UA27467C2 - ПОХІДНІ ІНДОЛУ ЯК 5-НТ<sub>1</sub> АГОНІСТИ ТА ПРОМІЖНІ СПОЛУКИ - Google Patents

ПОХІДНІ ІНДОЛУ ЯК 5-НТ<sub>1</sub> АГОНІСТИ ТА ПРОМІЖНІ СПОЛУКИ

Info

Publication number
UA27467C2
UA27467C2 UA94105899A UA94105899A UA27467C2 UA 27467 C2 UA27467 C2 UA 27467C2 UA 94105899 A UA94105899 A UA 94105899A UA 94105899 A UA94105899 A UA 94105899A UA 27467 C2 UA27467 C2 UA 27467C2
Authority
UA
Ukraine
Prior art keywords
present
indole derivatives
intermediates
relates
chiral carbon
Prior art date
Application number
UA94105899A
Other languages
English (en)
Russian (ru)
Inventor
Джон І. Мейкор
Джон И.. Мейкор
Мартін Дж. Уітс
Мартин Дж. Уитс
Original Assignee
Пфайзер Інк.
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Інк., Пфайзер Инк. filed Critical Пфайзер Інк.
Publication of UA27467C2 publication Critical patent/UA27467C2/uk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Даний винахід стосується індольних похідних і їхніх проміжних сполук. Активні сполуки даного винаходу можуть бути використані для лікування мігрені і інших розладів. Даний винахід стосується похідних індолів формули (I): (І), де R1 являє собою атом водню, метил, 2-метоксиетил, * – означає перший хіральний центр, # – означає другий хіральний центр, і, крім того, даний винахід стосується фармацевтично прийнятних солей описаних сполук. Ці сполуки можуть бути використані для лікування мігрені і інших розладів. До сполук даного винаходу також відносяться всі оптичні ізомери формули (I) (наприклад, R- і S-стереоізомери при будь-якому хіральному центрі), їх рацемічні, діастереомерні або епімерні суміші.
UA94105899A 1992-04-07 1993-03-10 ПОХІДНІ ІНДОЛУ ЯК 5-НТ<sub>1</sub> АГОНІСТИ ТА ПРОМІЖНІ СПОЛУКИ UA27467C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86473792A 1992-04-07 1992-04-07
PCT/US1993/001967 WO1993020073A1 (en) 1992-04-07 1993-03-10 Indole derivatives as 5-ht1 agonists

Publications (1)

Publication Number Publication Date
UA27467C2 true UA27467C2 (uk) 2000-09-15

Family

ID=25343950

Family Applications (1)

Application Number Title Priority Date Filing Date
UA94105899A UA27467C2 (uk) 1992-04-07 1993-03-10 ПОХІДНІ ІНДОЛУ ЯК 5-НТ<sub>1</sub> АГОНІСТИ ТА ПРОМІЖНІ СПОЛУКИ

Country Status (26)

Country Link
US (7) US5747501A (uk)
EP (1) EP0635017A1 (uk)
JP (1) JP2644088B2 (uk)
KR (1) KR0179072B1 (uk)
CN (2) CN1050841C (uk)
AU (1) AU670579B2 (uk)
BR (1) BR9306201A (uk)
CA (1) CA2133413C (uk)
CZ (1) CZ281763B6 (uk)
EG (1) EG20226A (uk)
FI (1) FI931558A (uk)
HR (1) HRP930752A2 (uk)
HU (1) HUT64062A (uk)
IL (1) IL105206A (uk)
MX (1) MX9302011A (uk)
MY (1) MY108909A (uk)
NO (1) NO303388B1 (uk)
NZ (1) NZ251086A (uk)
PL (1) PL172405B1 (uk)
RU (1) RU2101283C1 (uk)
SK (1) SK280193B6 (uk)
TW (1) TW341565B (uk)
UA (1) UA27467C2 (uk)
WO (1) WO1993020073A1 (uk)
YU (1) YU48931B (uk)
ZA (1) ZA932440B (uk)

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US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
CA2133413C (en) * 1992-04-07 2001-04-10 John Eugene Macor Indole derivatives as 5-ht1 antagonists
ES2070087B1 (es) * 1993-08-13 1996-02-16 Pfizer Derivados de indol
DK0716649T3 (da) * 1993-08-31 1999-02-08 Pfizer 5-Arylindolderivater
JPH10501212A (ja) * 1994-05-19 1998-02-03 メルク シヤープ エンド ドーム リミテツド ５−ｈｔ▲下１ｄ▼−アルファ作働薬としてのインドール−３−イルアルキルのピペラジン、ピペリジンおよびテトラヒドロピリジン誘導体
GB9415575D0 (en) * 1994-08-02 1994-09-21 Merck Sharp & Dohme Therapeutic agents
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
EP0796258A1 (en) * 1994-12-06 1997-09-24 MERCK SHARP &amp; DOHME LTD. Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists
PT848004E (pt) * 1995-07-31 2003-07-31 Shionogi & Co Derivados pirrolidina tendo actividade inibidora da fosfolipase a2
GB9519558D0 (en) * 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
US6051593A (en) * 1997-06-20 2000-04-18 Sugen, Inc. 3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors
EP1100501A4 (en) * 1998-06-30 2002-12-04 Lilly Co Eli PYRROLIDINE AND PYRROLIDINE DERIVATIVES INFLUENTING THE SYSTEMS ASSOCIATED WITH SEROTONIN
US6355672B1 (en) * 1998-08-07 2002-03-12 Takeda Chemical Industries, Ltd. Benzothiepin derivatives, process for the preparation of the same and uses thereof
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US6326388B1 (en) * 1999-12-21 2001-12-04 Celgene Corporation Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level
US7041697B2 (en) * 2002-09-12 2006-05-09 Wyeth Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan
CA2635010A1 (en) * 2005-12-30 2007-07-19 Amjad Ali Oxazolidinone derivatives as cetp inhibitors
BRPI0920354A2 (pt) * 2008-10-16 2017-06-27 Addex Pharmaceuticals Sa derivados de indol e benzomorfolina como moduladores de receptores de glutamato metabotrópicos
US20100217013A1 (en) * 2008-12-15 2010-08-26 Wenge Li Enantioselective process for the preparation of zolmitriptan
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神***病を処置するための方法および組成物
DK3447051T3 (da) * 2016-04-28 2022-01-17 Jiangsu Hengrui Medicine Co Fremgangsmåde til fremstilling af tyrosinkinaseinhibitor og derivat deraf
AU2021215709A1 (en) * 2020-02-04 2022-09-01 Mindset Pharma Inc. 3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders

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Also Published As

Publication number Publication date
MX9302011A (es) 1994-03-31
JP2644088B2 (ja) 1997-08-25
CA2133413C (en) 2001-04-10
IL105206A0 (en) 1993-07-08
BR9306201A (pt) 1998-06-23
CN1225362A (zh) 1999-08-11
KR950700906A (ko) 1995-02-20
RU2101283C1 (ru) 1998-01-10
US6150388A (en) 2000-11-21
EP0635017A1 (en) 1995-01-25
FI931558A (fi) 1993-10-08
US6436957B1 (en) 2002-08-20
NO943762D0 (no) 1994-10-06
US6387941B1 (en) 2002-05-14
CN1050841C (zh) 2000-03-29
US6465500B1 (en) 2002-10-15
YU48931B (sh) 2002-12-10
SK120694A3 (en) 1995-05-10
CN1082543A (zh) 1994-02-23
NO303388B1 (no) 1998-07-06
IL105206A (en) 1999-04-11
HUT64062A (en) 1993-11-29
SK280193B6 (sk) 1999-09-10
ZA932440B (en) 1994-10-05
AU670579B2 (en) 1996-07-25
CZ246494A3 (en) 1995-06-14
NZ251086A (en) 1996-09-25
MY108909A (en) 1996-11-30
TW341565B (en) 1998-10-01
CZ281763B6 (cs) 1997-01-15
HU9301003D0 (en) 1993-06-28
AU3789893A (en) 1993-11-08
EG20226A (en) 1997-12-31
US6387937B1 (en) 2002-05-14
KR0179072B1 (ko) 1999-03-20
YU23893A (sh) 1996-10-09
WO1993020073A1 (en) 1993-10-14
PL172405B1 (en) 1997-09-30
HRP930752A2 (en) 1994-10-31
FI931558A0 (fi) 1993-04-06
CN1083443C (zh) 2002-04-24
CA2133413A1 (en) 1993-10-14
US6410739B1 (en) 2002-06-25
RU94045897A (ru) 1996-09-10
NO943762L (no) 1994-10-06
US5747501A (en) 1998-05-05
JPH07504919A (ja) 1995-06-01

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