентгендиагностики глубины инвазии рецидива рака вульвы в мягкие ткани
CA2970719C (en) 2014-12-15 2023-08-01 Memorial Sloan Kettering Cancer Center Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging
CA3007657A1 (en) 2015-12-15 2017-06-22 Memorial Sloan Kettering Cancer Center Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization
JP2020500863A (ja) 2016-11-30 2020-01-16 メモリアル スローン ケタリング キャンサー センター 阻害剤官能化超小型ナノ粒子およびその方法
EP4015004A1 (en) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglycan specific branched peptides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000095758A (ja) * 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
DE19947559A1 (de) * 1999-09-24 2001-04-19 Schering Ag Antikörper-Farbstoffkonjugate gegen Zielstrukturen der Angiogenese zur intraoperativen Tumorranddarstellung
CA2514131A1 (en) * 2003-01-24 2004-08-05 Schering Ag Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis
EP1619501B1 (en) * 2004-07-22 2007-09-26 Bayer Schering Pharma Aktiengesellschaft Use of cyanine dyes for the diagnosis of disease associated with angiogenesis
EP1679082A1 (en) * 2005-01-07 2006-07-12 Schering AG Use of cyanine dyes for the diagnosis of proliferative diseases

Also Published As

Publication number Publication date
MX2007008300A (es) 2007-09-07
CA2594390A1 (en) 2006-07-13
UY29323A1 (es) 2006-10-02
CR9232A (es) 2007-11-23
ZA200706533B (en) 2009-07-29
IL182499A0 (en) 2007-09-20
EP1833513B1 (en) 2013-03-06
TW200635612A (en) 2006-10-16
EP1679082A1 (en) 2006-07-12
CA2594390C (en) 2013-10-22
RU2007129919A (ru) 2009-02-20
AU2006204496A1 (en) 2006-07-13
KR20070092270A (ko) 2007-09-12
AR052190A1 (es) 2007-03-07
DOP2006000005A (es) 2006-07-15
GT200600001A (es) 2006-08-22
PA8659101A1 (es) 2006-09-08
NZ554917A (en) 2010-01-29
EP1833513A1 (en) 2007-09-19
NO20074036L (no) 2007-08-03
PE20060872A1 (es) 2006-10-01
JP5578765B2 (ja) 2014-08-27
CN101128218A (zh) 2008-02-20
BRPI0606411A2 (pt) 2009-06-23
PE20100449A1 (es) 2010-07-25
WO2006072580A1 (en) 2006-07-13
JP2008526802A (ja) 2008-07-24

Similar Documents

Publication Publication Date Title
TW200635612A (en) Use of cyanine dyes for the diagnosis of proliferative diseases
TW200700406A (en) Novel thiophene derivatives
MY147949A (en) Hydrogenated benzo[c]thiophene derivatives as immunomodulators
MY154909A (en) Novel thiophene derivatives
DE602005026789D1 (de) Le
EP1906968A4 (en) NEW SCHEMES FOR ORAL MONOPHASIC CONTRAZEPTIVA
NZ591425A (en) Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases
MX2010005889A (es) Derivados de tiofeno como agonistas de s1p1/edg1.
CL2008001303A1 (es) Compuestos derivados de heterociclos, moduladores de gamma secretasa; composicion farmaceutica; kit farmaceutico; y uso en el tratamiento del alzheimer.
PL2026803T3 (pl) Kompozycje R(+) i S(-) pramipeksolu i sposoby ich zastosowania
WO2007025103A3 (en) Organic compounds for treating reduced dopamine receptor signalling activity
TW200626132A (en) Topical nepafenac formulations
TW200731987A (en) Cytotoxicity mediation of cells evidencing surface expression of CD44
WO2007016352A3 (en) Oral liquid losartan compositions
IL191763A0 (en) Pyrrolo [2,3-b]pyridine derivatives as h3 receptor modulators
EP2004637A1 (en) Substituted ring fused azines and their use in cancer therapy
JO2578B1 (en) Compounds Theophene benzimidazole
WO2011053901A3 (en) Magnetic nanostructures as theranostic agents
WO2007095729A8 (en) Cytotoxicity mediation of cells evidencing surface expression of cd63
EP1667716A4 (en) CYTOTOXICITY ASSAY OF CELLS WITH ADVICE ON SURFACE EXPRESSION OF CD44
SI2185561T1 (sl) Derivati 1,2,3,4-tetrahidropirolo(1,2-alfa)pirazin-6-karboksamidov in 2,3,4,5-tetrahidropirolo(1,2-alfa)-diazepin-7-karboksamidov, njihova priprava in njihova terapevtska uporaba
TNSN05226A1 (en) Treatment of proliferative diseases with epothilone derivatives and radiation
WO2008151003A3 (en) Novel fluorine-18 labeled rhodamine derivatives for myocardial perfusion imaging with positron emission tomography
TW200610526A (en) Novel hydrophilic analogs of 4,8-dihydrobenzodithiophene-4,8-diones as anticancer agents
TW200744645A (en) Contrast agents for myocardium perfusion imaging