UA73727C2 - Способ приготовления кальциевой композиции для перорального применения в форме таблеток - Google Patents
Способ приготовления кальциевой композиции для перорального применения в форме таблеток Download PDFInfo
- Publication number
- UA73727C2 UA73727C2 UA2001053232A UA2001053232A UA73727C2 UA 73727 C2 UA73727 C2 UA 73727C2 UA 2001053232 A UA2001053232 A UA 2001053232A UA 2001053232 A UA2001053232 A UA 2001053232A UA 73727 C2 UA73727 C2 UA 73727C2
- Authority
- UA
- Ukraine
- Prior art keywords
- calcium
- granulate
- mentioned
- water
- vitamin
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract description 44
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 239000011575 calcium Substances 0.000 title claims abstract description 33
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 27
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 239000008187 granular material Substances 0.000 claims abstract description 73
- 229940043430 calcium compound Drugs 0.000 claims abstract description 40
- 150000001674 calcium compounds Chemical class 0.000 claims abstract description 40
- 239000002245 particle Substances 0.000 claims abstract description 37
- 239000003232 water-soluble binding agent Substances 0.000 claims abstract description 20
- 238000002156 mixing Methods 0.000 claims abstract description 18
- 238000001035 drying Methods 0.000 claims abstract description 11
- 239000007864 aqueous solution Substances 0.000 claims abstract description 9
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 77
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 38
- 235000010216 calcium carbonate Nutrition 0.000 claims description 37
- 229960003563 calcium carbonate Drugs 0.000 claims description 37
- 229940088594 vitamin Drugs 0.000 claims description 31
- 229930003231 vitamin Natural products 0.000 claims description 31
- 235000013343 vitamin Nutrition 0.000 claims description 31
- 239000011782 vitamin Substances 0.000 claims description 31
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 30
- 229960005069 calcium Drugs 0.000 claims description 23
- 239000000945 filler Substances 0.000 claims description 22
- 229920001202 Inulin Polymers 0.000 claims description 16
- 238000005469 granulation Methods 0.000 claims description 16
- 230000003179 granulation Effects 0.000 claims description 16
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 16
- 229940029339 inulin Drugs 0.000 claims description 16
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 14
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 12
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 12
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 12
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 claims description 10
- 235000008696 isoflavones Nutrition 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 10
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- 229930003448 Vitamin K Natural products 0.000 claims description 9
- 150000002515 isoflavone derivatives Chemical class 0.000 claims description 9
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 9
- 239000011712 vitamin K Substances 0.000 claims description 9
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- 229940046010 vitamin k Drugs 0.000 claims description 9
- 235000003599 food sweetener Nutrition 0.000 claims description 8
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 7
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- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 6
- 239000005913 Maltodextrin Substances 0.000 claims description 6
- -1 calcium phosphoric acid compound Chemical class 0.000 claims description 6
- 238000009826 distribution Methods 0.000 claims description 6
- 229940035034 maltodextrin Drugs 0.000 claims description 6
- 239000000600 sorbitol Substances 0.000 claims description 6
- 235000010356 sorbitol Nutrition 0.000 claims description 6
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 5
- 239000001506 calcium phosphate Substances 0.000 claims description 5
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 5
- 238000003825 pressing Methods 0.000 claims description 5
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 5
- 239000000811 xylitol Substances 0.000 claims description 5
- 235000010447 xylitol Nutrition 0.000 claims description 5
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 5
- 229960002675 xylitol Drugs 0.000 claims description 5
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
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- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 4
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- 150000004676 glycans Chemical class 0.000 claims description 4
- 239000000905 isomalt Substances 0.000 claims description 4
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- OPSXJNAGCGVGOG-DKWTVANSSA-L Calcium L-aspartate Chemical compound [Ca+2].[O-]C(=O)[C@@H](N)CC([O-])=O OPSXJNAGCGVGOG-DKWTVANSSA-L 0.000 claims description 3
- 239000001736 Calcium glycerylphosphate Substances 0.000 claims description 3
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Abstract
Изобретение относится к приготовлению кальциевой композиции для перорального применения в форме таблеток. В соответствии с изобретением, физиологически приемлемое кальциевое соединение в форме частиц кристаллической структуры величиной 3-40 мкм и удельной площадью поверхности 0,1-1,2 м2/г смешивают с раствором водорастворимого связующего агента вместе с водорастворимым наполнителем в грануляторе с псевдоожиженным слоем. После высушивания полученной смеси получают первый гранулят, в котором упомянутое кальциевое соединение составляет от 60,5 до 96% от массы гранулята. В качестве варианта полученный гранулят может далее смешиваться с одним или несколькими дополнительными компонентами для получения второго гранулята. Таблетки прессуют из первого или второго гранулята.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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GBGB9825033.5A GB9825033D0 (en) | 1998-11-13 | 1998-11-13 | Process |
PCT/GB1999/003666 WO2000028973A1 (en) | 1998-11-13 | 1999-11-05 | Process for preparing oral calcium compositions |
Publications (1)
Publication Number | Publication Date |
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UA73727C2 true UA73727C2 (ru) | 2005-09-15 |
Family
ID=10842483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA2001053232A UA73727C2 (ru) | 1998-11-13 | 1999-05-11 | Способ приготовления кальциевой композиции для перорального применения в форме таблеток |
Country Status (22)
Country | Link |
---|---|
US (3) | US20050232989A1 (ru) |
EP (2) | EP1743629A1 (ru) |
JP (1) | JP4213867B2 (ru) |
CN (1) | CN1183902C (ru) |
AT (1) | ATE342714T1 (ru) |
AU (1) | AU6481999A (ru) |
CA (1) | CA2349565C (ru) |
CY (1) | CY1106299T1 (ru) |
DE (1) | DE69933689T2 (ru) |
DK (1) | DK1128815T3 (ru) |
EA (1) | EA004951B1 (ru) |
EE (1) | EE04740B1 (ru) |
ES (1) | ES2273510T3 (ru) |
GB (1) | GB9825033D0 (ru) |
HK (1) | HK1040615B (ru) |
NO (1) | NO331462B1 (ru) |
PL (1) | PL197146B1 (ru) |
PT (1) | PT1128815E (ru) |
SI (1) | SI1128815T1 (ru) |
TR (1) | TR200101347T2 (ru) |
UA (1) | UA73727C2 (ru) |
WO (1) | WO2000028973A1 (ru) |
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1998
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1999
- 1999-05-11 UA UA2001053232A patent/UA73727C2/ru unknown
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- 1999-11-05 AU AU64819/99A patent/AU6481999A/en not_active Abandoned
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- 1999-11-05 DE DE69933689T patent/DE69933689T2/de not_active Expired - Lifetime
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- 1999-11-05 CA CA002349565A patent/CA2349565C/en not_active Expired - Lifetime
- 1999-11-05 CN CNB998132055A patent/CN1183902C/zh not_active Expired - Lifetime
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- 1999-11-05 EA EA200100415A patent/EA004951B1/ru not_active IP Right Cessation
- 1999-11-05 EE EEP200100260A patent/EE04740B1/xx unknown
- 1999-11-05 EP EP06021395A patent/EP1743629A1/en not_active Withdrawn
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- 1999-11-05 JP JP2000582021A patent/JP4213867B2/ja not_active Expired - Lifetime
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