UA77165C2 - (n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition - Google Patents

(n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition Download PDF

Info

Publication number: UA77165C2
Authority: UA; Ukraine
Prior art keywords: formula; compound; amino; methyl; group
Prior art date: 2000-11-17

Application number

UA2003054406A

Other languages

English (en)

Ukrainian (uk)

Inventor

James Edmund Audia

Lowell Engel

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-17

Filing date

2001-02-11

Publication date

2006-11-15

2001-02-11 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2006-11-15 Publication of UA77165C2 publication Critical patent/UA77165C2/uk

Links

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239000013049 sediment Substances 0.000 description 1
239000012056 semi-solid material Substances 0.000 description 1
239000004208 shellac Substances 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
229920002545 silicone oil Polymers 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
WRIKHQLVHPKCJU-UHFFFAOYSA-N sodium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([Na])[Si](C)(C)C WRIKHQLVHPKCJU-UHFFFAOYSA-N 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000017550 sodium carbonate Nutrition 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000011343 solid material Substances 0.000 description 1
238000010996 solid-state NMR spectroscopy Methods 0.000 description 1
238000007711 solidification Methods 0.000 description 1
230000008023 solidification Effects 0.000 description 1
230000003595 spectral effect Effects 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
230000000707 stereoselective effect Effects 0.000 description 1
238000012916 structural analysis Methods 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
125000005156 substituted alkylene group Chemical group 0.000 description 1
239000000758 substrate Substances 0.000 description 1
230000001629 suppression Effects 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
238000010998 test method Methods 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
125000005404 thioheteroaryloxy group Chemical group 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
239000003656 tris buffered saline Substances 0.000 description 1
229960001005 tuberculin Drugs 0.000 description 1
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
229910052720 vanadium Inorganic materials 0.000 description 1
229940099259 vaseline Drugs 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
235000012431 wafers Nutrition 0.000 description 1
239000002699 waste material Substances 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
239000002023 wood Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Cephalosporin Compounds (AREA)

UA2003054406A 2000-11-17 2001-02-11 (n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition UA77165C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US24965600P	2000-11-17	2000-11-17
PCT/US2001/027795 WO2002040451A2 (en)	2000-11-17	2001-11-02	Lactam compound

Publications (1)

Publication Number	Publication Date
UA77165C2 true UA77165C2 (en)	2006-11-15

Family

ID=22944436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2003054406A UA77165C2 (en)	2000-11-17	2001-02-11	(n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition

Country Status (33)

Country	Link
US (1)	US20040248878A1 (cs)
EP (1)	EP1353910B1 (cs)
JP (1)	JP4116431B2 (cs)
KR (1)	KR20030045194A (cs)
CN (2)	CN101624372A (cs)
AR (1)	AR031356A1 (cs)
AT (1)	ATE362919T1 (cs)
AU (2)	AU2432102A (cs)
BR (1)	BR0115424A (cs)
CA (1)	CA2425497C (cs)
CY (1)	CY1106682T1 (cs)
CZ (1)	CZ20031340A3 (cs)
DE (1)	DE60128587T2 (cs)
DK (1)	DK1353910T3 (cs)
DZ (1)	DZ3454A1 (cs)
EA (1)	EA006919B1 (cs)
EC (1)	ECSP034598A (cs)
ES (1)	ES2286162T3 (cs)
HR (1)	HRP20030385A2 (cs)
HU (1)	HUP0301862A3 (cs)
IL (1)	IL155275A0 (cs)
MX (1)	MXPA03004250A (cs)
MY (1)	MY141607A (cs)
NO (1)	NO325217B1 (cs)
PE (1)	PE20020798A1 (cs)
PL (1)	PL211018B1 (cs)
PT (1)	PT1353910E (cs)
SK (1)	SK287794B6 (cs)
SV (1)	SV2003000741A (cs)
TW (1)	TWI235151B (cs)
UA (1)	UA77165C2 (cs)
WO (1)	WO2002040451A2 (cs)
ZA (1)	ZA200303411B (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA74849C2 (en) *	2000-11-17	2006-02-15	Lilly Co Eli	Lactam
ATE441417T1 (de)	2002-12-20	2009-09-15	Glaxo Group Ltd	Benzoädüazepinderivate für die behandlung von neurologischen krankheiten
ES2295816T3 (es)	2003-01-14	2008-04-16	Arena Pharmaceuticals, Inc.	Derivados arilo y heteroarilo 1,2,3-trisustituidos como moduladores del metabolismo, y profilaxis y tratamiento de transtornos relacionados con los mismos, tales como la diabetes y la hiperglucemia.
JP5039543B2 (ja)	2005-04-08	2012-10-03	第一三共株式会社	ピリジルメチルスルホン誘導体
US8258302B2 (en) *	2006-01-31	2012-09-04	Api Corporation	Method for producing benzazepinone
TW200920362A (en)	2007-09-11	2009-05-16	Daiichi Sankyo Co Ltd	Alkylsulfone derivatives
FR2932800B1 (fr) *	2008-06-20	2015-02-20	Servier Lab	Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
CN103539791B (zh)	2010-09-22	2017-01-11	艾尼纳制药公司	Gpr119 受体调节剂和对与其相关的障碍的治疗
KR101899014B1 (ko)	2012-01-06	2018-09-17	삼성전자주식회사	비엘디씨 모터의 제어 장치 및 그 방법
CN102690231B (zh) *	2012-04-11	2014-07-09	南京友杰医药科技有限公司	治疗阿尔茨海默病潜在药物司马西特的合成方法
WO2014171434A1 (ja)	2013-04-19	2014-10-23	国立大学法人岡山大学	アミロイドβ蛋白質により誘発される認知障害の治療剤およびアルツハイマー病治療薬、ならびにこれらに関連する治療方法および病態解析方法
CN107405332A (zh)	2015-01-06	2017-11-28	艾尼纳制药公司	治疗与s1p1受体有关的病症的方法
US10301262B2 (en)	2015-06-22	2019-05-28	Arena Pharmaceuticals, Inc.	Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders
EP3582772A1 (en)	2017-02-16	2019-12-25	Arena Pharmaceuticals, Inc.	Compounds and methods for treatment of primary biliary cholangitis
MX2022011800A (es)	2020-03-26	2023-01-19	Seagen Inc	Metodos para tratar mieloma multiple.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ335583A (en) *	1996-12-23	2001-03-30	Lilly Co Eli	Cycloalkyl, lactam, lactone and analogs, and pharmaceutical compositions
WO1999067219A1 (en) *	1998-06-22	1999-12-29	Elan Pharmaceuticals, Inc.	Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
JP2003513958A (ja) *	1999-11-09	2003-04-15	イーライ・リリー・アンド・カンパニー	β−アミロイドペプチド放出および／またはその合成を阻害するために有用なβ−アミノ酸化合物

2001
- 2001-02-11 UA UA2003054406A patent/UA77165C2/uk unknown
- 2001-11-02 AU AU2432102A patent/AU2432102A/xx active Pending
- 2001-11-02 CA CA2425497A patent/CA2425497C/en not_active Expired - Fee Related
- 2001-11-02 JP JP2002542779A patent/JP4116431B2/ja not_active Expired - Fee Related
- 2001-11-02 AU AU2002224321A patent/AU2002224321B2/en not_active Ceased
- 2001-11-02 EA EA200300579A patent/EA006919B1/ru unknown
- 2001-11-02 DK DK01996530T patent/DK1353910T3/da active
- 2001-11-02 EP EP01996530A patent/EP1353910B1/en not_active Expired - Lifetime
- 2001-11-02 AT AT01996530T patent/ATE362919T1/de active
- 2001-11-02 IL IL15527501A patent/IL155275A0/xx unknown
- 2001-11-02 PL PL360991A patent/PL211018B1/pl unknown
- 2001-11-02 WO PCT/US2001/027795 patent/WO2002040451A2/en active IP Right Grant
- 2001-11-02 DZ DZ013454A patent/DZ3454A1/fr active
- 2001-11-02 KR KR10-2003-7006660A patent/KR20030045194A/ko not_active Application Discontinuation
- 2001-11-02 HU HU0301862A patent/HUP0301862A3/hu unknown
- 2001-11-02 CN CN200910203885A patent/CN101624372A/zh active Pending
- 2001-11-02 ES ES01996530T patent/ES2286162T3/es not_active Expired - Lifetime
- 2001-11-02 MX MXPA03004250A patent/MXPA03004250A/es active IP Right Grant
- 2001-11-02 CZ CZ20031340A patent/CZ20031340A3/cs unknown
- 2001-11-02 SK SK543-2003A patent/SK287794B6/sk not_active IP Right Cessation
- 2001-11-02 PT PT01996530T patent/PT1353910E/pt unknown
- 2001-11-02 CN CNB018189962A patent/CN100516047C/zh not_active Expired - Fee Related
- 2001-11-02 US US10/415,548 patent/US20040248878A1/en not_active Abandoned
- 2001-11-02 DE DE60128587T patent/DE60128587T2/de not_active Expired - Lifetime
- 2001-11-02 BR BR0115424-9A patent/BR0115424A/pt not_active Application Discontinuation
- 2001-11-15 TW TW090128351A patent/TWI235151B/zh not_active IP Right Cessation
- 2001-11-15 MY MYPI20015251A patent/MY141607A/en unknown
- 2001-11-15 AR ARP010105339A patent/AR031356A1/es not_active Application Discontinuation
- 2001-11-16 SV SV2001000741A patent/SV2003000741A/es unknown
- 2001-11-16 PE PE2001001143A patent/PE20020798A1/es not_active Application Discontinuation
2003
- 2003-05-02 ZA ZA200303411A patent/ZA200303411B/en unknown
- 2003-05-13 EC EC2003004598A patent/ECSP034598A/es unknown
- 2003-05-14 HR HR20030385A patent/HRP20030385A2/hr not_active Application Discontinuation
- 2003-05-15 NO NO20032215A patent/NO325217B1/no unknown
2007
- 2007-06-28 CY CY20071100848T patent/CY1106682T1/el unknown

Also Published As

Publication number	Publication date
CA2425497C (en)	2010-08-17
EA006919B1 (ru)	2006-04-28
NO325217B1 (no)	2008-02-25
MY141607A (en)	2010-05-31
JP2004521084A (ja)	2004-07-15
CA2425497A1 (en)	2002-05-23
CZ20031340A3 (cs)	2004-06-16
CY1106682T1 (el)	2012-05-23
PT1353910E (pt)	2007-08-20
DK1353910T3 (da)	2007-09-10
PL360991A1 (en)	2004-09-20
EP1353910B1 (en)	2007-05-23
AU2002224321B2 (en)	2006-10-19
DZ3454A1 (fr)	2002-05-23
HUP0301862A2 (hu)	2003-09-29
SK5432003A3 (en)	2004-09-08
IL155275A0 (en)	2003-11-23
TWI235151B (en)	2005-07-01
SK287794B6 (sk)	2011-10-04
DE60128587D1 (de)	2007-07-05
ES2286162T3 (es)	2007-12-01
CN100516047C (zh)	2009-07-22
CN1575282A (zh)	2005-02-02
MXPA03004250A (es)	2003-09-22
PL211018B1 (pl)	2012-03-30
AR031356A1 (es)	2003-09-17
KR20030045194A (ko)	2003-06-09
US20040248878A1 (en)	2004-12-09
HUP0301862A3 (en)	2007-09-28
WO2002040451A2 (en)	2002-05-23
NO20032215L (no)	2003-07-16
NO20032215D0 (no)	2003-05-15
PE20020798A1 (es)	2002-09-06
AU2432102A (en)	2002-05-27
EA200300579A1 (ru)	2003-12-25
ECSP034598A (es)	2003-06-25
WO2002040451A3 (en)	2003-08-28
HRP20030385A2 (en)	2003-08-31
EP1353910A2 (en)	2003-10-22
CN101624372A (zh)	2010-01-13
DE60128587T2 (de)	2008-01-31
ZA200303411B (en)	2004-08-02
ATE362919T1 (de)	2007-06-15
JP4116431B2 (ja)	2008-07-09
SV2003000741A (es)	2003-01-13
BR0115424A (pt)	2003-10-21

Publication	Publication Date	Title
UA74849C2 (en)	2006-02-15	Lactam
UA77165C2 (en)	2006-11-15	(n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition
US7468365B2 (en)	2008-12-23	Lactam compound
JP2004521084A5 (cs)	2005-12-22
AU2002224321A1 (en)	2002-08-01	Lactam compound
EP1345955B1 (en)	2008-08-20	Lactam dipeptide and its use in inhibiting beta-amyloid peptide release
US20040077627A1 (en)	2004-04-22	Lactam compound
WO2023133457A1 (en)	2023-07-13	Novel kalirin inhibitors for regulation of synaptic plasticity and neuropathic pain treatment
NZ525365A (en)	2005-04-29	Lactam compound