UA35559C2 - Фармацевтична композиція, продукт трансетерифікації кукурудзяної олії гліцерином та спосіб його одержання - Google Patents

Фармацевтична композиція, продукт трансетерифікації кукурудзяної олії гліцерином та спосіб його одержання

Info

Publication number
UA35559C2
UA35559C2 UA93003147A UA93003147A UA35559C2 UA 35559 C2 UA35559 C2 UA 35559C2 UA 93003147 A UA93003147 A UA 93003147A UA 93003147 A UA93003147 A UA 93003147A UA 35559 C2 UA35559 C2 UA 35559C2
Authority
UA
Ukraine
Prior art keywords
pharmaceutical composition
transetherification
glycerol
manufacture
product
Prior art date
Application number
UA93003147A
Other languages
English (en)
Russian (ru)
Inventor
Брігіт Хауер
Армін Майнцер
Ульріх Позанскі
Жеккі Фондершер
Original Assignee
Новартіс Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697415&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA35559(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартіс Аг filed Critical Новартіс Аг
Publication of UA35559C2 publication Critical patent/UA35559C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/04—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils
    • C11C3/06—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils with glycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Wood Science & Technology (AREA)
  • Medical Informatics (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fats And Perfumes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Confectionery (AREA)

Abstract

Винахід належить до нових фармацевтичних композицій. Пропонується фармацевтична композиція у вигляді мікроемульсії, що містить циклоспорин і носій, що складається з гідрофільної фази, ліпофільної фази і поверхнево-активної речовини. При цьому композиція містить 1-30 мас.% циклоспорину, носій включає як гідрофільну фазу 1,2-пропіленгліколь, як ліпофільну фазу – суміш моно-, ди- і тригліцеридів жирних кислот C12-C20, при такому вмісті компонентів в носії, мас.%: 1,2-пропіленгліколь 1-50 ліпофільна фаза 5-65 поверхнево-активна речовина 25-75
UA93003147A 1991-06-27 1993-06-18 Фармацевтична композиція, продукт трансетерифікації кукурудзяної олії гліцерином та спосіб його одержання UA35559C2 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919113872A GB9113872D0 (en) 1991-06-27 1991-06-27 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
UA35559C2 true UA35559C2 (uk) 2001-04-16

Family

ID=10697415

Family Applications (1)

Application Number Title Priority Date Filing Date
UA93003147A UA35559C2 (uk) 1991-06-27 1993-06-18 Фармацевтична композиція, продукт трансетерифікації кукурудзяної олії гліцерином та спосіб його одержання

Country Status (38)

Country Link
EP (2) EP0953630B1 (uk)
JP (2) JP2653958B2 (uk)
KR (3) KR0131064B1 (uk)
CN (1) CN1077798C (uk)
AT (1) AT403436B (uk)
AU (1) AU659460B2 (uk)
CA (2) CA2175842C (uk)
CH (2) CH684163A5 (uk)
CY (1) CY1906A (uk)
CZ (1) CZ281790B6 (uk)
DE (3) DE4244930C2 (uk)
DK (2) DK0539319T3 (uk)
EE (1) EE03108B1 (uk)
ES (2) ES2142818T3 (uk)
FI (2) FI109454B (uk)
FR (2) FR2678169B1 (uk)
GB (2) GB9113872D0 (uk)
GR (1) GR3032366T3 (uk)
HK (2) HK57196A (uk)
HU (1) HU216792B (uk)
IE (1) IE73662B1 (uk)
IL (3) IL118546A (uk)
IT (1) IT1254401B (uk)
LU (1) LU88138A1 (uk)
MX (1) MX9203236A (uk)
MY (1) MY109512A (uk)
NO (2) NO303964B1 (uk)
NZ (1) NZ243309A (uk)
PH (1) PH30337A (uk)
PT (2) PT539319E (uk)
RO (2) RO111021B1 (uk)
RU (1) RU2143919C1 (uk)
SA (1) SA92130213B1 (uk)
SK (1) SK278759B6 (uk)
TW (1) TW267943B (uk)
UA (1) UA35559C2 (uk)
UY (1) UY23864A1 (uk)
ZA (1) ZA924719B (uk)

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CN103120653B (zh) 2007-04-04 2015-09-30 希格默伊德药业有限公司 一种口服药物组合物
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Also Published As

Publication number Publication date
RU2143919C1 (ru) 2000-01-10
JP3420897B2 (ja) 2003-06-30
HUT62201A (en) 1993-04-28
CY1906A (en) 1992-06-24
ITRM920476A1 (it) 1993-12-23
GB2257359A (en) 1993-01-13
GR3032366T3 (en) 2000-04-27
FR2678169A1 (fr) 1992-12-31
HK57196A (en) 1996-04-12
FI922958A0 (fi) 1992-06-25
FR2685706B1 (uk) 1994-12-23
CA2175842C (en) 2002-05-07
DK0953630T3 (da) 2004-11-01
AU1852792A (en) 1993-03-11
EP0539319A3 (en) 1993-06-09
IT1254401B (it) 1995-09-14
FR2678169B1 (fr) 1994-08-26
IL102310A (en) 1997-03-18
HU9201975D0 (en) 1992-09-28
ES2227921T3 (es) 2005-04-01
ATA129892A (de) 1997-07-15
NO325267B1 (no) 2008-03-17
RO111021B1 (ro) 1996-06-28
JPH05186365A (ja) 1993-07-27
JP2653958B2 (ja) 1997-09-17
IL102310A0 (en) 1993-01-14
NO922506D0 (no) 1992-06-25
MY109512A (en) 1997-02-28
AU659460B2 (en) 1995-05-18
KR0131064B1 (ko) 1998-04-17
CA2175842A1 (en) 1992-12-28
HU216792B (hu) 1999-08-30
SK278759B6 (sk) 1998-02-04
PH30337A (en) 1997-04-02
CN1079907A (zh) 1993-12-29
EP0539319B1 (en) 1999-12-08
PT953630E (pt) 2004-11-30
EP0539319A2 (en) 1993-04-28
NO964382L (no) 1992-12-28
NO964382D0 (no) 1996-10-15
ZA924719B (en) 1993-12-27
FI961513A0 (fi) 1996-04-03
FR2685706A1 (fr) 1993-07-02
CA2072509C (en) 1996-07-30
FI922958A (fi) 1992-12-28
AT403436B (de) 1998-02-25
PT539319E (pt) 2000-05-31
IL118546A0 (en) 1996-10-16
CA2072509A1 (en) 1992-12-28
FI109454B (fi) 2002-08-15
DE4219526A1 (de) 1993-03-18
GB9113872D0 (en) 1991-08-14
IE73662B1 (en) 1997-06-18
EP0953630B1 (en) 2004-09-08
KR100231385B1 (en) 1999-11-15
HK157696A (en) 1996-08-30
UY23864A1 (es) 1995-05-29
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NZ243309A (en) 1995-02-24
LU88138A1 (fr) 1994-03-01
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KR930000113A (ko) 1993-01-15
IL118546A (en) 1998-09-24
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RO111110B1 (ro) 1996-06-28
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