UA66864C2 - Похідні сечовини, фармацевтична композиція і спосіб лікування або профілактики запальних, аутоімунних або респіраторних захворювань - Google Patents

Похідні сечовини, фармацевтична композиція і спосіб лікування або профілактики запальних, аутоімунних або респіраторних захворювань

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Publication number
UA66864C2
UA66864C2 UA2000127651A UA00127651A UA66864C2 UA 66864 C2 UA66864 C2 UA 66864C2 UA 2000127651 A UA2000127651 A UA 2000127651A UA 00127651 A UA00127651 A UA 00127651A UA 66864 C2 UA66864 C2 UA 66864C2
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Ukraine
Prior art keywords
autoimmune
treating
methods
pharmaceutical composition
respiratory diseases
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UA2000127651A
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English (en)
Russian (ru)
Inventor
Аллен Якоб Дюплантьє
Ентоні Джон Мілічі
Луіс Стенлі Чупак
Луис Стенли Чупак
Original Assignee
Пфайзер Продактс Інк.
Пфайзер Продактс Инк.
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Application filed by Пфайзер Продактс Інк., Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Інк.
Publication of UA66864C2 publication Critical patent/UA66864C2/uk

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
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Abstract

Описані сполуки формули (1.0.0) , (1.0.0) в яких А означає A1-NHC(=O)NH-A2-, де A2 є фенілом і A1 є фенілом або піридилом, де кожен, необов‘язково, заміщений 1 або 2 R10, Y означає -C(=O)-, B означає елемент, незалежно вибраний з групи, яка включає наступні елементи: E означає простий зв’язок, -CH=CH- або замісник формули (1.9.0) , (1.9.0) в якій R1a означає водень у випадку, коли R1 означає моновалентний замісник, і R1a означає простий зв’язок, коли R1 означає дивалентний замісник. Такі сполуки використовуються у способах лікування або профілактики запальних, автоімунних або респіраторних захворювань шляхом інгібування клітинної адгезії і пов'язаних з нею або таких, що є її наслідком, патогенних процесів, які згодом опосередковуються антигеном VLA-4.
UA2000127651A 1998-06-30 1999-05-31 Похідні сечовини, фармацевтична композиція і спосіб лікування або профілактики запальних, аутоімунних або респіраторних захворювань UA66864C2 (uk)

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PCT/IB1999/000973 WO2000000477A1 (en) 1998-06-30 1999-05-31 Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases

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