UA85597C2 - Четвертичные соли как антагонисты ccr2 - Google Patents

Четвертичные соли как антагонисты ccr2

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Publication number
UA85597C2
UA85597C2 UAA200614021A UAA200614021A UA85597C2 UA 85597 C2 UA85597 C2 UA 85597C2 UA A200614021 A UAA200614021 A UA A200614021A UA A200614021 A UAA200614021 A UA A200614021A UA 85597 C2 UA85597 C2 UA 85597C2
Authority
UA
Ukraine
Prior art keywords
quaternary salt
ccr2 antagonists
antagonists
salt ccr2
ccr2
Prior art date
Application number
UAA200614021A
Other languages
English (en)
Ukrainian (uk)
Inventor
Бхарат Лагу
Майкл П. Уочтер
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of UA85597C2 publication Critical patent/UA85597C2/ru

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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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Abstract

(I)Изобретение относится к четвертичным солям Формулы (І) или их фармацевтически приемлемым формам, которые являются антагонистами CCR2, и полезны при предупреждении, лечении или облегчении воспалительных синдромов, расстройств или болезней, опосредованных CCR2, у субъекта, который в этом нуждается.
UAA200614021A 2004-06-25 2005-06-22 Четвертичные соли как антагонисты ccr2 UA85597C2 (ru)

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